Search clinical trials for: drug related toxicity

Total 281646 results

Groupe Hospitalier Pitie-Salpetriere

Completed

Monitoring the Antiphospholipid Syndrome:TOXicity of Drugs (APSTOX) (APSTOX)

Antiphospholipid Syndrome | Adverse Drug Event | Drug Toxicity | Immune Disease

France
Groupe Hospitalier Pitie-Salpetriere

Completed

Monitoring the Hyperammonaemia:TOXicity of Drugs (AmmoTOX) (AmmoTOX)

Metabolic Disease | Adverse Drug Event | Hyperammonemia | Drug Toxicity

France
Grupo Espanol de Investigacion en Sarcomas

Active, not recruiting

Selinexor as Single Agent and With Imatinib in Metastatic and/or Unresectable Gastrointestinal Stromal Tumors (SeliGIST) (SeliGIST)

Drug Use | GIST | Drug Toxicity | Metastatic Adult Soft Tissue Sarcoma | Maximum Tolerated Dose

Spain
Jessa Hospital
Hasselt University

Completed

Novel Skin Care for Chemotherapy- Related Dermatologic Toxicities (ChemoSkin)

Skin Toxicity

Belgium
Giulio Stefanini
Agenzia Italiana del Farmaco

Active, not recruiting

Cardioprotective Effects of Nebivolol Versus Placebo in Patients Undergoing Chemotherapy With Anthracyclines (CONTROL)

Lymphoma, Large B-Cell, Diffuse | Breast Cancer | Chemotherapy Effect | Cardiotoxicity | Left Ventricular Dysfunction

Italy
Nanjing Medical University

Completed

Immune Checkpoint Inhibitors(ICPis)-Induced Endocrine Immune-related Adverse Events (irAEs)

Immune Checkpoint Inhibitor | Endocrine Toxicity

China
Linda Van Eldik
National Institute on Aging (NIA); Duke Clinical Research Institute

Completed

MW151-101: First-in-human Study of MW151

Drug Toxicity

United States
Ruijin Hospital
RenJi Hospital; Shanghai 10th People's Hospital; Xinhua Hospital, Shanghai Jiao... and other collaborators

Active, not recruiting

The Safety Management of Cardiac Toxicity in Breast Cancer Patients Under Multidiscipline Therapy.

Breast Neoplasms | Cardiotoxicity

China
Southwest Oncology Group
National Cancer Institute (NCI)

Completed

S1013: Validation of Cancer Questionnaire for Skin Toxicities in Patients With Colorectal Cancer or Lung Cancer Receiving Cetuximab, Panitumumab, or Erlotinib Hydrochloride

Colorectal Cancer | Lung Cancer | Dermatologic Complications | Therapy-related Toxicity

United States
University of California, San Francisco
National Institute on Drug Abuse (NIDA); National Institutes of Health (NIH)

Withdrawn

Cigarette Harm Reduction With Electronic Cigarette Use (NIDA-SREC)

Cardiovascular Risk Factor | Nicotine Dependence | Nicotine Dependence, Cigarettes | Nicotine Withdrawal | Tobacco Toxicity

United States
Nova Scotia Health Authority

Completed

Exercise to Prevent AnthrCycline-based Cardio-Toxicity Study (EXACT)

Neoplasms | Inflammation | Heart; Disease, Functional

Canada
Swansea University
Abertawe Bro Morgannwg University Health Board

Completed

CARdiac Function Evaluation in Breast Cancer Patients (CARE-B)

Breast Cancer Female

United Kingdom
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Completed

Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity in Patients With Colon Cancer or Rectal Cancer Receiving Oxaliplatin-Based Combination Chemotherapy

Colorectal Cancer | Neurotoxicity | Neuropathy | Chemotherapeutic Agent Toxicity

United States, Puerto Rico
Shanghai Mental Health Center

Completed

Prolactin Change in Chinese Patients With Schizophrenia After Antipsychotics Treatment

Schizophrenia | Antipyretics Toxicity | Prolactin Excess

China
Tanta University

Enrolling by invitation

Role of Silymarin in Chemotherapy Toxicity and Cognition Improvement in Breast Cancer Patients

Breast Cancer | Cognitive Impairment | Peripheral Neuropathy | Cardiac Toxicities | Hepatic Toxicity

Egypt
Oslo University Hospital
Swedish Orphan Biovitrum

Completed

Trabectedin/Caelyx vs Cisplatin Hypersensitivity in Relapsed Ovarian Cancer Patients Allergic to Platinum (TvsCH)

Chemotherapy-induced Nausea and Vomiting | Chemotherapy Effect | Chemotherapeutic Toxicity | Ovarian Neoplasm | Chemotherapy-induced Neutropenia
Mayo Clinic
National Cancer Institute (NCI)

Completed

Doxorubicin and Cyclophosphamide Followed By Trastuzumab, Paclitaxel, and Lapatinib in Treating Patients With Early-Stage HER2-Positive Breast Cancer That Has Been Removed By Surgery

Breast Cancer | Cardiac Toxicity

United States
Institut Cancerologie de l'Ouest

Completed

Efficacy and Tolerance Evaluation in FOLFIRINOX Dose Adjusted in Elderly Patients With a Metastatic Pancreatic Cancer (PAMELA70)

Toxicity | Pancreatic Metastatic Cancer

France
Azienda Ospedaliera Città della Salute e della...

