Search clinical trials for: Liver Function

Total 39141 results

Agios Pharmaceuticals, Inc.

Completed

A Pharmacokinetic Study of Mitapivat in Participants With Moderate Hepatic Impairment Compared to Matched Healthy Control Participants With Normal Hepatic Function

Moderate Hepatic Impairment

United States
National Institute of Allergy and Infectious Diseases...
Regeneron Pharmaceuticals

Withdrawn

Safety and Immunotherapeutic Activity of Cemiplimab in Participants With HBV on Suppressive Antiviral Therapy

Hepatitis B Virus

United States, Thailand, Canada, Brazil
Bayer

Completed

A Study to Learn How the Study Treatment Asundexian Moves Into, Through and Out of the Body, How it Works, How Safe it is, and How it Affects the Body in Participants With Mild or Moderate Reduction of Liver Function Compared to Participants With Normal Liver Function

Atrial Fibrillation | Hepatic Impairment | Acute Myocardial Infarction | Prevention of Thromboembolic Events | Non-cardioembolic Ischemic Stroke

Germany
RenJi Hospital

Completed

Dexmedetomidine and Liver Transplantation

Dexmedetomidine, Liver Transplantation, Allograft Function, Survival

China
VectivBio AG

Completed

A Phase 1, Open-Label Evaluation of the Pharmacokinetics and Safety of a Single Dose of Apraglutide in Subjects With Normal and Impaired Hepatic Function

Hepatic Impairment

Germany, Slovakia
Daiichi Sankyo, Inc.

Completed

A Study of Quizartinib Pharmacokinetics in Participants With Moderate Hepatic Impairment

Hepatic Impairment | Moderate Impaired Hepatic Function

United States
Saglik Bilimleri Universitesi Gazi Yasargil Training...

Completed

Effect of Liver Injury on Mortality in Coronavirus Disease-2019 Patients Admitted to Intensive Care Unit

Covid19; Liver Injury; Mortality

Turkey
Novartis Pharmaceuticals

Completed

Pharmacokinetic (PK) and Safety Study of Iptacopan (LNP023) in Participants With Mild, Moderate, and Severe Hepatic Impairment Compared to Matched Control Healthy Participants With Normal Hepatic Function.

Hepatic Impairment

United States
Insmed Incorporated

Completed

A Study to Evaluate the Pharmacokinetics (PK) and Safety of a Single Dose of Brensocatib in Participants With Normal Hepatic Function and Participants With Hepatic Impairment

Hepatic Impairment

United States
University of Pittsburgh

Suspended

Genomic Resources for Enhancing Available Therapies (GREAT1.0) Study (GREAT1)

Multiple Sclerosis | Diabetes Mellitus | Chronic Kidney Diseases | Gastritis | Rheumatoid Arthritis | Chronic Pain | Irritable Bowel Syndrome | Hepatitis | Inflammatory Bowel Diseases | Dyslipidemias | Chronic Disease | Celiac Disease | Cholecystitis | Crohn Disease | Cystic Fibrosis | Chronic Pancreatitis | NASH - Nonalcoholic... and other conditions

United States
Memorial Sloan Kettering Cancer Center
National Cancer Institute (NCI); University of Medicine and Dentistry of New...

Active, not recruiting

Adjuvant Hepatic Arterial Infusion and Combination Chemotherapy in Treating Patients With Resectable Hepatic Metastases From Colorectal Cancer

Colorectal Cancer | Metastatic Cancer

United States
AstraZeneca
Parexel

Completed

Observational Study of Obstructive Lung Disease (NOVELTY) (NOVELTY)

Chronic Obstructive Pulmonary Disease | Asthma | COPD

United States, Canada, Germany, Italy, Spain, United Kingdom, Mexico, Australia, Argentina, France, China, Japan, Brazil, Korea, Republic of, Colombia, Denmark, Netherlands, Norway, Sweden
Rigshospitalet, Denmark

Active, not recruiting

Muscle Dysfunction in Gastrointestinal or Hepatobiliary Cancer

Cancer | Cancer of Liver | Cancer of Pancreas | Cancer of Stomach | Cancer of Esophagus | Cancer, Metastatic

Denmark
The University of Texas Medical Branch, Galveston

Withdrawn

Liver, Pancreas and Thyroid Function in Burn Patients

Burns | Thyroid Diseases | Pancreas Disease | Liver Fibroses

United States
Fondazione Policlinico Universitario Agostino Gemelli...

