Search clinical trials for: Multiple Dose Escalation

Total 31776 results

Amakem, NV

Completed

Multiple Dose-escalation Study of AMA0076 in Patients With Ocular Hypertension or Primary Open-angle Glaucoma

Ocular Hypertension | Glaucoma | Eye Disease

United States
Millennium Pharmaceuticals, Inc.

Completed

A Phase 1 Dose Escalation Study of TAK-901 in Subjects With Advanced Hematologic Malignancies

Acute Myeloid Leukemia | Multiple Myeloma | Myelofibrosis | Acute Lymphoblastic Leukemia | Chronic Lymphocytic Leukemia | Waldenstrom's Macroglobulinemia | Myelodysplastic Syndrome | Chronic Myelogenous Leukemia | Non-Hodgkins Lymphoma | Myeloid Metaplasia | Philadelphia Chromosome-negative CML | Advanced Polycythemia

United States
Ono Pharma USA Inc

Completed

Single and Multiple Dose Escalation and Two-sequence Crossover Study of ONO-9054 in Patients With Ocular Hypertension or Mild Open-angle Glaucoma

Ocular Hypertension (OHT) | Mild Open Angle-glaucoma (OAG)

United States
Johnson & Johnson Taiwan Ltd

Completed

A Post-Approval Pharmacokinetic Study of Bortezomib in Participants With Multiple Myeloma

Multiple Myeloma
National Cancer Institute (NCI)

Completed

Sorafenib and Bortezomib in Treating Patients With Advanced Cancer

Stage III Multiple Myeloma | Unspecified Adult Solid Tumor, Protocol Specific | Refractory Multiple Myeloma | Refractory Chronic Lymphocytic Leukemia | Stage IV Chronic Lymphocytic Leukemia

United States
Bayer

Completed

Multiple Dose Escalation Study (14 Days) to Investigate Safety, Tolerability, PK and PD of Vardenafil and BAY60-4552

Erectile Dysfunction

Germany
Pfizer

Completed

Multiple Dose Escalation Study In Medically Stable Subjects With Psoriasis

Psoriasis | Immunomodulation

United States
Cephalon

Completed

Study of Bendamustine Combined With Bortezomib for Patients With Relapsed/Refractory Multiple Myeloma

Multiple Myeloma

United States
Gilead Sciences

Completed

Dose Escalation Study of CAL-101 in Select Relapsed or Refractory Hematologic Malignancies

Chronic Lymphocytic Leukemia (CLL) | Acute Myeloid Leukemia (AML) | Multiple Myeloma (MM) | Lymphoma, Non-Hodgkin (NHL)

United States
Abbott
Bristol-Myers Squibb

Terminated

A Phase 1/2, Multi-center, Open-label, Dose-escalation Study of Elotuzumab(Humanized Anti-CS1 Monoclonal IgG1 Antibody) and Bortezomib in Subjects With Multiple Myeloma Following One to Three Prior Therapies.

Multiple Myeloma

United States
AstraZeneca

Terminated

To Assess the Safety, Tolerability, Pharmacokinetics and Pharmakodynamics of AZD2820 After Multiple Ascending Doses

Obesity

United Kingdom
Millennium Pharmaceuticals, Inc.

Completed

PS-341 (VELCADE™) Versus High-Dose Dexamethasone in Patients With Relapsed or Refractory Multiple Myeloma

Multiple Myeloma

United States, Canada, Spain, Israel, United Kingdom, Germany, Austria, Belgium, France, Italy, Ireland, Netherlands, Sweden
Novartis Pharmaceuticals

Completed

Safety, Tolerability and Pharmacokinetic Study of Single and Multiple Intravenous Doses of RSV604 in Healthy Subjects.

Healthy

United Kingdom
ArQule, Inc. (a wholly owned subsidiary of Merck...

