Search clinical trials for: MEK162, MEK inhibitor; oral

Total 3488 results

Merck Sharp & Dohme LLC

Completed

A Study of Oral and Intravenous (IV) Tedizolid Phosphate in Hospitalized Participants, Ages 2 to <12 Years, With Confirmed or Suspected Bacterial Infection (MK-1986-013)

Gram-Positive Bacterial Infections
Perle Bioscience, Inc.
Syreon Corporation

Withdrawn

The Insulin Independence Trial (IIT) Evaluating the Safety and Efficacy of Oral Cyclosporine and Oral Omeprazole for Insulin Independence Among Recent Onset Type 1 Diabetes Patients (IIT)

Type 1 Diabetes
Cumberland Pharmaceuticals

Active, not recruiting

Oral Ifetroban to Treat Aspirin Exacerbated Respiratory Disease (AERD)

Asthma, Aspirin-Induced

United States
Medikine, Inc.

Terminated

A Dose Escalation/Expansion Study of MDK-703 in Patients With Advanced or Metastatic Solid Tumors (ORCHID-1)

Advanced or Metastatic Solid Tumors

United States
University of Alabama at Birmingham
University Teaching Hospital, Lusaka, Zambia; Cameroon Baptist Convention Health and other collaborators

Not yet recruiting

Intrapartum Sildenafil in Laboring Mothers (PRISM)

Development, Infant | Neonatal Asphyxia | Intrapartum Fetal Distress | Intrapartum Asphyxia

Zambia, Cameroon, Kenya
Assistance Publique - Hôpitaux de Paris

Completed

Mechanical Bowel Preparation and Oral Antibiotics Before Rectal Cancer Surgery (PREPACOL2)

Rectal Cancer Surgery

France
Jennifer Eva Selfridge

Not yet recruiting

Oral TGF-beta Receptor I Inhibitor Vactosertib in SOC Chemoradiotherapy for Esophageal Adenocarcinoma

Siewert Type II Adenocarcinoma of Esophagogastric Junction | Adenocarcinoma Esophagus | Siewert Type I Adenocarcinoma of Esophagogastric Junction | Locally Advanced Adenocarcinoma
National Cancer Institute (NCI)

Active, not recruiting

Trametinib With or Without Whole Brain Radiation Therapy in Treating Patients With Brain Metastases

Metastatic Malignant Neoplasm in the Brain

United States
ArriVent BioPharma, Inc.
Allist Pharmaceuticals, Inc.

Recruiting

Study to Compare Furmonertinib to Platinum-Based Chemotherapy for Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) With Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations (FURVENT)

Advanced Non-Small Cell Lung Cancer | Metastatic Non-Small Cell Lung Cancer | EGFR Exon 20 Mutations

United States, Australia, Spain, France, Italy, China, Japan, Korea, Republic of, Malaysia, Netherlands, Philippines, Singapore, Taiwan, Thailand, Brazil, Israel, United Kingdom
Aarhus University Hospital
Odense University Hospital; Rigshospitalet, Denmark; University of Copenhagen; Herning... and other collaborators

Recruiting

The MASTER Study (MAmmary Cancer STatin ER Positive Study)

Breast Cancer Female | Estrogen Receptor Positive Tumor

Denmark
University of Michigan Rogel Cancer Center

Withdrawn

Phase IV Multi-arm Study of CDK4/6 Pharmacokinetics in Healthy Volunteers With Known CYP3A4*22 Genotype

CYP3A4*22
Pfizer

Completed

Single Dose Study With Unlabeled Dose and 14C-labeled Microdose of PF-06700841 in Healthy Male Subjects

Healthy Male Subjects

Netherlands
Chinese University of Hong Kong

Terminated

A Comparison of Gastric pH Control With High Dose Intravenous or Oral Esomeprazole

Gastrointestinal Hemorrhage

China
Oregon Health and Science University

Unknown

Prophylactic Therapy for Cytomegalovirus in Liver Transplant Recipients

Liver Transplantation
Memorial Sloan Kettering Cancer Center
Ascenta Therapeutics

Terminated

Erlotinib and AT-101 in Advanced Non-Small Cell Lung Cancer (NSCLC) Patients With Epidermal Growth Factor Receptor (EGFR) Activating Mutations

Lung Cancer

United States
OHSU Knight Cancer Institute
Genentech, Inc.; Oregon Health and Science University; American Association for... and other collaborators

