Search clinical trials for: Moderate renal impairment

Total 26630 results

Kyowa Kirin China Pharmaceutical Co., Ltd.

Completed

Efficacy and Safety of Cinacalcet in Ca, P and iPTH Levels in Patients With Mild, Moderate and Severe SHPT (ACTIVE)

Hyperparathyroidism; Secondary, Renal

China
Merck Sharp & Dohme LLC

Completed

A Study of Belzutifan (MK-6482) in Participants With Renal Impairment (MK-6482-021)

End Stage Renal Disease | Renal Impairment

United States
Amgen

Completed

Pharmacokinetics of Sotorasib in Healthy Participants and Participants With Moderate or Severe Hepatic Impairment

Hepatic Impairment

United States
argenx

Active, not recruiting

A Study to Test How Kidney Problems Influence the Blood Concentrations of Efgartigimod

Renal Impairment

Germany
KBP Biosciences

Completed

Safety, Tolerability and Pharmacokinetics of KBP-5074 in Healthy Subjects and Subjects With Renal Impairment

Healthy | Renal Insufficiency

United States
Chiesi Farmaceutici S.p.A.

Completed

Clinical Study to Investigate the Pharmacokinetics, Safety and Tolerability Following Single Administration of CHF6001 in Subjects With Mild, Moderate and Severe Liver Impairment in Comparison With Matched Healthy Control Subjects

Chronic Obstructive Pulmonary Disease

Bulgaria
Spero Therapeutics
United States Department of Defense

Completed

Phase 1 Study of PK and Safety of SPR206 in Subjects With Various Degrees Of Renal Function

Renal Impairment

New Zealand
Bo Feldt-Rasmussen

Completed

Long-term Effects of the New Nordic Renal Diet in Patients With Moderate Chronic Kidney Disease (CKD)

Blood Pressure | Hyperphosphatemia | Chronic Kidney Disease(CKD)

Denmark
Renalytix AI, Inc.

Active, not recruiting

Prospective Decision Impact Trial of KidneyIntelX

Diabetic Kidney Disease | Chronic Kidney Disease, Stage 3 (Moderate) | Chronic Kidney Disease Stage 2 | Chronic Kidney Disease Stage 1

United States
Incyte Corporation

Completed

A Study to Evaluate the Pharmacokinetics and Safety of INCB054707 in Participants With Normal Hepatic Function and Participants With Hepatic Impairment

Kidney Diseases | Renal Insufficiency

United States, Germany
Vifor Fresenius Medical Care Renal Pharma
Tigermed Consulting Co., Ltd

Active, not recruiting

Phase 3 Study of Difelikefalin in Haemodialysis Chinese Adult Subjects With Moderate-to-Severe Pruritus

Uremic Pruritus

China
Galderma R&D

Completed

To Evaluate the Efficacy and Safety of Nemolizumab for 12 Weeks in Participants With Chronic Kidney Disease With Associated Moderate to Severe Pruritus (NemoCKDaP)

Chronic Kidney Disease Associated Moderate to Severe Pruritus

Spain, United States, Hungary, Poland
Cerevel Therapeutics, LLC

Completed

To Evaluate Pharmacokinetics (PK) and Safety of Tavapadon in Participants With Severe Renal Impairment Compared to Participants With Normal Renal Function

Renal Impairment

United States
Astellas Pharma Global Development, Inc.

Completed

A Study About How ASP5354 Affects the Body in Healthy Adults and in Adults Whose Kidneys do Not Work Well

Renal Impairment | Healthy Volunteers

United States, Japan
Hellenic Society of Hematology
Janssen Pharmaceuticals

Completed

Efficacy of Daratumumab in Patients With Relapsed/Refractory Myeloma With Renal Impairment (DARE)

Relapsed/Refractory Multiple Myeloma

Greece
Vertex Pharmaceuticals Incorporated

Completed

Evaluation of the Pharmacokinetics and Safety of VX-548 in Participants With Mild or Moderate Hepatic Impairment

Pain

United States
Astellas Pharma Global Development, Inc.

