Search clinical trials for: Therapeutic window, Healthy controls

Total 40233 results

Ji Xing Pharmaceuticals (Shanghai) Co., Ltd.
LENZ Therapeutics, Inc

Completed

Safety, Tolerability and Pharmacokinetics of LNZ101 and LNZ100 Ophthalmic Solutions in Healthy Adult Chinese With Presbyopia

Presbyopia

China
Chinook Therapeutics, Inc.

Active, not recruiting

Safety and Tolerability of BION-1301 in Healthy Volunteers and Adults With IgA Nephropathy (IgAN)

IgA Nephropathy

Korea, Republic of, United States, United Kingdom
Stanford University

Active, not recruiting

Reliability of [18F]-FTC-146 Brain Uptake in Healthy Controls (rSIG)

Healthy Controls

United States
Nykode Therapeutics ASA
Vaccibody AS

Completed

A Phase 1/2 Study to Determine Safety and Immunogenicity of Two COVID 19 Vaccines VB10.2129 (RBD Candidate) and VB10.2210 (T Cell Candidate) Previously Vaccinated in Healthy Adult Volunteers

Infections | COVID-19 | Infection Viral

Norway
The Hospital for Sick Children
MOUNT SINAI HOSPITAL; Crohn's and Colitis Foundation

Active, not recruiting

Assessing the Drug Exposure Risk of Infants Breastfed by Women With Inflammatory Bowel Disease

Crohn's Disease | Ulcerative Colitis | Healthy Controls

Canada
Pfizer
Valneva Austria GmbH

Active, not recruiting

Phase 2 Study Of VLA15, A Vaccine Candidate Against Lyme Borreliosis, In A Healthy Pediatric And Adult Study Population

Lyme Borreliosis

United States
Atlas Molecular Pharma

Completed

Study to Assess the Safety and Pharmacokinetics of ATL-001 (Ciclopirox Olamine) in Healthy Volunteers

Adverse Effect of Drugs and Medicaments in Therapeutic Use

United States
Forma Therapeutics, Inc.
Medpace, Inc.

Completed

A SAD/MAD to Assess the Safety, PK/PD of FT-4202 in Healthy Volunteers and Sickle Cell Disease Patients

Healthy Volunteers | Sickle Cell Disease

United States
Johns Hopkins University
Virginia Polytechnic Institute and State University; Johns Hopkins Discovery...

Completed

Use of Real-Time Functional Magnetic Resonance Imaging Neurofeedback to Improve Motor Function in Cerebellar Ataxia (fMRI)

Healthy

United States
University of Missouri-Columbia

Completed

Effects of Walking and Heating on Vascular Function in Diabetic Patients

Obesity | Type 2 Diabetes Mellitus

United States
Gilead Sciences

Active, not recruiting

Study of HBV Therapeutic Vaccines GS-2829 and GS-6779 in Healthy Participants and Participants With Chronic Hepatitis B

Chronic Hepatitis B

Taiwan, New Zealand
ModernaTX, Inc.

Active, not recruiting

A Study of mRNA-1608, a Herpes Simplex Virus -2 (HSV-2) Therapeutic Candidate Vaccine, in Healthy Adults 18 to 55 Years of Age With Recurrent HSV-2 Genital Herpes

Genital Herpes

United States
Cerevel Therapeutics, LLC

Completed

A Trial to Evaluate the Effects of Itraconazole and Carbamazepine on the Pharmacokinetics of Emraclidine and of Emraclidine on the Pharmacokinetics of Metformin in Healthy Adult Participants

Healthy Volunteers

United States
Cerevel Therapeutics, LLC

Completed

To Evaluate Pharmacokinetics (PK) and Safety of Tavapadon in Participants With Severe Renal Impairment Compared to Participants With Normal Renal Function

Renal Impairment

United States
Juno Therapeutics, Inc., a Bristol-Myers Squibb...
Celgene Corporation

Withdrawn

A Study to Compare the Efficacy and Safety of Lisocabtagene Maraleucel vs Investigator's Choice Options in Adult Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma, Whose Disease Has Failed Treatment With Both BTKi and BCL2i Therapies

Leukemia, Lymphocytic, Chronic, B-Cell

United States, Austria, Belgium, France, Germany, Italy, Netherlands, Norway, Spain, Sweden, United Kingdom
siRNAgen Therapeutics Inc.

