Search clinical trials for: Immune cell metabolism

Total 111782 results

Ixaka Ltd
Andalusian Network for Design and Translation of Advanced Therapies

Terminated

The Efficacy and Safety of REX-001 to Treat Ischemic Ulcers in Subjects With CLI Rutherford Category 5 and DM

Cardiovascular Disease | Diabetes Mellitus, Type 2 | Diabetes Mellitus, Type 1 | Critical Limb Ischemia (CLI) | Peripheral Arterial Disease (PAD) | Diabetes Mellitus (DM)

Spain, Netherlands, United Kingdom, Czechia, Portugal, Hungary
Incyte Corporation

Completed

Arginase Inhibitor INCB001158 as a Single Agent and in Combination With Immune Checkpoint Therapy in Patients With Advanced/Metastatic Solid Tumors

Head and Neck Cancer | Gastric Cancer | Lung Cancer | Metastatic Cancer | Mesothelioma | Bladder Cancer | Solid Tumors | Renal Cell Carcinoma (RCC) | Colorectal Cancer (CRC) | UC (Urothelial Cancer)

Italy, Spain, United States, Netherlands
Canadian Medical and Surgical Knowledge Translation...
Unity Health Toronto; Western University, Canada

Completed

The Role of South Asian vs European Origins on Circulating Regenerative Cell Exhaustion (ORIGINS-RCE)

Cardiovascular Diseases | Diabetes | Ischemic Stroke | Peripheral Vascular Diseases | Type 1 Diabetes | Type 2 Diabetes | Ischemic Heart Disease

Canada
Brigham and Women's Hospital
Oregon Health and Science University; Vanderbilt University; Geisinger Clinic

Completed

Improving Quality by Maintaining Accurate Problems in the EHR (IQ-MAPLE)

Myocardial Infarction | Coronary Artery Disease | Smoking | Stroke | Hypertension | Chronic Obstructive Pulmonary Disease | Atrial Fibrillation | Asthma | Tuberculosis | Sleep Apnea | Sickle Cell Disease | Hyperlipidemia | Congestive Heart Failure

United States
Eledon Pharmaceuticals

Withdrawn

Safety, Tolerability, and Efficacy of Immunomodulation With AT-1501 in Combination With Transplanted Islet Cells in Adults With Brittle T1D

Brittle Type 1 Diabetes Mellitus

United States
Janssen Research & Development, LLC

Completed

A Study of SIMPONI® to Arrest Beta-cell Loss in Type 1 Diabetes (T1GER)

Diabetes Mellitus, Type 1

United States
The Hospital for Sick Children

Active, not recruiting

International Rare Histiocytic Disorders Registry (IRHDR) (IRHDR)

Rare Histiocytic Disorders (RHDs) | Juvenile Xanthogranuloma (JXG) | Reticulohistiocytoma (Epithelioid Histiocytoma) | Xanthoma Disseminatum (XD) | Multicentric Reticulohistiocytosis (MRH) | Systemic Juvenile Xanthogranuloma | Erdheim-Chester Disease (ECD) | Multi-system Rosai-Dorfman Disease (RDD)

Canada, United States, Poland, Argentina, Austria, Czechia, Germany, Italy, Russian Federation, Spain
Hackensack Meridian Health

Active, not recruiting

A Pilot Study of the Therapeutic Potential of Stem Cell Educator Therapy in Type 1 Diabetes

Diabetes Mellitus Type 1

United States
Joanne Kurtzberg, MD
Duke University; Miltenyi Biotec, Inc.

Available

Expanded Access to T-cell Depleted Haplo-Identical Stem Cells for Patients Receiving Haplo-Identical and Unrelated Cord Blood Transplants

Hematologic Malignancies | Immune Deficiencies | Inborn Errors of Metabolism Disorders

United States
Jaeb Center for Health Research
Juvenile Diabetes Research Foundation; University of Minnesota; Medtronic; DexCom... and other collaborators

Completed

Hybrid Closed Loop Therapy and Verapamil for Beta Cell Preservation in New Onset Type 1 Diabetes (CLVer)

Type1 Diabetes

United States
Sansum Diabetes Research Institute
Novo Nordisk A/S

Completed

Comparison of Insulin Degludec With Insulin Glargine U100 for Adults With Type 1 Diabetes Crossing Multiple Time Zones. (SafrTravlT1D)

Diabetes Mellitus, Type 1

United States
New York Medical College

Completed

Human Placental-Derived Stem Cell Transplantation (HPDSC)

Mucopolysaccharidosis I | Myelodysplastic Syndrome | Acute Lymphocytic Leukemia | Acute Myelogenous Leukemia | Niemann-Pick Disease | Mucopolysaccharidosis VI | Wolman Disease | Adrenoleukodystrophy | Batten Disease | Metachromatic Leukodystrophy | Diamond-Blackfan Anemia | Severe Aplastic Anemia | Fucosidosis | Gaucher... and other conditions

United States
Santa Catarina Federal University

Completed

Flaxseed Oil and Pomegranate Extract on Inflammation, Lipid Profile and Nutritional Status of Hemodialysis Patients

