Search clinical trials for: Agonist treatment failure

Total 87488 results

Brigham and Women's Hospital
Charles A. King Trust Postdoctoral Fellowship Program

Not yet recruiting

Role of Caveolin 1 (CAV-1) Deficiency in Response to Glucagon-like Peptide 1 (GLP-1) Receptor Agonist Treatment

Overweight and Obesity
RenJi Hospital

Not yet recruiting

SALT for Treatment of Patients With Early ACLF

Acute-On-Chronic Liver Failure

China
Peking University People's Hospital

Recruiting

The Optimization of Conditioning Regimen for HLA Matched HSCT in SAA

Severe Aplastic Anemia

China
AstraZeneca

Recruiting

A Study to Evaluate the Effect of Budesonide, Glycopyrronium, Formoterol Fumarate (BGF) Metered Dose Inhaler (MDI), Budesonide and Formoterol Fumarate (BFF) MDI and Placebo MDI on Exercise Parameters in Participants With Chronic Obstructive Pulmonary Disease (COPD). (ATHLOS)

Chronic Obstructive Pulmonary Disease

Germany, Spain, United States, China, Korea, Republic of, Argentina, United Kingdom, Canada
Novo Nordisk A/S

Recruiting

A Research Study to See How Well CagriSema Compared to Semaglutide, Cagrilintide and Placebo Lowers Blood Sugar and Body Weight in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 Inhibitor (REIMAGINE 2)

Type 2 Diabetes Mellitus

Korea, Republic of, United States, Hungary, Serbia, Spain, China, Australia, Finland, United Kingdom, Italy, Denmark, Canada, Taiwan, Poland, Germany, Sweden, South Africa, India, Argentina, Brazil, Bulgaria, Japan, Mexico, Turkey, Greece, Colomb... and more
Hoffmann-La Roche

Recruiting

A Study to Evaluate Efficacy and Safety of Giredestrant Compared With Fulvestrant (Plus a CDK4/6 Inhibitor), in Participants With ER-Positive, HER2-Negative Advanced Breast Cancer Resistant to Adjuvant Endocrine Therapy (pionERA Breast Cancer)

Estrogen Receptor-Positive, HER2-Negative Advanced Breast Cancer

Belgium, Korea, Republic of, United States, Canada, China, Italy, France, Finland, Brazil, Australia, Argentina, Hong Kong, Portugal, Spain, Taiwan, India, Costa Rica, Israel, Thailand, Germany, New Zealand, Poland, Chile, Colombia, Gua... and more
University Medical Center Groningen
Rijnstate Hospital

Not yet recruiting

Bariatric Surgery Evaluation and Assessment of Treatment Efficacy - Intervention Trial (BEAT-IT)

Atrial Fibrillation | Heart Failure With Preserved Ejection Fraction

Netherlands
Consorcio Centro de Investigación Biomédica en...
Instituto de Salud Carlos III

Not yet recruiting

Multidisciplinary Design to Optimize Schizophrenia Treatment Based on Multi-omics Data and Systems Biology Analysis (SchizOMICS)

Diabetes | Schizophrenia | Lipid Metabolism Disorders | NAFLD | Psychosis | Treatment-resistant Schizophrenia | Side Effect
Anhui Provincial Hospital

Recruiting

QH103 Cell Injection for the Treatment of Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia

B-cell Acute Lymphoblastic Leukemia

China
Vanderbilt University Medical Center

Recruiting

Tranexamic Acid in Nasal Mohs Reconstruction

Skin Cancer Face | Postoperative Bleeding

United States
National Institute of Allergy and Infectious Diseases...
University of Pennsylvania Clinical Cell and Vaccine Production Facility...

Recruiting

CAR-T Cell Therapy for Desensitization in Kidney Transplantation

Kidney Failure | End Stage Renal Failure on Dialysis | Kidney Transplant

United States
National Cancer Institute (NCI)

Recruiting

Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer

Anatomic Stage II Breast Cancer AJCC v8 | Anatomic Stage III Breast Cancer AJCC v8 | Hormone Receptor-Positive Breast Carcinoma | HER2-Negative Breast Carcinoma

United States
Jasper A. Smits
National Cancer Institute (NCI); University of Oklahoma; University of Houston; YMC...

Recruiting

Community-based Smoking Cessation Treatment for Adults With High Stress Sensitivity. (STEP3)

Nicotine Dependence

United States
Riyadh Elm University

Not yet recruiting

White Spot Lesions Treatment in Orthodontic (WSL)

White Spot Lesion
Imperial College London

Recruiting

Physiological Versus Right Ventricular Outcome Trial Evaluated for Bradycardia Treatment Upgrades (PROTECT-UP)

Heart Failure | Pacing-Induced Cardiomyopathy

United Kingdom
Astellas Pharma Global Development, Inc.