Completed

Prothrombin Time Predicts Steroid Response in Severe Alcoholic Hepatitis. (AH2023)

Alcoholic Hepatitis

Italy
Cerevel Therapeutics, LLC

Completed

To Evaluate the Pharmacokinetics (PK) and Safety of Tavapadon in Participants With Mild and Moderate Hepatic Impairment Compared to Participants With Normal Hepatic Function

Hepatic Impairment

United States
Indiana University

Terminated

Everolimus Plus Mycophenolic Acid for Kidney Preservation in Liver Transplant Recipients With Impaired Kidney Function

Kidney Failure

United States
Yan Bi

Enrolling by invitation

Cognitive Assessment and Brain Function Evaluation in Patients With Non-alcoholic Fatty Liver Disease

Cognitive Impairment | Non-Alcoholic Fatty Liver Disease

China
Incyte Corporation

Completed

Study to Evaluate the Pharmacokinetics, Safety, and Pharmacodynamics of INCB000928 in Participants With Impaired Renal Function and Hemodialysis

Hemodialysis | Renal Impairment

United States
The University of Hong Kong

Active, not recruiting

Stopping Antiviral Treatment in Chronic Hepatitis B

Chronic Hepatitis b

Hong Kong
Postgraduate Institute of Medical Education and...

Active, not recruiting

Point-of-Care Echocardiography to Assess Impact of Dynamic Cardiac Function, Renal and Cardiac Biomarkers in Cirrhosis With Hepatorenal Syndrome-Acute Kidney Injury

Acute-On-Chronic Liver Failure | AKI | Cirrhosis, Liver | Hepatorenal Syndrome | Refractory Ascites

India
Rambam Health Care Campus
Hadassah Medical Organization; Tel-Aviv Sourasky Medical Center; Soroka University...

Completed

α1-antitrypsin (AAT) Levels and Functions in Allogeneic Bone Marrow Transplantation and Throughout Progression Into GVHD (AATGVHD-MARK)

GVHD | Bone Marrow Transplant Failure | Alpha 1-Antitrypsin

Israel
Helsingborgs Hospital
Lund University; Region Skåne - Skånevård SUND; Copenhagen Trial Unit, Center... and other collaborators

Completed

Targeted Hypothermia Versus Targeted Normothermia After Out-of-hospital Cardiac Arrest (TTM-2)

Out-of-hospital Cardiac Arrest

Norway, Sweden, Denmark, France, New Zealand, United Kingdom, Belgium, United States, Australia, Austria, Czechia, Germany, Italy, Switzerland
Eli Lilly and Company

Completed

A Study of Tirzepatide in Participants With Impaired Liver Function

Hepatic Insufficiency

United States
Norwegian University of Science and Technology
St. Olavs Hospital; Liverpool John Moores University; Australian Catholic University

Completed

Adipose Tissue Function and Response to Exercise Training in Women With and Without Polycystic Ovary Syndrome (HIT-FAT)

Polycystic Ovary Syndrome

Australia, Norway
Orion Corporation, Orion Pharma

Terminated

Effects of Oral Levosimendan on Respiratory Function in Patients With Amyotrophic Lateral Sclerosis (ALS): Open-Label Extension (REFALS-ES)

Amyotrophic Lateral Sclerosis

Canada, United States, Australia, Germany, Belgium, Finland, Spain, Austria, Italy, France, Ireland, Netherlands, Sweden, United Kingdom
Maria dels Angels Cebria i Iranzo, PT, PhD
University of Valencia

Enrolling by invitation

Prehabilitation and Posttransplant Training Program in Liver Transplantation (PreLiveR-T)

Liver Transplant; Complications | Cirrhosis, Liver | Hepatic Carcinoma

Spain
Azienda Ospedaliera Universitaria Policlinico Paolo...

Completed

Elbasvir/Grazoprevir Fixed-Dose Combination for 8 Weeks in G1b Treatment-Naïve, HCV-Infected Patients (EGG-18)

Chronic HCV Hepatitis

Italy
Children's Hospital of Fudan University

Withdrawn

BSEP Function Rescue During Childhood Inhereditary Cholestatic Diseases

Cholestasis, Intrahepatic | Hereditary Diseases
Assiut University

Active, not recruiting

Hepatic Manifestations and Effect of Long COVID-19 on Patients With Chronic Liver Disease

COVID-19

Egypt
King Saud University

Completed

Effects of Aerobic Training Program On Liver Functions

Liver Functions

Saudi Arabia
Philip Morris Products S.A.

