Search clinical trials for: Front-line treatment

Total 63186 results

GeneCradle Inc

Recruiting

Evaluation of Safety and Efficacy of Gene Therapy Drug in the Treatment of Spinal Muscular Atrophy (SMA) Type 3 Patients

Spinal Muscular Atrophy Type 3

China
Shanghai Jiao Tong University School of Medicine

Recruiting

Epidemiological Investigation of Helicobacter Pylori-infected Patients and the Effect of Eradication Treatment on Dyspepsia Symptoms

Dyspepsia | Helicobacter Pylori Infection

China
Regeneron Pharmaceuticals

Not yet recruiting

A Study to Test the Safety, Tolerability, and Efficacy of an Antibody, REGN7999, Injected Under the Skin for the Treatment of Iron Overload in Adult Participants With Non-Transfusion Dependent β-thalassemia, Using MRI Scans to Measure Iron Levels in the Body (FERVENT-1)

Non-transfusion Dependent Beta-thalassemia (NTDT)
Jorge Javier Osma López
Hospital General Universitario de Castellón; Hospital Universitario La Plana...

Not yet recruiting

Online Prevention of Emotional Disorders in Women Undergoing Fertility Treatments (RE-FER moodle)

Infertility | Emotional Disorder | Anxiety Depression

Spain
British University In Egypt

Not yet recruiting

Efficacy of Thyme Honey in The Management of Oral Aphthous Ulcers

Treatment Compliance | Aphthous Stomatitis (Major) (Minor)

Egypt
Zhejiang Chinese Medical University

Recruiting

A Randomized Controlled Study on the Treatment of Postherpetic Neuralgia in the Head and Face With Superficial Needling Combined With Electroacupuncture

Postherpetic Neuralgia | Electroacupuncture | Infrared Thermography

China
Lan Zhu

Not yet recruiting

A Randomized Controlled Trail of Uterosacral Ligament Suspension in the Treatment of Pelvic Organ Prolapse

Pelvic Organ Prolapse
Lan Zhu

Not yet recruiting

A Randomized Controlled Trial of Modified Ischial Spinous Fascia Fixation and Sacrospinous Ligament Fixation in the Treatment of Pelvic Organ Prolapse

Pelvic Organ Prolapse
Changhai Hospital
Shanghai 10th People's Hospital; Ruijin Hospital; Shanghai Ninth People's Hospital... and other collaborators

Not yet recruiting

Real-World Clinical Study on the Efficacy of Vibrating Capsule (Vibrabot Capsule) for Chronic Functional Constipation (RWS-VC)

Clinical Study | Chronic Functional Constipation

China
Biohaven Therapeutics Ltd.

Recruiting

BHV-7000 Acute Treatment of Bipolar Mania

Bipolar Disorder

United States
Pfizer

Not yet recruiting

A Study to Understand How Effective is Tofacitinib When Compared to Other Advanced Treatments in Patients With Rheumatoid Arthritis

Rheumatoid Arthritis
Zhujiang Hospital

Recruiting

The Correlation of Intracranial Artery Calcification and Outcomes of Mechanical Thrombectomy (CAIS-MT)

Vascular Diseases | Stroke | Cerebrovascular Disorders | Brain Diseases | Central Nervous System Diseases | Nervous System Diseases | Ischemic Stroke | Stroke, Acute | Intracranial Arterial Calcification

China
Hanoi Medical University

Recruiting

Efficacy of Combining Low Level Laser Therapy With Cognitive-behavioral Therapy on Myalgia in Temporomandibular Joint Disorders

Temporomandibular Joint Disorders

Vietnam
Beijing 302 Hospital

Not yet recruiting

Adebrelimab Plus Apatinib and Etoposide for the Treatment of HER2-Negative Breast Cancer Brain Metastasis

HER2-negative Breast Cancer Brain Metastases

China
Mannkind Corporation

Not yet recruiting

ICoN-1 Phase 3 Study of the Efficacy and Safety of Treatment With MNKD-101, Clofazimine Inhalation Suspension (ICoN-1)

Mycobacterium Infections, Nontuberculous | MAC Lung Disease | Treatment Refractory MAC Lung Disease

United States
Second Affiliated Hospital, School of Medicine,...