Recruiting

A Study Following Women in Menopause Treated With a Non-hormonal Therapy for Hot Flashes and Night Sweats (OPTION-VMS)

Hot Flashes

United States
Ji Xing Pharmaceuticals (Shanghai) Co., Ltd.
LENZ Therapeutics, Inc

Recruiting

Evaluation of the Efficacy and Safety of LNZ101 and LNZ100 for the Presbyopia

Eye Diseases | Presbyopia | Miosis | Near Vision

China
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Recruiting

Pharmacokinetic and Safety Study of Oral Lofexidine in Neonates Experiencing Opioid Withdrawal Due to Intrauterine Exposure to Opioids

Opioid Withdrawal (Disorder)

United States
Maastricht University Medical Center

Recruiting

Empagliflozin for Peripheral Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction

Heart Failure With Preserved Ejection Fraction | Microvascular Dysfunction

Netherlands
University of Sao Paulo General Hospital
Brazilian Research In Intensive Care Network; Latin American Intensive Care...

Recruiting

Adherence to Low Tidal Volume in the Transition to Spontaneous Ventilation in Patients With Acute Respiratory Failure (SPIRAL)

Respiratory Insufficiency | Respiration, Artificial | Acute Hypoxemic Respiratory Failure

Chile, Brazil, Argentina, Bolivia, Colombia, Ecuador, Paraguay, Peru, Uruguay, Mexico
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

Dose-Reduced Docetaxel With Cyclophosphamide for the Treatment of Vulnerable Older Women With Stage I-III HER2 Negative Breast Cancer, the DOROTHY Trial

Anatomic Stage I Breast Cancer AJCC v8 | Anatomic Stage II Breast Cancer AJCC v8 | Anatomic Stage III Breast Cancer AJCC v8 | HER2-Negative Breast Carcinoma

United States
Anhui Provincial Hospital

Recruiting

Conditioning Regimen Containing Low Dose ATG for The Treatment of Acquired SAA Receiving sUCBT

Severe Aplastic Anemia

China
Colorado Prevention Center
Bayer; Saint Luke's Hospital of Kansas City

Not yet recruiting

A Study to Evaluate Finerenone on Clinical Efficacy and Safety in Patients With Heart Failure Who Are Intolerant or Not Eligible for Treatment With Steroidal Mineralocorticoid Receptor Antagonists (FINALITY-HF)

Heart Failure
University Hospital Ostrava

Not yet recruiting

Determination of Drug Levels for Pharmacotherapy of Heart Failure

Cardiovascular Diseases | Heart Failure With Reduced Ejection Fraction

Czechia
Chulalongkorn University

Not yet recruiting

The Treatment Effects of Empagliflozin on Renal Outcomes in Cardiorenal Syndrome Type 1 (TREAT-CRS)

Empagliflozin in Cardiorenal Syndrome Type 1

Thailand
St. Jude Children's Research Hospital

Recruiting

Treatment of Newly Diagnosed Rhabdomyosarcoma Using Molecular Risk Stratification and Liposomal Irinotecan Based Therapy in Children With Intermediate and High Risk Disease

Rhabdomyosarcoma

United States
VA Office of Research and Development
VA Pittsburgh Healthcare System; Nashville VA Medical Center; Iowa City VA Health...

Recruiting

Empagliflozin Treatment in Kidney Transplant Recipients (SEKTR)

Type 2 Diabetes | Kidney Transplant

United States
Peking Union Medical College Hospital

Recruiting

Efficacy of IST Combined With TPO-RA in the Treatment of AA and Establishment of a Recurrence Prediction System

Aplastic Anemia | Drug Therapy | CSA

China
Peking Union Medical College Hospital

Not yet recruiting

Romiplostim in Combination With CsA vs. CsA in the Treatment of Newly Diagnosed NSAA

Non Severe Aplastic Anemia

China
Juventas Cell Therapy Ltd.

Not yet recruiting

A Study of HY004 Treatment in Adult Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia (r/r B-ALL) (B-ALL)

B-cell Acute Lymphoblastic Leukemia
Peking Union Medical College Hospital

Not yet recruiting

A Prospective, Randomized, Controlled Study of rhTPO in Combination With Herombopag + CsA vs Herombopag + CsA for the Treatment of Primary TD-NSAA

Drug Effect | Aplastic Anemia

China
Novartis Pharmaceuticals

Recruiting

Characterizing Guideline Adoption and Treatment Quality in Clinical Routine of German HFrEF Care (CONNECT)

Heart Failure

Germany
Peking Union Medical College Hospital

Recruiting

Efficacy and Safety of CsA+AVA in the Treatment of NSAA in the Elderly

Aplastic Anemia

China
Ain Shams University

Recruiting

Single Shot Intrathecal Analgesia in Vaginal Delivery

Effectiveness of Single Shot Intra-thecal Analgesia in Multiparous Women Scheduled for Normal Vaginal Delivery