Inflammation | Chronic Kidney Diseases | Lipid Metabolism Disorders | Dialysis; Complications

Brazil
Anelixis Therapeutics, LLC

Withdrawn

Safety, Tolerability and Efficacy of Immunomodulation With AT-1501 in Islet Cell Transplantation

Type 1 Diabetes Mellitus

Canada
Brigham and Women's Hospital
Agency for Healthcare Research and Quality (AHRQ)

Completed

Improving Safety of Diagnosis and Therapy in the Inpatient Setting (PSLL2-0)

Pneumonia | Sepsis | Delirium | Confusion | Hip Pain Chronic | Hypoxia | Back Pain | Vomiting | Abdominal Pain | Diarrhea | Cough | Asthma | Chest Pain | Neck Pain | Fever | Cellulitis | Syncope | Headache | Deep Vein Thrombosis | Venous Thromboembolism | Soft Tissue Infections | Failure to Thrive | COPD | Pulmonary Embolism | Dyspnea | Leg Pain | Mental... and other conditions

United States
Chinese University of Hong Kong

Completed

Effects of Dorzagliatin on 1st Phase Insulin and Beta-cell Glucose Sensitivity in T2D and Monogenic Diabetes

Diabetes Mellitus, Type 2

Hong Kong
Talaris Therapeutics Inc.
Duke University

No longer available

Allogeneic Stem Cell Transplantation for the Treatment of Multiple Sclerosis (Compassionate Use)

Metachromatic Leukodystrophy

United States
Charite University, Berlin, Germany

Completed

Pizza Meal Challenge and Immunometabolism (PIMETA) (PIMETA)

Healthy

Germany
University Hospital, Grenoble

Active, not recruiting

Health Economic Analysis of Islet Cell Transplantation for the Stabilization of the Severe Forms of Type 1 Diabetes (STABILOT)

Type 1 Diabetes

France, Switzerland
Sidney Kimmel Comprehensive Cancer Center at Johns...

Completed

A Pilot Study of Allopurinol As A Modifier of 6-MP Metabolism in Pediatric ALL

Acute Lymphoblastic Leukemia (ALL)

United States
University of Alberta
Sernova Corp

Terminated

A Phase I/II Study of the Safety and Efficacy of Sernova's Cell PouchTM for Therapeutic Islet Transplantation

Type I Diabetes

Canada
Vifor Pharma

Terminated

Ferric Carboxymaltose for Treatment of Anaemia of Cancer in Subjects With Multiple Myeloma Receiving Chemotherapy (AOC-MM)

Iron-Deficiency Anemia

France, Greece
Hadassah Medical Organization

Withdrawn

GLP Analogs for Diabetes in Wolfram Syndrome Patients

Wolfram Syndrome | Diabetes Mellitus Associated With Genetic Syndrome
University of Edinburgh

Completed

Pancreatic Calcium Handling in Islet Beta Cells in Patients With Type 1 Diabetes Mellitus (Pancreas MEMRI)

Type 1 Diabetes

United Kingdom
Hvidovre University Hospital
University of Copenhagen

Completed

Effect of RYGB on Alpha- and Beta Cell Function and Sensitivity to Incretins in Patients With Type 2 Diabetes (BETASIN)

Obesity, Morbid | Type2 Diabetes

Denmark
4SC AG

Completed

A Phase 1, Open-label Study of the Absorption, Metabolism, Excretion of [14C]-Resminostat

Mycosis Fungoides | Sezary Syndrome | Cutaneous T Cell Lymphoma

United Kingdom
Radboud University Medical Center

Terminated

Beta Cell Imaging in T1D Patients With a Different Glycemic Control (GLP1-reg)

Type 1 Diabetes Mellitus

Netherlands
Radboud University Medical Center

Terminated

Visualizing Beta Cells After Islet Transplantation (GLP1-transpl)

Type 1 Diabetes Mellitus

Netherlands, Sweden
Carla Greenbaum, MD
Juvenile Diabetes Research Foundation

Completed

Targeting Beta Cell Dysfunction With Liraglutide or Golimumab in Longstanding T1D

Type 1 Diabetes Mellitus

United States
Benjamin U. Nwosu, MD
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); University...

Completed

Vitamin D and Residual Beta-Cell Function in Type 1 Diabetes (PCR)

Type 1 Diabetes

United States
Azienda Ospedaliero, Universitaria Pisana

Completed

Impact of Plasma Lipids on β Cell Function and Insulin Sensitivity

Glucose Intolerance | Hypertriglyceridemia

Italy
Mesoblast, Inc.
Juvenile Diabetes Research Foundation

Completed

PROCHYMAL® (Human Adult Stem Cells) for the Treatment of Recently Diagnosed Type 1 Diabetes Mellitus (T1DM)

Type 1 Diabetes | Type 1 Diabetes Mellitus | Diabetes Mellitus, Insulin-Dependent | Juvenile Diabetes

United States
University of Arkansas
Arkansas Children's Hospital Research Institute