Active, not recruiting

The First-in-human Study of SRN-001 in Healthy Participants

Idiopathic Pulmonary Fibrosis

Australia
Emory University
Centers for Disease Control and Prevention

Completed

Sentinel Cohort REACT

Multi-Drug Resistant Organism

United States
Electra Therapeutics Inc.

Completed

Evaluation of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ELA026 in Single and Multiple Doses in Healthy Volunteers

Healthy Volunteers

United States, Austria
Spero Therapeutics

Completed

A Study to Compare Two Bioanalytical Assays for Tebipenem

Healthy Volunteers

United States
Celldex Therapeutics

Active, not recruiting

A Study of CDX-0159 in Patients With Chronic Inducible Urticaria

Chronic Inducible Urticaria

United States, Latvia, Spain, Poland, Georgia, South Africa, Germany, Lithuania, Estonia, Hungary, Bulgaria
Celldex Therapeutics

Active, not recruiting

A Phase 2 Study of CDX-0159 in Patients With Chronic Spontaneous Urticaria

Chronic Spontaneous Urticaria

Spain, United States, Poland, Georgia, South Africa, Bulgaria, Hungary, Estonia, Germany
Weill Medical College of Cornell University
National Institute of Neurological Disorders and Stroke (NINDS)

Active, not recruiting

Quantitative Mapping of Substantia Nigra Iron in Parkinson's Disease (Stages I-IV, REM Sleep Behavior Disorder) and Controls

Healthy | Parkinson Disease | REM Sleep Behavior Disorder

United States
Pfizer

Terminated

A Clinical Trial to Assess the Safety, Tolerability and Immunogenicity of MenABCWY in Healthy Infants

Meningococcal Vaccine

Spain, Germany, Greece
AN2 Therapeutics, Inc

Completed

Phase 1 Study of Epetraborole Tablets

Healthy Volunteers

Australia
Emergent BioSolutions
National Institute of Allergy and Infectious Diseases (NIAID)

Terminated

Safety and Pharmacokinetics of UV-4B Solution Administered Orally as Multiple Ascending Doses to Healthy Subjects

Viral Infection

United States
Emergent BioSolutions
Quintiles, Inc.; Unither Virology

Completed

Study to Determine the Safety, Tolerability and Pharmacokinetics of UV-4B Solution Administered Orally in Healthy Subjects (UV)

Viral Infection

United States
Kazia Therapeutics Limited
Quotient Sciences

Completed

Mass Balance Recovery, Metabolite Profile, and Metabolite Identification of [14C]-Paxalisib in Healthy Male Subjects

Healthy

United Kingdom
Aligos Therapeutics

Terminated

A Study of ALG-125755 to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics After Single Doses in Healthy Volunteers, and Single and Multiple Doses in CHB Subjects

Chronic Hepatitis B

New Zealand, Bulgaria, Moldova, Republic of, Romania
Xiaomei Shao
First People's Hospital of Hangzhou; Zhejiang Provincial Tongde Hospital

Completed

The Biological Specificity of Acupoints Between Major Depressive Disorder Patients and Healthy Controls

Major Depressive Disorder

China
Mirati Therapeutics Inc.

Completed

A PK Study to Assess the Drug-drug Interaction of a Strong CYP2C8 Inhibitor on Adagrasib

Healthy Adults

United States
Mirati Therapeutics Inc.

Completed

A PK Study to Assess the Drug-drug Interaction of a BCRP Inhibitor on Adagrasib

Healthy Adults

United States
AusperBio Therapeutics Inc.

Active, not recruiting

A Study Evaluating AHB-137 in Healthy Participants and Participants With Chronic Hepatitis B

Chronic Hepatitis B

United States, Hong Kong, Taiwan, New Zealand
NorthSea Therapeutics B.V.