Recruiting

Targeted Pathway Inhibition in Patients With Pancreatic Cancer

Stage II Pancreatic Cancer AJCC v8 | Stage III Pancreatic Cancer AJCC v8 | Stage IV Pancreatic Cancer AJCC v8 | Metastatic Pancreatic Ductal Adenocarcinoma | Locally Advanced Pancreatic Ductal Adenocarcinoma | Unresectable Pancreatic Ductal Adenocarcinoma

United States
Pfizer

Completed

A Study to Determine the Effects of PF-04965842 on the Pharmacokinetics of Oral Contraceptive Steroids in Healthy Female Subjects

Healthy Females

United States
Merck Sharp & Dohme LLC

Completed

Letermovir Treatment in Pediatric Participants Following Allogeneic Haematopoietic Stem Cell Transplantation (HSCT) (MK-8228-030)

Cytomegalovirus (CMV) Infection

United States, Australia, Colombia, France, Germany, Israel, Japan, Mexico, Poland, Spain, Turkey
Fundación FLS de Lucha Contra el Sida, las Enfermedades...
National Department of Health, Papua New Guinea; School of Medicine and Health...

Recruiting

Repurposing Clinically Approved Drugs for Yaws With an Insight Into the Cutaneous Ulcer Disease Syndrome (Trep-AByaws) (Trep-AByaws)

Yaws | Cutaneous Ulcer

Papua New Guinea
Ophirex, Inc.

Recruiting

Broad-spectrum Rapid Antidote: Varespladib IV to Oral Trial for Snakebite (BRAVIO) (BRAVIO)

Snakebite | Envenoming, Snake

United States
The Cleveland Clinic
RTI International

Completed

Pomalidomide for the Treatment of Bleeding in HHT (PATH-HHT)

Telangiectasia, Hereditary Hemorrhagic

United States
Institut Bergonié
Novartis

Terminated

Phase III Trial Evaluating the Effectiveness of a Dose Adjustment of Imatinib Mesylate on the Molecular Response (MIM)

Leukemia, Myeloid, Chronic-Phase

France
Assiut University

Completed

Hydoxycarbamide and L-Carnitine Therapy in Sickle Cell Anemia

Sickle Cell Disease

Egypt
EMD Serono
Merck KGaA, Darmstadt, Germany

Completed

Trial of Gemcitabine With or Without MSC1936369B in Pancreatic Cancer

Pancreatic Adenocarcinoma

United States, Germany
Hospital Universitari Vall d'Hebron Research Institute

Unknown

Effectiveness of the Vasodilator Test With Revatio, Made in Patients With Acute Pulmonary Hypertension

Pulmonary Hypertension

Spain
National Cancer Institute (NCI)

Active, not recruiting

Selumetinib Sulfate in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial)

Advanced Malignant Solid Neoplasm | Refractory Malignant Solid Neoplasm | Recurrent Malignant Solid Neoplasm | Recurrent Neuroblastoma | Refractory Neuroblastoma | Refractory Non-Hodgkin Lymphoma | Refractory Primary Central Nervous System Neoplasm | Ann Arbor Stage III Childhood Non-Hodgkin Lymphoma and other conditions

United States, Puerto Rico
Duke University
National Heart, Lung, and Blood Institute (NHLBI); National Institute on Aging... and other collaborators

Recruiting

Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults (PREVENTABLE)

Cardiovascular Diseases | Dementia | Cognitive Impairment, Mild

United States, Puerto Rico
Virginia Commonwealth University

Withdrawn

HDAC Inhibitor Augmentation to Clozapine

Schizophrenia

United States
Bulent Ecevit University

Completed

The Effects of a Synbiotic Addition on Eradication Therapy of Helicobacter Pylori Infection in Children

Helicobacter Pylori Infection
Cairo University

Unknown

Combined Oral Contraceptives and Fluoxetine Versus Combined Oral Contraceptives in Severe Premenstrual Syndrome

Premenstrual Syndrome

Egypt
Sunnybrook Health Sciences Centre

Recruiting

Anticoagulation Therapy Timing in Atrial Fibrillation After Acute and Chronic Subdural Hematoma (ATTAACH)

Atrial Fibrillation | Subdural Hematoma

Canada
ViiV Healthcare

Completed

Dolutegravir Pediatric Liquid Formulation Study

HIV Infections

United Kingdom
Elliot Israel, MD
Brigham and Women's Hospital

Completed

Therapeutic Control of Aspirin-Exacerbated Respiratory Disease (Aspirin) (Aspirin)

