Search clinical trials for: "First-in-Human"

Total 302447 results

Bayer

Completed

First-in-human Study of ATR Inhibitor BAY1895344 in Patients With Advanced Solid Tumors and Lymphomas

Non-Hodgkin's Lymphoma | Mantle Cell Lymphoma | Advanced Solid Tumor

United States, Canada, China, Japan, Singapore, United Kingdom, Switzerland
International Vaccine Institute
Bill and Melinda Gates Foundation; SK Bioscience Co., Ltd.

Completed

Safety, Reactogenicity and Immunogenicity of Vi-DT;Typhoid Conjugate Vaccine

Typhoid

Philippines
Aelix Therapeutics

Completed

Safety and Immunogenicity Study of DNA.HTI, MVA.HTI and ChAdOx1.HTI in HIV-1-positive Patients (AELIX-002)

HIV

Spain
Pfizer

Completed

A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single Doses of PF-06852231 in Healthy Subjects

Healthy Volunteers

Belgium
GlaxoSmithKline

Completed

Phase I Study to Evaluate Safety, Pharmacokinetics and Pharmacodynamics of GSK2256098 in Healthy Volunteers (FTIH)

Cancer

Australia
GlaxoSmithKline

Completed

A Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of GSK2330811 in Healthy Subjects

Scleroderma, Systemic

United Kingdom
Bristol-Myers Squibb

Recruiting

A Study to Evaluate the Safety, Tolerability and Drug Levels of BMS-986454 in Healthy Participants

Healthy Participants

United Kingdom
GlaxoSmithKline

Completed

Safety, Tolerability and Pharmacokinetics (PK) Investigation of GSK3494245 in Healthy Participants

Leishmaniasis

United Kingdom
ViiV Healthcare

Completed

GSK3739937 First-Time-In-Human (FTIH) Study in Healthy Volunteers

HIV Infections

United States
Rockefeller University

Completed

First-in-human Study of 10-1074-LS Alone and in Combination With 3BNC117-LS

Human Immunodeficiency Virus

United States
Rockefeller University

Completed

3BNC117-LS First-in-Human Phase 1 Study

Human Immunodeficiency Virus

United States
Alios Biopharma Inc.

Completed

A Study of Orally Administered JNJ-440 to Evaluate the Safety, Tolerability, and Pharmacokinetics After Single Ascending Doses Including Food Effect Evaluation; After Multi-Day Dosing in Healthy Participants; and After Multiple (Ascending) Doses in Participants With Chronic Hepatitis B

Chronic Hepatitis B

Korea, Republic of, Moldova, Republic of, New Zealand, Thailand, Ukraine
AstraZeneca
Parexel

Completed

A Study to Evaluate the Safety, Tolerability and Absorption to the Blood After Administration of Single and Multiple Doses of AZD8154 in Healthy Participants.

Asthma

Germany
GlaxoSmithKline

Completed

Anti-MAG First Administration to Human

Cerebrovascular Accident

United States, Australia
BioCryst Pharmaceuticals

Completed

First-in-Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BCX7353 in Healthy Western and Japanese Volunteers

Hereditary Angioedema

United Kingdom
BlueWillow Biologics
Porton Biopharma Ltd.

Completed

A Safety and Immunogenicity of Intranasal Nanoemulsion Adjuvanted Recombinant Anthrax Vaccine in Healthy Adults (IN NE-rPA)

Anthrax

United States
Hospitales Universitarios Virgen del Rocío

Unknown

COmparing CeNters ThRombectomy Aspiration STentretriever (CONTRAST)

Acute Stroke

Spain
State University of New York - Upstate Medical...
Walter Reed Army Institute of Research (WRAIR); U.S. Army Medical Research...

Completed

Dengue 3 Human Infection Model (DENV-3)

Dengue

United States
Gliknik Inc.

Recruiting

Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study in Healthy Male and Female Subjects and Safety, Tolerability, Pharmacokinetics, and Pilot Efficacy Biomarkers in Subjects With Cold Agglutinin Disease

First in Man Study to Evaluate Initial Safety

United Kingdom
Circadian Technologies Ltd.

Completed

Study of VGX-100 Administered Alone and Co-administered With Bevacizumab in Adult Subjects With Advanced Solid Tumors

Neoplasms | Cancer

United States
Ostfold University College

Active, not recruiting

Intervention for Low-performing First Graders in Mathematics

Mathematics Disorder

Norway
SpectraWAVE, Inc.

Completed

First in Human Study

Coronary Artery Disease

Colombia
State University of New York - Upstate Medical...
U.S. Army Medical Research and Development Command; Janssen Pharmaceutica N...

Completed

Expansion of a Dengue-1 Live Virus Human Challenge

Dengue

United States
Ankara Medipol University

Completed

The Effect of Psychoeducation on Hopelessness, Death Anxiety and Caregiver Burden

Support, Family

Turkey
Amnon Zung

Unknown

First-Voided Urinary LH vs. GnRH-stimulation in Differentiating Slowly- From Rapidly Progressive-Precocious Puberty

Precocious Puberty, Gonadotropin-dependent

Israel
Technical University of Munich

Completed

SUbstition of PERioperative Albumin Deficiency Disorders (SUPERADD)

Hypoalbuminemia

Germany
University of Calgary
International Society of Psychiatric-Mental Health Nurses

Completed

Evaluation of the First Pathways Game on Parent-child Interactions and Development for Vulnerable Children

Internet-Based Intervention

Canada
InnoVital Systems, Inc.
Medstar Health Research Institute

Completed

SureCRIC Standardized Patient Study

Airway Obstruction

United States
HK inno.N Corporation

Completed

Clinical Trial to Evaluate the Safety and Efficacy of IN-C006 Inj. Compared With RCN301

