Search clinical trials for: PARP inhibition

Total 1739 results

National Eye Institute (NEI)

Completed

Vascular Remodeling and the Effects of Angiogenic Inhibition in Diabetic Retinopathy

Diabetic Retinopathy

United States
China Medical University Hospital

Unknown

The Variation of Movement Related Cortical Potential, Cortico-cortical Inhibition, and Motor Evoked Potential in Intracerebral Implantation of Antologous Peripheral Blood Stem Cells(CD34)in Old Ischemic Stroke

Stroke

Taiwan
Rijnstate Hospital

Completed

Short-term Effects of Aromatase Inhibition in Obese Men

Obesity | Hypogonadotrophic Hypogonadism

Netherlands
Massachusetts General Hospital
National Institute of Mental Health (NIMH)

Completed

Early Intervention for Children at Risk for Anxiety

Anxiety Disorder

United States
Assaf-Harofeh Medical Center

Unknown

Correlation Between CYP2C19 Genotype, Level Of Clopidogrel Metabolite And Platelet Inhibition Status

PRIMARY FOCUS:PATIENT THAT TAKE CLOPIDOGREL

Israel
National Heart, Lung, and Blood Institute (NHLBI)
Pediatric Heart Network

Completed

Trial of Angiotensin Converting Enzyme Inhibition in Infants With Single Ventricle--Pediatric Heart Network (ISV)

Heart Defects, Congenital | Heart Failure, Congestive

United States, Canada
AstraZeneca

Terminated

Oral AZD8165 After Single Oral Ascending Doses in Healthy Male Subjects

Thrombin Inhibition

United States
Hanmi Pharmaceutical Company Limited

Completed

Duration of P-glycoprotein Inhibition After Oral Administration of HM30181AK Tablet (PGP inhibitor)

Healthy

Korea, Republic of
Vrije Universiteit Brussel
Research Foundation Flanders

Unknown

Diffuse Noxious Inhibitory Controls (DNIC): Nociceptive Modulation and Interaction With Neurocognitive Performance in Chronic Pain

Chronic Pain | Fibromyalgia | Whiplash

Belgium
Vrije Universiteit Brussel

Completed

Influence of Painphysiolgy Education on the Pain Inhibition in Fibromyalgia

Fibromyalgia

Belgium
Vrije Universiteit Brussel
University Hospital, Antwerp; Universiteit Antwerpen; Research Foundation Flanders and other collaborators

Unknown

Pain Inhibition in Patients With Rheumatoid Arthritis and Central Sensitivity Syndromes

Arthritis, Rheumatoid | Fibromyalgia | Fatigue Syndrome, Chronic

Belgium
R&D Cardiologie

Completed

Platelet Inhibition and Transcranial Doppler (TCD)-Detected Microemboli During and After Carotid Artery Stenting (CAS) in Asymptomatic Patients Prior to Cardiac Surgery (IMPACT)

Carotid Stenosis

Netherlands
Centers for Disease Control and Prevention
PATH; World Health Organization; MCM Vaccines B.V.; Pan American Health Organization and other collaborators

Completed

Needle-free Jet Injection of Reduced-dose, Intradermal, Influenza Vaccine in >= 6 to < 24-month-old Children

Influenza

Dominican Republic
Uppsala University

Completed

Tailoring Of Platelet Inhibition to Avoid Stent Thrombosis (TOPAS-1)

Myocardial Infarction | Heart Diseases | Coronary Artery Disease | Acute Coronary Syndrome | Stent Thrombosis

Sweden
The Prince Charles Hospital
Sanofi; Merck Sharp & Dohme LLC

Completed

Tirofiban and Enoxaparin in High Risk Coronary Intervention

Acute Coronary Syndrome

Australia
Heidelberg University
Baxter Healthcare Corporation; Boehringer Ingelheim; Aventis Pharmaceuticals; European...

