Search clinical trials for: pharmacologic actions

Total 96031 results

Johns Hopkins University

Completed

Pilot Study: Effects of Psilocybin on Behavior, Psychology and Brain Function in Long-term Meditators

Psilocybin | Therapeutic Uses | Psychotropic Drugs | Hallucinogens | Pharmacologic Actions | Central Nervous System Agents

United States
Assistance Publique - Hôpitaux de Paris

Terminated

Study of Sunitinib in Patients With Advanced/Inoperable Fibrolamellar Carcinoma (Fibrolam)

Hepatocellular Carcinoma | Fibrolamellar Hepatocellular Carcinoma

France
Göteborg University
Eisai Inc.

Completed

Zonisamide for the Treatment of Obstructive Sleep Apnea in Overweight/Obese Patients

Obesity | Obstructive Sleep Apnea | Sleep Apnea

Sweden
Barts & The London NHS Trust
National Health Service, United Kingdom

Completed

Trial of Vitamin D Supplementation for the Prevention of Influenza and Other Respiratory Infections (ViDiFlu) (ViDiFlu)

Respiratory Tract Infections | Influenza

United Kingdom
AVEO Pharmaceuticals, Inc.

Completed

A Phase 1 Dose-Escalation Study in Advanced Solid Tumors, Lymphomas or Multiple Myeloma (P05538)

Multiple Myeloma | Lymphomas | Malignant Solid Tumor

United States
Gilead Sciences

Approved for marketing

Expanded Access Program of Sofosbuvir With Ribavirin and With or Without Pegylated Interferon in Aggressive Post-transplant Hepatitis C

Post-transplant Hepatitis C
Unity Health Toronto

Completed

Efficacy and Safety Study to Evaluate Two Doses of Oral DMI-5207 in Adult Subjects With Diabetic Macular Edema

Diabetic Macular Edema
Osel, Inc.

Withdrawn

Safety and Clinical Effectiveness of Oral Probiotic MIYA-BM to Prevent Recurrent Clostridium Difficile Infections

Clostridium Difficile Infection
H. Lundbeck A/S

Completed

Safety and Efficacy of Nalmefene in Patients With Alcohol Dependence (SENSE)

Alcohol Dependence

Poland, Russian Federation, Ukraine, Czech Republic, Estonia, Hungary, Latvia, Lithuania, Slovakia, United Kingdom
H. Lundbeck A/S

Completed

Efficacy of Nalmefene in Patients With Alcohol Dependence (ESENSE2)

Alcohol Dependence

Poland, Belgium, Czech Republic, France, Italy, Portugal, Spain
Astellas Pharma Europe B.V.

Completed

A Study to Compare the Actions in the Body of Healthy Subjects of Three Modified Release Formulations of YM178 Under Fasted and Fed Conditions With One Immediate Release Formulation of YM178 Under Fasted Conditions

Healthy Subjects | Pharmacokinetics of YM178

Netherlands
Astellas Pharma Europe B.V.

Completed

A Study to Evaluate the Safety and Tolerability of YM150 in Healthy Caucasian and Japanese Male and Female Subjects, and to Assess the Effect That Gender May Have on Its Actions in the Body

Healthy Subjects | Pharmacokinetics | Pharmacodynamics | Japanese | Caucasian

Germany
Johnson & Johnson Pharmaceutical Research & Development...
PharmaMar; PharmaMar S.A.U.

Completed

A Safety Study Utilizing Yondelis and Doxorubicin in Patients With a Type of Cancer Called Soft Tissue Sarcoma

Sarcoma | Neoplasms | Soft Tissue Sarcoma | Neoplasms, Connective and Soft Tissue | Neoplasms by Histologic Type
University of Sao Paulo

Unknown

Potentiation of Quetiapine Treatment With Lithium or Aripiprazole in Bipolar 1 Nonresponders Patients (ARIQUELI)

Bipolar I Disorder

Brazil
Abbott

Terminated

Efficacy and Tolerability of ABT-869 Versus Sorafenib in Advanced Hepatocellular Carcinoma (HCC)

Liver Diseases | Digestive System Diseases | Neoplasms | Neoplasms by Histologic Type | Neoplasms by Site | Adenocarcinoma | Carcinoma | Neoplasms, Glandular and Epithelial | Digestive System Neoplasms | Carcinoma, Hepatocellular | Liver Neoplasms | Hepatocellular Carcinoma Non-resectable | Hepatocellular Carcinoma...