Egypt
D'Or Institute for Research and Education
Oswaldo Cruz Foundation; Rio de Janeiro State Research Supporting Foundation... and other collaborators

Not yet recruiting

Extracellular Vesicles From Mesenchymal Cells in the Treatment of Acute Respiratory Failure

Pneumonia | Acute Respiratory Distress Syndrome (ARDS) | Severe Acute Respiratory Syndrome (SARS)

Brazil
Peking Union Medical College Hospital

Not yet recruiting

CsA+ATG+AVA vs. CsA+AVA for the Treatment of Newly-diagnosed SAA in the Elderly

Aplastic Anemia

China
Centre for Addiction and Mental Health
Canadian Institutes of Health Research (CIHR); Canadian Cancer Society (CCS)

Recruiting

Helping People Adhere to Their Varenicline Treatment by Co-creating a Conversational Agent: A Feasibility Study

Smoking Cessation | Medication Adherence

Canada
Albert Einstein College of Medicine
FDNY World Trade Center Health Program

Recruiting

Tobacco Cessation at FDNY

Tobacco Use | Tobacco Smoking | Tobacco Use Cessation

United States
University of Pennsylvania

Recruiting

Pregabalin Plus Lofexidine for the Outpatient Treatment of Opioid Withdrawal (UH3)

Opioid Use | Opiate Withdrawal Syndrome

United States
The First Hospital of Jilin University
CSPC Ouyi Pharmaceutical Co., Ltd.

Not yet recruiting

The Efficacy and Safety of the RCMOP Sequential Therapy as a First-line Treatment for Patients With Intermediate-to-high Risk Diffuse Large B-cell Lymphoma Who Had Incomplete Remission.

Diffuse Large B-cell Lymphoma

China
Beijing 302 Hospital
Shenzhen Third People's Hospital; Shulan (Hang Zhou) Hospital; BeijingYouan Hospital and other collaborators

Recruiting

Human Umbilical Cord Mesenchymal Stem Cell Transplantation for The Treatment of Acute-on-Chronic Liver Failure

Acute-On-Chronic Liver Failure

China
Saglik Bilimleri Universitesi

Not yet recruiting

The Effect of Individualized Education Using the Teach-Back Method Treatment on Treatment Adherence and the Coping Skills

End Stage Renal Disease on Dialysis
HuiKai Li

Not yet recruiting

Hepatic Artery Infusion of Adebrelimab Combined With Bevacizumab in the Treatment of Advanced Hepatocellular Carcinoma With Failure of Systemic Therapy Combined With Interventional Therapy

Hepatocellular Carcinoma

China
Institute of Hematology & Blood Diseases Hospital

Recruiting

Cyclophosphamide Added to Standard Immunosuppressive Therapy With Eltrombopag as Front-line Therapy in Patients With Severe Aplastic Anemia

Severe Aplastic Anemia

China
Dr. Inge Winter
Universität Münster

Recruiting

The Effect of a Six Week Intensified Pharmacological Treatment for Bipolar Depression Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment. (INTENSIFY BD)

Bipolar Depression

Austria, Germany, Italy, Spain, United Kingdom
Brigham and Women's Hospital

Not yet recruiting

Pilot Study 1: Efficacy and Safety of Sublingual Dexmedetomidine (BXCL501) for the Treatment of Agitation in the Emergency Department

Schizophrenia | Schizoaffective Disorder | Bipolar Disorder | Agitation | Schizophreniform Disorders
Dr. Inge Winter
Universität Münster

Recruiting

The Effect of a Six Week Intensified Pharmacological Treatment for Major Depressive Disorder Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment. (INTENSIFY MDD)

Major Depressive Disorder | Treatment Resistant Depression

Austria, Germany, Italy, Spain, United Kingdom
Greater Manchester Mental Health NHS Foundation...
University of Manchester; National Institute for Health Research, United Kingdom and other collaborators

Recruiting

Cardiac Rehabilitation for Young People (CardioActive)

Heart Failure | Heart Valve Diseases | Cardiomyopathies | Congenital Heart Disease | Cardiac Arrythmias | Cerebrovascular Event

United Kingdom
Sequana Medical N.V.

Recruiting

Management of Volume Overload HF Patients by Individual DSR Treatment adJustment-a clinicAl inVestigation of InfusatE2.0 (MOJAVE)

Heart Failure | Volume Overload

United States
ONY
Avania

Not yet recruiting

InfasurfAero™ Versus Sham Treatment in Preterm Newborns With RDS (Aero-05)

Intubation Complication | Death; Neonatal | Respiratory Distress Syndrome (Neonatal)

United States

Search clinical trials for: Agonist treatment failure

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