Search clinical trials for: severe co-morbidity,

Total 25508 results

Eli Lilly and Company

Completed

Back Pain in Patients With Severe Osteoporosis

Osteoporosis

India, Mexico, Hong Kong, Taiwan, Korea, Republic of, Thailand, Malaysia, Pakistan, Singapore
Fundació Institut de Recerca de l'Hospital de la...

Unknown

Comparative Study About the Impact of Two Oil Emulsions Administered Intravenously on Severe Acute Pancreatitis

Severe Acute Pancreatitis

Spain
ARI Research Cell
World Health Organization

Completed

Efficacy Study for Standard Versus Double Dose of Amoxicillin in WHO Defined Non-severe Pneumonia

Pneumonia

Pakistan
Novartis Pharmaceuticals
Genentech, Inc.

Completed

Observational and Epidemiologic Study of the Disease Course and Unmet Needs in Children With Symptomatic Moderate to Severe Allergic Asthma

Moderate to Severe Allergic Asthma

United States, Puerto Rico
Sun Yat-sen University

Completed

Efficacy of Thymosin alpha1 for Severe Sepsis (ETASS)

Severe Sepsis

China
Endo Pharmaceuticals

Terminated

Safety and Efficacy of Lidoderm (Lidocaine Patch 5%) in Treating Moderate to Severe Pain Associated With Carpal Tunnel Syndrome

Carpal Tunnel Syndrome

United States
Johnson & Johnson Pharmaceutical Research & Development...
PriCara, Unit of Ortho-McNeil, Inc.

Completed

A Study of the Safety and Effectiveness of Oral Levofloxacin Compared With Cefuroxime Axetil in the Treatment of Adults With Persistent Bronchitis Experiencing Rapid Onset of Severe Worsening of Symptoms Caused by Bacteria

Bronchitis, Chronic
Tenax Therapeutics, Inc.
Virginia Commonwealth University

Completed

Study of Oxycyte in Severe Closed Head Injury

Traumatic Brain Injury

United States
University of Manitoba
Hoffmann-La Roche

Terminated

Trial Comparing High Versus Standard Dose Oseltamivir in Severe Influenza Infection in ICU (ROSII)

Influenza A Virus

Canada
Johnson & Johnson Pharmaceutical Research & Development...
Ortho-McNeil Neurologics, Inc.

Completed

A Study of the Effectiveness and Safety of Topiramate in the Treatment of Moderate to Severe Binge-eating Disorder Associated With Obesity

Obesity | Binge-Eating Disorder
Johnson & Johnson Pharmaceutical Research & Development...
PriCara, Unit of Ortho-McNeil, Inc.

Completed

A Study of the Safety and Effectiveness of Levofloxacin Compared With Amoxicillin/Clavulanate Potassium in the Treatment of Adults With Rapid Onset of Severe Inflammation/Infection of the Sinuses

Sinusitis | Maxillary Sinusitis
Rottapharm Spain

Completed

Study to Evaluate the Effect of Megestrol Acetate in Severe Chronic Obstructive Pulmonary Disease With Loss of Weight

Chronic Obstructive Pulmonary Disease

Spain
Johnson & Johnson Pharmaceutical Research & Development...

Completed

A Study of the Effectiness and Safety of Levofloxacin in Treating Children With a Rapid and Severe Onset of Infection and Inflammation of the Middle Ear That is Difficult to Treat

Otitis Media
Kaohsiung Veterans General Hospital.
National Science Council, Taiwan

Completed

Left Atrial Distensibility to Predict Left Ventricular Filling Pressure and Prognosis in Patients With Severe Mitral Regurgitation

Heart Failure | Atrial Fibrillation | Mitral Valve Insufficiency

Taiwan
The University of Queensland
Royal Brisbane and Women's Hospital

Unknown

Exercise in Critically Ill Patients With Sepsis

Sepsis Syndromes

Australia
University Hospital, Lille
Ministry of Health, France

Completed

Double-blind Randomized Controlled Trial in Severe Alcoholic Hepatitis (CorpentoxHAA)

Alcoholic Liver Disease | Alcoholic Hepatitis

France, Belgium
Professor Fernando Figueira Integral Medicine Institute
Conselho Nacional de Desenvolvimento Científico e Tecnológico

