Search clinical trials for: Proton Pump Inhibitors

Total 66089 results

Indiana University
Hala Fadda; Butler University

Active, not recruiting

Assessment of Gastric pH Changes Induced by Ascorbic Acid Tablets

Hypochlorhydria

United States
Washington University School of Medicine

Active, not recruiting

Role of Proton Pump Inhibitors on the Postoperative Course Following Pancreaticoduodenectomy

Pancreatic Cancer | Pancreatitis | Pancreas Cancer | Duodenal Cancer | Ampullary Cancer | Pancreas Neuroendocrine Tumor | Distal Extrahepatic Cholangiocarcinoma

United States
Christiana Care Health Services

Active, not recruiting

Metformin and Esomeprazole in Preterm Pre-eclampsia

Pre-Eclampsia | Preeclampsia | Preterm | Preeclampsia Severe | Preeclampsia Second Trimester | Preeclampsia Complicating Childbirth | Preeclampsia Puerperium

United States
Mario Negri Institute for Pharmacological Research
Federico II University; IRCCS Multimedica

Completed

Proton Pump Inhibitors (PPI): a Study to Improve Appropriate Prescriptions in the Elderly (LAPTOP-PPI)

Proton Pump Inhibitor | Primary Care

Italy
Pfizer

Terminated

PREA, PK And Safety PASS Study Of IV Pantoprazole In Pediatric Subjects

Gastroesophageal Reflux Disease

United States, Bosnia and Herzegovina, Slovakia, Italy, Germany, Argentina, Georgia, Serbia, Ukraine
TenNor Therapeutics (Suzhou) Limited

Completed

Efficacy and Safety of Rifasutenizol (TNP 2198) in Participants With H. Pylori Infection

H.Pylori Infection

China
TenNor Therapeutics Inc.

Completed

The Safety and Tolerability, Pharmacokinetics of TNP-2092 Capsules in Combination With Rabeprazole Sodium Enteric-coated Tablets

Helicobacter Pylori Infection

China
Shandong University
Zibo Central Hospital; Peking University Care Luzhong Hospital; Yuncheng Traditional... and other collaborators

Completed

Bismuth-containing Quadruple Therapy for Helicobacter Pylori First-line Treatment of Different Tetracycline Doses

Helicobacter Pylori Infection

China
Vertex Pharmaceuticals Incorporated

Completed

Evaluation of the Effects of Omeprazole and Rifampin on the Pharmacokinetics of VX-548 in Healthy Participants

Pain

Australia
Boehringer Ingelheim

Completed

A Study in Healthy People to Compare Two Different Tablets of BI 685509 and to Test How Food and Esomeprazole Influence the Amount of BI 685509 in the Blood

Healthy

Germany
Takeda

Completed

Effect of Dexlansoprazole on Bone Homeostasis

Bone and Bones | Homeostasis

United States
Helwan University

Completed

Safety and Efficacy of Triple and Quadruple Regimens as First Line Therapy for Management of Helicobacter Pylori Infection in Egyptians

H.Pylori Infection

Egypt
Bristol-Myers Squibb

Active, not recruiting

A Study to Evaluate the Safety and Tolerability of BMS-986408 Alone and in Combination With Nivolumab or Nivolumab and Ipilimumab in Participants With Advanced Solid Tumors

Advanced Solid Tumors

Canada, United States, Spain, France, Switzerland
PMV Pharmaceuticals, Inc

Active, not recruiting

A Study to Investigate the Effects of Acid Reducing Agents on Pharmacokinetics of PC14586 in Healthy Participants

Healthy Volunteers

United States
Hutchmed

Completed

HMPL-689 Drug Interaction Study With CYP3A Inhibitor/CYP2C9 Inhibitor/CYP3A Inducer/PPI

Relapsed or Refractory Lymphoma

United States
AstraZeneca
Parexel

Completed

A Study to Compare Bioavailability of AZD5055 Film-coated Tablet With AZD5055 Oral Suspension and to Assess the Effect of Food and an Acid Reducing Agent on Pharmacokinetics (PK) of AZD5055 in Healthy Subjects.

