Search clinical trials for: PK

Total 3466 results

University of Guelph
McMaster University

Recruiting

PKU Carriers Trial (Pilot Study): Impact on Cognition, Mental Health, Blood Pressure and Metabolism

Autosomal Recessive Disorder (Genetic Carriers of PKU)

Canada
Arbutus Biopharma Corporation

Recruiting

Safety, Tolerability, PK & PD of AB-101 Following Oral Administration in Healthy and CHB Subjects.

Chronic Hepatitis b

New Zealand
Yale University
National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Recruiting

Investigating the Mu:Kappa Opioid Receptor Imbalance in Alcohol Use Disorder (Mu Kappa)

Alcohol Use Disorder

United States
Beni-Suef University

Not yet recruiting

Progesterone Primed Ovarian Stimulation Versus GnRH Antagonist in With Expected High Ovarian Response Undergoing in Vitro Fertilization

IVF | PCO

Egypt
BeiGene

Recruiting

Study to Evaluate the Efficacy and Safety of BGB-11417 in Participants With Waldenström's Macroglobulinemia

Waldenstrom Macroglobulinemia | Waldenstrom's Macroglobulinemia Recurrent | Waldenstrom's Macroglobulinemia Refractory

United States, Australia, France, China, Spain, United Kingdom
St George's, University of London
University College, London

Recruiting

Medical Device (MD) Derived Pharmacokinetic (PK) Parameters for Vancomycin (MD-PK) (MD-PK)

Sepsis | Critical Illness | Septic Shock | Bacteremia | Infection, Bacterial | Antibiotic Side Effect | Antibiotic Resistant Infection | Adult Children

United Kingdom
Peking University People's Hospital
Shanghai Hansen Biopharmaceutical Technology Co., Ltd; MEDx Translational Medicine...

Recruiting

Soluble B7-H3 as a Biomarker for Osteosarcoma

Progression | Osteosarcoma | Surveillance | Biomarker

China
Shanxi Kangbao Biological Product Co., Ltd.
Institute of Pathogen Biology, Chinese Academy of Medical Sciences

Recruiting

Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Immunogenicity of LP-98 Injection in Healthy Subjects

Hiv

China
Peking University People's Hospital
Peking University First Hospital; Beijing Friendship Hospital; Chinese PLA General... and other collaborators

Recruiting

Low-dose Baricitinib Plus High-dose Dexamethasone for Patients With Newly Diagnosed Immune Thrombocytopenia

Immune Thrombocytopenia

China
Forest Hills Lab

Not yet recruiting

Study to Evaluate the Safety, Tolerability, Efficacy, and PK of FHL-301 in Parkinson's Disease Patients.

Parkinson Disease
Wake Forest University Health Sciences
National Institute of Neurological Disorders and Stroke (NINDS)

Recruiting

Defining a PK and PD Model for Peripheral Analgesia After IV Oxytocin

Chronic Pain | Acute Pain | Healthy Volunteer

United States
Michael Hoelscher
Radboud University Medical Center; University College, London; University of...

Recruiting

BTZ-043 Dose Evaluation in Combination and Selection (DECISION)

Tuberculosis, Pulmonary | Other Specified Pulmonary Tuberculosis

South Africa, Tanzania
Shenzhen Sciencare Medical Industries Co., Ltd.

Recruiting

Exploring the PK of Different Doses of Naltrexone in Patients With AUD

AUD

China
AstraZeneca

Recruiting

A Phase I Study to Investigate the Effect of Hepatic Impairment on the PK, Safety, and Tolerability of AZD2693

Hepatic Impairment

United States
Peking University Cancer Hospital & Institute

Recruiting

Phase 2 Study of SBRT Plus Tislelizumab and Regorafenib in Unresectable or Oligometastatic HCC

Unresectable Hepatocellular Carcinoma | Oligometastatic Disease

China
Yale University
National Institute on Drug Abuse (NIDA); VA Connecticut Healthcare System

Recruiting

PK/PD of Oral and Vaporized Delta-9-Tetrahydrocannabinol (THC) in Older Adults

Pain, Tolerance | Oral vs Vaporized THC | Abuse Liability

United States
PCOS Challenge: The National Polycystic Ovary Syndrome...

Recruiting

PCOS Indirect and Intangible Economic Burden (PCOSCHALLENGE)

Polycystic Ovary Syndrome

United States
The First Affiliated Hospital with Nanjing Medical...

Recruiting

Goal-directed LCVP Based on HP in Laparoscopic Hepatectomy

Hepatocellular Carcinoma

China
Rocket Pharmaceuticals Inc.

