Search clinical trials for: DAA therapy

Total 52716 results

Institut de Recherches Cliniques de Montreal

Withdrawn

Closed-loop Control of Glucose Levels (Artificial Pancreas) for 5 Days in Adults With Type 1 Diabetes

Type 1 Diabetes

Canada
Masonic Cancer Center, University of Minnesota

Terminated

Donor Umbilical Cord Blood Natural Killer Cells, Aldesleukin and Umbilical Cord Blood Transplant in Patients With Refractory Hematologic Cancers.

Myelodysplastic Syndromes | Leukemia

United States
ViiV Healthcare
GlaxoSmithKline

Terminated

Dose-finding Study of GSK2248761 in Antiretroviral Therapy-Naive Subjects (SIGNET) (SIGNET)

Infection, Human Immunodeficiency Virus

Spain, France, Germany
Kaohsiung Veterans General Hospital.

Completed

Concomitant, Sequential, and Standard Triple Therapy for H. Pylori Infection

Helicobacter Pylori Infection

Taiwan
ViiV Healthcare
GlaxoSmithKline

Terminated

Dose-finding Study of GSK2248761 in Antiretroviral Therapy-experienced Subjects With NNRTI-resistant HIV Infection (SONNET)

Infection, Human Immunodeficiency Virus

United States, Canada, Italy, Belgium, Romania
Hospices Civils de Lyon

Completed

Benefit of DAA Therapy in HCV Monoinfected and HIV-HCV Coinfected Patients With Mixed Cryoglobulinemia

Hepatitis C, Chronic | Mixed Cryoglobulinemia

France
University of British Columbia
Gilead Sciences

Completed

Elvitegravir/Cobicistat/Tenofovir DF/Emtricitabine With Darunavir Treatment Simplification Strategy (QuaDar)

HIV Infection

Canada
Institut de Recherches Cliniques de Montreal
Juvenile Diabetes Research Foundation

Withdrawn

Closed-loop Control of Postprandial Glucose Levels in Children and Adults With Type 1 Diabetes

Type 1 Diabetes

Canada
OHSU Knight Cancer Institute
National Cancer Institute (NCI)

Terminated

Donor Stem Cell Transplant or Donor White Blood Cell Infusions in Treating Patients With Hematologic Cancer

Lymphoma | Myelodysplastic Syndromes | Leukemia | Chronic Myeloproliferative Disorders | Multiple Myeloma and Plasma Cell Neoplasm | Myelodysplastic/Myeloproliferative Neoplasms | Unusual Cancers of Childhood

United States
Postgraduate Institute of Medical Education and...

Completed

Role of Midodrine and Tolvaptan in Patients With Cirrhosis With Refractory or Recurrent Ascites

Cirrhosis | Refractory/Recurrent Ascites

India
AbbVie

Completed

A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of ABT-493 and ABT-530 With and Without Ribavirin in Adults With HCV Who Failed a Prior DAA Containing Therapy

Chronic Hepatitis C | Hepatitis C Virus | HCV | Direct-Acting Antiviral Agent (DAA)-Experienced
Klemens Budde
Charite University, Berlin, Germany; DESCARTES Working Group On Transplantation and other collaborators

Unknown

Efficacy and Safety of a Reduced Immunosuppression vs. Standard Triple Therapy in Senior Renal Transplant Recipients (REDUCE)

Immunosuppression After Renal Transplantation
PD Dr. med. Volker Heinemann
Boehringer Ingelheim

Unknown

Afatinib as Cancer Therapy for Exocrine Pancreatic Tumours (ACCEPT)

Focus of Study Instead

Germany
Soroka University Medical Center

Completed

The Influence of Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers on Renal Function in Patients Undergoing Non-emergent Coronary Angiography

Blood Pressure

Israel
GlaxoSmithKline
The TIMI Study Group

Completed

A Phase 3 Clinical Outcomes Study to Compare the Incidence of Major Adverse Cardiovascular Events in Subjects Presenting With Acute Coronary Syndrome Treated With Losmapimod Compared to Placebo (LATITUDE-TIMI 60) (LATITUDE)

Acute Coronary Syndrome

United States, Australia, France, Spain, Taiwan, Estonia, Poland, Russian Federation, Belgium, Philippines, Sweden, Thailand, Germany, Israel, Bulgaria, Hong Kong, Netherlands, Norway, Slovakia, South Africa, Korea, Republic of, R... and more
Ain Shams University

Completed

Early Treatment of Recurrent HCV- Infection Post Liver Transplantation in the Era of DAAs

Liver Transplantation
Kirby Institute
Janssen-Cilag Ltd.