Healthy Volunteers

United States
Genentech, Inc.
Quotient Clinical

Completed

Bioavailability of GDC-0134 and the Effect of Food and Proton Pump Inhibitor on Pharmacokinetics of GDC-0134 in Healthy Female Participants

Amyotrophic Lateral Sclerosis

United Kingdom
Pfizer
Ono Pharmaceutical Co. Ltd; Pierre Fabre Laboratories

Completed

A Relative Bioavailability Study Evaluating Two New Encorafenib Formulations (ERBA)

Healthy

United States
Stanford University
SPARK (Stanford University)

Suspended

A Study of Esomeprazole in Children With Autism

Autism Spectrum Disorder | Autism

United States
Bellus Health Inc. - a GSK company

Completed

Evaluation of the Effect of Rifampin and Rabeprazole on the Pharmacokinetics of Camlipixant

Healthy

Canada
National Institute of Public Health, Slovenia
Community Healthcare Center dr. Adolf Drolc Maribor (HCM)

Enrolling by invitation

Feasibility Study of the Proposed Test-and-treat Screening Program in Younger Participants With H. Pylori Infection

Helicobacter Pylori Infection

Slovenia
HALEON

Completed

Bioequivalence Study of Esomeprazole 20 Milligram (mg) Delayed-Release Capsules in Healthy Adult Participants

Gastrointestinal Diseases

Canada
Pfizer

Completed

Voxelotor CYP and Transporter Cocktail Interaction Study

Sickle Cell Disease

United States
Brooklyn ImmunoTherapeutics, LLC

Completed

IRX-2 Regimen in Patients With Newly Diagnosed Stage II, III, or IVA Squamous Cell Carcinoma of the Oral Cavity (INSPIRE)

Squamous Cell Carcinoma of the Oral Cavity

United States, Brazil, United Kingdom, Canada
University of Maryland, Baltimore
National Cancer Institute (NCI); National Heart, Lung, and Blood Institute... and other collaborators

Completed

Clopidogrel Pharmacogenetics (PGX) Bench to Bedside (PGXB2B)

Metabolism of Clopidogrel

United States
Providence Health & Services
Brooklyn ImmunoTherapeutics, LLC

Active, not recruiting

Pre-operative IRX-2 in Early Stage Breast Cancer (ESBC)

Breast Neoplasm | Triple Negative Breast Cancer | Breast Neoplasm, Male

United States
Yungjin Pharm. Co., Ltd.
Seoul National University Hospital

Completed

A Study to Compare the Safety, Pharmacokinetics and Pharmacodynamics of YPI 011 to Rabeprazole in Healthy Adult Subjects

Gastroesophageal Reflux Disease

Korea, Republic of
Eli Lilly and Company
Loxo Oncology, Inc.

Completed

A Study of Effect of Multiple Doses of LOXO-305 on the Pharmacokinetics of Single Oral Doses of CYP1A2, CYP2C9, CYP2C19 Substrates in Healthy Participants

Healthy

United States
Amgen

Completed

A Study to Evaluate the Impact of Omeprazole on the Pharmacokinetics of Sotorasib Co-administered With an Acidic Beverage in Healthy Volunteers

Healthy Volunteers

United States
Università Vita-Salute San Raffaele
IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale...

Completed

Esomeprazole to Reduce Organ Failure in Sepsis (PPI-SEPSIS)

Sepsis | Septic Shock

Italy, Kazakhstan, Russian Federation
ViiV Healthcare

Completed

Evaluation of Pharmacokinetic Interaction Between GSK3640254 and Caffeine, Metoprolol, Montelukast, Flurbiprofen, Omeprazole, Midazolam, Digoxin, and Pravastatin in Healthy Adults

HIV Infections

United States
Columbia University

Terminated

Effect of Acid Suppression Medication on Pediatric Microbiome

Clostridium Difficile Infection

United States
Eli Lilly and Company
Loxo Oncology, Inc.

Completed

A Study Comparing Different Formulations of LY3410738 in Healthy Adult Participants

Healthy

United States
University Hospital, Strasbourg, France

Completed

Inventory of Inappropriate Prescriptions of Proton Pump Inhibitors (PPIs) in People Over 75 Years of Age (Etaliepre-IPP)

Peptic Ulcer Disease

France
Jiangsu Carephar Pharmaceutical Co., Ltd.

