Clinical Trials Sponsored by Synapse bv

Total 311 results

University College, London
Stryker EU Operations BV

Completed

Inflammatory Response Conventional Total Knee Replacement Versus Mako Total Knee Replacement

Arthritis | Knee Osteoarthritis | Surgery

United Kingdom
Khondrion BV
Drug Research Unit Ghent, Belgium

Completed

A Dose-escalating Clinical Trial With KH176

Mitochondrial Disease | MELAS | Leigh Syndrome | LHON | Mitochondrial DNA tRNALeu(UUR) m.3243A<G Mutation

Belgium
SMART Clinical Products BV
Ziekenhuis Oost-Limburg

Completed

Evaluation of the iD-SystemTM, One-Handed Disposable Internal Defibrillation System. (iD-System)

Ventricular Fibrillation | Ventricular Tachycardia

Belgium
Enceladus Pharmaceuticals BV
University Hospital, Aachen; Accelovance

Terminated

A Evaluation of the Safety of Oncocort IV Pegylated Liposomal Dexamethasone Phosphate in Patients With Progressive Multiple Myeloma (AMETHYST)

Multiple Myeloma
Wageningen University and Research
Asahimatsu Support BV

Completed

Kori-tofu Proteins and Blood Glucose Response (KoPro)

Glucose Intolerance

Netherlands
ECRI bv
GE Healthcare; Amgen; HeartFlow, Inc.

Withdrawn

Multislice Computed Tomography Assessment of PCSK9 Inhibition on Coronary Perfusion (MARKOV)

Coronary Artery Disease
Acerta Pharma BV
Merck Sharp & Dohme LLC

Completed

Pembrolizumab Alone and In Combination With Acalabrutinib (ACP-196) in Subjects With Advanced Non-small Cell Lung Cancer (KEYNOTE166)

Carcinoma, Non-Small-Cell Lung

United States
Janssen Research & Development, LLC
Janssen Biologics BV

Completed

A Long Term Safety Study of Infliximab (Remicade) in in Ulcerative Colitis Patients

Ulcerative Colitis

United States, France, United Kingdom, Belgium, Switzerland, Israel, Canada, Australia, Netherlands, New Zealand, Austria, Germany, Denmark, Czechia, Argentina
Sahajanand Medical Technologies Pvt. Ltd.
Cardialysis BV

Terminated

SERIES III RUN-IN Clinical Trial: A Comparison of the Supralimus® Stent With the Xience V™ Stent

Coronary Artery Disease

India, Brazil, Saudi Arabia
Maastricht University Medical Center
Biomet Nederland BV

Unknown

Is the Use of Blood Platelets Effective in the Treatment of Difficult Fistulas Related to the Anal Sphincter?

Rectal Fistula

Netherlands
Khondrion BV
Julius Clinical; ProPharma Group; Certara

Completed

The KHENEREXT Study

Mitochondrial Diseases | Mitochondrial DNA tRNALeu(UUR) m.3243A<G Mutation | Maternally Inherited Diabetes and Deafness (MIDD) | Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke Like Episodes (MELAS) | Chronic Progressive External Ophthalmoplegia (CPEO)

Netherlands, Denmark, United Kingdom, Germany
ECRI bv
Boston Scientific Corporation; Philips Healthcare

Active, not recruiting

The OPTIMAL Randomized Controlled Trial (OPTIMAL)

Left Main Coronary Artery Stenosis

Spain, United Kingdom, Italy
Atlantia Food Clinical Trials
Caelus Pharmaceuticals BV

Completed

Efficacy and Safety of 12-weeks Supplementation of Eubacterium Hallii on Insulin Sensitivity and Glycaemic Control

Glucose Metabolism Disorders | Metabolic Syndrome | Insulin Resistance | Impaired Glucose Tolerance | Insulin Sensitivity | Pre Diabetes

Ireland, United States, United Kingdom
ECRI bv
Sahajanand Medical Technologies Pvt. Ltd.

Completed

Thin Strut Sirolimus-eluting Stent in All Comers Population vs Everolimus-eluting Stent (TALENT)

Coronary Stenosis

Bulgaria, Hungary, Italy, Netherlands, Poland, Spain, United Kingdom
Acerta Pharma BV
Merck Sharp & Dohme LLC

Completed

Study of the Combination of Acalabrutinib (ACP-196) and Pembrolizumab in Advanced Head and Neck Squamous Cell Carcinoma (KEYNOTE147)

Squamous Cell Carcinoma of the Head and Neck

United States
Acerta Pharma BV
Merck Sharp & Dohme LLC

Completed

Study of the Combination of ACP-196 and Pembrolizumab in Subjects With Platinum Resistant Urothelial Bladder Cancer (KEYNOTE143)