Completed

DAA Based Therapy for Recently Acquired Hepatitis C (DARE-C) (DARE-C)

Hepatitis C, Chronic

Australia
European Mantle Cell Lymphoma Network
Nordic Lymphoma Group; HOVON - Dutch Haemato-Oncology Association; Lymphoma Study... and other collaborators

Unknown

Induction Chemotherapy (R-CHOP Vs. R-FC) Followed by Interferon Maintenance Versus Rituximab Maintenance in MCL (MCLelderly)

Lymphoma, Mantle-Cell

Czech Republic, Denmark, France, Germany, Italy, Netherlands, Poland
GlaxoSmithKline

Completed

Benign Prostatic Hyperplasia Trial With Dutasteride And Tamsulosin Combination Treatment

Prostatic Hyperplasia

United States, Netherlands, Spain, Taiwan, Bulgaria, Estonia, Hungary, Italy, Belgium, Thailand, Israel, Germany, Canada, Korea, Republic of, Norway, Finland, Russian Federation, Romania, Brazil, France, Slovakia, Philippines, South... and more
Novartis

Completed

Efficacy of add-on Therapy With Vildagliptin in Chinese Patients With Type 2 Diabetes Inadequately Controlled With Prior Metformin Monotherapy

Type 2 Diabetes Mellitus

China
Valme University Hospital
Hospital Universitario de Canarias; Hospital Universitario Virgen Macarena; Hospital... and other collaborators

Unknown

Real-life Security and Efficacy of DAA-based Therapy in HCV/HIV-Coinfected Patients

Hepatitis C, Chronic | Human Immunodeficiency Virus

Spain
Columbia University

Withdrawn

Therapy for Chronic Fatigue Syndrome: A Presumptive Mitochondrial Disorder

Chronic Fatigue Syndrome

United States
German CLL Study Group

Completed

Combination Chemotherapy, Total-Body Irradiation, and Alemtuzumab in Treating Patients Undergoing an Autologous Stem Cell Transplant for Stage I, Stage II, Stage III, or Stage IV Chronic Lymphocytic Leukemia

Chronic Lymphocytic Leukemia

Germany
University of Regensburg

Unknown

Immune Monitoring of Hepatitis C Under DAA Therapy (IMHC)

Hepatitis C

Germany
Livzon Pharmaceutical Group Inc.

Completed

Efficacy and Safety of 1-week Triple Therapy With Ilaprazole for the Eradication of Helicobacter Pylori

Helicobacter Pylori Eradication
Novartis Pharmaceuticals

Terminated

This Study Will Evaluate the Efficacy and Safety of LCZ696 Compared to Enalapril on Morbidity and Mortality of Patients With Chronic Heart Failure (PARADIGM-HF)

Heart Failure With Reduced Ejection Fraction

China, Germany, United States, Colombia, Korea, Republic of, Romania, South Africa, Canada, Belgium, Estonia, Hungary, Italy, Russian Federation, Taiwan, Turkey, United Kingdom, Spain, France, Netherlands, Hong Kong, Bulgaria, Israel and more
ANRS, Emerging Infectious Diseases
Institut National de la Santé Et de la Recherche Médicale, France; University... and other collaborators

Completed

Evaluation of Simplified Antiretroviral Treatment Strategies in HIV Infected Children Treated by Antiretroviral (ARV) Before One Year of Age

HIV Infections

Burkina Faso, Côte D'Ivoire
Ruhr University of Bochum

Completed

Wound Dressings Adapted to Wound Exudate and Bacterial Load in Therapy Resistant Large Sized Leg Ulcers

Varicose Ulcer

Germany
Humanity and Health Research Centre
Emory University; Beijing 302 Hospital

Completed

Triple DAAs Regimen in Treating Non-cirrhotic HCV GT1b Subjects

Chronic Hepatitis C Infection

China
Memorial Sloan Kettering Cancer Center
Pfizer; Dana-Farber Cancer Institute; University of Pittsburgh; University of Virginia

Completed

Phase II Trial of Sunitinib (SU011248) in Patients With Recurrent or Inoperable Meningioma

Neurofibromatosis | Meningioma | CNS Cancer | Hemangioblastoma | Intracranial Hemangiopericytoma

United States
Singapore Clinical Research Institute
Singapore General Hospital; Duke-NUS Graduate Medical School

Terminated

The Effect of 90-day Oral Testosterone Therapy in Chinese Males With Type 2 Diabetes (T2DM) (OTEST)

Assess the Effects of a the 90-day Oral TS Study Regimen on PSA, IPSS, Haemoglobin and Haematocrit, and to Assess Adverse and Serious Adverse Events.

