Search clinical trials for: Hepatic function

Total 27133 results

Novartis Pharmaceuticals

Completed

Effect of Hepatic Impairment on LDK378 Pharmacokinetics

Normal Hepatic Function | Impaired Hepatic Function

United States
Novartis Pharmaceuticals

Completed

Pharmacokinetics and Safety of Panobinostat in Patients With Advanced Solid Tumors and Various Degrees of Hepatic Function

Advanced Solid Tumors

Switzerland, Sweden, Netherlands, United States, United Kingdom
Gilead Sciences

Completed

Study to Evaluate the Pharmacokinetics of Firsocostat or Fenofibrate in Adults With Normal and Impaired Hepatic Function (HI)

Nonalcoholic Steatohepatitis (NASH)

United States
Novartis Pharmaceuticals

Completed

INC280 in Healthy Subjects With Impaired Hepatic Function and Subjects With Normal Hepatic Function

Hepatic Impairment

United States
Novartis Pharmaceuticals

Completed

A Study of Patupilone in Patients With Advanced Solid Tumors and Varying Degrees of Hepatic Function

Advanced Malignancies | Tumors

United States
Novartis Pharmaceuticals

Terminated

An Open-label, Dose Escalation Study to Assess the Pharmacokinetics of of ASA404 in Adult Cancer Patients With Impaired Hepatic Function

Histologically-proven and Radiologically-confirmed Solid Tumors

Italy, New Zealand
Gilead Sciences

Completed

Study to Evaluate the Pharmacokinetics of Tenofovir Alafenamide (TAF) in Adults With Normal Hepatic Function and Adults With Severe Hepatic Impairment

Hepatitis B Virus

United States, Germany, New Zealand
Novartis Pharmaceuticals

Completed

A Trial to Evaluate the Pharmacokinetics of ABL001 in Healthy and Hepatic Impaired Subjects

Hepatic Impairment

United States
Novartis Pharmaceuticals

Terminated

Pharmacokinetics of Dabrafenib in Subjects With Hepatic Impairment

Hepatic Impairment

United States
Memorial Hospital Groups

Completed

The Early Strength Training Program in Post-transplant Liver Cases

Quality of Life | Fatigue | Muscle Weakness | Sarcopenia | Chronic Liver Failure | Liver Transplant Disorder | Muscle Loss | End Stage Liver DIsease

Turkey
Henry Ford Health System

Completed

Hepatic Vein Flow During Orthotopic Liver Transplantation as Predictive Factor for Postoperative Graft Function

Postoperative Graft Function

United States
University of Aarhus
AbbVie; Aarhus University Hospital

Completed

Macrophages, Portal Hypertension, and Liver Function During AbbVie Treatment of Chronic Hepatitis C

Hepatitis C

Denmark
Chuncheon Sacred Heart Hospital

Completed

Cognitive Function of Alcoholic Compensated Liver Cirrhosis

Alcoholic Liver Disease

Korea, Republic of
Array Biopharma, now a wholly owned subsidiary...

Terminated

MEK162 in Healthy Subjects With Normal Hepatic Function and Subjects With Impaired Hepatic Function (MEK162)

Hepatic Impairment

United States
Bristol-Myers Squibb

Completed

An Investigational Study of Experimental Medication BMS-986231 Given in Participants With Different Levels of Liver Function

Congestive Heart Failure | Liver Dysfunction | Heart Decompensation | Cardiac Failure | Liver Insufficiency | Myocardial Failure | Hepatic Failure

Hungary, Poland
Professor C ICHAI

Withdrawn

Hepatic Mitochondrial Function in Sepsis

Sepsis | Peritonitis

France
GlycoMimetics Incorporated

Completed

A Study to Evaluate the Effect of IV Doses of Rivipansel in Subjects With Moderate Hepatic Impairment and in Healthy Subjects With Normal Hepatic Function

Moderate Hepatic Impairment | Normal Hepatic Function

United States
The Cleveland Clinic

Completed

Hepatic Effects of Gastric Bypass Surgery

Liver Diseases

United States
Hopital Foch

Unknown

Portal Hypertension and Systemic Endothelial Function (ENDOTH-MUCO)

Cystic Fibrosis | Portal Hypertension

France
Hospital General Universitario Gregorio Marañon

Completed

Major Liver Resection: Early Clotting Disorders and Functional Impairment.