Metastatic Urothelial Carcinoma

United States
University of Pittsburgh
MucoVax, BV, the Netherlands

Terminated

Whey Protein Concentrate 40% Made of Milk of Immunized Cows to Aid in the Prevention of Relapse of Clostridium Difficile-Diarrhea

Positive C-Diff Culture

United States
Vissum, Instituto Oftalmológico de Alicante
AkkoLens Clinical bv

Completed

Efficacy of the AkkoLens IOL in Patients With Cataract

Cataract
Cardiovascular Research Foundation, New York
Cardialysis BV; Avania

Active, not recruiting

Transcatheter Aortic Valve Replacement to UNload the Left Ventricle in Patients With ADvanced Heart Failure (TAVR UNLOAD)

Aortic Valve Stenosis

United States, Canada, Netherlands
ECRI bv
Terumo Europe N.V.; Abbott Medical Devices

Completed

ABSORB STEMI: the TROFI II Study

Acute ST Segment Elevation Myocardial Infarction

Denmark, Netherlands, Spain, Switzerland
Maastricht University Medical Center
Winclove Bio Industries BV

Completed

The Effect of a Multispecies Probiotic on Hypersensitivity in Irritable Bowel Syndrome (IBS) Patients

Hypersensitivity | Irritable Bowel Syndrome

Netherlands
Maastricht University Medical Center
Stryker European Operations BV

Completed

RCT Comparing the DEXA Results of the HA-Omnifit Versus the Symax Uncemented Hip Stem

Patients With Osteoarthritis of the Hip Joint Elligable for a Uncemented Hipprosthesis
LiteVax BV
University Hospital, Ghent; HarmonyCR, Melle, Belgium

Recruiting

Safety, Tolerability, Immunogenicity and Immunological Mechanisms of TETRALITE, a Novel Seasonal Influenza Vaccine (TETRALITE-Ib)

Vaccination Reaction

Belgium
Fondazione Policlinico Universitario Agostino Gemelli...
Onera BV

Recruiting

Ultrasound and Respiratory Physiological Signals in Lung Diseases (SAURON)

Chronic Obstructive Pulmonary Disease | Ultrasonography | Interstitial Lung Disease | Ultrasound | Emphysema or COPD | Ultrasound Imaging | Interstitial Lung Diseases | Interstitial Pneumonia

Italy
ECRI bv
Siemens Healthineers AG; Pie Medical Imaging

Recruiting

Fractional Flow Reserve or 3D-Quantitative-Coronary-Angiography Based Vessel-FFR Guided Revascularization (FAST III)

Coronary Artery Disease

Germany, Ireland, Italy, Netherlands, Spain, United Kingdom, France
Acerta Pharma BV
National Institutes of Health (NIH)

Active, not recruiting

Acalabrutinib in Patients With Relapsed/Refractory and Treatment naïve Deletion 17p CLL/SLL

Chronic Lymphocytic Leukemia | Small Lymphocytic Lymphoma

United States
Washington University School of Medicine
Acerta Pharma BV

Active, not recruiting

Acalabrutinib With Bendamustine / Rituximab Followed by Cytarabine / Rituximab for Untreated Mantle Cell Lymphoma

Mantle Cell Lymphoma

United States
GSO Global Clinical Research BV
Karyopharm Therapeutics Inc

Terminated

Phase 1 Trial To Evaluate mFOLFOX6 With Selinexor In Patients With Metastatic Colorectal Cancer (SENTINEL)

Colorectal Neoplasm

Germany, Belgium
GSO Global Clinical Research BV
Karyopharm Therapeutics Inc

Completed

A Phase II Study of Selinexor Plus Cytarabine and Idarubicin in Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML)

Acute Myeloid Leukemia (Relapsed/Refractory)

Germany
Newtricious R&D BV
Sprim Advanced Life Sciences

Completed

Intervention Trial in Early Age-related Macular Degeneration (I-TEAM)

Age-related Macular Degeneration (AMD)

United States, Germany, Netherlands, United Kingdom
Abbott
Quintiles, Inc.; Synexus; author! et al. BV

Completed

Comparison of the Effect of Eprosartan and Eprosartan Mesylate on Blood Pressure in Essential Hypertension

Essential Hypertension

Germany, Russian Federation, United Kingdom
University Medical Center Groningen
Netherlands Heart Foundation; Disphar International B.V.; Teva Nederland BV; Tiofarma... and other collaborators

Active, not recruiting

Digoxin Evaluation in Chronic Heart Failure: Investigational Study In Outpatients in the Netherlands (DECISION)

Heart Failure

Netherlands
ECRI bv
AstraZeneca; The Medicines Company; Biosensors International

Completed

GLOBAL LEADERS: A Clinical Study Comparing Two Forms of Anti-platelet Therapy After Stent Implantation

