Clinical Trials Sponsored by Significantis GmbH

Total 3278 results

ClinNovis GmbH

Completed

Validation of a Combined Symptom and Medication Score in Patients Suffering From Allergic Rhinoconjunctivitis

Rhinoconjunctivitis, Allergic

Germany
Grünenthal GmbH

Completed

Safety of Intravenous Neridronic Acid in CRPS

Complex Regional Pain Syndrome

United States, Germany
Novaliq GmbH

Completed

CyclASol for the Treatment of Moderate to Severe Dry-eye Disease (DED)

Dry Eye Syndromes

United States
EyeSense GmbH

Completed

Clinical and Home Use Feasibility Study of a Percutaneous Optical Glucose Fiber Sensor

Diabetes (DM)

Germany
Grünenthal GmbH

Completed

Intravenous Tapentadol in Post-Bunionectomy Pain

Pain | Bunion

United States
Grünenthal GmbH

Terminated

Lidocaine 5% Medicated Plaster in Chronic Neuropathic Postoperative Pain

Pain | Chronic Pain | Postoperative Pain | Neuropathic Pain

France
Grünenthal GmbH

Completed

Efficacy and Safety of Topical Versus Systemic Treatment in Postherpetic Neuralgia and Diabetic Polyneuropathic Pain

Neuropathic Pain

United Kingdom
Grünenthal GmbH

Completed

A Study to Look at Tapentadol Tablets in Children and Adolescents in Pain

Pain

Belgium, Bulgaria, Chile, France, Germany, Hungary, Italy, Portugal, Spain, United Kingdom
Grünenthal GmbH

Completed

Effect of a Multiple-dose Oral Administration of CG5503 PR on the Electrical Activity of the Heart in 48 Healthy Men and Women

Prolonged QTc Interval | Pharmacokinetic

Germany
ProFem GmbH

Completed

ProF-001_Phase IIa

Vulvovaginal Candidiasis (VVC)

Austria
Grünenthal GmbH

Terminated

Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Chronic Low Back Pain Taking WHO Step III Analgesics But Showing a Lack of Tolerability

Pain | Low Back Pain | Chronic Pain | Neuropathic Pain | Nociceptive Pain

Belgium, Czechia, France, Germany, Netherlands, Poland, Spain, Switzerland
Grünenthal GmbH

Completed

Clinical Pilot Study in Healthy Men to Characterize the Uptake of Buprenorphine Into and Its Elimination From the Body After Topical Application of Two New Forms of a Skin Patch in Comparison to a Reference Patch

Pain

Switzerland
Vimecon GmbH

Terminated

Vimecon CAI Trial for the Interventional Treatment of Paroxysmal Atrial Fibrillation (AF) (CAI)

Atrial Fibrillation

Czechia, Belgium, Germany
Grünenthal GmbH

Completed

Clinical Study in Healthy Men to Investigate the Uptake of Buprenorphine and Its Elimination From the Body After Dermal Application as Patches for 96 Hours and for 72 Hours

Pain | Pharmacokinetics

Germany
Grünenthal GmbH

Completed

A Clinical Study in Healthy Adults Who Sometimes Take Drugs for Pleasure Which Aims to Evaluate Whether GRT0151Y is Likely to be Abused

Pain | Acute Pain

Canada
afreeze GmbH

Completed

Cryoablation of Atrial Fibrillation Using a Novel Cryoablation System

Atrial Fibrillation

Austria
Grünenthal GmbH

Completed

A Clinical Study in Healthy Women Which Aims to Explore the Intestinal Uptake of Two Different Tablets of GRTA9906 Into the Body and the Effect of Food on it

Pain | Chronic Pain | Neuropathic Pain | Visceral Pain

Germany
Synthes GmbH

Completed

Facet Wedge Post Market Study

Degenerative Disc Disease | Chronic Low Back Pain | Facet Joint Disease | Pseudo Arthrosis Post Anterior Instrumentation

Germany, Slovakia
Physeon GmbH

Completed

Assess Veinplicity Venous Access Device Safety and Effectiveness

Phlebotomy
Phenox GmbH

Completed

Acute Recanalization of Thrombo-Embolic Ischemic Stroke With pREset (ARTESp) (ARTESp)

Stroke

Germany
Grünenthal GmbH

Withdrawn

A Comparison of Plasma Concentrations of Hydrocodone and Acetaminophen After Administration of a New and a Marketed Tablet Formulation Under Fasted and Fed Conditions in Healthy Adults

Pain, Postoperative | Pain, Acute | Opioid-Related Disorders

United States
Grünenthal GmbH

Withdrawn

A Comparison of Plasma Concentrations of Hydrocodone and Acetaminophen After Administration of Different Amounts of Tablets of a New and a Marketed Tablet Formulation in Healthy Adults

Pain, Postoperative | Pain, Acute | Opioid-Related Disorders

United States
Synthes GmbH

Completed

Study on the Treatment of Osteoporotic Vertebral Fractures Using Vertebral Body Stenting

Vertebral Body Fractures

Germany, Austria
InflaRx GmbH

Completed

Studying Complement Inhibition in Complex Cardiac Surgery (CARDIAC)

Systemic Inflammatory Response Syndrome | C.Surgical Procedure; Cardiac

Germany
Tomorrowlabs GmbH

Unknown

Investigation of a Novel Cosmeceutical to Reduce the Visible Signs of Cutaneous Aging (REDUCEAGE)

Aging
InflaRx GmbH

Completed

Studying Complement Inhibition in Early, Newly Developing Septic Organ Dysfunction (SCIENS)

Septic Shock | Severe Sepsis

Germany
Grünenthal GmbH

Completed

Tapentadol Prolonged Release (PR) Versus Oxycodone/Naloxone Prolonged Release in Severe Chronic Low Back Pain With a Neuropathic Component.

