Search clinical trials for: Antitumor drugs

Total 257401 results

Ilyse Kenis
KU Leuven; University Ghent; Kom Op Tegen Kanker

Unknown

Collaborative Network to Take Responsibility for Oral Anticancer Therapy 2 (CONTACT-2)

Oncologic Disorders

Belgium
GlaxoSmithKline
Merck Sharp & Dohme LLC

Withdrawn

Clinical Trial of Safety, Tolerability and Antitumor Activity of Genetically Engineered T Cells in Combination With Anti-Cancer Agents in Relapsed and Refractory Synovial Sarcoma Expressing New York Esophageal Antigen-1 (NY-ESO-1) and/or LAGE-1a

Neoplasms
Astellas Pharma Inc

Terminated

An Open Study of ASP8273 in Patients With Non-Small-Cell Lung Cancer (NSCLC) Who Have Epidermal Growth Factor Receptor (EGFR) Mutations

Non-small Cell Lung Cancer

Japan, Korea, Republic of, Taiwan
M.D. Anderson Cancer Center

Completed

Melanoma Vaccine With Peptides and Leuprolide

Melanoma

United States
Ahmed A. H. Abdellatif

Unknown

Targeted Polymeric Nanoparticles Loaded With Cetuximab and Decorated With Somatostatin Analogue to Colon Cancer

Colon Cancer | Colo-rectal Cancer

Egypt, Saudi Arabia
Eli Lilly and Company

Completed

A Phase 3 Study in Participants With Moderate to Severe Psoriasis (UNCOVER-1)

Psoriasis

Italy, United States, Australia, Germany, Canada, Denmark, Japan, Poland, Hungary, Romania, United Kingdom
AstraZeneca

Completed

To Assess Safety and Effect of Olaparib on the Pharmacokinetics of Anastrozole, Letrozole & Tamoxifen, and Their Effect on Olaparib, in Patients With Advanced Solid Cancer

Solid Tumours

Belgium, Denmark, France, United Kingdom, Netherlands
AstraZeneca

Completed

Study to Assess the Blood Levels and Safety of Olaparib in Patients With Advanced Solid Tumours and Normal Liver Function or Mild or Moderate Liver Impairment

Solid Tumours

France, United Kingdom, Czechia, Korea, Republic of, Netherlands
PCI Biotech AS

Completed

Study to Assess Safety, Tolerability and Immune Response of Fimaporfin-induced Photochemical Internalisation of Antigen/Adjuvant

Healthy Volunteer

United Kingdom
Hoffmann-La Roche

Completed

A Study to Assess the Feasibility of an E-Health System (ZEMY) Designed to Manage Symptoms in Participants With Breast Cancer Under Anti-Cancer Treatment (ZEMY)

Breast Cancer

France
Novartis Pharmaceuticals

Completed

A Rollover Study to Provide Continued Treatment With GSK2118436 to Subjects With BRAF Mutation-Positive Tumors

Cancer

United States, Canada, Australia, France, Germany, Poland, Spain, United Kingdom, Italy
Taipei Veterans General Hospital, Taiwan

Unknown

Entecavir for Biological Agents Associated HBV Reactivation in Inflammatory Arthritis Patients

Rheumatoid Arthritis | Exposure to Hepatitis B Virus | Hepatitis B Reactivation

Taiwan
AstraZeneca

Completed

Study to Assess the Blood Levels and Safety of AZD9291 in Patients With Advanced Solid Tumours and Normal Liver Function or Mild or Moderate Liver Impairment

Solid Tumours

United States, Spain, Belgium, France, Korea, Republic of, United Kingdom
Innovent Biologics (Suzhou) Co. Ltd.

Completed

Comparative Clinical Trial to Evaluate Bioequivalency and Safety of Monoclonal Antibody Injection and Adalimumab in Chinese Healthy Volunteers

Healthy
Sun Yat-sen University

Completed

Chemoembolization With or Without Mixing the Chemotherapy With Lipiodol for Unresectable HCC

Hepatocellular Carcinoma

China
MedImmune LLC

Completed

A Dose-escalation Study to Evaluate the Safety, Tolerability, and Antitumor Activity of MEDI-573 in Subjects With Advanced Solid Tumors

Cancer

United States
Changhai Hospital
Stemirna Therapeutics

Unknown

Clinical Study of Personalized mRNA Vaccine Encoding Neoantigen in Patients With Advanced Digestive System Neoplasms

Pancreatic Adenocarcinoma | Gastric Adenocarcinoma | Colorectal Adenocarcinoma | Advanced Esophageal Squamous Carcinoma

China
National Cancer Institute (NCI)

Completed

AMP-224, a PD-1 Inhibitor, With Stereotactic Body Radiation Therapy in Metastatic Colorectal Cancer