Asthma, Aspirin-Induced | Aspirin Exacerbated Asthma

United States
University of Maryland, Baltimore

Terminated

The Effect of Donepezil on Glycemic Control in Type II Diabetics

Diabetes Mellitus, Type 2

United States
National Cancer Centre, Singapore

Completed

Study of Combination of Metronomic Oral Vinorelbine and Sorafenib in Patients With Advanced Non-small Cell Lung Cancer

Non-Small Cell Lung Cancer

Singapore
National Cancer Institute (NCI)

Active, not recruiting

Trametinib and Docetaxel in Treating Patients With Recurrent or Stage IV KRAS Mutation Positive Non-small Cell Lung Cancer

KRAS Gene Mutation | Recurrent Lung Non-Small Cell Carcinoma | Stage IV Lung Non-Small Cell Cancer AJCC v7

United States
ViiV Healthcare
GlaxoSmithKline

Completed

A Drug-drug Interaction Study Between BMS-663068 and Oral Contraceptives in Healthy Female Volunteers (DDI)

Infection, Human Immunodeficiency Virus

United States
Pfizer

Completed

A Study of ARRY-371797 in Patients With Osteoarthritis of the Knee

Osteoarthritis of the Knee

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

Modified Immune Cells (CD19 CAR T Cells) and Acalabrutinib for the Treatment of Relapsed or Refractory Mantle Cell Lymphoma

Recurrent Mantle Cell Lymphoma | Refractory Mantle Cell Lymphoma

United States
Fundacion para la Investigacion Biomedica del Hospital...
Merck Sharp & Dohme LLC

Completed

ARTiBIOME: Observational Study on the Effect of HIV and ART on Gut Microbiome

HIV Infections

Spain
GlaxoSmithKline

Completed

An Efficacy Study of GSK2269557 Added to Standard Care in Subjects With an Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Pulmonary Disease, Chronic Obstructive

Romania, Russian Federation, Belgium, Denmark, Netherlands
University of Washington

Recruiting

Decitabine With Ruxolitinib, Fedratinib or Pacritinib for the Treatment of Accelerated/Blast Phase Myeloproliferative Neoplasms

Acute Myeloid Leukemia | Primary Myelofibrosis | Polycythemia Vera | Essential Thrombocythemia | Myelodysplastic Syndrome | Myeloproliferative Neoplasm | Myelodysplastic/Myeloproliferative Neoplasm | Secondary Myelofibrosis | Myeloproliferative Neoplasm, Unclassifiable

United States
Brian Druker
AbbVie; Oregon Health and Science University; Incyte Corporation

Active, not recruiting

Ruxolitinib and Venetoclax in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome | Recurrent Acute Myeloid Leukemia | Refractory Acute Myeloid Leukemia

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Long-Term Side Effects of Ruxolitinib in Treating Patients With Myelofibrosis

Myelofibrosis

United States
University Hospital, Gentofte, Copenhagen
University of Copenhagen

Unknown

Intact Vagal Innervation for and Glucagon-like Peptide-1 (GLP-1) Effects

Vagotomy, Truncal

Denmark
University of Washington
Ortho-McNeil Pharmaceutical

Unknown

Oral Versus Patch Hormonal Contraceptive Effects on Metabolism, Clotting, Inflammatory Factors and Vascular Reactivity

Contraception

United States
Virginia Commonwealth University

Completed

Oral Contraceptives in the Metabolic Syndrome

Cardiovascular Diseases | Obesity | Insulin Resistance | Metabolic Syndrome X

United States
Merck Sharp & Dohme LLC

Terminated

An Investigational Drug Study In Patients With COPD (Chronic Obstructive Pulmonary Disease) (MK-0873-005)

Lung Diseases | Pulmonary Disease, Chronic Obstructive
University of Minnesota

Suspended

Sustained Release Oral Formulation for Treatment of Parkinson's Disease

Idiopathic Parkinson Disease

United States
Celgene

Active, not recruiting

Safety and Efficacy Study of CC-486 With MK-3475 to Treat Locally Advanced or Metastatic Non-small Cell Lung Cancer

Carcinoma, Non-Small-Cell Lung

United States, Italy, France, Germany, Greece, Spain

Search clinical trials for: MEK162, MEK inhibitor; oral

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