Completed

Effect of Strict Blood Pressure Control and ACE-Inhibition on Progression of Chronic Renal Failure in Pediatric Patients (ESCAPE)

Hypertension | Children | Chronic Renal Failure | Acquired Kidney Disease | Congenital Kidney Disease

Czech Republic, France, Germany, Hungary, Italy, Lithuania, Poland, Portugal, Serbia, Sweden, Switzerland, Turkey
US Department of Veterans Affairs
Muscular Dystrophy Association

Completed

Safety Study of Oral Sodium Phenylbutyrate in Subjects With ALS (Amyotrophic Lateral Sclerosis)

Amyotrophic Lateral Sclerosis

United States
Pfizer

Completed

A Pharmacokinetic (PK) Study Of PF-00299804 And Dextromethorphan In Healthy Volunteers

Healthy Volunteers

Belgium
Arete Therapeutics

Completed

Evaluation of Soluble Epoxide Hydrolase (s-EH) Inhibitor in Patients With Mild to Moderate Hypertension and Impaired Glucose Tolerance

Hypertension | Impaired Glucose Tolerance

United States
Gyeongsang National University Hospital

Completed

Adjunctive Cilostazol Versus High Maintenance-dose ClopidogrEL in Acute Myocardial Infarction (AMI) Patients According to CYP2C19 Polymorphism (ACCELAMI2C19)

Myocardial Infarction

Korea, Republic of
University of Pennsylvania
Bayer; National Institutes of Health (NIH)

Completed

Mechanism Based Resistance to Aspirin

Aspirin Resistance | Pharmacological Aspirin Non-responsiveness
University Health Network, Toronto
Anthera Pharmaceuticals

Completed

sPLA2 Inhibition to Decrease Enzyme Release After PCI Trial (SPIDER-PCI)

Coronary Artery Disease

Canada
University of Milan

Completed

Chronic Sildenafil Treatment in Heart Failure

Heart Failure

Italy
General Hospital of Beijing PLA Military Region
Chinese Academy of Sciences

Completed

Smoking Cessation Effect of Tea Filter Through Inhibition of Nicotine Receptor

Tobacco Cessation

China
Bp Consulting, Inc

Completed

Randomized, Double Blind Trial of Bromfenac BID (0.09%) as an Adjunct to Argon Laser Therapy in the Treatment of Diabetic Macular Edema.

Diabetic Macular Edema

United States
AstraZeneca

Completed

Open Label, Dose Escalation Phase I Study of AZD2281

Advanced Solid Malignancies

Japan
Università degli Studi di Ferrara

Completed

Efficacy of Abciximab Bolus Only Regimen in Providing Inhibition of Platelet Action Over Time (FABOLUS)

Acute Coronary Syndrome

Italy
Hospital de Clinicas de Porto Alegre

Unknown

Therapeutic Efficacy of Oral L-Ornithine-L-Aspartate on Minimal Encephalopathy (PORTOALEGRE)

Hepatic Encephalopathy

Brazil
vTv Therapeutics

Completed

Factor IX Inhibition in Thrombosis Prevention (The FIXIT Trial)

Embolism and Thrombosis | Hip Fractures | Venous Thromboembolism

Denmark, Czech Republic, Norway, Sweden
AstraZeneca
KuDOS Pharmaceuticals Limited

Completed

A Study to Assess the Safety and Pharmacokinetics of an Inhibitor of PARP in Combination With Dacarbazine

Melanoma Neoplasms

United States, United Kingdom
Gyeongsang National University Hospital

Unknown

Comparison of Platelet Inhibition With Adjunctive Cilostazol Versus High Maintenance-Dose Clopidogrel According to Hepatic Cytochrome 2C19 Allele (CYP2C19) Polymorphism (ACCEL2C19)

Coronary Artery Stenosis | Maximal Platelet Aggregation | Late Platelet Aggregation | High Post-Treatment Platelet Reactivity

Korea, Republic of
Rigel Pharmaceuticals

Completed

Treatment of Arthritis With Syk Kinase Inhibition (TASKI-1)

Rheumatoid Arthritis

United States, Mexico
University Hospital, Antwerp

Completed

Influence of Tonic and Burst Transcranial Magnetic Stimulation (TMS) Characteristics on Acute Inhibition of Subjective Tinnitus

Tinnitus

Belgium
University Hospital, Gentofte, Copenhagen
University of Copenhagen; Hvidovre University Hospital; Glostrup University Hospital...