Completed

Mitochondrial Function in Circulating Cells and Muscle Tissue (MitoWomen)

Healthy | Obesity | Insulin Sensitivity | Women

United States
Shanghai Jiao Tong University School of Medicine

Completed

Autologous Hematopoietic Stem Cell Transplantation for Early Onset Type 1 Diabetes

Type 1 Diabetes Mellitus

China
Lund University
Juvenile Diabetes Research Foundation

Active, not recruiting

TEFA Family Prevention: Glutenfree Diet to Preserve Beta-cell Function (TEFA)

Type 1 Diabetes | Prediabetes

Sweden
University of California, San Francisco

Completed

Study of Melphalan Drug Exposure in Pediatric Hematopoietic Stem Cell Transplant Patients

Sickle Cell Disease | Hemoglobinopathies | Thalassemia | Hematologic Malignancies | Immunodeficiencies | Fanconi's Anemia | Nonmalignant Diseases | Genetic Inborn Errors of Metabolism

United States
University of California, San Francisco

Completed

Study of Clofarabine and Fludarabine Drug Exposure in Pediatric Bone Marrow Transplantation (HCT)

Sickle Cell Disease | Hemoglobinopathies | Thalassemia | Hematologic Malignancies | Immunodeficiencies | Fanconi's Anemia | Nonmalignant Diseases | Genetic Inborn Errors of Metabolism

United States
University of California, San Francisco
Thrasher Research Fund

Completed

Study of Fludarabine Drug Exposure in Pediatric Bone Marrow Transplantation (HCT)

Sickle Cell Disease | Hemoglobinopathies | Fanconi Anemia | Thalassemia | Hematologic Malignancies | Immunodeficiencies | Nonmalignant Diseases | Genetic Inborn Errors of Metabolism

United States
National Institute of Allergy and Infectious Diseases...
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); Clinical...

Completed

Safety and Effectiveness of Low Molecular Weight Sulfated Dextran in Islet Transplantation

Diabetes Mellitus, Type I

Sweden, Norway
Immunomolecular Therapeutics, Inc.
WCCT Global

Completed

Multiple Ascending Dose (MAD) Study of IMT-002 in HLA-DQ8-positive Type 1 Diabetes

Type1 Diabetes

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI); National Heart, Lung, and Blood Institute... and other collaborators

Completed

Treosulfan and Fludarabine Phosphate Before Donor Stem Cell Transplant in Treating Patients With Nonmalignant Inherited Disorders

Non-Neoplastic Hematologic and Lymphocytic Disorder

United States
National Institute of Diabetes and Digestive and...
National Heart, Lung, and Blood Institute (NHLBI); National Eye Institute (NEI)

Completed

TODAY2 Phase 2 Follow-up (T2P2)

Type 2 Diabetes

United States
Hospital Italiano de Buenos Aires
Universidad Nacional de La Plata; Instituto Tecnológico de Buenos Aires; Fundación...

Completed

Is the Artificial Pancreas, Without Carbohydrate Counting, Efficient and Safe in an Outpatient Setting

Type 1 Diabetes | Autoimmune Diabetes

Argentina
National Institute for Medical Research, Tanzania
London School of Hygiene and Tropical Medicine; Rigshospitalet, Denmark; University... and other collaborators

Active, not recruiting

Diabetes Mellitus and HIV Study in Mwanza (CICADA)

Diabetes Mellitus | HIV/AIDS

Tanzania
Universidade Federal do Rio de Janeiro

Completed

Mesenchymal Stem Cells in Patients With Type 1 Diabetes Mellitus

Type 1 Diabetes Mellitus

Brazil
Gdansk University of Physical Education and Sport

Active, not recruiting

Short to Long Effects of Whole Body Cryostimulation on Insulin Sensitivity Among Overweight

Overweight | Training | Insulin | Cryotherapy

Poland
Ixaka Ltd
Andalusian Network for Design and Translation of Advanced Therapies

Terminated

The Efficacy and Safety of REX-001 to Treat Ischemic Rest Pain in Subjects With CLI Rutherford Category 4 and DM

Cardiovascular Disease | Diabetes Mellitus, Type 2 | Diabetes Mellitus, Type 1 | Critical Limb Ischemia (CLI) | Peripheral Arterial Disease (PAD) | Diabetes Mellitus (DM)

Spain, Czechia, Portugal, Hungary, Germany, Poland
University of California, Los Angeles
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Completed

Effects of Vitamin D3 Versus 25OHD3 on Mineral Metabolism and Immune Function

Vitamin D Deficiency

United States
University of British Columbia

Completed

Ketone Supplementation, Glucose Control, and Cardiovascular Function

Overweight and Obesity | Hyperglycemia, Postprandial | Diabetes Mellitus Risk

Canada
Institute for Clinical and Experimental Medicine

Completed

Sirolimus vs Mycophenolate With Tacrolimus in Simultaneous Pancreas and Kidney Transplantation

Diabetes Mellitus, Type 1

Czechia

Search clinical trials for: Immune cell metabolism

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