Clinical Trials Sponsored by Wellcome Trust

Total 6266 results

Glaxo Wellcome

Completed

A Study of Zidovudine and T Lymphocyte Transfer in the Treatment of HIV Type III in Patients With AIDS

HIV Infections

United States
Glaxo Wellcome

Completed

Trial of an Alternative Dosing Regimen of Oral Retrovir in Patients With AIDS or Advanced ARC

HIV Infections

United States, Puerto Rico
Glaxo Wellcome

Completed

Safety and Effectiveness of Lamivudine When Given Once a Day Versus Twice a Day in Combination With Other Anti-HIV Drugs in HIV-Infected Adults Who Have Never Received Anti-HIV Drugs

HIV Infections

United States, Canada, Argentina, Brazil, Puerto Rico
Glaxo Wellcome

Completed

A Study of Amprenavir in Patients With Protease Inhibitor-Related Complications

HIV Infections

United States
Glaxo Wellcome

Unknown

Effectiveness and Safety of Epivir/Ziagen/Zerit (3TC/ABC/d4T) Versus Epivir/Ziagen/Sustiva (3TC/ABC/EFV) Versus Epivir/Ziagen/Agenerase/Norvir (3TC/ABC/APV/RTV) in HIV Patients Who Have Never Received Treatment

HIV Infections

United States
Glaxo Wellcome

Completed

An Open-Label Study to Evaluate the Efficacy and Safety of Amprenavir (141W94) and Abacavir Combination Therapy in Protease Inhibitor Experienced Subjects With HIV-1 Infection Who Are Failing Their Current Antiretroviral Treatment Regimen

HIV Infections

United States
Glaxo Wellcome

Completed

A Phase I Study to Evaluate the Pharmacokinetics, Safety and Antiviral Effects of Concurrent Administration of Zidovudine (AZT) and 2'3'-Dideoxyinosine (ddI) in Patients With Human Immunodeficiency Virus (HIV)

HIV Infections

United States
Glaxo Wellcome

Completed

A Prospective Double-Blind Study of Retrovir in Early HIV Infection

HIV Infections

United States
Glaxo Wellcome

Completed

A Randomized Trial to Evaluate the Safety and Efficacy of Combination Therapy With Retrovir ( AZT ) and HIVID ( ddC ) Versus Retrovir, HIVID, and Wellferon ( Interferon Alfa-n1 ) for the Treatment of HIV Infection

HIV Infections

United States
Glaxo Wellcome

Completed

A Study of Retrovir and Epivir Alone or in Combination With 141W94 in HIV-Infected Patients

HIV Infections

United States
Glaxo Wellcome

Completed

A Comparison of 141W94 and Indinavir in HIV-Infected Patients

HIV Infections

United States
Glaxo Wellcome

Completed

A Study of the Effects of Amprenavir, a Protease Inhibitor, on Carbohydrate and Fat Metabolism in HIV-Infected Patients

HIV Infections

United States
Glaxo Wellcome

Completed

A Comparison of 882C87 Versus Acyclovir in the Treatment of Herpes Zoster in Patients With Weakened Immune Systems

HIV Infections | Chickenpox

United States
Glaxo Wellcome

Completed

A Study of the Safety and Effectiveness of Different Doses of 1592U89 in HIV-Infected Patients

HIV Infections

France, Germany
Glaxo Wellcome

Completed

A Phase II Open Randomized Comparison of 566C80 and Pentamidine Isethionate for the Treatment of Pneumocystis Carinii Pneumonia in AIDS Patients Who Are Intolerant of Trimethoprim / Sulfamethoxazole

HIV Infections | Pneumonia, Pneumocystis Carinii

United States
Glaxo Wellcome

Unknown

Comparison of GW433908/Ritonavir to Nelfinavir When Used With Abacavir and Lamivudine in Patients That Have Not Taken Antiretroviral Drugs

HIV Infections

United States
Glaxo Wellcome

Completed

An Oral Dose-Ranging Finding Study in Patients With HIV Disease, CDC Classification Groups IIB, III, and IV-C2

