Search clinical trials for: TKI-258

Total 557 results

Fujian Cancer Hospital

Recruiting

Radiotherapy Combined With TKI and Anti-PD-1 Antibody for Stage IIIA Hepatocellular Carcinoma

Stage IIIA Hepatocellular Carcinoma

China
AstraZeneca

Completed

Comparing Efficacy Between Anti-microtubule and Non-anti-microtubule as 3th Therapy After 2nd Line EGFR-TKI Therapy

Cancer

Taiwan
Jin Hyoung Kang

Recruiting

Lazertinib in Patients With NSCLC With Asymptomatic or Mild Symptomatic Brain Metastases After Failure of EGFR TKI.

Lung Neoplasms

Korea, Republic of
Betta Pharmaceuticals Co., Ltd.

Completed

Safety and Efficacy Study of Icotinb in Non-small Cell Lung Cancer (NSCLC) Patients (ICOGEN)

Non-small Cell Lung Cancer

China
National Cancer Institute (NCI)

Completed

Pembrolizumab in Recurrent or Metastatic Medullary Thyroid Cancer

Medullary Thyroid Cancer (MTC)

United States
Daping Hospital and the Research Institute of Surgery...

Completed

Combination of Metformin With Gefitinib to Treat NSCLC (CGMT)

NSCLC | Advanced Cancer | EGFR Gene Amplification | Stage IV NSCLC | Stage IIIB NSCLC

China
Kyowa Kirin Co., Ltd.

Completed

ARQ 197 Plus Erlotinib in Patient With Locally Advanced or Metastatic EGFR Mutation-positive Non-small-cell Lung Cancer

Non-small-cell Lung Cancer

Japan
Guangdong Association of Clinical Trials
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Unknown

Anlotinib Hydrochloride Combined With EGFR-Tyrosine Kinase Inhibitor (TKI) in Treating Advanced NSCLC Patients With Acquired Resistance to EGFR-TKI

NSCLC

China
Qingdao Central Hospital

Completed

Weekly Use First-generation EGFR-TKI in the Treatment of EGFR-TKI Acquired Resistance Non-small Cell Lung Cancer (NSCLC)

EGFR-TKI Resistant Mutation

China
Groupe Français de Pneumo-Cancérologie

Completed

Retrospective Study in Non Small Cell Lung Cancer (NSCLC) With Epidermal Growth Factor Receptor (EGFR) (EGFR-RETRO)

NSCLC Non Small Cells Lung Cancer

France
Institut Bergonié
French Sarcoma Group

Recruiting

Patterns of Care and Outcomes of Patients With METAstatic Gastrointestinal Stromal Tumors (METAGIST) (METAGIST)

Gastro Intestinal Stromal Tumor

France
Ankara University

Unknown

Leukemic Stem Cell Detection for Chronic Myeloid Leukemia Patients With Major Molecular Response

Chronic Myeloid Leukemia

Turkey
Intergroupe Francophone de Cancerologie Thoracique
Novartis

Completed

RW Effectiveness of Capmatinib in Advanced MET-dysregulated NSCLC Included in the French Compassionate Use Program (ATU) (CapmATU)

Non Small Cell Lung Cancer | MET Alterations | METex14 Mutations

France
Wageningen University and Research
Amsterdam UMC, location VUmc; Fonterra (Europe) Cooperatie U.A.; Carezzo B.V.; Hogeschool...

Completed

Increase Protein Intake in Elderly

Markedly Reduced Food Intake

Netherlands
First Hospital of Shijiazhuang City
Tianjin Hengjia Biotechnology Development co., LTD

Unknown

Clinical Study of Neoantigen Vaccine Combined With Targeted Drugs in the Treatment of Non-small Cell Lung Cancer

Non Small Cell Lung Cancer

China
National Research Center for Hematology, Russia

Active, not recruiting

A Study of REduction And DIscontinuation Treatment of TKI (Imatinib, Nilotinib, Dasatinib and Bosutinib) (READIT)

Chronic Myeloid Leukemia | Chronic Myeloid Leukemia in Remission | BCR-ABL Positive Chronic Myelogenous Leukemia

Russian Federation
Kartos Therapeutics, Inc.

