Search clinical trials for: Drug absorption, distribution, metabolism, and excretion (ADME)

Total 473871 results

F2G Biotech GmbH
PRA Health Sciences

Completed

Absorption, Metabolism and Excretion of 14C-olorofim in Man (hAME)

Invasive Fungal Infections

Netherlands
Celgene

Completed

A Phase 1 Open-Label Study to Evaluate the Metabolism and Excretion of CC-223 and the Effect of Food on the Pharmacokinetics of CC-223 in Healthy Male Adult Subjects (AME/FE)

Safety and Pharmacokinetics in Healthy Volunteer Subjects

United States
King's College London

Completed

Absorption, Metabolism and Excretion of Artichoke Polyphenols in Healthy Individuals

Healthy Men and Women

United Kingdom
University of Minnesota

Completed

Exparel PK and Breast Milk Excretion

Milk Expression, Breast

United States
AstraZeneca
Contract Research Organization: USA; PAREXEL Early Phase Clinical Unit Baltimore and other collaborators

Completed

A Study to Assess the Effect of Intensive Uric Acid (UA) Lowering Therapy With RDEA3170, Febuxostat, Dapagliflozin on Urinary Excretion of UA

Asymptomatic Hyperuricemia

United States
Homerton University Hospital NHS Foundation Trust

Completed

Sebum Excretion in Neonates of Women With Polycystic Ovary Syndrome (PCOS)

Polycystic Ovary Syndrome

United Kingdom
Michel Burnier

Completed

Effect of the Diet on Urinary Excretion of Alpha-ketoglutarate

Acid Base Disorder

Switzerland
Millennium Pharmaceuticals, Inc.

Completed

A Study to Evaluate the Mass Balance, Pharmacokinetics (PK), Metabolism and Excretion of TAK-954 Containing Microtracer ([14C]-TAK-954) in Healthy Male Participants

Healthy Volunteers

Netherlands
Pfizer

Completed

Study to Characterize Absorption, Distribution, Metabolism and Excretion of 14C PF-06651600 and to Evaluate the Absolute Oral Bioavailability and Fraction Absorbed of PF-06651600. (B7981011)

Healthy Volunteers

Netherlands
Clinical Evaluation Research Unit at Kingston General...

Unknown

The Impact of a Low or High Phosphate Diet on Phosphate and Calcium Excretion in Healthy People

Cardiovascular Diseases | Aging | Nutrient; Excess

Canada
Augusta University

Unknown

Effects of an Immunosuppressant Mycophenolate Mofetil or MMF on the Urinary Sodium Excretion Response to Mental Stress (MMF)

Hypertension, Renal | Psychological Stress

United States
Augusta University
The University of Texas at Arlington

Completed

Effectiveness of Prazosin on the Urinary Sodium Excretion Response to Mental Stress

Hypertension | Stress, Psychological | Blood Pressure

United States
Cyclerion Therapeutics

Completed

A Trial to Study the Absorption, Metabolism, and Excretion of [14C]-Praliciguat in Healthy Male Volunteers

Healthy Volunteers

United States
Allena Pharmaceuticals

Completed

Evaluating ALLN-177 for Reducing Urinary Oxalate Excretion in Calcium Oxalate Kidney Stone Formers With Hyperoxaluria

Nephrolithiasis | Hyperoxaluria

United States
AstraZeneca
Quintiles, Inc.

Completed

Absorption, Metabolism, Excretion and Pharmacokinetics of a Single Dose [14C]AZD2014 Followed by a Multiple Dose Phase (14C)

Solid Malignancies

United Kingdom
Texas A&M University

Unknown

Cholesterol and Statin in Healthy Adults

Elevated HMB Excretion

United States
Brigham and Women's Hospital
Otsuka Pharmaceutical Co., Ltd.

Completed

The Role of Vasopressin Antagonism on Renal Sodium Handling

Healthy
Mirum Pharmaceuticals, Inc.

Completed

Study to Assess the Relative Potency of Multiple Oral Doses of LUM001 and SHP626 in Overweight and Obese Adults as Assessed by Fecal Bile Acid Excretion

Healthy Volunteers

United States
Esperion Therapeutics, Inc.

Completed

Single Radiolabeled Dose Study to Investigate the Absorption, Metabolism and Excretion of [14C]-ETC-1002

Hyperlipidemia

United Kingdom
Astellas Pharma Global Development, Inc.

Completed

A Study to Look at How a Single Oral Dose of 14C-OSI-906 is Absorbed, Broken Down and Eliminated in the Body

Advanced Solid Tumors | Pharmacokinetics of 14C-OSI-906

United States
SPD Development Company Limited

Completed

Biotin Sample Collection Study

Healthy Volunteers | Biotin Excretion

United Kingdom
NYU Langone Health

Withdrawn

Fractional Urate Excretion in Nonedematous Hyponatremia

SIADH | Cerebral Hyponatremia | Cerebral Salt-wasting Syndrome | Reset Hypothalamic Osmostat

United States
Brigham and Women's Hospital

Completed

Atomoxetine and Oxybutynin in Obstructive Sleep Apnea (ATOSA)

Obstructive Sleep Apnea (OSA)

United States
Betta Pharmaceuticals Co., Ltd.