Singapore
Kaohsiung Veterans General Hospital.
Baylor College of Medicine

Completed

Comparison of Sequential or Concomitant Therapy for Helicobacter Pylori Infection (960025)

Helicobacter Infection

Taiwan
Kaohsiung Veterans General Hospital.
Baylor College of Medicine; Kaohsiung Medical University

Completed

Sequential and Hybrid Therapies for H Pylori Infection

Helicobacter Pylori Infection

Taiwan
City of Hope Medical Center
National Cancer Institute (NCI)

Terminated

Total Marrow and Total Lymph Node Irradiation, Fludarabine, and Melphalan Followed By Donor Stem Cell Transplant in Treating Patients With Advanced Hematological Cancer That Has Not Responded to Treatment

Lymphoma | Myelodysplastic Syndromes | Leukemia | Chronic Myeloproliferative Disorders | Multiple Myeloma and Plasma Cell Neoplasm | Myelodysplastic/Myeloproliferative Neoplasms

United States
Massachusetts General Hospital

Terminated

Extended Duration Nicotine Replacement Therapy and Bupropion in Smokers With Schizophrenia

Schizophrenia | Nicotine Dependence

United States
Johns Hopkins University
National Institute on Drug Abuse (NIDA)

Completed

Directly Administered HIV Therapy in Methadone Clinics

HIV Infections | Heroin Dependence

United States
Johns Hopkins University
National Institute on Drug Abuse (NIDA)

Withdrawn

Directly Administered Antiretroviral Therapy (DAART) Among HIV-1infected Injecting Drug Users (IDUs) in Chennai, India (DAART+)

HIV Infections | Heroin Dependence

India
Baylor College of Medicine

Completed

Fludarabine, Cyclophosphamide, and Alemtuzumab in Treating Patients With Recurrent or Metastatic Renal Cell Carcinoma (Kidney Cancer) Undergoing Allogeneic Stem Cell Transplantation

Kidney Cancer

United States
Boehringer Ingelheim
Pfizer

Completed

Comparison of Two Daily Dose Regimens of Tiotropium 5 µg Once Daily and Tiotropium 2.5 µg Twice Daily for 4 Weeks on Top of Maintenance Therapy With Inhaled Corticosteroid Controller Medication

Asthma

Austria, Germany, Hungary, Slovenia
Changi General Hospital

Completed

RCT: Triple vs Sequential vs Concomitant Therapy H Pylori

Bacterial Infection Due to Helicobacter Pylori (H. Pylori)

Singapore
Boehringer Ingelheim

Completed

Phase II Trial of BIBW 2992 in Patients With HER2-positive Metastatic Breast Cancer After Failure of Trastuzumab Therapy

Breast Neoplasms

United States, United Kingdom
Medical Research Council
GlaxoSmithKline; Department for International Development, United Kingdom; ViiV...

Completed

Efficacy Study of Different Laboratory Management Strategies and Drug Regimens in HIV-infected Children in Africa (ARROW)

Human Immunodeficiency Virus

Uganda, Zimbabwe
Milton S. Hershey Medical Center

Unknown

Umbilical Cord Blood for Stem Cell Transplantation in Treating Young Patients With Malignant or Nonmalignant Diseases

Sarcoma | Lymphoma | Unspecified Childhood Solid Tumor, Protocol Specific | Myelodysplastic Syndromes | Leukemia | Fanconi Anemia | Neuroblastoma | Childhood Langerhans Cell Histiocytosis

United States
PENTA Foundation
Medical Research Council; ANRS, Emerging Infectious Diseases

Completed

KONCERT A Kaletra ONCE Daily Randomised Trial of the Pharmacokinetics, Safety and Efficacy of Twice-daily Versus Once-daily Lopinavir/Ritonavir Tablets Dosed by Weight as Part of Combination Antiretroviral Therapy in Human Immunodeficiency Virus-1 (HIV-1) Infected Children (PENTA 18) (KONCERT)

Antiretroviral Therapy in HIV-1 Infected Children

Netherlands, Germany, United Kingdom, Ireland, Thailand
Duke University
Philip Morris USA, Inc.

Completed

Evaluation of a Tailored Smoking Cessation Treatment Algorithm Based on Initial Treatment Response and Genotype (ConNic3)

Smoking Cessation

United States
Arbeitsgemeinschaft medikamentoese Tumortherapie
Roche Pharma AG; Celgene Corporation

Completed

Lenalidomide Dose Escalation Combined With Rituximab/Fludarabine in Untreated CLL

Leukemia, Lymphocytic, Chronic, B-Cell

Austria
Taunton and Somerset Hospital

Completed

Chlorambucil or Fludarabine as First-Line Therapy in Treating Patients With Previously Untreated Waldenström Macroglobulinemia, Splenic Lymphoma, or Lymphoplasmacytic Lymphoma

Lymphoma

Australia, United Kingdom
Sun Yat-sen University

Unknown

Chemoembolization With or Without Antiviral Therapy for Unresectable HBV-related HCC With Low HBV DNA Replication

Hepatocellular Carcinoma

China
Fox Chase Cancer Center
National Cancer Institute (NCI)

Withdrawn

Peripheral Stem Cell Transplantation in Treating Patients With Metastatic or Recurrent Kidney Cancer

Kidney Cancer
National Cancer Institute (NCI)

Terminated

Vaccine Therapy With or Without Interleukin-2 After Chemotherapy and an Autologous White Blood Cell Infusion in Treating Patients With Metastatic Melanoma

Recurrent Melanoma | Stage IV Melanoma

United States

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