Completed

A Study to Evaluate the Safety, Tolerability and Pharmacokinetics/Pharmacodynamics of Oral Doses of H008

Erosive Esophagitis

United States
Takeda

Completed

Vonoprazan Study in Patients With Erosive Esophagitis to Evaluate Long-term Safety

Erosive Esophagitis

Japan
TenNor Therapeutics (Suzhou) Limited

Completed

Efficacy and Safety After Multiple Doses of TNP-2198 Capsules, Rabeprazole Sodium Enteric-coated Tablets and Amoxicillin Capsules in Helicobacter Pylori Infected-positive Participants

Helicobacter Pylori Infection

China
Jiangsu HengRui Medicine Co., Ltd.

Completed

Effect of Omeprazole on Pharmacokinetics of SHR2554 in Healthy Subjects

Malignant Tumor

China
University of Karachi
SAMI Pharmaceutical, Karachi Pakistan

Completed

Bioequivalence Study of DelanzoᵀᴹDR 60mg (Dexlansoprazole) Capsule With Dexilant® 60mg (Dexlansoprazole) Capsule in Healthy Pakistani Subjects. (BABE)

Healthy | Bioequivalence Study

Pakistan
St. Luke's Medical Center, Philippines

Terminated

Effectiveness of Vonoprazan vs Omeprazole as Empiric Therapy for Gastroesophageal Reflux Disease (GERD) Patients Without Alarm Features

Gastro Esophageal Reflux | GERD

Philippines
TenNor Therapeutics (Suzhou) Limited

Completed

A Study to Evaluate Preliminary Helicobacter Pylori Eradication After Multiple Doses of TNP-2198 Capsules Combined With Rabeprazole Sodium Enteric-coated Tablets, or Rabeprazole Sodium Enteric-coated Tablets and Amoxicillin Capsules

Helicobacter Pylori Infection

China
Qianfoshan Hospital

Completed

Risk Factors and Machine Learning Model for Proton Pump Inhibitor Related Acute Kidney Injury

Acute Kidney Injury | Proton Pump Inhibitor

China
MicuRx
Worldwide Clinical Trials

Completed

Single Dose and Multiple Dose Escalation Trial of an Oral Formulation of MRX-4

Safety
National Cancer Center, Korea

Active, not recruiting

Effects of H. Pylori Eradication on the Gastric Preneoplastic Lesion and Neoplasm After ESD

Early Gastric Cancer | Helicobacter Pylori Infection | Endoscopic Resection

Korea, Republic of
Cinclus Pharma AG
Parexel

Completed

A Study in Patients With Erosive Esophagitis to Investigate Safety, Tolerability, and Healing Rates After 4 Weeks Treatment of X842 or Lansoprazole and Symptom Pattern During Subsequent 4 Weeks Treatment With Lansoprazole

Erosive Esophagitis

Poland, Bulgaria, Serbia, Georgia, United States, Czechia, Hungary, Ukraine
Bristol-Myers Squibb

Completed

A Study to Assess the Effect of BMS-986419 on the Single Dose Drug Levels of Probe Substrates in Healthy Participants

Healthy Volunteers

United States
Uayporn Kaosombatwattana

Completed

Efficacy of Vonoprazan Versus Intravenous Proton Pump Inhibitors for Prevention of Rebleeding in High Risk Peptic Ulcers Bleeding After Successful Endoscopic Hemostasis

Peptic Ulcer With Haemorrhage

Thailand
Kaohsiung Veterans General Hospital.

Completed

Comparing the Efficacy of Hybrid, High-dose Dual and Bismuth Quadruple Therapies

Helicobacter Pylori Infection

Taiwan
Ain Shams University

Completed

Potassium Copetitive Acid Blockers Efficacy in H.Pylori Eradication (P-CABs)

Helicobacter Pylori Eradication

Egypt
Ping-I (William) Hsu, M.D.

Completed

Efficacies of Two Bismuth Quadruple Therapies in the Second-line Treatment of H Pylori Infection

Helicobacter Pylori Infection

Taiwan

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