Completed

A Smoking Cessation Study to Understand the Biological and Functional Changes After One Year of Smoking Cessation (RIBESC)

Cigarette Smoking

United States, Poland, Germany, Japan, United Kingdom
Nottingham University Hospitals NHS Trust

Active, not recruiting

Gut Imaging for Function and Transit in Cystic Fibrosis 3 Junior (GIFT-CFJunior)

Cystic Fibrosis

United Kingdom
Astellas Pharma Global Development, Inc.

Completed

A Study to Evaluate ASP0367 in Participants With Mild/Moderate Hepatic Impairment Compared to Participants With Normal Hepatic Function

Healthy Volunteers | Hepatic Impairment

United States
Bayer

Completed

Study on the Safety of BAY1817080, How it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Drug in Participants With Impaired Liver Function or Normal Liver Function

Overactive Bladder | Diabetic Neuropathic Pain | Endometriosis Related Pain | Refractory or Unexplained Chronic Cough

United States
Replicor Inc.

Available

Replicor Compassionate Access Program (RCAP)

Decompensated Cirrhosis | Hepatocellular Carcinoma | Cirrhosis, Liver | Ascites Hepatic | Viral Hepatitis B | Viral Hepatitis D | Varices, Esophageal

Austria, France, Israel
Medical University of Graz

Completed

Neutrophil Function During Therapy With Protease Inhibitors in Chronic Hepatitis C

Chronic Hepatitis C

Austria
Meridian Bioscience, Inc.

Completed

Equivalence of New Breath AnalyzerCompared to Currently BreathID System in Assessment of Liver Function

Healthy Volunteers | Chronic Liver Disease (CLD)

Israel
Idorsia Pharmaceuticals Ltd.

Completed

The Effect of Reduced Liver Function on Selatogrel Pharmacokinetics

Healthy Subjects | Hepatic Impairment

Germany
HULYA KESKIN

Completed

Effect of Exercise on Liver Cirrhosis

Liver Function Tests

Turkey
Novartis Pharmaceuticals

Completed

Efficacy and Safety of LCZ696 Compared to Valsartan on Cognitive Function in Patients With Chronic Heart Failure and Preserved Ejection Fraction (PERSPECTIVE)

Chronic Heart Failure (CHF)

Spain, Croatia, Taiwan, Germany, Italy, United States, Australia, Netherlands, Switzerland, Belgium, United Kingdom, Bulgaria, Lithuania, Russian Federation, France, Argentina, Korea, Republic of, Poland, Canada, Turkey
University of Aarhus
Aarhus University Hospital

Completed

sCD163 and sMR in Wilsons Disease - Associations With Disease Severity and Fibrosis

Wilsons Disease

Denmark
University of Copenhagen
Radboud University Medical Center; University of Leeds; Johannes Gutenberg University... and other collaborators

Completed

Vascular Health With Immobilization and Exercise Training

Physical Activity | Immobilization, Tonic

Denmark
Sunshine Lake Pharma Co., Ltd.

Completed

To Evaluate the Pharmacokinetics and Safety of Yimitasvir Phosphate Capsules in Subjects With Moderate and Severe Liver Function Impairment and in Healthy Subjects

Hepatic Impairment

China
Texas A&M University

Completed

Cherries Role in Gut Microbiota-liver-brain Function

Obesity

United States
Northwestern University
Novartis Pharmaceuticals

Completed

Biomarkers Predicting Successful Tacrolimus Withdrawal and Everolimus (Zortress) Monotherapy Early After Liver Transplantation

Liver Transplantation

United States
Tel-Aviv Sourasky Medical Center
Technion, Israel Institute of Technology

Completed

Characterization of the Relationship Between the Human Mesolimbic Reward System and Immune Functioning

Immune Hepatitis

Israel
Tongji Hospital

Completed

Clinical Study on BIFICO Accelerating Postoperative Liver Function Recovery in Patients With Hepatocellular Carcinoma

Hepatocellular Carcinoma | Gut Microbiota | Bifidobacterium

China
Incyte Corporation

Completed

To Evaluate the Safety, and Pharmacokinetics of Parscaclisib in Participants With Normal Hepatic Function and Hepatic Impairment.

Advanced Malignancies

United States
National Institute of Neurological Disorders and...

Completed

Study of Hepatic Function in Patients With Spinal and Bulbar Muscular Atrophy

Motor Neuron Disease | Spinal and Bulbar Muscular Atrophy (SBMA)

United States

Search clinical trials for: Liver Function

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