Recruiting

KRT-232 and TKI Study in Chronic Myeloid Leukemia

Chronic Myeloid Leukemia

Italy, Spain, United States, Korea, Republic of, France, Poland, Canada, Russian Federation
University Medical Center Groningen
Dutch Cancer Society

Recruiting

GIST: Assessment of Tumor Mutations and TKI Plasma Exposure

Gastro-intestinal Stromal Tumor

Netherlands
Sun Yat-sen University

Recruiting

Neoadjuvant Osimertinib + Chemotherapy for EGFR-mutant Stage III NSCLC (NOCE01)

Non-Small Cell Lung Cancer

China
National Cancer Institute (NCI)

Not yet recruiting

Erlotinib in Combination With Select Tyrosine Kinase Inhibitors in Adult Patients With Advanced Solid Tumors

Neoplasms

United States
Bayer

Completed

Duration of Treatment With Tyrosine Kinase Inhibitors in the Treatment of Metastatic Renal Cell Carcinoma (TURCOS)

Renal Cell Carcinoma

Turkey
Degan Lu
Wu Jieping Medical Foundation

Not yet recruiting

A Single Center, Single Arm Clinical Study on the Treatment of Advanced Non-small Cell Lung Cancer With Positive EGFR Sensitive Mutations and Failed EGFR TKIs With the Combination of Enrotinib and Paclitaxel Monoclonal Antibody

Lung Cancer | Anlotinib | TKI Resistance | EGFR Sensitive Mutation | Pianzumab
Daping Hospital and the Research Institute of Surgery...

Not yet recruiting

Combination of Osimertinib and Aspirin to Treat Osimertinib Resistance Non-small Cell Lung Cancer ( NSCLC)

EGFR T790M | Non-small Cell Lung Cancer Stage IV | Non-Small Cell Lung Cancer Stage IIIB
Fondazione IRCCS Istituto Nazionale dei Tumori,...

Terminated

Second Line Sorafenib After Pazopanib in Patients With RCC (SOAP)

Metastatic Renal Cell Carcinoma

Italy
Institute of Cancer Research, United Kingdom

Active, not recruiting

Stereotactic Body Radiotherapy for the Treatment of OPD (HALT)

NSCLC

United Kingdom, France, Switzerland, Italy, Spain
Sun Yat-sen University

Unknown

Apatinib in the Treatment of Advanced Non-squamous Non-small Cell Lung Cancer

Non-small Cell Lung Cancer

China
Amsterdam UMC, location VUmc

Terminated

Iressa Re-challenge in Advanced NSCLC EGFR-mutated Patients (IRENE)

Lung Cancer

Netherlands
China Medical University Hospital

Not yet recruiting

Nintedanib Plus EGFR TKI In EGFR-mutated Non-small Cell Lung Cancer Patients

Non-small Cell Lung Cancer | EGFR Gene Mutation | EGFR-TKI Resistant Mutation
Sierra Oncology, Inc.

Terminated

Erlotinib and Momelotinib for the Treatment of Epidermal Growth Factor Receptor (EGFR) Mutated EGFR Tyrosine Kinase Inhibitor (TKI) Naive Metastatic Non-Small Cell Lung Cancer (NSCLC)

EGFR Mutated EGFR TKI Naive Metastatic NSCLC

United States
Shanghai Chest Hospital
Changhai Hospital; Ruijin Hospital

Unknown

Chemotherapy Plus Gefitinib for Advanced Lung Adenocarcinoma and Sensitive EGFR Mutations: a Randomized Controlled Trial

Lung Adenocarcinoma
Ocular Therapeutix, Inc.

Completed

Study Evaluating the Treatment of OTX-TKI for Subjects With Neovascular Age-related Macular Degeneration

Neovascular Age-Related Macular Degeneration

United States
Tian Xie
LinkDoc Technology (Beijing) Co. Ltd.

Recruiting

Synergistic Effect of Elemene Plus TKIs Compared With TKIs in EGFR-mutated Advanced NSCLC：Prospective Study (SELECT-2)

Adenocarcinoma | Carcinoma | Non-Small-Cell Lung Cancer

China
Yunfei Yuan

Completed

TACE-HAIC Combined With TKIs and Immunotherapy Versus TACE Alone for Hepatocellular Carcinoma With PVTT

Hepatocellular Carcinoma

China
Poitiers University Hospital

Active, not recruiting

Innate T Cells and TKI Discontinuation (TIBIOP-LMC)

Chronic Myeloid Leukemia

France
Sung Yong Lee
Yuhan Corporation

Recruiting

A Study of Lazertinib as Consolidation Therapy in Patients With Locally Advanced, Unresectable, EGFR-Mutant Non-Small Cell Lung Cancer (Stage III) Following Chemoradiation Therapy (PLATINUM)

Non-small Cell Lung Cancer Stage III | Non-squamous Non-small-cell Lung Cancer | EGFR Positive Non-small Cell Lung Cancer

Korea, Republic of
Ruijin Hospital
The First Affiliated Hospital of Nanchang University; Second Affiliated Hospital... and other collaborators

Recruiting

Treatment of EGFR-TKI for Residual Lesions of Multiple Synchronous Ground-glass Opacities (TERMGGO)

Multiple Primary Lung Cancers

China
Ocular Therapeutix, Inc.

Active, not recruiting

CLN-0046: Treatment of AMD Subjects With OTX-TKI

Neovascular Age-related Macular Degeneration

Australia
China Medical University, China

Recruiting

Tyrosine Kinase Inhibitor (TKI) + Anti-PD-1 Antibody in TKI-responded Microsatellite Stability/Proficient Mismatch Repair (MSS/pMMR) Metastatic Colorectal Adenocarcinoma.

Metastatic Colorectal Adenocarcinoma | MSS | pMMR

China
European LeukemiaNet

Completed

European Stop Tyrosine Kinase Inhibitor Study (EURO-SKI)

Chronic Myeloid Leukemia

France, Denmark, Norway, Sweden, Czechia, Portugal, Germany, Netherlands, Finland, Greece
Novartis Pharmaceuticals

Completed

Study of Efficacy and Safety of Brolucizumab vs. Aflibercept in Patients With Visual Impairment Due to Diabetic Macular Edema (KESTREL)

Diabetic Macular Edema

United States, Austria, Japan, Australia, Spain, Canada, Israel, Netherlands, Italy, United Kingdom, Portugal, Colombia, Puerto Rico, Argentina
Beijing Chest Hospital

Unknown

The Efficacy and Drug Resistance Molecular Biology of Apatinib Combined With EGFR-TK1 Treated for Advanced Slow-progressed Non-Small Cell Lung Cancer (NSCLC)

Non Small Cell Lung Cancer

China
Instituto Nacional de Cancerologia de Mexico

Unknown

Metformin Plus TKI Use in Patients With Non-Small Cell Lung Carcinoma

EGFR Gene Mutation | Tyrosine Kinase Mutation | Non-Small Cell Adenocarcinoma

Mexico
Novartis Pharmaceuticals

Completed

Study of Dovitinib Versus Sorafenib in Patients With Metastatic Renal Cell Carcinoma

Metastatic Renal Cell Carcinoma

United States, Canada, France, Italy, Spain, Belgium, Germany, Hungary, Saudi Arabia, Netherlands, Switzerland, Australia, Austria, Poland, Sweden, United Kingdom, Thailand, Korea, Republic of, Greece, Israel, Argentina, Japan, Colo... and more
National Taiwan University Hospital

Recruiting

Primary Tumor Resection With EGFR TKI for Stage IV NSCLC

NSCLC Stage IV

Taiwan
Imperial College London
University of Sheffield; Medical Research Council; University of Cambridge; National...

Active, not recruiting

Positioning Imatinib for Pulmonary Arterial Hypertension (PIPAH)

Pulmonary Arterial Hypertension

United Kingdom
Geneplus-Beijing Co. Ltd.
Shanghai Chest Hospital

Completed

Therapeutic ResistAnce and Clonal Evolution Assessed With Liquid Biopsy of NSCLC Patients in China

Lung Neoplasms | Adenocarcinoma of Lung | Lung Cancer, Nonsmall Cell | Squamous Cell Lung Cancer

China
Fujian Cancer Hospital

Not yet recruiting

Double Dose of Third-generation EGFR-TKI Plus Intrathecal Pemetrexed Versus Double Dose of Third-generation EGFR-TKI in Patients With LM Progression Following the Treatment of Routine Dose of Third-generation EGFR-TKI

Leptomeningeal Metastasis

China
Jonkoping University

Completed

I-CBT Tailored to Patients With Cardiovascular Disease and Insomnia (Hit-IT)

Cardiovascular Diseases | Insomnia

Sweden
Cairo University

Unknown

Fentanyl Versus Midazolam As Additives To Bupivacaine In Ultrasound Guided Transversus Abdominis Plane Block

Postoperative Pain

Egypt
Regional Health Center in Kartuzy, Poland
Medical University of Gdansk

Completed

ProGrip Mesh Repair vs Lichtenstein Operation

Inguinal Hernia

Poland

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