Colorectal Neoplasms | Colorectal Cancer | Colorectal Carcinoma

United States
University Health Network, Toronto
Novartis Pharmaceuticals

Terminated

Study of AUY922 in Metastatic Pancreatic Cancer Who Are Resistant to First Line Chemotherapy

Adenocarcinoma of the Pancreas | Metastatic Disease

Canada
Imunon

Completed

A Study of ThermoDox™ in Combination With Radiofrequency Ablation (RFA) in Primary and Metastatic Tumors of the Liver

Liver Neoplasms | Hepatocellular Carcinoma

United States
Ipsen

Completed

The Study of Oral Steroid Sulphatase Inhibitor BN83495 Versus Megestrol Acetate (MA) in Women With Advanced or Recurrent Endometrial Cancer

Endometrial Cancer

Czechia, France, United Kingdom, Belgium, Latvia, Hungary, Lithuania, Moldova, Republic of, Poland, Russian Federation, Spain, Ukraine
Hoffmann-La Roche

Completed

Study To Evaluate the Efficacy and Safety Of Bevacizumab, and Associated Biomarkers, In Combination With Paclitaxel Compared With Paclitaxel Plus Placebo as First-line Treatment Of Patients With Her2-Negative Metastatic Breast Cancer

Metastatic Breast Cancer

United States, Korea, Republic of, United Kingdom, Italy, Russian Federation, Argentina, Belgium, Brazil, Panama, Germany, Japan, Ukraine, Chile, South Africa, Bulgaria, Romania
Boehringer Ingelheim

Completed

LUME-Lung 1: BIBF 1120 Plus Docetaxel as Compared to Placebo Plus Docetaxel in 2nd Line Non Small Cell Lung Cancer

Carcinoma, Non-Small-Cell Lung

Spain, Germany, China, Israel, Denmark, Belgium, Switzerland, Croatia, Poland, Romania, South Africa, Czechia, Greece, Portugal, United Kingdom, India, Italy, Austria, Belarus, Ukraine, Russian Federation, France, Bulgaria, Georgia, Korea... and more
Biocad

Completed

A Safety and Efficacy Study of BCD-022 With Paclitaxel Compared to Herceptin With Paclitaxel in HER2+ Metastatic Breast Cancer Patients

Human Epithelial Receptor (HER)-2 Positive Breast Cancer

Ukraine, Russian Federation, Belarus, India
Sidney Kimmel Comprehensive Cancer Center at Johns...
National Cancer Institute (NCI)

Completed

Chemotherapy, Vaccine Therapy, and Stem Cell Transplantation in Patients With Newly Diagnosed Multiple Myeloma

Multiple Myeloma

United States
Ain Shams University

Unknown

Itraconazole in Non Small Cell Lung Cancer

Lung Cancer

Egypt
Parent Project, Italy

Completed

To Compare the Pharmacokinetics Profiles of ISO 20, IBU 200 and IBU Plus ISO Combinations 200 + 20 (ISOFEN1)

Duchenne Muscular Dystrophy (DMD)

Italy
Puma Biotechnology, Inc.

Completed

Study Evaluating Neratinib Plus Paclitaxel VS Trastuzumab Plus Paclitaxel In ErbB-2 Positive Advanced Breast Cancer (NEFERTT)

Breast Cancer

Spain, China, United States, Australia, Hong Kong, Malaysia, Korea, Republic of, Singapore, Belgium, Japan, India, France, Hungary, Romania, Italy, Bulgaria, Germany, Serbia, United Kingdom, South Africa, Canada, Israel, Taiwan, Switz... and more
AstraZeneca

Completed

Study to Assess the Effect of AZD9291 on the Blood Levels of Rosuvastatin, in Patients With EGFRm+ Non-small Cell Lung Cancer

Non Small Cell Lung Cancer

Spain, United Kingdom, France, United States
Pfizer
PRA Health Sciences

Completed

Evaluation of Safety, Pharmacokinetics and Efficacy of Ceftazidime and Avibactam (CAZ-AVI ) Compared With Cefepime in Children From 3 Months to Less Than 18 Years of Age With Complicated Urinary Tract Infections (cUTIs)

Complicated Urinary Tract Infections

United States, Taiwan, Turkey, Czechia, Hungary, Greece, Poland, Romania, Russian Federation
MedImmune LLC

Completed

A Dose Escalation, Dose Expansion Study to Evaluate the Safety, Tolerability, and Antitumor Activity of MEDI-575, in Subjects With Advanced Tumors. (MEDI-575)

Cancer

United States
Oshadi Drug Administration

Suspended

Oshadi D & Oshadi R Combined With Salvage Chemotherapy for Relapsed Acute Myeloid Leukemia or Lymphoid Leukemia Patients

Acute Myeloid Leukemia | Lymphoid Leukemia
Boehringer Ingelheim

Completed

BIBW 2992 (Afatinib) Versus Chemotherapy as First Line Treatment in NSCLC With EGFR Mutation