Hepatic Insufficiency | Blood Coagulation Disorders

Spain
University of Michigan Rogel Cancer Center

Completed

Assessment Of Liver Function in Patients Undergoing Hepatic Irradiation (IC-Green)

Hepatic Irradiation

United States
BeiGene

Completed

Safety and Pharmacokinetics of Zanubrutinib (BGB-3111) in Healthy Subjects and Those With Impaired Liver Function

Hepatic Insufficiency & Healthy Subjects

United States
Stanley Dudrick's Memorial Hospital

Completed

Lipid Emulsions and Liver Function - Results After 5 Years. (5ylipids)

Liver Failure | Parenteral Nutrition-Related Hepatitis

Poland
Albert Einstein Healthcare Network

Completed

Monitoring of Symptoms and Cognitive Function Using Telehealth

End Stage Liver Disease

United States
Geisinger Clinic

Completed

Comparison of 19g FNA and 19g FNB Needles for EUS-LB

Abnormal Liver Function

United States
Gilead Sciences

Completed

Pharmacokinetics of Voxilaprevir in Adults With Normal Hepatic Function and Moderate or Severe Hepatic Impairment

HCV Infection

United States, Germany, New Zealand
University of North Carolina, Chapel Hill
National Institute of General Medical Sciences (NIGMS)

Completed

ADPKD Alterations in Hepatic Transporter Function

Renal Disease | Autosomal Dominant Polycystic Kidney Disease | ADPKD

United States
Universidad Santo Tomas
Universidad Pública de Navarra; Universidad del Rosario; Universidad de Santiago... and other collaborators

Withdrawn

Exercise, Gut Microbiota in Sedentary Adults With Overweight

Metabolic Disturbance

Colombia
Pharbil Waltrop GmbH

Completed

Bioavailability Study With Oral Single Dose Administration of Ethinylestradiol and Dienogest

Focus: Bioequivalence

Germany
Kartal Kosuyolu Yuksek Ihtisas Education and Research...

Completed

The Investigation of the Causes of Hepatic Dysfunction in the Postoperative Period During Open-heart Surgeries

Surgery | Hepatic Impairment | Cardiac Disease | Hyperbilirubinemia
ObsEva SA

Completed

Safety and Pharmacokinetics Study of Linzagolix in Female Subjects With Normal and Impaired Hepatic Function

Hepatic Impairment | Healthy Participants

United States
Shanghai Zhongshan Hospital

Unknown

The Effect of Terlipressin on Recovery of Liver Function After Hepatectomy

Liver Failure | Acute Kidney Injury | Ascites Hepatic | Terlipressin Adverse Reaction

China
The University of Texas Health Science Center at...
Janssen Scientific Affairs, LLC

Completed

Effect of Combined Incretin-Based Therapy Plus Canagliflozin on Glycemic Control and the Compensatory Rise in Hepatic Glucose Production in Type 2 Diabetic Patients

Type 2 Diabetes Mellitus

United States
Bausch Health Americas, Inc.