Unknown

Anti-Hypertensive Treatment In Stable Pregnant Women With Severe Pre-Eclampsia (Metildopape) (METILDOPAPE)

Preeclampsia

Brazil
Allergan

Completed

Six Month Clinical Research Study for Patients With Moderate or Severe Dry Eye Syndrome

Arthritis, Rheumatoid | Lupus Erythematosus, Systemic | Scleroderma, Systemic | Keratoconjunctivitis Sicca | Sjogren's Syndrome

United States
Charite University, Berlin, Germany
German Research Foundation

Completed

Reconstruction of Monocytic Immunocompetence by Granulocyte-macrophage-colony Stimulating Factor (GM-CSF) in Patients With Severe Sepsis and Septic Shock

Sepsis
Johann Wolfgang Goethe University Hospital

Unknown

Bronchial Inflammation in Patients With Severe Immune Deficiency Under Immunoglobulin Treatment

Immune Deficiency

Germany
Johnson & Johnson Pharmaceutical Research & Development...

Completed

A Study of the Enzyme Activity and Safety of Pancrelipase in Patients With Severe Exocrine Pancreatic Insufficiency (EPI)

Steatorrhea | Pancreatitis | Pancreatitis, Chronic | Exocrine Pancreatic Insufficiency
Janssen-Cilag, S.A.

Completed

A Study to Evaluate the Safety and Effectiveness of Fentanyl-TTS Compared to Weak Opioids in Patients With Moderate to Severe Chronic Cancer Pain Previously Treated With NSAIDS (Non-steroidal Anti-inflammatory Drugs).

Pain
Cairo University

Completed

Effective Study of Live Attenuated Varicella Vaccine to Treat Severe Resistant Psoriasis

Psoriasis

Egypt
University of Washington
National Heart, Lung, and Blood Institute (NHLBI); Canadian Institutes of Health... and other collaborators

Terminated

Hypertonic Resuscitation Following Severe Traumatic Brain Injury (TBI)

Brain Injuries, Traumatic

United States, Canada
Johnson & Johnson Pharmaceutical Research & Development...
Grünenthal GmbH

Completed

Efficacy and Safety of Tapentadol Extended Release Tablets in the Treatment of Moderate to Severe Pain in Subjects With Knee Osteoarthritis

Chronic Pain | Knee Pain | Osteoarthitis
Impliant, Ltd.

Completed

Safety and Effectiveness Study of the TOPS System, a Total Posterior Arthroplasty Implant Designed to Alleviate Pain Resulting From Moderate to Severe Lumbar Stenosis

Low Back Pain | Lumbar Spinal Stenosis | Spondylolisthesis | Leg Pain

United States
Janssen-Ortho Inc., Canada

Completed

A Study to Evaluate the Safety and Efficacy of Epoetin Alfa Versus Placebo to Reduce the Need for Blood Transfusions and Reduce the Occurrence of Severe Anemia During the Time Period Surrounding Total Hip Replacement Surgery

Anemia
GenVec

Completed

A Study to Treat Patients Whose Chronic Angina Symptoms Are Not Relieved by Medication and Have an Area of the Heart That Cannot be Treated by Standard Therapies

Moderate to Severe Angina Pectoris

Denmark, Israel
Novartis

Completed

Efficacy and Safety of Aliskiren/Amlodipine/Hydrochlorothiazide in Patients With Moderate-severe Hypertension

Hypertension

Sweden, United States, Romania, Denmark, Israel, Italy, Germany, Australia, Canada, Latvia, Lithuania, Turkey
Eli Lilly and Company

Completed

A Study for Teriparatide in Severe Osteoporosis (ISSO)

Osteoporosis | Osteoporosis, Postmenopausal

Italy
Abbott

Completed

Study of Adalimumab in Subjects With Moderate to Severe Chronic Hidradenitis Suppurativa

Hidradenitis Suppurativa

United States, Denmark, Germany, Netherlands
Revotar Biopharmaceuticals AG

Completed

Study to Evaluate Safety and Efficacy of Inhaled Bimosiamose for the Treatment of Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)

Chronic Obstructive Pulmonary Disease

Germany
Bristol-Myers Squibb

Completed

A Study of Brivanib (BMS-582664) in Patients With Liver Cancer and Mild, Moderate or Severe Liver Dysfunction