HIV Infections

United States
Glaxo Wellcome

Completed

An Open-Label, Uncontrolled Clinical Trial of Oral 566C80 for the Treatment of Patients With Severe PCP Who Are Intolerant and/or Unresponsive to Therapy With Trimethoprim/Sulfamethoxazole and Parenteral Pentamidine

HIV Infections | Pneumonia, Pneumocystis Carinii

United States
Glaxo Wellcome

Completed

A Phase I Trial to Evaluate the Safety, Pharmacokinetics and Antiviral Activity of 141W94 After Multiple Dosing in Patients With HIV Infection

HIV Infections

United States
Glaxo Wellcome

Completed

A Study of 1592U89 in HIV-Infected Patients

HIV Infections

United States
Glaxo Wellcome

Completed

A Study of 1592U89 in HIV-Infected Children

HIV Infections

United States
Glaxo Wellcome

Completed

A Study of Retrovir in the Prevention of HIV Infection in Health Care Workers Accidentally Exposed to the Virus

HIV Infections

United States
Glaxo Wellcome

Completed

The Safety and Effectiveness of Different Dose Levels of 1263W94 in the Treatment of Cytomegalovirus (CMV) of the Eyes in HIV-Infected Patients

HIV Infections | Cytomegalovirus Infections

United States
Glaxo Wellcome

Completed

A Study of the Safety and Effectiveness of Combination Anti-HIV Therapy in HIV-Infected Adults

HIV Infections

United States
Glaxo Wellcome

Completed

A Study of Amprenavir in HIV-Infected Patients

HIV Infections

United States
Glaxo Wellcome

Completed

A Treatment IND for 566C80 Therapy of Pneumocystis Carinii Pneumonia

HIV Infections | Pneumonia, Pneumocystis Carinii

United States
Glaxo Wellcome

Completed

The Safety and Effectiveness of Zidovudine Plus Lamivudine, Used With and Without 1592U89, in HIV-1 Infected Children Who Have Taken Anti-HIV-1 Drugs

HIV Infections

United States
Glaxo Wellcome

Completed

A Phase III, Randomized, Double-Blind, Multicentre Study to Evaluate the Safety and Efficacy of 1592U89 in Patients With AIDS Dementia Complex

HIV Infections | AIDS Dementia Complex

United States, Canada
Glaxo Wellcome

Completed

Treatment of AIDS and AIDS Related Complex. Part-1- Treatment of Patients With ARC (AZT Vs. Placebo)

HIV Infections

United States
Glaxo Wellcome

Completed

Safety and Effectiveness of Giving Two Nucleoside Reverse Transcriptase Inhibitors Alone or in Combination With 141W94 to HIV-Infected Children Who Have Never Received Protease Inhibitors

HIV Infections

United States
Glaxo Wellcome

Completed

A Pilot Study of 566C80 for the Salvage Treatment of Toxoplasmic Encephalitis in Patients Infected With the Human Immunodeficiency Virus (HIV) Who Have Failed or Are Intolerant of Pyrimethamine-Sulfadiazine

HIV Infections | Toxoplasmosis, Cerebral

United States, Canada
Glaxo Wellcome

Completed

A Study of Azidothymidine (AZT) in the Treatment of HIV Infection in Patients Receiving a Bone Marrow Transplant

HIV Infections | Lymphoma, Non-Hodgkin

United States
Glaxo Wellcome

Completed

A Study to Compare the Safety and Effectiveness of Two Dosing Schedules of Lamivudine in Combination With Two Other Anti-HIV Drugs

HIV Infections

United States
Glaxo Wellcome

Completed

The Efficacy and Safety of Retrovir in Patients Infected With HIV Who Are Asymptomatic (CDC Group II) or Have Persistent Generalized Lymphadenopathy (CDC Group III)

HIV Infections | Lymphatic Disease

United States
Glaxo Wellcome

Unknown

Comparison of GW433908 and Nelfinavir in HIV Patients Who Have Not Had Antiretroviral Therapy