Completed

Subclinical Cardio-toxicities Evaluation With Strain Rate Echocardiography After Chemotherapy and/or Mediastinal Radiotherapy in Patient With Lymphoma (Cardiocare)

Lymphoma, Non-Hodgkin | Hodgkin Lymphoma | Toxicity, Cardiac

Italy
Tyme, Inc

Completed

A Randomized Phase 2/3 Multi-Center Study of SM-88 in Patients With Metastatic Pancreatic Cancer

Pancreatic Cancer

United States
University of California, Los Angeles
Gilead Sciences

Completed

Relative Mitochondrial Toxicity of Tenofovir Alafenamide (TAF) vs. Tenofovir Disoproxil Fumarate (TDF) (UCLACAREMITO)

HIV/AIDS | Mitochondrial Alteration | Antiviral Toxicity | Antiviral Drug Adverse Reaction

United States
Tata Memorial Hospital
Department of Atomic Energy

Active, not recruiting

To Study the Impact of Radiation Treatment After Surgery in Patient With Locally Advanced Thyroid Cancer. (THYRO-RT)

Radiation Toxicity | Thyroid Cancer Stage IV

India
Peking University People's Hospital
Peking University Shougang Hospital

Completed

Apatinib + Ifosfamide and Etoposide for Relapsed or Refractory Osteosarcoma

Effect of Drug | Toxicity, Drug | Secondary Resistance

China
Bristol-Myers Squibb

Completed

Real-world Incidence Proportion of Hepatic Toxicity and All Adverse Drug Reactions (ADRs) in Japanese Patients Receiving Daclatasvir (DCV) Trio Therapy

Hepatitis C

Japan
CHU de Reims

Completed

Association Between Proton Pump Inhibitors and Hematologic Toxicity of Pemetrexed (IPPEM)

Patients With Non-small Cell Lung Cancer (NSCLC) and Pleural Mesothelioma and Treated With a Pemetrexed-based Chemotherapy

France
University Hospital, Bordeaux

Completed

Early Detection of Anthracycline Cardiotoxicity by Echocardiographic Analysis of Myocardial Deformation in 2D Strain (CA2D)

Leukemia | Cardiac Toxicity

France
China Medical University Hospital

Completed

Prophylactic TCM for Mitigation of EGFR-TKI Related Dermatological Adverse Effect

Advanced Lung Adenocarcinoma
Fondation Ophtalmologique Adolphe de Rothschild

Completed

Studying the Performance of OCT C-scan in the Screening for Retinopathy Related to Synthetic Antimalarials (PERFOCTAPS)

Maculopathy | Toxicity, Drug

France
M.D. Anderson Cancer Center
Sanofi

Completed

Fludarabine-IV Busulfan ± Clofarabine and Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS)

Leukemia | Transplantation Infection | Disorder Related to Bone Marrow Transplantation

United States
National Institute of Allergy and Infectious Diseases...

Completed

A Phase I Clinical Trial To Evaluate the Toxicity, Antiviral and Immunomodulatory Effects of a Range of Doses of Ampligen in HIV-Infected Subjects

HIV Infections

United States
National Institute of Allergy and Infectious Diseases...

Completed

Aerosols in the Treatment of Pneumocystis Pneumonia: A Pilot Study Quantitating the Deposition of Aerosolized Pentamidine as Delivered in ACTG 040 and Comparing Its Toxicity With Parenteral Pentamidine Therapy

HIV Infections | Pneumonia, Pneumocystis Carinii

United States
National Institute of Allergy and Infectious Diseases...