Completed

Pharmacokinetics, Safety, and Tolerability of Methylnaltrexone in Volunteers With Impaired Hepatic Function

Liver Dysfunction

United States
Eli Lilly and Company
Algorithme Pharma Inc; CoLucid Pharmaceuticals

Completed

Pharmacokinetic Single Dose Study of Oral Lasmiditan in Participants With Normal and Impaired Hepatic Function

Migraine

United States, Canada
Augusta University
Yale University; University of Alabama at Birmingham; Tufts University

Unknown

Vitamin K and Glucose Metabolism in Adults at Risk for Diabetes (Vita-K 'n' Adults Study)

Obesity | Insulin Resistance | Insulin Sensitivity | Prediabetes | Beta-Cell Dysfunction

United States
University of Edinburgh
Perspectum; Hampshire Hospitals NHS Foundation Trust

Completed

HepaT1ca: Quantifying Liver Health in Surgical Candidates for Liver Malignancies (Hepatica)

Surgery | Colorectal Cancer Metastatic | Liver Cancer | Liver Regeneration

United Kingdom
AstraZeneca

Completed

Study to Assess the Blood Levels and Safety of Olaparib in Patients With Advanced Solid Tumours and Normal Liver Function or Mild or Moderate Liver Impairment

Solid Tumours

France, United Kingdom, Czechia, Korea, Republic of, Netherlands
Gilead Sciences

Completed

Pharmacokinetics of Eleclazine in Adults With Normal and Impaired Hepatic Function

Long QT Syndrome

United States, Romania, New Zealand, Germany
Zagazig University

Unknown

Coenzyme Q10 and Meclofenoxate in Hepatic Encephalopathy (EH)

Hepatic Encephalopathy | Coenzyme Q10 | Intellectual Functioning Disability

Egypt
Novo Nordisk A/S

Completed

Investigation of Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Multiple Doses of Somapacitan in Subjects With Mild and Moderate Degrees of Hepatic Impairment Compared to Subjects With Normal Hepatic Function.

Growth Hormone Disorder | Growth Hormone Deficiency in Children | Adult Growth Hormone Deficiency

Slovakia
Aragon Pharmaceuticals, Inc.

Completed

A Study to Evaluate the Pharmacokinetics of JNJ-56021927 in Participants With Mild or Moderate Hepatic Impairment Compared With Participants With Normal Hepatic Function

Hepatic Impairment

United States
Astellas Pharma Inc

Completed

Pharmacokinetics Study in Patients With Impaired Hepatic Function

Patients With Impaired Hepatic Function

Japan
Akebia Therapeutics

Completed

A Single Dose Study of Oral Vadadustat in Subjects With Normal and Impaired Hepatic Function

Hepatic Impairment

United States
AstraZeneca

Completed

Study to Assess the Blood Levels and Safety of AZD9291 in Patients With Advanced Solid Tumours and Normal Liver Function or Mild or Moderate Liver Impairment

Solid Tumours

United States, Spain, Belgium, France, Korea, Republic of, United Kingdom
Aga Khan University

Unknown

Intermittent Fasting in Dyslipidemia

Kidney Diseases | Anemia | Dyslipidemias | Cardiac Function | Intermittent Fasting | HDL Cholesterol, Low Serum | Hepatic Enzymes and Function Abnormalities

Pakistan
Vital Therapies, Inc.

Terminated

Safety and Efficacy of the ELAD System (ELAD) to Treat Acute Liver Failure (ALF)

Acute Liver Failure | Fulminant Hepatic Failure | Primary Graft Non-Function | Surgically-Induced Liver Failure

United States
Fundacion para la Investigacion Biomedica del Hospital...

Completed

Effect of Beta-adrenergic Blockers on Cardiac Function, Systemic and Splanchnic Haemodynamic and Kidney Function in Cirrhotic Patiets With Refractory Ascites (ALB-BET)

Hepatic Cirrhosis

Spain
Instituto Grifols, S.A.

Completed

Effects on Plasma Exchange on Functional Capacity of Serum Albumin, Circulatory Dysfunction, Renal and Cerebral Function in Cirrhotic Patients With "Acute-on-chronic Liver Failure"

Liver Failure | Liver Cirrhosis

Spain
Children's Medical Center Dallas

Completed

Compassionate Use of Omegaven in the Treatment of Parenteral Nutrition Induced Hepatic Injury

Liver Disease | Parenteral Nutrition Associated Liver Disease | Impaired Liver Function

United States

Search clinical trials for: Hepatic function

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