Recruiting

Efficacy and Safety Trial of Using Ultra-Pulsed Shockwaves to Deliver Tranexamic Acid for the Treatment of Melasma

Chloasma

China
University of Cologne
AstraZeneca

Not yet recruiting

Maintenance Durvalumab (MEDI4736) and Olaparib (AZD2281) After Standard 1st Line Treatment (Carboplatin/Cisplatin, Etoposide, Durvalumab) in HRD Positive Extensive Disease (ED) Small-cell Lung Cancer (SCLC) (GUIDANCE)

Small Cell Lung Carcinoma
China-Japan Friendship Hospital

Recruiting

Combining Chinese Medicine and Nutrition to Enhance Weight Loss After Bariatric Surgery

Weight Change | Traditional Chinese Medicine Treatment

China
Zhejiang University
Gracell Biotechnology Shanghai Co., Ltd.

Recruiting

An Exploratory Clinical Study of GC012F Injection for the Treatment of Refractory Generalized Myasthenia Gravis

Refractory Generalized Myasthenia Gravis

China
University Hospital, Toulouse

Not yet recruiting

Leukocyte- and Platelet-Rich Fibrin in the Surgical Treatment of Medication-related Osteonecrosis of the Jaw (PeRFOrMand)

Osteonecrosis of the Jaw

France
Jay Alberts

Recruiting

Dual-task Augmented Reality for PD DBS (DART for DBS)

Parkinson's Disease | Deep Brain Stimulation

United States
Biotheus Inc.

Not yet recruiting

PM8002 or Placebo Plus Nab-Paclitaxel as First-line Treatment in Inoperable Locally Advanced/Metastatic Triple-negative Breast Cancer

Triple Negative Breast Cancer(TNBC)

China
VA Office of Research and Development

Not yet recruiting

Ketamine-assisted Integrative Treatment for Veterans With Chronic Low Back Pain and Comorbid Depression

Depression | Chronic Low Back Pain

United States
University of Las Palmas de Gran Canaria

Recruiting

Usefulness of NESA Microcurrents in the Treatment of Children With Autism Spectrum Disorders

Autism Spectrum Disorder

Spain
Cancer Institute and Hospital, Chinese Academy...

Not yet recruiting

Fruquintinib and Albumin-paclitaxel Combined With or Without PD-1 Antibody in 2nd-line Treatment of G/GEJ Adenocarcinoma

Gastric Cancer
Federal University of Rio Grande do Sul

Not yet recruiting

Efficacy of Photobiomodulation in the Treatment and Relief of Pain in Recurrent Aphthous Stomatitis

Stomatitis, Aphthous | Photobiomodulation
Sormland County Council, Sweden
Eskilstuna municipality

Not yet recruiting

Behavioral Activation for the Prevention and Treatment of Depression in Older Adults in a Municipal Context (DePrevent)

Depression | Depressive Symptoms
University of Minnesota

Recruiting

Optimizing the Dose of Flucytosine for the Treatment of Cryptococcal Meningitis

Cryptococcal Meningitis

Uganda
Ming Lv

Not yet recruiting

General Anesthesia vs Local Anesthesia for Endovascular Treatment in Patients With Unruptured Intracranial Aneurysm Using Flow Diverter

Intracranial Aneurysm
Liangjing Lu
Shanghai Ming Ju Biotechnology Co., Ltd.

Not yet recruiting

Relmacabtagene Autoleucel for the Treatment of Systemic Sclerosis

Systemic Sclerosis

China
Shanghai University of Traditional Chinese Medicine
Shanghai Minimally Invasive Surgery Center

Not yet recruiting

Clinical Evaluation of Acupuncture Treatment on Alzheimer's Disease in APOE e4 Carriers and Non-Carriers

Cognitive Impairment | Alzheimer Disease

China
Philip Combiths
National Institute on Deafness and Other Communication Disorders (NIDCD)

Not yet recruiting

Treatment Targets in Spanish and English Bilingual Speech Intervention

Speech Sound Disorder
Masaryk University

Recruiting

Effect of Speech Therapy in Combination With Non-invasive Brain Stimulation on Speech of Patients With Parkinson's Disease