Parenteral Nutrition

Korea, Republic of
University of California, San Francisco
California Institute for Regenerative Medicine (CIRM)

Enrolling by invitation

In Utero Hematopoietic Stem Cell Transplantation for Alpha-thalassemia Major (ATM)

Hemoglobinopathies | Alpha Thalassemia Major | Thalassemia Major | Fetal Hydrops | Hemoglobinopathy; With Thalassemia | Fetal Anemia | Alpha; Thalassemia | Thalassemia Alpha | A-Thalassemia

United States
Assiut University

Completed

Ozone Therapy in the Treatment of Digital Ulcers in Patients With Systemic Sclerosis

Ulcer | Scleroderma
Logical Therapeutics
PRA Health Sciences

Completed

Rates of Gastric Ulcer by Endoscopy in Knee Osteoarthritis Patients Receiving LT-NS001 Versus Naprosyn®

Osteoarthritis

United States
Institut Paoli-Calmettes
INATHERYS

Recruiting

Study of Escalating Doses of INA03 Administered Intravenously as Single Agent in Adult Patients With Relapse/Refractory Acute Leukemia (INA03)

Acute Lymphoblastic Leukemia, in Relapse | Acute Myeloid Leukemia, in Relapse | Mixed Phenotype Acute Leukemia | Acute Lymphoblastic Leukemia Recurrent | Acute Myeloid Leukaemia Recurrent

France
Food and Drug Administration (FDA)
National Eye Institute (NEI)

Completed

Patient Reported Outcomes With LASIK: PROWL-2 (PROWL-2)

Laser in Situ Keratomileusis

United States
BlueWillow Biologics
National Institute of Allergy and Infectious Diseases (NIAID); University of...

Active, not recruiting

A Safety and Immunogenicity of Intranasal Nanoemulsion Adjuvanted Recombinant Pandemic Flu Vaccine in Healthy Adults (IN-NE-rH5)

Influenza, Pandemic

United States
Birmingham Women's and Children's NHS Foundation...

Active, not recruiting

Amino Acid Kinetics of GMP-AA in Healthy Human Volunteers

Phenylketonurias

United Kingdom
University of Zurich

Unknown

Effects of OXY111A in Primary and Secondary Hepato-Pancreato-Biliary Neoplasm (OXY1A)

Colorectal Neoplasms | Pancreatic Neoplasms | Cholangiocarcinoma | Hepatocellular Cancer

Switzerland
University Hospital, Geneva
Oncovir, Inc.; Immatics Biotechnologies GmbH

Completed

Phase I/II Trial of IMA950 Multi-peptide Vaccine Plus Poly-ICLC in Glioblastoma

CNS Tumor, Adult

Switzerland
Assiut University

Unknown

Progesterone and Doppler in Recurrent Abortion

Abortion in First Trimester

Egypt
Centre for Evidence-Based Practice, Belgium
Belgian Red Cross; Rwanda Red Cross

Active, not recruiting

The Impact of First Aid Blended Learning Training on Learning Outcomes and Helping Behaviour of Adult Laypeople in Rwanda

Emergencies | Injuries | Illness Physical

Rwanda
Gaziantep Islam Science and Technology University
Adiyaman University Research Hospital

Completed

Effects of Web-Based Training on HbA1c, Quality of Life and Depression Levels in Adolescents With Type 1 Diabetes

Behavioral Symptoms | Problem Behavior | Mental Disorder in Adolescence

Turkey
Azienda Ospedaliera Cardinale G. Panico

Completed

Rate RESPONSIVe Pacing in Patients With Permanent AF Underwent AV Node ABLation and bivEntricular Pacing (RESPONSIBLE) (RESPONSIBLE)

Atrial Fibrillation | Left Ventricular Dysfunction

Italy
Statens Serum Institut
Bill and Melinda Gates Foundation; Aurum Institute; Leiden University Medical... and other collaborators

Recruiting

First-in-Human Trial of the Novel Tuberculosis Vaccine Candidate, H107e/CAF®10b (nTB-01)

Healthy

South Africa
GlaxoSmithKline

Recruiting

A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of Oral GSK4172239D Compared With Placebo in Sickle Cell Disease Participants Aged 18 to 50 Years

Hematologic Diseases | Anaemia, Sickle Cell

United States
AstraZeneca

Recruiting

First in Human Study of AZD9592 in Solid Tumors (EGRET)

Head and Neck Neoplasms | Colorectal Neoplasms | Advanced Solid Tumours | Carcinoma Non-small Cell Lung

United States, China, Korea, Republic of, Spain, Australia, Japan, Malaysia, Taiwan, Canada, France, Italy
AstraZeneca

Completed

A Study to Assess the Safety, Tolerability, and Pharmacokinetics of AZD5462 Following Single and Multiple Ascending Dose Administration to Healthy Volunteers

Healthy Participants

United States
Theravance Biopharma

Completed

Single Ascending Dose Study of TD-0714 in Healthy Subjects

Healthy

United States
MyMD Pharmaceuticals, Inc.

Completed

Single Ascending-dose Study to Evaluate Safety, Tolerability, and PK of MYMD1 in Healthy Male Adult Subjects

Undefined

United States
GlaxoSmithKline

Completed

Open-label Study to Investigate the Safety, PK, and Pharmacodynamics of GSK1120212 in Subjects With Solid Tumors or Lymphoma

Solid Tumours

United States
Ono Pharma USA Inc

Completed

Single-Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ONO-2952 in Healthy Adult Subjects

Healthy Adult Subjects

United States

Search clinical trials for: "First-in-Human"

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