Search clinical trials for: s-EH enzyme inhibition

Total 49218 results

Rockefeller University

Completed

Celecoxib Inhibition of Aromatase Expression and Inflammation in Adipose Tissue of Obese Postmenopausal Women

Obesity

United States
Imperial College London
National Institute for Health Research, United Kingdom

Completed

AARDVARK (Aortic Aneurysmal Regression of Dilation: Value of ACE-Inhibition on RisK) (AARDVARK)

Abdominal Aortic Aneurysm

United Kingdom
Kafrelsheikh University

Unknown

Efficacy of Aerosol Combination Therapy of 13 Cis Retinoic Acid and Captopril for Treating Covid-19 Patients Via Indirect Inhibition of Transmembrane Protease, Serine 2 (TMPRSS2)

Covid19
Johannes Gutenberg University Mainz
Leap Therapeutics, Inc.

Unknown

DKN-01 Inhibition in Advanced Liver Cancer

Hepatocellular Carcinoma

Germany
TriHealth Inc.
TriHealth Cancer Institute; TriHealth Surgical Institute; TriHealth Ultrasound... and other collaborators

Withdrawn

Neoadjuvant Use of Talimogene Laherparepvec and BRAF/MEK Inhibitor for Advanced Nodal BRAF Mutant Melanoma

Melanoma (Skin) | Tumor Skin | BRAF Gene Mutation | Melanoma Stage IIIb-IVM1a | Metastasis Skin

United States
Qianfoshan Hospital
Jiangsu Hengrui Pharmaceutical Co., Ltd.

Unknown

Camrelizumab Combined With Apatinib in the Treatment of Epithelial Ovarian Cancer

Immune Checkpoint Inhibition

China
Astex Pharmaceuticals, Inc.

Completed

A Study to Investigate the Effect of CYP3A4 Inhibition on the Single Dose Pharmacokinetics of ASTX660 and the Effect of a Single Dose of ASTX660 on the Pharmacokinetics of the CYP3A4 Substrate Midazolam

Healthy Volunteer

United States
Chinese PLA General Hospital

Unknown

Combined Inhibition of PD-1 and DNA Hypomethylating Agent +/- Chemotherapy in High-risk AML or Elderly Patients With AML Who Are Unfit for Intensive Chemotherapy

Acute Myeloid Leukemia, in Relapsed or Refractory | Acute Myeloid Leukemia, Elderly, Unfit | Acute Myeloid Leukemia With Positive Minimal Residual Disease

China
Laval University

Terminated

Olaparib for PAH: a Pilot Study (OPTION-p)

Pulmonary Arterial Hypertension

Canada
H. Lundbeck A/S

Completed

Study That Evaluates the Effect of CYP3A4 Inhibition on Lu AG06466 in Healthy Men and Women

Healthy

United States
National Cancer Institute (NCI)
Eastern Cooperative Oncology Group; Canadian Cancer Trials Group; Southwest Oncology... and other collaborators

Completed

Doxorubicin Hydrochloride, Cyclophosphamide, and Pacltaxel With or Without Trastuzumab in Treating Women With HER2-Positive Node-Positive or High-Risk Node-Negative Breast Cancer

HER2 Positive Breast Carcinoma | Stage IA Breast Cancer AJCC v7 | Stage IB Breast Cancer AJCC v7 | Stage IIA Breast Cancer AJCC v6 and v7 | Stage IIB Breast Cancer AJCC v6 and v7 | Stage IIIA Breast Cancer AJCC v7 | Breast Adenocarcinoma

United States, Canada, Peru, South Africa
University of Utah

Completed

Phase 1 Pilot Study of 4-MP to Treat Stargardt Macular Dystrophy

Macular Dystrophy, Corneal

United States
Bristol-Myers Squibb

Completed

An Investigational Study to Determine the Drug Level Profile of BMS-986165 in Healthy Male Volunteers Following Transporter Inhibition.