Back Pain | Low Back Pain | Neuropathic Pain

Germany, Spain, Austria, Italy
Ethicare GmbH

Unknown

Follow-up Safety Trial in Children With Chronic Heart Failure Therapy Receiving Orodispersible Minitablets of Enalapril (LENA-WP10)

Heart Failure | Dilated Cardiomyopathy | Congenital Heart Disease

Austria, United Kingdom, Netherlands, Serbia, Hungary
Novaliq GmbH

Completed

NovaTears® Eye Drops Observational Study

Dry Eye Disease

Germany
Labtec GmbH

Withdrawn

A Safety and Efficacy Study of Sufentanil Transdermal System in Patients With Chronic Pain Due to Cancer

Chronic Pain
Eurocor GmbH

Unknown

The 001-DIOR Multicenter Registry

Coronary Artery Disease

Spain
Affimed GmbH

Completed

A Study to Assess AFM13 in Patients With Hodgkin Lymphoma

Hodgkin Lymphoma

United States, Germany
medac GmbH

Terminated

Trial of Oncaspar® and Three Doses of Pegylated Recombinant Asparaginase in Adult Patients With Newly Diagnosed Acute Lymphoblastic Leukaemia

Acute Lymphoblastic Leukaemia

Germany
Synthes GmbH

Withdrawn

Use of Demineralised Bone Matrix (DBX) in Osteochondritis Dissecans (OCD)

Osteochondritis Dissecans

Finland
InflaRx GmbH

Completed

Clinical Assessment of Safety and Tolerability of the New Monoclonal Humanized Antibody CaCP29

Drug Safety

Germany
Eurocor GmbH

Completed

The Valentines Trial

Instent Restenosis

Netherlands, Italy, Germany
cerbomed GmbH

Completed

Pilot Study of the Effect of Transcutaneous Stimulation of the Vagus Nerve on Pain Perception and Parameters of the Autonomic Nervous System

Pain

Germany
Jeder GmbH

Unknown

Clinical Investigation to Assess the Safety and Feasibility of the Crestal, Minimal-invasive Sinus Floor Augmentation With the Pressure Chamber Drill (DKK) and the Sinus Vibration Pump (SVP) (DKK SVP)

Insufficient Bone Mass in the Maxilla for Dental Implants

Austria
medac GmbH

Completed

Treosulfan Based Conditioning Myelodysplastic Syndrome (MDS)

Myelodysplastic Syndrome

Finland
Awenydd GmbH

Unknown

Medication Optimisation for Reducing Events in a Private Practice Setting (MORE)

Pharmacogenetic Analysis to Reduce Events.

Germany
RobotDreams GmbH

Recruiting

AI Algorithms in Prediction of ACS Based on Leukocyte Properties

Angina Pectoris | Acute Coronary Syndrome | NSTEMI - Non-ST Segment Elevation MI | STEMI - ST Elevation Myocardial Infarction

Austria
Novaliq GmbH

Recruiting

A Clinical Trial to Evaluate the Corneal Endothelial Health of DED Subjects Treated With Cyclosporine

Dry Eye Disease

United States
ViGeneron GmbH

Recruiting

Safety and Tolerability of Intravitreal Administration of VG901 in Patients With Retinitis Pigmentosa Due to Mutations in the CNGA1 Gene

Retinitis Pigmentosa

Germany
CatalYm GmbH

Recruiting

Neoadjuvant Immunotherapy in Combination With the Anti-GDF-15 Antibody Visugromab (CTL-002) for Treatment of Muscle Invasive Bladder Cancer

Adult Solid Tumor | Bladder Cancer

Italy
Affimed GmbH

Recruiting

First-in-Human Dose Escalation Study of AFM28 in Patients With Relapsed/Refractory Acute Myeloid Leukemia

Acute Myeloid Leukemia

Spain, France, Denmark
NVT GmbH

Recruiting

Investigation of the NVT ALLEGRA Plus THV System in Patients With Severe Aortic Stenosis or Failed Surgical Aortic Bioprosthesis (EMPIRE-II)

Transcatheter Aortic Valve Implantation

Finland, Spain, Germany, Poland, Switzerland
JOTEC GmbH

Recruiting

EASYII - E-tegra Stent Graft System - Imaging Cohort (EASYII)

Vascular Aneurysm

Netherlands
Acandis GmbH

Recruiting

REscue Stenting With CREDO® Heal for Recanalisation After Unsuccessful Thrombectomy (RECHRUT) (RECHRUT)

Rescue Stenting

Germany
Arcensus GmbH

Recruiting

Metabolic FingerPrinting (MetaPrint)

Genetic Disease

Albania, Pakistan
Peschke GmbH

Recruiting

Safety and Effectiveness of the PXL Platinum 330 System With Riboflavin Solution for Refractory Corneal Ulcers

Keratitis | Corneal Ulcer

United States

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