Carcinoma, Hepatocellular

United States, Spain
Assistance Publique - Hôpitaux de Paris

Completed

Efficacy of Steroid Versus Steroid Plus Cyclophosphamide for Severe Henoch-Schoenlein Purpura

Henoch-Schoenlein Purpura

France
Abbott

Completed

Efficacy and Safety of Adalimumab in Subjects With Moderately to Severely Active Ulcerative Colitis

Ulcerative Colitis

United States, Argentina, Australia, Austria, Belgium, Canada, Czech Republic, Denmark, France, Germany, Hungary, Israel, New Zealand, Norway, Poland, Portugal, Spain, Switzerland
AviGenics

Completed

Safety and Efficacy Study of GCSF Therapy to Treat Patients at High Risk for Chemotherapy Induced Severe Neutropenia

Breast Cancer | Neutropenia

United States, India
Assistance Publique - Hôpitaux de Paris

Completed

EVA3S: Endarterectomy Versus Angioplasty in Patients With Severe Symptomatic Carotid Stenosis

Atherosclerosis | Transient Ischemic Attack | Carotid Stenosis

France
Azienda Sanitaria Locale 4, Teramo

Unknown

Evaluation of the Efficacy and Tolerability of Etoricoxib Monotherapy Versus Combination Oxycodone-etoricoxib in Moderate to Severe Pain From Chronic Low Back Pain

Low Back Pain

Italy
TCA Cellular Therapy

Completed

Combination Stem Cell Therapy for the Treatment of Severe Leg Ischemia (mesendo)

Peripheral Vascular Disease | Critical Limb Ischemia

United States
TCA Cellular Therapy

Completed

Combination Stem Cell Therapy for the Treatment of Severe Coronary Ischemia (CI)

Coronary Artery Disease | Coronary Disease | Coronary Arteriosclerosis | Coronary Atherosclerosis | Coronary Ischemia

United States
Bristol-Myers Squibb
Sanofi

Completed

Irbesartan/Hydrochlorothiazide (HCTZ) Combination Therapy as First Line Treatment for Severe Hypertension

Hypertension

United States, Belgium, Canada, Germany, Russian Federation, France, Israel, Netherlands
Abbott

Completed

Efficacy and Safety of Adalimumab in Subjects With Moderate to Severe Chronic Plaque Psoriasis

Psoriasis

United States, Austria, Belgium, Canada, France, Germany, Poland, Puerto Rico, Spain, Switzerland
Abbott

Completed

Adalimumab in Combination With Topical Treatment (Calcipotriol/Betamethasone) in Subjects With Moderate to Severe Psoriasis and Insufficient Response to Classic Systemic Treatment (BELIEVE)

Chronic Plaque Psoriasis

Belgium, Denmark, France, Germany, Spain, Sweden, Switzerland, Finland, Turkey, Italy, Czech Republic, Austria, Netherlands, United Kingdom, Greece
Medical Centre Leeuwarden
Lithuanian University of Health Sciences

Completed

Microcirculatory Changes During Magnesium Sulphate Infusion in Sepsis

Septic Shock | Severe Sepsis

Lithuania
Abbott

Completed

Efficacy and Safety of Adalimumab in Subjects With Moderately to Severely Acute Ulcerative Colitis

Ulcerative Colitis

United States, Austria, Belgium, Canada, Czech Republic, Germany, Hungary, Italy, Netherlands, Poland, Puerto Rico, Slovakia, Sweden
Stanford University
University of Colorado, Denver; University of Toronto

Completed

Impact of Hydrocortisone Administration on White Blood Cell Gene Expression in Patients With Severe Sepsis

Sepsis | Relative Adrenal Insufficiency

United States
Alfact Innovation

Unknown

Efficacy & Safety of ALF-5755 in Patients With Nonacetaminophen Severe Acute Hepatitis & Early Stage Acute Liver Failure

Liver Failure, Acute

France
University of Aarhus

Completed

Physical Activity in Patients With Severe Mental Illness

Mental Disorders
Assaf-Harofeh Medical Center

Unknown

The Effect on Small Airways of Addition of Theophylline as Inducer of Histone Deacilase Activity for Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD), Treated With Inhaled Steroids and Long Acting Beta Agonists (COPD)

COPD

Israel
Mayo Clinic

Completed

The Effects of HIV Protease Inhibitors in Severe Sepsis

Sepsis

United States

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