Adenocarcinoma | Carcinoma, Non-Small-Cell Lung

Hong Kong, Canada, Korea, Republic of, Belgium, Australia, United States, Taiwan, United Kingdom, Germany, Italy, Japan, Austria, Thailand, Peru, Ireland, Russian Federation, Philippines, France, Brazil, Chile, Argentina, Hungary, M... and more
H. Kim Lyerly
Susan G. Komen Breast Cancer Foundation

Completed

A Phase I Study To Evaluate The Antitumor Activity And Safety Of AVX901

HER2+ Cancer

United States
Novartis Pharmaceuticals

Completed

Continuation Study of Lapatinib Monotherapy or Lapatinib in Combination With Other Anti-cancer Agents

Neoplasms, Breast

Canada, Netherlands, United States, Spain, Korea, Republic of
Dean Felsher
The Leukemia and Lymphoma Society; Burroughs Wellcome; Damon Runyon Cancer Research...

Completed

Phase 2 Study of Atorvastatin Safety and Antitumor Effects in Non-Hodgkin's Lymphoma

Lymphoma, Non-Hodgkin | Leukemia

United States
Janssen Research & Development, LLC

No longer available

A Study to Provide Access to Trabectedin in Participants With Locally Advanced or Metastatic Soft Tissue Sarcoma Who Have Persistent or Recurrent Disease and Who Are Not Expected to Benefit From Currently Available Standard of Care Treatment

Sarcoma

United States, Canada, Israel
NYU Langone Health

Completed

Phase II Study for Solid Metastatic Tumors

Breast Cancer | Solid Tumor | Metastatic Breast Cancer
University Hospital, Clermont-Ferrand
Fondation Apicil; Ligue contre le cancer - Auvergne

Completed

Prevention of Oxaliplatin-induced Neuropathic Pain by a Specific Diet (NEUROXAPOL)

Neuropathy | Digestive Cancer System

France
National Cancer Institute (NCI)

Withdrawn

A Phase I Study of IMC-A12 in Combination With Temsirolimus in Pediatric Patients With Recurrent or Refractory Solid Tumors

Glioma | Pinealoma | Brain Stem Neoplasms
Novartis Pharmaceuticals

Terminated

Efficacy and Safety of Letrozole vs. Letrozole Plus Zoledronic Acid as Endocrine Therapy Before Surgery in Postmenopausal Patients With Breast Cancer (FEMZONE)

Breast Neoplasms

Germany
Novartis Pharmaceuticals
University of Athens

Completed

Effect Of Zoledronic Acid On Circulating And Bone Marrow-Residing Prostate Cancer Cells In Patients With Clinically Localized Prostate Cancer

Prostate Cancer

Greece
Seoul National University Hospital

Unknown

Clinical Study of Anti-tumor Necrosis Factor Therapy in Patients With Takayasu Arteritis

Takayasu's Arteritis

Korea, Republic of
Eisai Inc.
Quintiles, Inc.

Terminated

E7050 in Combination With Cisplatin and Capecitabine Versus Cisplatin and Capecitabine Alone in Patients With Advanced or Metastatic Solid Tumors and Previously Untreated Gastric Cancer

Advanced or Metastatic Solid Tumors | Previously Untreated Gastric Cancer

United States, Russian Federation, United Kingdom, Ukraine
University of Nottingham
AstraZeneca; Cancer Research UK; National Cancer Research Network

Completed

AKT Inhibitor in Oestrogen Positive Breast Cancer (STAKT)

Invasive Breast Cancer

United Kingdom
MedImmune LLC

Completed

A Study to Evaluate the Safety and Antitumor Activity in Subjects With Advanced Solid Tumors

Advanced Solid Tumors | Advanced Recurrent Ovarian Tumors

United States
Galena Biopharma, Inc.

Completed

Efficacy and Safety Study of NeuVax™ (Nelipepimut-S or E75) Vaccine to Prevent Breast Cancer Recurrence (PRESENT)

Breast Cancer With Low to Intermediate HER2 Expression

United States, United Kingdom, France, Israel, Germany, Canada, Russian Federation, Romania, Bulgaria, Czech Republic, Hungary, Poland, Ukraine
China Medical University, China
General Hospital of Shenyang Military Region; Shengjing Hospital; Liaoning Tumor... and other collaborators

Unknown

Irinotecan Plus Raltitrexed as Second-line Treatment in Advanced Colorectal Cancer Patients

ColoRectal Cancer

China
Innovaderm Research Inc.

Terminated

Etanercept in Rheumatoid Arthritis and Vascular Inflammation

Rheumatoid Arthritis | Vascular Inflammation

Canada
Altor BioScience
James and Esther King Biomedical Research Program

Unknown

A Study of ALT-801 in Patients With Bacillus Calmette-Guerin (BCG) Failure Non-Muscle Invasive Bladder Cancer

Non-muscle Invasive Bladder Cancer

United States

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