Healthy Male Volunteers

United States
Centre Hospitalier Universitaire Vaudois
AstraZeneca

Completed

Platelet Inhibition After Pre-hospital Ticagrelor Using Fentanyl Compared to Morphine in Patients With ST-segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention (PERSEUS)

Acute Myocardial Infarction

Switzerland
University College Dublin

Completed

Dipeptidyl Peptidase-4 Inhibition in Psoriasis Patients With Diabetes (DIP): A Randomized Clinical Trial. (DIP)

Type 2 Diabetes Mellitus | Psoriasis

Ireland
Vanderbilt University
National Heart, Lung, and Blood Institute (NHLBI)

Completed

The Effect of Dipeptidyl Peptidase 4 Inhibition on Growth Hormone Secretion in Women With Polycystic Ovarian Syndrome

Polycystic Ovary Syndrome

United States
Hospices Civils de Lyon

Unknown

MEK and Autophagy Inhibition in Metastatic/Locally Advanced, Unresectable Neuroblastoma RAS (NRAS) Melanoma (CHLOROTRAMMEL)

Metastatic NRAS Melanoma

France
Hoffmann-La Roche

Completed

A Study to Investigate the Effect of CYP3A Inhibition on the Pharmacokinetics of RO7017773 in Healthy Participants

Healthy Volunteers

France
University of Milan
Fondazione "Un Cuore per Milano" - a no profit foundation

Completed

Enhanced Platelet Inhibition in Critically Ill Patients With COVID-19 (PIC-19)

Pneumonia, Viral | Embolism and Thrombosis | Respiratory Failure | Corona Virus Infection

Italy
Abramson Cancer Center of the University of Pennsylvania
University of Pittsburgh; Rutgers Cancer Institute of New Jersey

Completed

Autophagy Inhibition to Augment Mammilian Target of Rapamycin (mTOR) Inhibition: A Phase I/II Trial of RAD001 and Hydroxychloroquine (HCQ) in Patients With Previously Treated Renal Cell Carcinoma

Metastatic Clear Cell Renal Cell Carcinoma

United States
University of North Carolina, Chapel Hill
National Heart, Lung, and Blood Institute (NHLBI)

Completed

The Effect of Rivaroxaban in Sickle Cell Disease

Sickle Cell Anemia | Sickle Cell-Beta0-Thalassemia

United States
Bayer

Completed

FactOr XIa inhibiTion for the pRevention of venOus Thromboembolism in Patients Undergoing Total Knee Arthroplasty (FOXTROT)

Knee Arthroplasty, Total

Lithuania, Spain, Bulgaria, Israel, Poland, Czechia, Greece, Russian Federation, Latvia, Portugal, Ukraine, Canada, South Africa
Bristol-Myers Squibb

Completed

A Study to Investigate the Effects of Itraconazole on the Pharmacokinetics of BMS-986256 in Healthy Participants

Healthy Participants

United States
Vastra Gotaland Region

Terminated

Effects of PDE-5 Inhibition on Postprandial Hyperglycemia in Type 2 Diabetes

Type 2 Diabetes

Sweden
Hoosier Cancer Research Network
Clovis Oncology, Inc.

Completed

PARP Inhibition for Triple Negative Breast Cancer (ER-/PR-/HER2-)With BRCA1/2 Mutations

Breast Cancer

United States
Dana-Farber Cancer Institute
Bristol-Myers Squibb

Withdrawn

A Phase II Trial of Neoadjuvant Treatment With PD-1 Inhibition (Nivolumab) With or Without IDO Inhibition (BMS-986205) and With or Without CTLA-4 Inhibition (Ipilimumab) in Resectable Stage III or IV Melanoma

Melanoma Stage IV | Melanoma Stage III

United States
University of Pennsylvania

Completed

Mechanisms of Action of Acetaminophen

Myocardial Infarction | Arthritis

United States
University of Kansas Medical Center
AstraZeneca

Completed

Inhibition of Gastric Acid is the Key to Satisfactory Relief of Symptoms With Esomeprazole in NUD Patients

Indigestion

United States
NHS Greater Glasgow and Clyde

Completed

Immune Metabolic Associations in Psoriatic Arthritis (IMAPA)

Psoriasis | Psoriatic Arthritis

United Kingdom
Celgene

Completed

A Phase 1 Open-Label Study to Evaluate the Effect of CYP450 and P-gp Inhibition and Induction on the Pharmacokinetics of Pomalidomide (CC-4047) in Healthy Male Subjects (DDI)

Healthy | Pharmacology, Clinical

United States
Celgene
Covance

Completed

Effect of P-glycoprotein Inhibition on Lenalidomide Pharmacokinetics in Healthy Males

Healthy

United States
University of Minnesota

Withdrawn

Phosphodiesterase-5 (PDE-5) Inhibition in Heart Transplant Recipients

Cardiac Allograft Vasculopathy

United States
Roberto S Kalil

Terminated

Xanthine Oxidase Inhibition in Renal Transplant Recipients (XART)