Coronary Artery Disease (CAD)

Australia, Austria, Belgium, Brazil, Bulgaria, Canada, Denmark, France, Germany, Hungary, Italy, Netherlands, Poland, Portugal, Singapore, Spain, Switzerland, United Kingdom
Maastricht University Medical Center
Stryker European Operations BV

Unknown

RSA Study Using Two Types of Uncemented Acetabular Components and the Uncemented HA Coated Symax Stem (RSA)

Osteoarthritis

Netherlands
Martini Hospital Groningen
Baxter Healthcare Corporation; Roche BV Netherlands

Terminated

Peritoneal Dialysis in Congestive Heart Failure (PDinCHF)

Congestive Heart Failure

Netherlands
BioSync Scientific Pvt. Ltd.
Cardialysis BV; MIV Therapeutics Inc.

Unknown

Hydroxyapatite Active Pro Healing Clinical Trial Program (HApFIM)

Coronary Artery Disease
University of Valencia
Armonea Group - La Saleta; Bonusan BV

Completed

Leucine Supplementation in Sarcopenic Older Individuals

Frail Elderly Syndrome | Sarcopenia

Spain
University Medical Center Groningen
VitalAire Nederland BV; SomnoMed Goedegebuure

Completed

MRA Therapy Versus CPAP Therapy in Moderate OSAS (REST)

Sleep Apnea, Obstructive

Netherlands
Nucletron Operations BV
Factory CRO for Medical Devices B.V.

Completed

First-In Man (FIM) Study MR-Linac (FIM MR-Linac)

Bone Metastases

Netherlands
ExThera Medical Europe BV
ExThera Medical Corporation; Vivantes Clinic Neukölln

Recruiting

Safety & Effectiveness Evaluation of Seraph 100 in Treatment of Pts With COVID-19 (CP022)

COVID-19

Spain, Germany
Ceriter Nederland BV
Ziekenhuis Oost Limburg (ZOL) Hospital Genk, Belgium

Unknown

Adaptive Auditive Cueing as a Therapy for Freezing of Gait in Parkinson Patients (BioFOGP-IPD1)

Parkinson Disease

Belgium
University Medical Center Groningen
PRA Health Sciences; TRACER Europe BV

Recruiting

Anti-COVID19 VaccinaTion AKS-452 BOOSTER (ACT-BOOSTER Study) (ACT-BOOSTER)

COVID-19

Netherlands
ExThera Medical Europe BV
ExThera Medical Corporation; Vivantes Clinic Neukölln

Recruiting

Reduction of Pathogen Load From the Blood in Septic Patients With Suspected, Life-threatening Bloodstream Infection

Bloodstream Infection

France, Germany, Netherlands, Austria, Belgium, Italy, Poland, Spain, United Kingdom
GlaxoSmithKline
Crucell Holland BV; The PATH Malaria Vaccine Initiative (MVI)

Completed

Safety, Immunogenicity and Efficacy Against of a Combined Malaria Vaccine in Healthy Malaria-naïve Adults

Malaria

United States
King Saud University
Warwick Medical School; Winclove Bio Industries BV

Completed

Study to Explore the Effects of Probiotics on Endotoxin Levels in Type 2 Diabetes Mellitus Patients

Diabetes Mellitus Type 2

Saudi Arabia
Henry Ford Health System
Edwards Lifesciences; BMEYE BV the Netherlands

Completed

PREMIUM Registry: PRognostic HEModynamIc Profiling in the AcUtely Ill EMergency Department Patient (PREMIUM)

Systemic Infections | Acute CHF | Acute Stroke Syndromes

United States, Netherlands, Italy
AM-Pharma
CRM Biometrics GmbH; Sintesi Research Srl; Vigilex BV

Completed

Safety/Efficacy Study of Bovine Intestinal Alkaline Phosphatase in Patients With Moderate to Severe Ulcerative Colitis

Ulcerative Colitis

Czech Republic, Italy
CLJI Worldwide
UMC Utrecht; University of Washington; University of Rotterdam, The Netherlands; Applied Clinical Services... and other collaborators

Completed

The VIBLOK SAfety and perFormancE Trial (SAFE)

Genital Herpes | HSV-2 Infection

Netherlands
Prof. Dr. Folkert W. Asselbergs
Radboud University Medical Center; University Medical Center Groningen; UMC Utrecht and other collaborators

Not yet recruiting

Check@Home: General Population Screening for Early Detection of Atrial Fibrillation and Chronic Kidney Disease

Diabetes Mellitus, Type 2 | Chronic Kidney Diseases | Atrial Fibrillation
Crucell Holland BV
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Assessment of CR6261, a Monoclonal Antibody Against the Influenza A Virus

Influenza

United States

Clinical Trials Sponsored by Synapse bv

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Lebanon

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

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