Completed

A Study to Investigate the Effect of Renal Impairment on the Safety and Tolerability of Fezolinetant Compared to Participants With Normal Renal Function

Renal Impairment | Healthy Volunteers

United States
Astellas Pharma Global Development, Inc.

Completed

A Study to Investigate the Effect of Mild and Moderate Hepatic Impairment on the Safety and Tolerability of Fezolinetant Compared to Participants With Normal Hepatic Function

Healthy Volunteers | Hepatic Impairment

United States
Ascelia Pharma AB

Completed

Safety and Diagnostic Efficacy of Mangoral in Participants With Focal Liver Lesions and Reduced Kidney Function (SPARKLE)

Severe Renal Impairment | Known or Suspected Focal Liver Lesions

United States, Italy, Germany, Poland, Russian Federation, Sweden, Turkey, Argentina, Colombia, Mexico
AstraZeneca

Completed

Study to Investigate Hepatic Impairment on PK, Safety, Tolerability of Camizestrant in Post-Menopausal Female Subjects

Hepatic Impairment

United States, Bulgaria, Slovakia
Pfizer

Completed

PF-04634817 Renal Impairment Study

Renal Insufficiency

United States
Vastra Gotaland Region

Completed

Accuracy and Treatment Experience of Two Glucose Monitoring Systems Tested in Patients With Type 1 Diabetes and Renal Impairment

Renal Impairment | Diabetes Mellitus Complication

Sweden
Novartis Pharmaceuticals
Pharmaceutical Research Associates

Withdrawn

Pharmacokinetics of TNO155 in Participants With Mild, Moderate, or Severe Hepatic Impairment Compared to Matched Healthy Participants

Hepatic Impairment
KBP Biosciences

Active, not recruiting

Efficacy and Safety of KBP-5074 in Uncontrolled Hypertension and Moderate or Severe CKD (Clarion-CKD)

Chronic Kidney Diseases

China, Spain, Australia, Hungary, Malaysia, United States, Germany, Bulgaria, Serbia, Hong Kong, Georgia, Bosnia and Herzegovina, Croatia, Czechia, South Africa, Canada, Israel, Korea, Republic of, Latvia, Lithuania, Poland, Taiwan
KBP Biosciences
Covance

Completed

Pharmacokinetics of KBP-5074 in Patients With Moderate Hepatic Impairment

Healthy | Moderate Hepatic Impairment

United States
Innovent Biologics (Suzhou) Co. Ltd.

Completed

Pharmacokinetics of IBI362 in Subjects With and Without Renal Impairment

Renal Impairment

China
Grigore T. Popa University of Medicine and Pharmacy

Completed

Frailty, Cognitive Function and Health-related Quality of Life in Older Adults With Advanced Chronic Kidney Disease.

Cognitive Impairment | Frailty | CKD Stage 4 | CKD Stage 5

Romania
State University of New York at Buffalo

Suspended

The Effect of Acute Exercise on Cardiac Autonomic, Cerebrovascular, and Cognitive Function in Spinal Cord Injury

Cognitive Impairment | Cardiovascular Abnormalities | Spinal Cord Injuries | Cerebrovascular Disease; Sequelae

United States
Incyte Corporation

Completed

Study to Evaluate the Pharmacokinetics, Safety, and Pharmacodynamics of INCB054707 in Participants With Normal and Impaired Renal Function and Participants on Hemodialysis

Kidney Diseases | Renal Insufficiency

United States, Germany
VA Office of Research and Development

Terminated

Foundations in Developing Precision Cognitive Restoration

Stroke | Traumatic Brain Injury | Moderate Cognitive Impairment

United States
University of Illinois at Chicago
Verdure Sciences

Active, not recruiting

Curcumin in Kidney Transplant Recipients

Disorder Related to Renal Transplantation

United States
UnicoCell Biomed CO. LTD
Protech Pharmaservices Corporation (PPC)

Completed

Adipose-derived Stem Cells (ADSCs) for Moderate to Severe Chronic Kidney Disease

Moderate to Severe Chronic Kidney Disease

Taiwan
Institut de Recherches Internationales Servier

Completed

A Study of Vorasidenib in Participants With Moderate or Mild Hepatic Impairment and Matched Participants With Normal Hepatic Function

Hepatic Impairment

United States
Merck Sharp & Dohme LLC

Completed

MK-0616 (Oral PCSK9 Inhibitor) Renal Impairment Study 2 (MK-0616-020)

Hypercholesterolaemia

United States
Sanofi

Completed

A Study in Adults to Investigate the Impact of Mild, Moderate, and Severe Hepatic Impairment on Pharmacokinetics of Venglustat Compared to Participants With Normal Hepatic Function

Hepatic Function Abnormal

United States, Germany
Guangdong Raynovent Biotech Co., Ltd

Completed

Pharmacokinetics of Leritrelvir(RAY1216) in Participants With Severe Kidney Disease

Kidney Impairment

China
Reata, a wholly owned subsidiary of Biogen

Completed

Single-Dose, Open-Label Pharmacokinetic Study of Bardoxolone Methyl in Subjects With Mild, Moderate, and Severe Hepatic Impairment and Normal Hepatic Function

Healthy | Hepatic Impairment

United States
Cara Therapeutics, Inc.

Completed

A Study to Evaluate the Safety and Efficacy of CR845 in Chronic Kidney Disease Patients With Moderate-to-Severe Pruritus

Chronic Kidney Diseases | Pruritus

United States
Pfizer

Completed

Renal Impairment Study of PF-06700841

Renal Impairment | Healthy Volunteer

United States
Jiangsu HengRui Medicine Co., Ltd.

Completed

Safety and Pharmacokinetics of Fluzoparib in Healthy Subjects and Those With Impaired Kidney Function

Renal Impairment

China
University of Southern California

Completed

Lifestyle Enriching Activities for Research in Neuroscience Intervention Trial: LEARNit Study

Aging | Cognitive Ability, General

United States
Ensoma

Completed

Study Assessing PK and Safety of MGTA-145 in Subjects With Normal Estimated GFR and Varying Degrees of Renal Impairment

Healthy | Renal Insufficiency

United States
Merck Sharp & Dohme LLC

Completed

Belzutifan (MK-6482) Hepatic Impairment Study (MK-6482-020)

Moderate Hepatic Impairment

United States
West China Hospital

Enrolling by invitation

Oxycodone and Sufentanil for Analgesia in Hip Surgery

Analgesia, Patient-Controlled

China
University of Michigan
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Active, not recruiting

Controlling Hypertension Through Education and Coaching in Kidney Disease (CHECK-D)

Chronic Kidney Diseases | Chronic Disease | Chronic Kidney Disease Stage 5 | Chronic Kidney Disease, Stage 4 (Severe) | Chronic Kidney Disease, Stage 3 (Moderate)

United States
Amgen

Completed

A Study to Evaluate the Pharmacokinetics, Safety, and Pharmacodynamics of Olpasiran in Participants With Normal Renal Function and Participants With Various Degrees of Renal Impairment

Renal Impairment

United States
Millennium Pharmaceuticals, Inc.

Completed

A Study of Mobocertinib Capsules in People With Severe Kidney Problems and People With Healthy Kidneys

Renal Impairment | Healthy Volunteers

United States
Sagimet Biosciences Inc.

Completed

A Phase I Pharmacokinetic Study of TVB-2640 (Denifanstat) in Subjects With Mild, Moderate, or Severe Hepatic Impairment Compared to Subjects With Normal Hepatic Function

Cirrhosis | Hepatic Impairment | Non-alcoholic Steatohepatitis

United States, Hungary
Hanmi Pharmaceutical Company Limited

Completed

Phase 1 PK Study to Assess Safety, PK, Tolerability of HM15912 in Subjects With Renal Impairment and Normal Renal Function

Renal Impairment

United States
University of Alabama at Birmingham

Active, not recruiting

Oxalobacter Formigenes Colonization and Urinary Oxalate Excretion

Calcium Oxalate Urolithiasis

United States

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