Unknown

The Absorption, Metabolism and Excretion of [14C]Ensartinib in Human

ALK-POSITIVE NSCLC

China
Eli Lilly and Company

Completed

C14 Study in Oncology Patients With Advanced and/or Metastatic Solid Tumors

Advanced Cancer

Switzerland
Cascadian Therapeutics Inc.

Completed

A Study of the Absorption, Metabolism, and Excretion of Tucatinib in Healthy Participants

Healthy

United States
Exeltis France
Insud Pharma

Completed

Benznidazole Absorption, Metabolism and Excretion Study

Healthy Male Subjects

United Kingdom
Astellas Pharma Inc

Completed

A Study to Assess the Pharmacokinetics, Pharmacodynamics of ASP1941 in Diabetes Mellitus Patients With Renal Impairment

Type 2 Diabetes Mellitus

Japan
Hoffmann-La Roche

Completed

A Study Investigating the Excretion Balance, Pharmacokinetics and Metabolism of a Single Oral Dose of [14C]-Labeled Risdiplam (RO7034067) in Healthy Male Participants

Healthy

Netherlands
Rennes University Hospital

Completed

Urinary Protein/Creatinine Ratio in a Single Urine Sample Versus 24-hour Proteinuria in Patients With Multiple Myeloma (RCP-MM)

Multiple Myeloma

France
Ark Biosciences Inc.

Completed

A Study to Evaluate the Pharmacokinetics, Metabolism, and Excretion of AK0529

Healthy

United Kingdom
Amgen

Completed

Pharmacokinetics and Excretion of [¹⁴C]Etelcalcetide (AMG 416) in Patients With End Stage Renal Disease (ESRD) Receiving Dialysis

Secondary Hyperparathyroidism in Patients With ESRD on Hemodialysis

United States
Bayer

Completed

Rogaratinib (BAY1163877) Human Mass Balance Study

Pharmacokinetics | Clinical Trial, Phase I

Netherlands
Global Alliance for TB Drug Development

Completed

A Study of the Safety, Tolerability, and Absorption, Metabolism, and Excretion of PA-824 in Healthy Adult Male Subjects. (CL-004)

Tuberculosis

United States
Bangabandhu Sheikh Mujib Medical University, Dhaka...

Completed

Estimation of Paracetamol in Urine to Assess the Diurnal Variation

Diurnal Variation of Paracetamol Excretion

Bangladesh
USDA Grand Forks Human Nutrition Research Center

Completed

Measurements of Body Iron Excretion of Healthy Adults

Healthy

United States
Universidad de Guanajuato

Completed

Effects of a High-CML Diet on Absorption and Excretion Levels in Healthy Adults

Healthy

Mexico
Washington University School of Medicine
National Heart, Lung, and Blood Institute (NHLBI); Utah State University

Completed

Phytosterols, Ezetimibe, and Cholesterol Metabolism (Phyteaux-III)

Hypercholesterolemia | Coronary Heart Disease

United States
Assistance Publique - Hôpitaux de Paris
Service de Bactériologie-Virologie-Hygiène, CHU Limoge; GO-CIC network (Réseau... and other collaborators

Completed

Search for the Measles Vaccine Virus Excretion in Breast Milk of Breastfeeding Women After Postpartum Vaccination With MMR (BREMEAVAC)

Measles | Rubella | Mumps

France
University of Western Ontario, Canada

Terminated

Effect of Oral 5-HTP Intake on Urinary 5-HIAA Excretion

Neuroendocrine Tumors | Carcinoid Tumors

Canada
University Health Network, Toronto
Merck Sharp & Dohme LLC

Completed

The INDORSE Study: Inhibition of Dipeptidyl Peptidase IV: Outcomes on Renal Sodium Excretion (INDORSE)

Type 2 Diabetes

Canada
Trakya University

Completed

Serum Bilirubin Levels in Normal-tension Glaucoma

Normal Tension Glaucoma | Bilirubin; Defect, Excretion

Turkey
Seoul National University Hospital

Completed

Investigation of the Absorption, Metabolism, and Excretion and the Absolute Bioavailability of YH12852

Constipation

Korea, Republic of
Pfizer

Completed

Absorption, Metabolism, Excretion and Absolute Bioavailability

Healthy

Netherlands
Galera Therapeutics, Inc.
Celerion

Completed

A Study to Investigate the Absorption, Metabolism, Excretion, and Mass Balance of GC4419 in Healthy Adult Subjects

Healthy | Healthy Volunteers

United States
University of California, Davis
Mars, Inc.

Completed

Absorption, Metabolism and Excretion of Dietary Polyphenolic Bioactives in Humans

Healthy

United States
Janssen Research & Development, LLC

Completed

A Study to Assess the Absorption, Metabolism, and Routes of Excretion Following Oral Administration of (14C) Radiolabeled JNJ--42756493 to Healthy Male Participants

Healthy

United States
GlaxoSmithKline

Completed

Restless Legs Patient Study On Absorption, Distribution, Metabolism And Excretion Of Ropinirole And The Effect Of Food

Restless Legs Syndrome

Germany, South Africa
Hangzhou ACEA Pharmaceutical Research Co., Ltd.

Completed

Study to Investigate the Absorption, Metabolism and Excretion of [14C] AC0010 in Patients With Advanced NSCLC

Carcinoma, Non-Small-Cell Lung

China
GlaxoSmithKline

Completed

Radiolabel Study In Healthy Volunteers For Insomnia-Targeting Drug

Sleep Initiation and Maintenance Disorders

United Kingdom

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