Completed

Dose Escalation Study of ARQ 621 in Adult Patients With Metastatic Solid Tumors and Hematologic Malignancies

Metastatic Solid Tumors, Refractory/Relapsed Hematologic Malignancies

United States
PETHEMA Foundation

Completed

Bortezomib/Adriamycine/Melfalan/Prednisone (VAMP)/Thalidomide/Cyclophosphamide/Dexamethasone (TaCyDex) or Bortezomib/Melfalan/Prednisone (V-MP)/TaCyDex) in Refractary or Relapsed Multiple Myeloma (TaCyDexVMP7)

Multiple Myeloma

Spain
Pfizer

Completed

Multiple Dose Escalation Trial Of PF-04308515 In Healthy Volunteers

Healthy

United States
Bristol-Myers Squibb

Completed

A Study of Tanespimycin (KOS-953) in Patients With Multiple Myeloma in First Relapse (BMS TIME-1)

Multiple Myeloma

United States, Canada
Cylene Pharmaceuticals

Unknown

Dose-escalation Study of Oral CX-4945

Breast Cancer | Multiple Myeloma | Advanced Solid Tumors | Inflammatory Breast Cancer | Castleman's Disease

United States
Second Military Medical University
Xiangya Hospital of Central South University; Peking University People's Hospital and other collaborators

Unknown

Efficacy Study of PAD and TAD in Newly Diagnosed Multiple Myeloma

Multiple Myeloma

China
Scios, Inc.

Completed

Study of Oral SCIO-469 in Relapsed, Refractory Patients With Multiple Myeloma

Multiple Myeloma
University of Arkansas

Completed

Study of Bortezomib and Revlimid™ for Patients Relapsing or Progressing on Total Therapy II

Multiple Myeloma

United States
Pfizer

Completed

Multiple Dose, Dose Escalation Study of Varenicline Controlled Release Formulation in Adult Smokers

Smoking Cessation

United States
Pfizer

Completed

A Multiple Dose Study To Determine Safety, Tolerability And Pharmacokinetics Of PF-04455242 In Healthy Adult Subjects

Healthy

Singapore
Pfizer

Completed

Multiple Oral Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of PF-04878691

Hepatitis C Virus

United States
Facet Biotech

Completed

Phase I, Multi-Center, Open-Label, Dose Escalation Study of HuLuc63 in Subjects With Advanced Multiple Myeloma

Multiple Myeloma

United States
Pfizer

Completed

A Phase 1 Multiple-Dose Escalation and Single Dose (Tablet) Study of PF-04171327 in Healthy Volunteers

Healthy Volunteers

Belgium
Pfizer

Terminated

Multiple Dose Escalation Trial Of PF-04603629 Given To Subjects With Type 2 Diabetes Mellitus

Diabetes Mellitus, Type 2

United States
Vertex Pharmaceuticals Incorporated

Completed

Single and Multiple Dose Escalation Study of VX-509 in Healthy Subjects

Healthy

United States
HiberCell, Inc.

Completed

Multiple-Dose, Dose-Escalation Safety, Pharmacodynamics, and Pharmacokinetics Study of Imprime PGG™ Injection

Healthy
University of Wuerzburg

Unknown

VELCADE as Maintenance Treatment in Patients With Multiple Myeloma Following Autologous Peripheral Blood Stem Cell Transplantation (PBSCT)

Multiple Myeloma

Austria, Germany, Italy
Hunan Cancer Hospital

Not yet recruiting

Liposomal Irinotecan Combination Regimen for Second-line Treatment of Advanced Gastric Cancer

Advanced Gastric Cancer
Chengdu Zenitar Biomedical Technology Co., Ltd

Not yet recruiting

Puesta Mesylate Combined With Pomalidomide Capsules and Low-dose Dexamethasone in Patients With Relapsed or Refractory Multiple Myeloma

Relapsed or Refractory Multiple Myeloma (RRMM)

China
University Medical Center Groningen
Dutch Cancer Society

Not yet recruiting

IMPT Dose Escalation for NSCLC (HyDose) (HyDose)

Carcinoma, Non-Small-Cell Lung

Netherlands
Connecta Therapeutics, S.L.
Adknoma Health Research; Ministerio de Ciencia e Innovación, Spain; Hospital...

Recruiting

CTH120 First-in-Human Study: Single and Multiple Ascending Doses and Potential Food Interaction (FIH-CTH120)

Fragile X Syndrome

Spain
DemeRx NB

Not yet recruiting

Multiple Ascending Dose Noribogaine PK/PD in Healthy Volunteers

Pharmacokinetics
Teva Branded Pharmaceutical Products R&D, Inc.