Recruiting

A Phase 1, Dose Escalation Trial of RP-A601 in Subjects With PKP2 Variant-Mediated Arrhythmogenic Cardiomyopathy (PKP2-ACM)

PKP2 Arrhythmogenic Cardiomyopathy (PKP2-ACM)

United States
ADARx Pharmaceuticals, Inc.
ADARx Australia Pty Ltd

Recruiting

Safety, Tolerability, PK and PD of ADX-038 in HV and Paroxysmal Nocturnal Hemoglobinuria (PNH) Patients (PNH)

Paroxysmal Nocturnal Hemoglobinuria (PNH)

Australia
Vertex Pharmaceuticals Incorporated

Recruiting

A Study to Evaluate Pharmacokinetics (PK) and Safety of Inaxaplin in Participants With Renal Impairment

Renal Impairment

United States
Turgut Ardika PTY LTD

Recruiting

Comparative PK, Safety, Tolerability, Immunogenicity, and PD Profile Study of TUR03 and Soliris in Healthy Participants

Healthy

Australia
Phramongkutklao College of Medicine and Hospital
Silpakorn University

Recruiting

Dose Optimization by Pharmacokinetic/Pharmacodynamic of Antibiotics to Improve Clinical Outcome of Carbapenem Resistant Klebsiella Pneumoniae Bloodstream Infections in Critically Ill Patients at Phramongkutklao Hospital

Carbapenem Resistant Klebsiella Pneumoniae

Thailand
Radboud University Medical Center

Recruiting

Pharmacokinetic Study of Minocycline in Patients With Pulmonary Nontuberculous Mycobacterial Disease (Mino-PK)

Mycobacterium Avium Complex Pulmonary Disease

Netherlands
OncoC4, Inc.
Avance Clinical; OncoC4 AU Pty Ltd

Recruiting

Safety, PK and Efficacy of AI-061 in Advanced Solid Tumors (PRESERVE-009)

Melanoma | Renal Cell Carcinoma | Cervical Cancer | Hepatocellular Carcinoma | Gastric Cancer | Colorectal Cancer | Esophageal Cancer | Fallopian Tube Cancer | Non Small Cell Lung Cancer | Bile Duct Cancer | Bladder Cancer | Endometrial Cancer | Head and Neck Squamous Cell Carcinoma | Anal Cancer | Primary Peritoneal... and other conditions

Australia
Sairopa B.V.

Recruiting

Phase 1 Study Evaluating the Safety and PK of ADU-1805 in Advanced Solid Tumors

Metastatic Solid Tumor | Solid Tumor, Adult | Refractory Cancer

United States, Moldova, Republic of
LAPIX Therapeutics Inc.

Recruiting

First-in-Human Trial in Healthy Adult Volunteers to Evaluate Safety, Tolerability and PK of LAPIX Study Drug; LPX-TI641

Multiple Sclerosis | Autoimmune Diseases

United States, Jordan
Peking University People's Hospital
Peking University First Hospital; Beijing Friendship Hospital; Chinese PLA General... and other collaborators

Recruiting

Low-dose Baricitinib Plus Danazol for Steroid-resistant/Relapse Immune Thrombocytopenia

Immune Thrombocytopenia

China
Dipenkumar Modi
Genmab

Recruiting

Safety and Efficacy of Epcoritamab With Gemcitabine, Dexamethasone, and Cisplatin (GDP) Salvage Chemotherapy in Relapsed Refractory Large B-cell Lymphoma

Relapsed Cancer | Refractory Cancer | Large Cell Lymphoma, Diffuse

United States
Robert Flavell, MD, PhD
Bristol-Myers Squibb; U.S. Army Medical Research Acquisition Activity

Recruiting

Magnetic Resonance (MR) Imaging With Hyperpolarized Bicarbonate (13C) to Measure Tissue pH in Prostate Cancer

Prostate Cancer | Localized Prostate Carcinoma

United States
Servier Bio-Innovation LLC
Institut de Recherches Internationales Servier

Recruiting

A Phase 1, Open-Label Study to Evaluate the Effect of a Low-Fat Meal and Multiple Doses of Ciprofloxacin on the Pharmacokinetics of Vorasidenib in Healthy Subjects

Healthy Subjects

United States
Agomab Spain S.L.

Recruiting

STENOVA - A Study to Evaluate Safety, Tolerability, PK and PD of AGMB-129 in Patients With Fibrostenotic Crohn's Disease

Fibrostenotic Crohn's Disease

United States, Italy, Poland, Spain, Denmark, Austria, Canada, Germany
APR Applied Pharma Research s.a.

Recruiting

Open-label, Randomized, 2-way Crossover, Monocentric, Controlled Study to Evaluate the Effect on Daily PHE Fluctuation of PKU GOLIKE Versus SoC in Patients With PKU.