Parkinson Disease

Czechia
Anhui Provincial Hospital

Not yet recruiting

A Study on the Safety and Preliminary Efficacy of NK042 in the Treatment of Malignant Ascites

Gynecologic Cancer

China
Cairo University
National Heart Institute, Egypt

Not yet recruiting

Efficacy and Safety of Combination Diuretic Therapy in Patients With Acute Decompensated Heart Failure and Volume Overload

Edema | Acute Decompensated Heart Failure | Volume Overload

Egypt
Zhiyong Huang

Not yet recruiting

Lenvatinib and Adebrelimab Combined With GEMOX in the Perioperative Treatment of Potentially Resectable Intrahepatic Cholangiocarcinoma

Intrahepatic Cholangiocarcinoma

China
Peking University First Hospital

Not yet recruiting

Evaluation of Efficacy and Safety of Combination Therapy of Henagliflozin Proline, Retagliptin and Metformin in New Diagnosed Type 2 Diabetes Patients

Type 2 Diabetes
Jacobio Pharmaceuticals Co., Ltd.

Not yet recruiting

JAB-21822 Combined With JAB-3312 Compared SOC in the First Line for Treatment of Advanced Non-small Cell Lung Cancer With KRAS p.G12C Mutation

Advanced Non-squamous Non-small-cell Lung Cancer | Metastatic Non-squamous Non Small Cell Lung Cancer
AlaMab Therapeutics (Shanghai) Inc.

Not yet recruiting

A Study to Evaluate the Efficacy of ALMB-0168 in Solid Tumor Patients With Bone Metastatic Whose Prior Standard Treatment Have Failed

Advanced Solid Tumors With Bone Only Metastasis
XIANG YANQUN

Not yet recruiting

Irinotecan Liposomes in Combination With Nituzumab for the Treatment of Recurrent/Metastatic Nasopharyngeal Carcinoma After Failure of First-Line or Higher Immunotherapy

Nasopharyngeal Cancer

China
PersonGen BioTherapeutics (Suzhou) Co., Ltd.

Not yet recruiting

Preliminary Clinical Study of UTAA09 Injection in the Treatment of Relapsed/Refractory Autoimmune Diseases

Rheumatoid Arthritis | Systemic Lupus Erythematosus | Systemic Sclerosis | Immune Thrombocytopenia | Sjogren's Syndrome | Idiopathic Inflammatory Myopathies | Primary Biliary Cholangitis
Aydin Adnan Menderes University

Not yet recruiting

Tapse/Pasp General Anesthesia

Hypotension

Turkey
M.D. Anderson Cancer Center

Not yet recruiting

18F-AraG PET/CT as a Non-Invasive Imaging Biomarker for Chemoradiation Treatment Response in Esophageal Cancer

Esophageal Cancer

United States
Royal Marsden NHS Foundation Trust

Not yet recruiting

LATe TreatmENT Related Toxicity in Melanoma (LATENT) (LATENT)

Melanoma

United Kingdom
Jesuína Lamartine Nogueira Araújo

Not yet recruiting

Effect of Pregabalin Gel in Controlling Cervical Dentin Hypersensitivity

Dentin Sensitivity
Sheba Medical Center

Recruiting

Artificial Intelligence for Mental Health Diagnoses and Treatment Plans: A Protocol for Actors and Patients

Mental Health Diagnosis

Israel
AstraZeneca

Not yet recruiting

Prevalence of Emerging Treatment-induced Mutations in Metastatic ER-positive Breast Cancer. (Pangeia-2)

Metastatic Breast Cancer

Brazil
Benev Company, Inc.

Recruiting

Sylfirm X Radiofrequency Microneedling for the Treatment of Melasma

Melasma

United States
Zealand University Hospital
Tampere University Hospital

Not yet recruiting

Surgical Versus Non-surgical Treatment of Displaced Proximal Humerus Fracture in Adults Aged 50 to 65 Years (PHF50-65)

Shoulder Fractures | Proximal Humeral Fracture

Finland, Denmark
Cell Energy Life Sciences Group Co. LTD
Beijing 302 Hospital

Recruiting

Stem Cell Treatment for Lung Injury Caused by Major Infectious Diseases

Lung Injury

China

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