United States, Argentina, Australia, Austria, Belgium, Canada, Chile, China, Czech Republic, Denmark, Egypt, France, Germany, Greece, Hong Kong, Italy, Japan, Korea, Republic of, Malaysia, Mexico, Netherlands, New Zealand, Norway, Puerto... and more
Biolex Therapeutics, Inc.

Completed

Study of Safety, Tolerability, and Anti-Viral Effect of Locteron Compared to PEG-Intron in Patients With Chronic Hepatitis C (PLUS)

Hepatitis C

United States
The Alfred
Monash University

Unknown

Oxytocin and Tibolone Adjuncts in Treatment Resistant Depression - A Pilot Study

Depression | Major Depressive Disorder

Australia
University of Limerick
Irish Research Council

Completed

Effect of 10mg Domperidone on Gastric Emptying of a High-fat Meal and Appetite Sensations in Healthy Adults

Diabetes Mellitus

Ireland
Yokohama City University Medical Center

Unknown

The Effects of Pravastatin and Rosuvastatin on Coronary Plaques in Patients With Stable Angina Pectoris

Coronary Disease | Hypercholesterolemia

Japan
National Institute of Allergy and Infectious Diseases...

Completed

A Study to Evaluate the Effects of Different Methods of Birth Control on the Drug Actions of Zidovudine (an Anti-HIV Drug) in HIV-Positive Women and to Compare Zidovudine Metabolism in Men and Women

HIV Infections

United States
Aichi Gakuin University

Unknown

Effects of Alogliptin on Pancreatic Beta Cell Function

Diabetes Mellitus, Type 2

Japan
Proto Pharma Ltd
Xidea Solutions Limited

Completed

Efficacy of ArTiMist™ in Children

Falciparum Malaria
CardioDex
Sheba Medical Center

Withdrawn

Hemostatic Closure of Femoral Artery Access Site, Using the QuickClose Design 9 System

Coagulation | Therapeutic Uses | Pharmacologic Actions

Israel
Eunice Kennedy Shriver National Institute of Child...

Completed

The Role of 5-alpha Reductase in Mediating Testosterone Actions (5aR)

Healthy

United States
Uppsala University

Completed

Tailoring Of Platelet Inhibition to Avoid Stent Thrombosis (TOPAS-1)

Myocardial Infarction | Heart Diseases | Coronary Artery Disease | Acute Coronary Syndrome | Stent Thrombosis

Sweden
Mayo Clinic
National Institutes of Health (NIH)

Completed

Steady-State Feedback Actions of Testosterone on Luteinizing Hormone Secretion in Young and Older Men

Hypogonadism

United States
Charite University, Berlin, Germany
University of Ulm

Completed

Anti-Inflammatory Actions of Valsartan in Patients With Type 2 Diabetes Mellitus

Coronary Artery Disease | Hypertension | Type 2 Diabetes Mellitus

Germany
Peking University First Hospital

Recruiting

Fractional Flow Reserve-guided Stenting Versus Medical Therapy in Atherosclerosis Renal Artery Stenosis (FAIR)

Renal Artery Stenosis Atherosclerotic | Secondary Hypertension Renal Arterial

China
Fudan University

Recruiting

Apatinib Combined With cdk4/6i in First-line Treatment for HR+/HER2- SNF4 Subtype Breast Cancer

Advanced Breast Cancer | HR+/HER2- Breast Cancer

China
University of North Carolina, Chapel Hill
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Not yet recruiting

Dose Optimization of Caffeine for HIE

Hypoxic-Ischemic Encephalopathy

United States
Changchun GeneScience Pharmaceutical Co., Ltd.

Not yet recruiting

Safety, Efficacy and Pharmacokinetic Behavior of Leuprolide Injectable Emulsion for Premenopausal Breast Cancer Subjects.