Phenylketonurias

Italy
Allecra
Linical Co., Ltd.

Recruiting

A Study to Investigate PK, Safety, Tolerability of Cefepime-enmetazobactam in Pediatric Participants With cUTI

Complicated Urinary Tract Infection

Spain, France, Czechia, Hungary, Poland, Slovakia
Istanbul Medipol University Hospital
Ankara Education and Research Hospital; Ataturk University; Yuzuncu Yıl University and other collaborators

Recruiting

Benign Prostate Surgery and QOL and Sexual Function (BEPS)

Quality of Life | Lower Urinary Tract Symptoms | Sexual Dysfunction | Erectile Dysfunction | Incontinence | Ejaculatory Dysfunction

Turkey
Bill & Melinda Gates Medical Research Institute
Merck Sharp & Dohme LLC

Recruiting

Safety, Tolerability, Pharmacokinetics (PK), and Food Effect of MK-7762 in Healthy Adults

Tuberculosis

United States
Dong Wha Pharmaceutical Co. Ltd.

Not yet recruiting

This Study is to Compare and Evaluate the Safety and Pharmacokinetic Characteristics (PK) After Administration of DW6014 and Each Component in Healthy Adult Volunteers in Fed Condition.

DW6014

Korea, Republic of
BioMarin Pharmaceutical

Recruiting

A Long-term, Post-marketing Safety Study of Palynziq in Patients With PKU (PALace) (PALace)

Phenylketonuria (PKU)

United States, Germany, Italy
Michael Hoelscher
Radboud University Medical Center; University College, London; University of...

Recruiting

PanACEA - STEP2C -01

Pulmonary Tuberculosis | Other Specified Pulmonary Tuberculosis

Gabon, South Africa, Tanzania, Malawi, Uganda, Mozambique
Crinetics Pharmaceuticals Inc.

Recruiting

A Study to Evaluate the Safety and PK of CRN04894 for the Treatment of Cushing's Syndrome

Cushing Syndrome | Cushing Disease | Ectopic ACTH Syndrome

United States
Daewoong Pharmaceutical Co. LTD.

Recruiting

To Evaluate the Effect of Food on the Safety and PK Characteristics of DWP16001 in Healthy Adult Volunteers

Healthy

Korea, Republic of
PCOS Challenge: The National Polycystic Ovary Syndrome...

Recruiting

The PCOS Challenge Study (PCOSCHALLENGE)

Polycystic Ovary Syndrome

United States
JIN JING

Not yet recruiting

Assess the Efficacy of Radiotherapy and Sequential Chemotherapy and AK104 Before TME Surgery for Local CRC（AK104-IIT-13） (AK104-IIT-13)

Locally Advanced Rectal Cancer
Peking University

Recruiting

The Efficacy of Guided Tissue Regeneration With Extracellular Matrix Scaffold of Small Intestinal Submucosa (SIS) Membrane: a Randomized Controlled Clinical Trial

Guided Tissue Regeneration | Extracellular Matrix Scaffold of Small Intestinal Submucosa

China
Indiana University
National Institute of General Medical Sciences (NIGMS)

Recruiting

Interaction of CYP2B6 Genotype and Efavirenz With Methadone and Tizanidine PK

Drug-Drug Interaction

United States
Overseas Pharmaceuticals, Ltd.
Beijing Capton Pharmaceutical Technology Development Co., LTD

Not yet recruiting

An Open Label, Balanced, Randomized, Two-Treatment, Two-Period, Two-Sequence, Two-way Crossover, Oralcomparative Pharmacokinetic（PK）Study of Lacosamide Extended-Release Tablets , Adult, Human Subjects Under Fasting Conditions.

Epilepsy

China
NextCure, Inc.

Recruiting

A Safety, Tolerability and Efficacy Study of NC525 in Subjects With Advanced Myeloid Neoplasms

Relapsed or Refractory Acute Myeloid Leukemia | Relapsed or Refractory Chronic Myelomonocytic Leukemia | Relapsed or Refractory Myelodysplastic Syndrome

United States
Jnana Therapeutics

Recruiting

First-in-Human, Multiple Part Clinical Study of JNT-517 in Healthy Participants and in Participants With Phenylketonuria

Phenylketonuria

United States, Australia
Jiangsu Hansoh Pharmaceutical Co., Ltd.

Recruiting

Comparing of the PK, PD, Safety and Immunogenicity of HS-20090 and Xgeva® in Healthy Adults

Healthy

China
Peking University

Recruiting

High-flow Nasal Oxygenation During Deep Sedation in Pediatric Dental Patients

Deep Sedation | Pediatric Patients | Dental Treatment

China

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