Unknown

Influence of Glucagon Inhibition in Relation to the Anti-Diabetic Effect of Glucagon-Like Peptide-1 (GLP-1) in Patients With Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus
Sanofi
Bristol-Myers Squibb

Completed

Platelet Aggregation Inhibition in Children on Clopidogrel (PICOLO)

Blood Platelet Disorders | Congenital Heart Defects

United States, France, Canada, Germany, Italy, Belgium
Centre for Addiction and Mental Health
Canadian Psychiatric Research Foundation

Completed

Neural Inhibition as a Mechanism of Nicotine Dependence Among Persons With Schizophrenia

Smoking | Schizophrenia | Schizoaffective Disorder | Psychosis | Nicotine Dependence | Schizophreniform Disorders

Canada
Genentech, Inc.

Terminated

A Study of Intravenous INO-1001 Plus Oral Temozolomide to Evaluate Tolerability, Safety, and Pharmacokinetics in Patients With Melanoma

Melanoma
Immune Technologies & Medicine GmbH

Unknown

Combined Inhibition of Dipeptidyl Peptidase IV (DPIV/CD26) and Aminopeptidase N (APN/CD13) in the Treatment of Psoriasis

Psoriasis

Switzerland
University Hospital, Basel, Switzerland

Completed

Inhibition of Food Intake in Response to Oral GLP-1 and Peptide YY3-36

Anti Obesity Agent

Switzerland
AstraZeneca
KuDOS Pharmaceuticals Limited

Completed

Study Assessing Metabolism, Excretion and Pharmacokinetics of a Poly (ADP-Ribose) Polymerase (PARP) Inhibitor in Patients With Solid Metastatic Tumours

Neoplasm Metastasis

United Kingdom
Shenyang Northern Hospital

Completed

Effects of Atorvastatin Versus Pravastatin on Platelet Inhibition by Clopidogrel

Ischemic Heart Disease | Acute Coronary Syndromes

China
University of Florence
Tuscany Region

Unknown

Dual Antiplatelet Therapy Tailored on the Extent of Platelet Inhibition (DANTE)

Unstable Angina | NSTEMI

Italy
Assistance Publique - Hôpitaux de Paris

Completed

Effects of Sodium Intake on (PK/PD) Relationship of a Single Dose of a Renin Angiotensin System-Blocker

Healthy

France
University of Washington
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

Glycosphingolipid Inhibition and Spermatogenesis in Man: A Pilot Study (MIG 2) (MIG-2)

Contraception

United States
Novartis

Completed

Safety of AEB071 in Healthy Volunteers and to Compare the Ethnicity, Metabolic, and Safety Effects Between Caucasian and Japanese Healthy Subjects

Healthy

Canada
Medical University of Vienna

Completed

Is There a Difference in Flicker Induced Vasodilatation Between Smokers and Non-Smokers?

Ocular Physiology | Retina | Blood Flow Velocity

Austria
Innovative Medical

Completed

Aqueous Concentrations and PGE2 Inhibition of Ketorolac 0.4% vs. Bromfenac 0.09% in Cataract Patients: Trough Drug Effects

Cataract

United States
Franklin D. Gaylis, MD Inc.

Completed

Treatment of Refractory Urinary Retention Secondary to Benign Prostatic Hyperplasia (BPH) With Dual Five Alpha Reductase Inhibition Combined With an Alpha Blocker (AUR)

Benign Prostatic Hyperplasia | Urinary Retention
Regional Hospital Holstebro

Completed

Short Term Effects of HMG-CoA Reductase Inhibition (Atorvastatin)on Renal Hemodynamics, Tubular Function and Vasoactive Hormones on Healthy Subjects

Healthy

Denmark
Regional Hospital Holstebro

Completed

Acute Effect of HMG-CoA Reductase Inhibition (Atorvastatin)on Renal Hemodynamics, Tubular Function and Vasoactive Hormones on Healthy Subjects

Healthy

Denmark

Search clinical trials for: PARP inhibition

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