Completed

Open-label Study to Evaluate the Effects of NST-1024 on the PK of Multiple Drugs in Healthy Subjects

Healthy Volunteers

United Kingdom
Spero Therapeutics

Completed

A Study to Assess the Intrapulmonary Pharmacokinetics (PK) of SPR719 by Comparing the Plasma, Epithelial Lining Fluid, and Alveolar Macrophage Concentrations Following the Oral Administration of Multiple Doses of SPR720 in Healthy Volunteers.

Healthy Volunteer

United States
Children's Hospital of Philadelphia
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); University... and other collaborators

Completed

Muscle Accrual and Function in Cystic Fibrosis-Impact of Glucose Intolerance

Cystic Fibrosis

United States
Hebrew University of Jerusalem

Completed

Transcranial Direct Current Stimulation (tDCS) as a Cognitive Functioning Enhancement Treatment for ADHD Patients Compared to Healthy Controls

Transcranial Direct Current Stimulation

Israel
JDP Therapeutics, Inc.
Algorithme Pharma Inc

Completed

A Pilot Single Dose Crossover Pharmacokinetics Study Of JDP-205 Injection, 10 mg, In Healthy Male And Female Volunteers

Acute Urticaria

Canada
Istanbul University

Completed

IL-6, IL-17 and IL-35 Levels in the Gingival Crevicular Fluid of Patients With Periodontitis and Healthy Controls

Periodontitis

Turkey
Spero Therapeutics

Completed

A Study to Evaluate the Effect of Co-administration on the Pharmacokinetics of SPR720, Azithromycin, and Ethambutol in Healthy Participants

Healthy Volunteers

United States
Novo Nordisk A/S

Completed

A Research Study to See How Well the New Weekly Medicine IcoSema, Which is a Combination of Insulin Icodec and Semaglutide, Controls Blood Sugar Level in People With Type 2 Diabetes Compared to Weekly Semaglutide (COMBINE 2) (COMBINE 2)

Diabetes Mellitus, Type 2

United States, China, Taiwan, Canada, Switzerland, Japan, Brazil, Russian Federation, Hungary, Greece, France, Israel, Sweden, Slovakia
Contineum Therapeutics

Completed

Study Evaluating Safety and Tolerability of Escalating Single and Multiple Doses of PIPE-791 and Food Effect in Healthy Volunteers

Multiple Sclerosis

United States
Celsius Therapeutics, Inc.

Completed

First-in-human, Single Ascending Dose Study of CEL383 in Healthy Adult Subjects

Healthy

United States
Advice Pharma Group srl

Active, not recruiting

DEMETRA - ADVICE-002-2022

Obesity | Nutrition Disorders | Body Weight | Weight Loss | Dietary Habits | Overweight and Obesity | Health Behavior | Diet, Healthy | Diet Habit | Life Style | Nutrition, Healthy | Behavioral Disorder

Italy
Bukwang Pharmaceutical
Dyna Therapeutics

Completed

A Study to Evaluate Safety, Tolerability, and Pharmacokinetics of SOL-804 in Healthy Male Subjects

Prostate Cancer

Korea, Republic of
Everstar Medicines (Shanghai) Limited

Completed

A Study of Ralinepag in Healthy Chinese Adult Subjects

Healthy Volunteer | Pharmacokinetic Study

China
Melinta Therapeutics, Inc.

Completed

A Study to Assess the Cardiac Safety of Oritavancin in Healthy Participants

Healthy

United States
Athira Pharma

Active, not recruiting

ATH-1017 for Treatment of Mild to Moderate Alzheimer's Disease (LIFT-AD)

Alzheimer Disease | Dementia of Alzheimer Type

United States
University of Zurich

Completed

Visa-versa! Breaking Instead of Pushing the Pedals-D

Healthy (Controls)

Switzerland
University of Pennsylvania

Active, not recruiting

The Physiological Chronobiome Modified by Age, Sex and Under Evoked Conditions

Healthy | Healthy Aging

United States
Lykos Therapeutics

Completed

Psychological Effects of Methylenedioxymethamphetamine (MDMA) When Administered to Healthy Volunteers (MT-1)

Psychological Effects of Study Drug

United States

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