Not yet recruiting

An Open-label Dose Escalation/Expansion Trial to Evaluate the Safety and Anti-tumor Activity of TEV-56278 Alone or in Combination With Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors

Advanced Solid Tumors
SWOG Cancer Research Network
National Cancer Institute (NCI)

Not yet recruiting

Testing Whether the Addition of Carboplatin Chemotherapy to Cabazitaxel Chemotherapy Will Improve Outcomes Compared to Cabazitaxel Alone in People With Castrate-Resistant Prostate Cancer That Has Spread Beyond the Prostate to Other Parts of the Body

Castration-Resistant Prostate Carcinoma | Stage IVB Prostate Cancer AJCC v8
BioNTech SE

Not yet recruiting

A First-in-human Safety Trial of BNT331 Administered as Single Ascending Doses in Healthy Women and as Multiple Ascending Doses in Women Diagnosed With Bacterial Vaginosis

Bacterial Vaginosis

United States
Longevity Biotech Australia Pty Ltd (subsidiary)

Not yet recruiting

A Two-Part Single and Multiple Ascending Dose Trial of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LBT-3627 in Healthy Participants and in Participants With Parkinson's Disease.

Parkinson Disease

Australia
GeneQuantum Healthcare (Suzhou) Co., Ltd.

Recruiting

A Study of GQ1010 in Subjects With Advanced Solid Tumors

Advanced Malignant Solid Tumors

China
Samsung Medical Center

Recruiting

Safety of Dose Escalation in Definitive Hypofractionated Radiation Therapy and Hormone Therapy With SpaceOAR TM for Patients With High - Risk Localized Prostate Cancer (DESAR-H) (DESAR-H)

High Risk Prostate Carcinoma

Korea, Republic of
Pfizer
AbbVie

Not yet recruiting

A Study to Learn About the Study Medicine Aztreonam-Avibactam (ATM-AVI) in Infants and Newborns Admitted in Hospitals With Bacterial Infection (CHERISH) (CHERISH)

Gram-negative Bacterial Infection
Samsung Medical Center

Recruiting

Safety of Dose Escalation in Definitive Hypofractionated Radiation Therapy With SPACEOAR TM for Patients With Low-to-intermediate Risk Localized Prostate Cancer (DESAR-L) (DESAR-L)

Low-to-intermediate-risk Prostate Carcinoma

Korea, Republic of
Heinrich-Heine University, Duesseldorf

Recruiting

Strategies for Adaptive Follow-up and Evaluation - Guiding Use of Indicators for De-Escalation in Multiple Sclerosis (SAFEGUIDE-MS)

Multiple Sclerosis

Germany
SURGE Therapeutics

Not yet recruiting

Study of STM-416p Administered to Patients Undergoing Radical Prostatectomy

Prostate Cancer
University Medical Center Groningen
M.D. Anderson Cancer Center

Not yet recruiting

PIRATES: Image-guided Hyper-fractioned Dose-escalation With Proton Therapy for Head and Neck Cancer (PIRATES)

Head and Neck Cancer | Oropharyngeal Cancer

Netherlands
Suzhou Zelgen Biopharmaceuticals Co.,Ltd

Not yet recruiting

Dose Escalation Study of ZG006 in Participants With Advanced Small Cell Lung Cancer or Neuroendocrine Carcinoma, Followed by Dose Expansion Study in Participants With Neuroendocrine Carcinoma.

Neuroendocrine Carcinoma

China
Fujian Shengdi Pharmaceutical Co., Ltd.

Recruiting

A Study of Single and Multiple Doses HRS9531 Tablets in Healthy Subjects

Overweight or Obesity; Type 2 Diabetes

China
Third Harmonic Bio, Inc.

Recruiting

A First in Human Trial Evaluating THB335 in Healthy Participants

Healthy

United States
Peking University People's Hospital
Xingtai People's Hospital; Hebei Provincial People's Hospital

Not yet recruiting

Efficacy and Safety of an Artificial-pancreas-like Learning-based Control in Type 1 Diabetes on Multiple Daily Injection Therapy (ELITE)

Diabetes Mellitus, Type 1

3

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