Breast Cancer Subjects

China
Academisch Medisch Centrum - Universiteit van Amsterdam...
Universitair Medical Centrum Groningen

Not yet recruiting

Head-to-Head Comparison of All Botulinum Neurotoxin Type A Products for Glabellar Rhytides

Wrinkle
Jonsson Comprehensive Cancer Center

Not yet recruiting

PH Weighted Chemical Exchange Saturation Transfer MRI-Based Surgical Resection to Improve Survival in Patients With Glioblastoma

Glioblastoma

United States
University of Maryland, Baltimore

Not yet recruiting

Effect of RECK in Posterior Spinal Fusion

Degenerative Disc Disease | Degenerative Spondylolisthesis | Degenerative Lumbar Spinal Stenosis | Degenerative Disease

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

Humanized CD19-Specific CAR T Cells for the Treatment of Patients With Positive Relapsed or Refractory CD19 Positive B-Cell Acute Lymphoblastic Leukemia

Recurrent Acute Lymphoblastic Leukemia | Refractory Acute Lymphoblastic Leukemia

United States
Pfizer

Not yet recruiting

A Study to Learn About the Study Medicine PF-07934040 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Genetic Mutation.

Carcinoma, Non-Small-Cell Lung | Colorectal Neoplasms | Carcinoma, Pancreatic Ductal
BioNTech SE

Not yet recruiting

Safety and Preliminary Effectiveness of BNT327, an Investigational Therapy for Breast Cancer, When Given in Combination With Chemotherapy

Triple Negative Breast Cancer | Locally Advanced Breast Cancer
Shanghai Zhongshan Hospital

Not yet recruiting

Combining Chemoradiotherapy With Sintilimab in First-Line ICC

ICC

China
BioNTech SE

Not yet recruiting

Safety, Preliminary Effectiveness of BNT327, an Investigational Therapy for Patients With Small-cell Lung Cancer in Combination With Chemotherapy

Small-cell Lung Cancer | Extensive-stage Small-cell Lung Cancer
Mersin Medicalpark Hastanesi

Not yet recruiting

Does Verapamil Given Orally Prevent Radial Artery Spasm During Transradial Coronary Angiography

Radial Artery Spasm
Ohio State University Comprehensive Cancer Center

Recruiting

Manipulating E-Cigarette Nicotine to Promote Public Health

Tobacco-Related Carcinoma

United States
Shandong University
Chinese PLA General Hospital

Not yet recruiting

Observational Study on the Sensitivity of Neoadjuvant Immunotherapy in Early Triple-Negative Breast Cancer

Triple Negative Breast Cancer | Sensitivity | Neoadjuvant Immunotherapy
Sichuan Kelun Pharmaceutical Research Institute...

Recruiting

A Study of SKB264 in Combination With Pembrolizumab Versus Pembrolizumab in Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

Non-Small Cell Lung Cancer

China
D. Bradley Welling, MD, PhD
Nobelpharma

Not yet recruiting

In-office Repair of Chronic Tympanic Membrane Perforations

Chronic Tympanic Membrane Perforation

United States
University of Milan
Kolfarma s.r.l. - Italy; Fondazione Telethon

Recruiting

Targeting the Gut to Improve Seizure Control in CDKL5 Deficiency Disorder (CDD) (NUTRIENT)

CDKL5

Italy
AstraZeneca

Not yet recruiting

Volrustomig Priming Regimens Exploratory Phase II Platform Study (eVOLVE-01)

Non-small Cell Lung Cancer
Huai'an First People's Hospital
The Affiliated Hospital of Xuzhou Medical University; The First People's Hospital... and other collaborators

Recruiting

A Clinical Study Evaluating the Safety and Efficacy of ZRMT Regimen in the Treatment of PCNSL

Primary Central Nervous System Lymphoma

China
The University of Texas Health Science Center at...
Baptist Health Foundation of San Antonio

Recruiting

Prevention of Progression of Prediabetes, Obesity and CV Risk (Pre-DM)

Cardiovascular Diseases | Weight, Body | Pre-Diabetes

United States
Merck Sharp & Dohme LLC

Not yet recruiting

Substudy 06D: Combination Therapies in Second Line (2L) Gastroesophageal Adenocarcinoma (MK-3475-06D/Keymaker-U06)

Esophageal Cancer | Esophageal Neoplasms | Gastroesophageal Adenocarcinoma | Gastroesophageal Junction
Sichuan Baili Pharmaceutical Co., Ltd.
Baili-Bio (Chengdu) Pharmaceutical Co., Ltd.

Not yet recruiting

A Study of BL-M07D1, BL-M07D1+Pertuzumab and BL-M07D1+Pertuzumab+Docetaxel in Patients With Unresectable Locally Advanced or Metastatic HER2-positive Breast Cancer

HER2-positive Breast Cancer

China

Search clinical trials for: pharmacologic actions

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