Completed

A Clinical Trial To Evaluate the Toxicity and Antiviral Effects of a Range of Doses of Ampligen in p24 Antigen Positive HIV-Infected Patients With AIDS or ARC

HIV Infections

United States
Gynecologic Oncology Group
National Cancer Institute (NCI)

Active, not recruiting

Chemotherapy Toxicity On Quality of Life in Older Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian Epithelial, Primary Peritoneal Cavity, or Fallopian Tube Cancer

Stage I Ovarian Cancer AJCC v6 and v7 | Stage IA Fallopian Tube Cancer AJCC v6 and v7 | Stage IB Fallopian Tube Cancer AJCC v6 and v7 | Stage IC Fallopian Tube Cancer AJCC v6 and v7 | Stage II Ovarian Cancer AJCC v6 and v7 | Stage IIA Fallopian Tube Cancer AJCC v6 and v7 | Stage IIB Fallopian... and other conditions

United States
Battelle Memorial Institute

Completed

Reduced Nicotine Cigarettes in Smokers With and Without Alcohol Use Disorder (RedNic)

Alcohol Drinking | Cigarette Smoking Toxicity

United States
Queen's University

Completed

Bupivacaine Levels in Liver Resection Patients

Hepatectomy | Analgesia, Epidural

Canada
Peking University Third Hospital

Unknown

Risk Assessment Model of Trastuzumab-related Cardiotoxicity in Breast Cancer Patients

Breast Cancer | Cardiac Toxicity | Antitumor Drugs

China
Myocardial Solutions

Completed

MyoStrain CMR for the Detection of Cardiotoxicity (Prefect)

Heart Failure | Cardiotoxicity | Chemotherapeutic Toxicity

Germany
UDA Centro Nacional Hepato-Bilio-Pancreático
University Hospital, Limoges; Universidad de la Republica; INSERM UMR-S850, Limoges... and other collaborators

Terminated

Study of PD/PK/PG Relationships of Tacrolimus and Cyclosporin in Liver Transplant Patients (3PIGREF)

End Stage Liver Disease | Diabetes | Toxicity | Rejection | Infection | Malignancy

Uruguay
Rush University Medical Center
National Cancer Institute (NCI)

Unknown

Amifostine and High-Dose Combination Chemotherapy in Treating Patients With Acute Myeloid Leukemia or Chronic Myelogenous Leukemia

Myelodysplastic Syndromes | Leukemia | Neutropenia | Drug/Agent Toxicity by Tissue/Organ

United States
Eagle Pharmaceuticals, Inc.

Terminated

Efficacy and Safety Study of Ryanodex as Adjuvant Treatment in Subjects With Psychostimulant Drug-Induced Toxicity (PDIT)

Drug Toxicity Psychotropic Agents Psychostimulants

United States
University of South Florida
National Cancer Institute (NCI)

Completed

Lisinopril or Coreg CR® in Reducing Side Effects in Women With Breast Cancer Receiving Trastuzumab

Breast Cancer | Cardiac Toxicity

United States
Pontificia Universidad Catolica de Chile

Unknown

PK/PD Levobupivacaine With and Without Epinephrine After Ultrasound Guided ESP Block

Surgery | Nerve Block | Anesthetic Toxicity | Anesthetics Complications | Bupivacaine Overdose

Chile
EmeraMed
NBMI Science AB

Completed

Pilot Proof of Concept Study of NBMI Treatment of Mercury Intoxication (NBMI)

Mercury Poisoning

Ecuador
Oncologia Medica dell'Ospedale Fatebenefratelli
Mario Negri Institute for Pharmacological Research

Completed

PAINTER: Polymorphism And INcidence of Toxicity in ERibulin Treatment

Metastatic Breast Cancer | Toxicity | Neurotoxicity | Adverse Drug Event | Drug Toxicity

Italy
Ottawa Hospital Research Institute

Completed

An Integrated Consent Model Study to Compare Two Standard of Care Schedules for Monitoring Cardiac Function in Patients Receiving Trastuzumab for Early Stage Breast Cancer (OTT 15-05)

Breast Cancer

Canada
Menoufia University

Enrolling by invitation

Adverse Effects of Ivermectin Used in Egypt During COVID-19

Covid19 | Drug Toxicity | Drug Side Effect | Ivermectin Poisoning

Egypt
University of South Florida
National Cancer Institute (NCI)

Terminated

Triptorelin for Preserving Ovarian Function in Premenopausal Women Receiving Chemotherapy for Early-Stage Breast Cancer

Breast Cancer | Drug Toxicity | Hormone Changes

United States
Institut Claudius Regaud

Completed

Cohort Study: Modelling Toxicity Processing in Patients Treated by Immunotherapy (MOTIVATE). (MOTIVATE)

Solid Tumor

France
Peking University People's Hospital

Completed

Apatinib for Inoperable Advanced Chondrosarcoma (AIAC)

Efficacy | Toxicity, Drug

China
Mabaret Al-Asafara Hospitals

Unknown

Antidote for Valproic Acid Toxicity: a New Indication for Meropenem Antibiotic.

Drug Toxicity

Egypt

Search clinical trials for: drug related toxicity

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Gambia

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations