Search clinical trials for: Prophylactic

Total 985 results

Eli Lilly and Company

Active, not recruiting

A Study of Abemaciclib (LY2835219) Plus Tamoxifen or Abemaciclib Alone in Women With Metastatic Breast Cancer (Next MONARCH 1)

Metastatic Breast Cancer

Spain, Taiwan, United States, Italy, Czechia, Germany, Belgium, Turkey, Brazil, Russian Federation, Argentina, Austria, France, Mexico
Ain Shams University

Completed

Prophylactic Use of Hydroxycobolamin in Vasoplegic Syndrome in Adult Patients Undergoing Cardiopulmonary Bypass

Vasoplegic Syndrome

Egypt
Medical University of South Carolina
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Completed

Stent vs. Indomethacin for Preventing Post-ERCP Pancreatitis (SVI)

Post-ERCP Pancreatitis

United States, Canada
Ain Shams University

Completed

Role of Fenofibrate in Neonatal Jaundice

Neonatal Jaundice

Egypt
CSL Behring

Active, not recruiting

Long-term Safety and Efficacy of CSL312 (Garadacimab) in the Prophylactic Treatment of Hereditary Angioedema Attacks

Hereditary Angioedema

Australia, Canada, United States, New Zealand, Germany, Hong Kong, Netherlands, Taiwan, Czechia, Israel, Hungary, Japan, Russian Federation, Spain
National Institute of Allergy and Infectious Diseases...
Gritstone bio, Inc.

Completed

Chimpanzee Adenovirus and Self-Amplifying mRNA Prime-Boost Prophylactic Vaccines Against SARS-CoV-2 in Healthy Adults

COVID-19

United States
Noah Merin
Teva Branded Pharmaceutical Products R&D, Inc.; Miltenyi Biomedicine GmbH

Active, not recruiting

Haploidentical Stem Cell Transplant With Prophylactic Natural Killer DLI for Lymphoma, Multiple Myeloma, and CLL

Lymphoma | Multiple Myeloma | Hodgkin Lymphoma | Chronic Lymphocytic Leukemia | CLL

United States
Zhejiang University

Completed

Postoperative TACE(Transhepatic Arterial Chemotherapy And Embolization) for Patients With Hepatocellular Carcinoma

Hepatocellular Carcinoma | Transcatheter Arterial Chemoembolization

China
Bayer

Active, not recruiting

Study to Evaluate the Efficacy (Effect on Disease) and Safety of Finerenone on Morbidity (Events Indicating Disease Worsening) & Mortality (Death Rate) in Participants With Heart Failure and Left Ventricular Ejection Fraction (Proportion of Blood Expelled Per Heart Stroke) Greater or Equal to 40% (FINEARTS-HF)

Heart Failure

United States, Spain, Denmark, Korea, Republic of, Taiwan, Australia, Hong Kong, Russian Federation, Israel, Canada, Malaysia, United Kingdom, Latvia, Netherlands, Japan, Brazil, China, Lithuania, Poland, Turkey, Italy, Austria, Bul... and more
CHRISTUS Health

Completed

Efficacy of Prophylactic Treatment of Oral Prochlorperazine for Acute Mountain Sickness (PAMS)

Acute Mountain Sickness | AMS

United States
Ascension Health

Withdrawn

Prophylactic Lisinopril to Prevent Anthracycline Cardiomyopathy.

Heart Failure, Systolic | Cardiomyopathy Due to Drug

United States
SWOG Cancer Research Network
National Cancer Institute (NCI)

Terminated

Prophylactic Antiviral Therapy in Patients With Current or Past Hepatitis B Virus Infection Receiving Anti-Cancer Therapy for Solid Tumors

Malignant Solid Neoplasm | Hepatitis B Infection

United States, Guam
M.D. Anderson Cancer Center

Active, not recruiting

Prophylactic Cranial Irradiation (PCI) for Small Cell Carcinoma of the Urothelium

Bladder Cancer

United States
M.D. Anderson Cancer Center

Active, not recruiting

Prophylactic Salpingectomy With Delayed Oophorectomy

Ovarian Carcinoma

United States
Universidad Autonoma de San Luis Potosí

Completed

Comparative Study Between Valproate and Memantine in the Prophylactic Management of Episodic Migraine.

Migraine Headache

Mexico
The University of Texas Health Science Center,...

Terminated

Topical Antibiotic Irrigation (Gentamicin) in Prophylaxis of Midfacial Fracture Surgical Wounds

Surgical Site Infection

United States
University of Miami

Active, not recruiting

Nipple-Areola Complex (NAC) Irradiation After Nipple-Sparing Mastectomy and Reconstruction

Breast Cancer | Ductal Carcinoma

United States
Wuhan Union Hospital, China

Withdrawn

Prophylactic Effects of Esketamine in Surgical Patients

Surgical Injury

China
University of Pavia

Enrolling by invitation

Erythritol vs Ultrasonic Scaler Prophylaxis Systems on Dental Implants With Crowns Made by Different Materials

Peri-Implantitis | Peri-implant Mucositis | Dental Implant Failed

Italy
King Edward Medical University

Completed

Comparison of Prophylactic Acyclovir and Placebo in Prevention of Eczema Herpeticum in Pediatric Burns (childburn)

Herpes Virus Infection

Pakistan
Dompé Farmaceutici S.p.A

Completed

Clinical Trial of Efficacy and Safety of Levopront® 30 mg/5 ml in Patients With Dry Cough (LDP0114)

Cough

Russian Federation
M.D. Anderson Cancer Center

Active, not recruiting

Intraoperative Acupoint Stimulation to Prevent Post-Operative Nausea and Vomiting (PONV)

Breast Cancer | Post-Operative Nausea and Vomiting

United States
Istituti Clinici Scientifici Maugeri SpA

Active, not recruiting

Seizures and Traumatic Brain Injury Rehabilitation

Seizures | Traumatic Brain Injury

Italy
Institut National de la Santé Et de la Recherche...
UPCET; PARTNERS for International clinical Research; European Fundation for the... and other collaborators

Active, not recruiting

Prophylactic Treatment of the Ductus Arteriosus in Preterm Infants by Acetaminophen (TREOCAPA)

Acetaminophen | Patency of the Ductus Arteriosus | Extreme Prematurity

France, Norway, Belgium, Estonia, Ireland, Switzerland, Sweden, Denmark, Finland, Hungary, Italy, Portugal
Tunis University

Completed

Prophylactic Occlusion Balloons of Both Internal Iliac Arteries in Caesarean Hysterectomy for PASD

Hemorrhage | Cesarean Section Complications | Placenta Accreta Spectrum

Tunisia
Odense University Hospital

Enrolling by invitation

UROtainer for Bladder Catheter Maintenance, Infection Prevention and Quality of Life (UROBIQ)

Catheter Blockage

Denmark
Yonsei University

Active, not recruiting

Prophylactic Administration of Neulapeg (Pegteograstim) in Patients With Locally Advanced or Metastatic Pancreatic Cancer Receiving the Modified FOLFIRINOX

Metastatic Pancreatic Cancer | Locally Advanced Pancreatic Cancer

Korea, Republic of
Matthew Neal MD
National Heart, Lung, and Blood Institute (NHLBI)

Active, not recruiting

Accelerating COVID-19 Therapeutic Interventions and Vaccines 4 ACUTE (ACTIV-4A)

Covid19

United States, Spain, Brazil, Italy
Hoffmann-La Roche

Active, not recruiting

Efficacy, Safety, and Pharmacokinetic Study of Prophylactic Emicizumab Versus No Prophylaxis in Hemophilia A Participants (HAVEN 5)

Hemophilia A

China, Thailand, Hong Kong, Malaysia
BioMarin Pharmaceutical

Active, not recruiting

Study to Evaluate the Efficacy and Safety of Valoctocogene Roxaparvovec, With Prophylactic Steroids in Hemophilia A (GENEr8-3)

Hemophilia A

United States, Australia, Taiwan, Brazil
Merck Sharp & Dohme LLC

Active, not recruiting

Open-label, Follow-up of Doravirine/Islatravir (DOR/ISL 100 mg/0.75mg) for Participants With Human Immunodeficiency Virus-1 (HIV-1) Infection (MK-8591A-033)

HIV-1 Infection

United States, Australia, Canada, Chile, Colombia, France, Germany, Italy, Japan, New Zealand, Poland, Russian Federation, South Africa, Spain, Switzerland, United Kingdom
Merck Sharp & Dohme LLC

Active, not recruiting

Safety and Efficacy of a Switch to Doravirine/Islatravir in Participants With HIV-1 (MK-8591A-017)

HIV Infection

United States, Australia, Canada, Chile, Colombia, France, Italy, Japan, New Zealand, Poland, Russian Federation, South Africa, Spain, Switzerland, United Kingdom
Northwestern University

Terminated

PROphylactic Manual RotatIon in the Second stagE of Labor (PROMISE)

Pregnancy Related | Labor Complication

United States
Ascension Via Christi Hospitals Wichita, Inc.
Youssef Yammine, MD; Abdel-Ghanie H. Abu-Samra, MD; Erica N Krantz, PharmD, BCCCP and other collaborators

Active, not recruiting

Prophylactic Endobronchial Tranexamic Acid to Reduce Bleeding in Transbronchial Cryobiopsy (CRYOTXA)

Endobronchial Mass | Hemorrhage Lung

United States
CHA Vaccine Institute Co., Ltd.

Completed

A Study to Evaluate the Safety, Reactogenicity and Immunogenicity of Prophylactic Hepatitis B Vaccine (CVI-HBV-002)

Hepatitis B | Vaccine-Preventable Diseases

Korea, Republic of
Zagazig University

Completed

Prophylactic Ilioinguinal Neurectomy During Open Tension-Free Inguinal Hernia Repair

Hernioplasty | Ilioinguinal Nerve Section | Pain Prevention

Egypt
Mayo Clinic

Active, not recruiting

Prophylactic Infrapatellar Saphenous Neurectomy in Primary Total Knee Arthroplasty

Knee Pain Chronic

United States
Pfizer

Terminated

A Clinical Trial to Assess the Safety, Tolerability and Immunogenicity of MenABCWY in Healthy Infants

Meningococcal Vaccine

Spain, Germany, Greece
Vertex Pharmaceuticals Incorporated

Completed

Evaluation of the Effects of Omeprazole and Rifampin on the Pharmacokinetics of VX-548 in Healthy Participants

Pain

Australia
Medical University Innsbruck

Completed

Experimental and Clinical Investigation of the Implant Surface Roughness Reduction Effect on Early-stage Fibrosis

Wounds and Injuries | Foreign-Body Reaction | Tissue Expander Disorder | Capsular Contracture Associated With Implant

Austria
William Carson

Active, not recruiting

Prospective Pilot Study of Robot-assisted Nipple Sparing Mastectomy (RNSM)

Anatomic Stage I Breast Cancer AJCC v8 | Anatomic Stage IA Breast Cancer AJCC v8 | Anatomic Stage IB Breast Cancer AJCC v8 | Anatomic Stage II Breast Cancer AJCC v8 | Anatomic Stage IIA Breast Cancer AJCC v8 | Anatomic Stage IIB Breast Cancer AJCC v8 | Anatomic Stage IIIA Breast Cancer AJCC v8 | Prognostic... and other conditions

United States
Immuron Ltd.
United States Department of Defense; Naval Medical Research Center

Active, not recruiting

Clinical Study to Assess the Efficacy of IMM-124E (Travelan®) in a Controlled Human Infection Model

Diarrhea | Infectious Diarrhea | Travelers Diarrhea

United States
King Faisal Specialist Hospital & Research Center
Security Forces Hospital; Dr. Sulaiman Alhabib Medical City, Riyadh

Terminated

Efficacy of Prophylactic Glycerin Suppositories for Feeding Intolerance in Very Low Birth Weight Preterm Infants: a Randomized Trial

Infant, Very Low Birth Weight

Saudi Arabia
Helsinn Healthcare SA
Chiltern International Inc.

Completed

Dose Finding Study in Colorectal Cancer Patients Receiving 5-FU-based Chemotherapy to Assess the Efficacy of Elsiglutide in the Prevention of Chemotherapy Induced Diarrhea (CID)

Drug and/or Toxin-induced Diarrhea

Ukraine, Germany, Poland, Russian Federation, Belarus, Bulgaria, Hungary, Czechia
Konya Meram State Hospital

Completed

Prophylactic Iron and Nutrition in Preventing Infant Iron Deficiency

Infant Nutrition Disorders | Iron Deficiencies | Iron Deficiency Anemia in Childbirth

Turkey
Entos Pharmaceuticals Inc.
Canadian Institutes of Health Research (CIHR); Aegis Life, Inc.; Clinical Pharma... and other collaborators

Completed

A Clinical Trial of a Prophylactic Plasmid DNA Vaccine for COVID-19 [Covigenix VAX-001] in Adults

SARS-CoV-2

Burkina Faso, Canada, Senegal, South Africa
University of Southern California
National Cancer Institute (NCI); Musculoskeletal Transplant Foundation

Active, not recruiting

PUBMIC (Prophylactic Use of Biologic Mesh in Ileal Conduit)

Hernia | Bladder Carcinoma

United States
Minia University Hospital

Completed

Use of Recombinant Factor VII as a Prophylactic Therapy for Adolescent Females With Heavy Menstrual Bleeding

Assessing the Bleeding Profile and the Quality of Life of the Enrolled Patients Before and 1 Year After Drug Intervention

Egypt
Assistance Publique - Hôpitaux de Paris
LEO Pharma

Completed

Therapeutic Anticoagulation Strategy for Acute Chest Syndrome (TASC)

Anemia | Acute Chest Syndrome | Sickle Cell | Low-Molecular-Weight Heparin

France
Claude Bernard University
Cheikh Anta Diop University, Senegal; University of Ouagadougou, Burkina Faso

Completed

Oral Prophylactic Measures on the Occurrence of Pre-eclampsia (OP-PE) (OP-PE)

Pregnancy Complications

Senegal

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