HIV Infections

United States
Glaxo Wellcome

Unknown

Safety and Effectiveness of Three Anti-HIV Drugs Combined in One Pill (Trizivir)

HIV Infections

United States
Glaxo Wellcome

Completed

A Study to Compare the Efficacy and Safety of Valacyclovir Hydrochloride ( 256U87 ) Versus Acyclovir in the Treatment of Recurrent Anogenital Herpes Infections in HIV Infected Patients

HIV Infections | Herpes Simplex

United States
Glaxo Wellcome

Completed

A Comparison of Two Multi-Drug Therapies in HIV-Infected Patients Who Have Never Received Anti-HIV Treatment

HIV Infections

United States
Glaxo Wellcome

Completed

The Safety and Effectiveness of Retrovir in HIV-Infected Patients Who Have Problems Related to the Nervous System

HIV Infections

United States
Glaxo Wellcome

Completed

Safety and Effectiveness of a Combination Anti-HIV Drug Treatment

HIV Infections

United States
Glaxo Wellcome

Completed

The Safety and Effectiveness of 524W91

HIV Infections

United States
Glaxo Wellcome

Completed

A Study of 1592U89 in Combination With Protease Inhibitors in HIV-Infected Patients Who Have Never Taken Anti-HIV Drugs

HIV Infections

United States
Universitätsklinikum Hamburg-Eppendorf
University Hospital, Geneva; Wellcome Trust; KEMRI-Wellcome Trust Collaborative... and other collaborators

Completed

Phase I Trial to Assess the Safety, Tolerability and Immunogenicity of a Ebola Virus Vaccine (rVSVΔG-ZEBOV-GP)

Hemorrhagic Fever, Ebola

Germany
Universidad de Antioquia
United States Agency for International Development (USAID); Bill and Melinda... and other collaborators

Completed

Impact of Wolbachia Deployment on Arboviral Disease Incidence in Medellin and Bello, Colombia (WMP-COL)

Dengue | Zika Virus Infection | Chikungunya Virus Infection

Colombia
International Vaccine Institute
GlaxoSmithKline; Wellcome Trust; University of Western Ontario, Canada; National...

Completed

Evaluation of the Vi Polysaccharide Vaccine Against Typhoid Fever

Typhoid | Paratyphoid Fever

India
London School of Hygiene and Tropical Medicine
Wellcome Trust; Aga Khan University; Aga Khan Health Services; Maywand Hospital...

Unknown

Kabul Vitamin D Supplementation Trial

Pneumonia | Vitamin D Deficiency

Afghanistan
Drugs for Neglected Diseases
Wellcome Trust grant 212346/Z/18/Z - 21st Century Treatments for Sustainable...

Completed

Single Oral Dose Escalation Study of DNDI-0690 in Healthy Subjects

Visceral Leishmaniasis | Cutaneous Leishmaniases

United Kingdom
Indian Institute of Science
Wellcome Trust; PATH; University of Liverpool; National Institute of Mental Health...

Completed

A Prospective, Open Label Study of Human T Cell Responses to Live Attenuated Japanese Encephalitis Vaccine SA14-14-2

Japanese Encephalitis | Japanese Encephalitis Vaccine

India
University College, London
London School of Hygiene and Tropical Medicine; Wellcome Trust; National Institute...

Completed

Ethnicity and Onset of Cardiovascular Disease: A CALIBER Study

Myocardial Infarction | Heart Failure | Stroke | Ischemic Stroke | Peripheral Arterial Disease | Transient Ischemic Attack | Coronary Heart Disease | Cardiac Arrest | Stable Angina Pectoris | Unstable Angina | Sudden Cardiac Death | Abdominal Aortic Aneurysm | Intracerebral Haemorrhage | Subarachnoid Haemorrhage
KEMRI-Wellcome Trust Collaborative Research Program
London School of Hygiene and Tropical Medicine; University of Oxford; University...

Completed

Amoxicillin Versus Benzyl Penicillin for Treatment of Children Hospitalised With Severe Pneumonia

Pneumonia

Kenya

3

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