Complications of Renal Transplant

United States
Aragon Institute of Health Sciences

Completed

Melatonin Associated to Acid Inhibition for Chemoprevention in Barret Esophagus: a Pilot Study

Barrett's Esophagus

Spain
Cambridge University Hospitals NHS Foundation Trust
AstraZeneca

Completed

Study of Olaparib (± Degarelix) Given to Men With Intermediate/High Risk Prostate Cancer Before Prostatectomy (CaNCaP03)

Prostate Cancer

United Kingdom
M.D. Anderson Cancer Center
Bristol-Myers Squibb

Completed

FOLFOX Chemotherapy Regimen (5-FU, Leucovorin, Oxaliplatin) in Metastatic Colorectal Cancer

Colorectal Cancer

United States
Galmed Pharmaceuticals Ltd
Hammersmith Medicines Research; Diamond Pharma Services Regulatory Affairs... and other collaborators

Completed

Study of Potential for Drug Interactions Mediated by CYP3A4 Inhibition With Aramchol in Healthy Volunteers

Healthy

United Kingdom
King's College London
King's College Hospital NHS Trust; AstraZeneca

Unknown

SRC Inhibition as a Potential Target for Parkinson's Disease Psychosis (SCRIPT)

Parkinson Disease Psychosis

United Kingdom
University of Alabama at Birmingham

Completed

Phosphodiesterase Type 5 Inhibition to Improve Endothelial Function and Vascular Remodeling in Chronic Kidney Disease and End Stage Renal Disease Patients Requiring New Arteriovenous Fistula

Improve Endothelial Function and Decrease Vascular Stenosis

United States
University of Minnesota
National Institute of General Medical Sciences (NIGMS)

Completed

Effects of Genotype on CYP2C9 Drug Interactions

Healthy

United States
University Hospital Inselspital, Berne
Merck Sharp & Dohme LLC

Unknown

Can Ibuprofen Delay Ovulation in Natural Cycle-IVF? (Ibudelay)

Pregnancy | Ovulation | Ovulation Inhibition | Ovulation Inhibition/Drug Effects | Fertilization in Vitro/Methods

Switzerland
Assistance Publique - Hôpitaux de Paris

Completed

Treatment With AZD4547 for Recurrent Malignant Glioma Expressing FGFR-TACC Gene Fusion" (TARGET)

Recurrent IDHwt Gliomas With FGFR3-TACC3 Fusion | Recurrent IDHwt Gliomas With FGFR1-TACC1 Fusion

France
Northwestern University
Genentech, Inc.; Amgen; OSI Pharmaceuticals

Completed

Dual Epidermal Growth Factor Receptor Inhibition With Erlotinib and Panitumumab With or Without Chemotherapy for Advanced Colorectal Cancer

Colorectal Cancer

United States
Washington University School of Medicine

Terminated

Aortic Stenosis and PhosphodiEsterase Type 5 iNhibition (ASPEN): A Pilot Study (ASPEN)

Aortic Stenosis | LV Remodeling, Hypertrophy

United States
Abramson Cancer Center of the University of Pennsylvania
National Cancer Institute (NCI)

Completed

Hydroxychloroquine and Temsirolimus in Treating Patients With Metastatic Solid Tumors That Have Not Responded to Treatment

Unspecified Adult Solid Tumor, Protocol Specific

United States
Peking Union Medical College Hospital

Completed

Platelet Inhibition of Ticagrelor Versus Clopidogrel in Type 2 Diabetic Patients After Elective Percutaneous Coronary Intervention (PLATIDE-PCI)

Coronary Artery Disease | Diabetes Mellitus, Type 2

China
Daiichi Sankyo Co., Ltd.

Completed

Late Phase 2 Study of DU-176b in Patients With Non-Valvular Atrial Fibrillation

Atrial Fibrillation

Japan
Celgene

Completed

Study Evaluating the Effects of Food, Cytochrome P450 Inhibition and Induction on the Pharmacokinetics of CC-122

Healthy Volunteer

United States
University of Wisconsin, Madison

Withdrawn

Impact of NOS, COX, and ROS Inhibition on Cerebral Blood Flow Regulation

Hypoxia | Hypercapnia

United States
Millennium Pharmaceuticals, Inc.

Completed

Effects of Fluconazole and Itraconazole CYP3A-Mediated Inhibition on the Pharmacokinetics, Safety, and Tolerability of MLN4924 in Participants With Advanced Solid Tumors

Advanced Solid Tumors

United States

Search clinical trials for: s-EH enzyme inhibition

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