Search clinical trials for: Variant of unknown significance

Total 431333 results

Stanford University

Recruiting

CYP2C19 Variants and Limonene Metabolism

CYP2C19 Genetic Variants

United States
Mayo Clinic

Recruiting

HEADLIGHT: Hypofractionated Proton Therapy for Head and Neck Cancers

Head and Neck Carcinoma | Metastatic Malignant Neoplasm in the Lymph Nodes | Nasal Cavity Carcinoma | Oral Cavity Carcinoma | Paranasal Sinus Carcinoma | Salivary Gland Carcinoma | Cutaneous Squamous Cell Carcinoma of the Head and Neck | Hypopharyngeal Carcinoma | Laryngeal Carcinoma | Oropharyngeal Carcinoma and other conditions

United States
Mahidol University

Recruiting

LV Diastolic Function vs IVC Diameter Variation as Predictor of Fluid Responsiveness in Shock

Shock | Septic Shock

Thailand
The Belgian Society of Medical Oncology
Illumina, Inc.; OncoDNA; PierianDx

Recruiting

A Study to Examine the Clinical Value of Comprehensive Genomic Profiling Performed by Belgian NGS Laboratories: a Belgian Precision Study of the BSMO in Collaboration With the Cancer Centre (BALLETT)

Solid Tumor | Metastatic Cancer

Belgium
NRG Oncology
National Cancer Institute (NCI)

Recruiting

Comparing High-Dose Cisplatin Every Three Weeks to Low-Dose Cisplatin Weekly When Combined With Radiation for Patients With Advanced Head and Neck Cancer

Advanced Head and Neck Squamous Cell Carcinoma | Squamous Cell Carcinoma of Unknown Primary | Advanced Hypopharyngeal Squamous Cell Carcinoma | Advanced Laryngeal Squamous Cell Carcinoma | Advanced Oropharyngeal Squamous Cell Carcinoma

United States, Canada
Arcturus Therapeutics, Inc.

Recruiting

A Trial Evaluating the Safety and Immunogenicity of 3 COVID-19 SARS-CoV-2 RNA Vaccines in Healthy Adults

COVID-19 | Corona Virus Infection | SARS-CoV-2 Infection

United States, Singapore
Bayer

Recruiting

Prophylaxis Regimen for Hemophilia A Patients (PREDICT)

Hemophilia A | Prophylaxis of Bleeding

United States
Washington University School of Medicine
Gateway for Cancer Research; Servier Hellas Pharmaceuticals Ltd.

Recruiting

Ivosidenib for Patients With Clonal Cytopenia of Undetermined Significance and Mutations in IDH1

Clonal Cytopenia of Undetermined Significance

United States
M.D. Anderson Cancer Center

Recruiting

ALX148, Rituximab and Lenalidomide for the Treatment of Indolent and Aggressive B-cell Non-Hodgkin Lymphoma

Refractory Primary Mediastinal (Thymic) Large B-Cell Lymphoma | Richter Syndrome | Refractory Mantle Cell Lymphoma | Refractory Aggressive B-Cell Non-Hodgkin Lymphoma | Refractory High Grade B-Cell Lymphoma | Refractory Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma | Refractory... and other conditions

United States
Xencor, Inc.

Recruiting

XmAb®20717 (Vudalimab) Alone or in Combination With Chemotherapy or Targeted Therapy in Patients With Metastatic Castration-Resistant Prostate Cancer

Metastatic Castration-Resistant Prostate Cancer

United States
Ospedale San Donato

Recruiting

CILCA Arch Registry: Management and Outcomes of Open and Endovascular Repair

Aortic Diseases | Aortic Arch | Bovine Arch

Italy
Parkinson's Foundation
Indiana University; The Parkinson Study Group; Fulgent Genetics

Recruiting

Parkinson's Foundation PD GENEration Genetic Registry

Parkinson's Disease

United States, Israel, Canada
Travera Inc
John B. Amos Cancer Center

Not yet recruiting

Defining the Clinical Potential of Mass Response as a Biomarker for Patient Tumor Sensitivity to Drugs

Carcinoma, Renal Cell | Carcinoma | Carcinoma, Non-Small-Cell Lung | Carcinoma, Hepatocellular | Carcinoma, Pancreatic | Mesothelioma | AML | Cholangiocarcinoma | Stage IV Lung Cancer | Carcinoma, Neuroendocrine | Stage IV Breast Cancer | Carcinoma, Ductal | Malignant Ascites | Carcinoma Prostate | Stage III Breast Cancer and other conditions

United States
GI Innovation, Inc.
Merck Sharp & Dohme LLC

Recruiting

GI-101 as a Single Agent or in Combination With Pembrolizumab, Lenvatinib or Local Radiotherapy in Advanced Solid Tumors

Melanoma | Sarcoma | Renal Cell Carcinoma | Cervical Cancer | Urinary Bladder Cancer | Vulvar Cancer | Advanced Solid Tumor | Metastatic Solid Tumor | Non-small Cell Lung Cancer | Head and Neck Squamous Cell Carcinoma | Esophageal Squamous Cell Carcinoma | Merkel Cell Carcinoma | Vaginal Cancer | Microsatellite Stable...

Korea, Republic of, United States
Avacta Life Sciences Ltd

Recruiting

A Study Evaluating the Safety, Pharmacokinetics and Early Efficacy of AVA6000 in Solid Tumours

Soft Tissue Sarcoma | Breast Cancer | Head and Neck Cancer | Colorectal Cancer | Pancreatic Cancer | Ovarian Cancer | Prostate Cancer | Bladder Cancer | Non-small Cell Lung Cancer | Biliary Tract Cancer | Oesophageal Cancer | Cancer of Unknown Primary Site

United States, United Kingdom
Second Affiliated Hospital, School of Medicine,...

Recruiting

Multicenter Study on the Pathogenic Germline Gene Variants of Colorectal Polyposis in China

Colorectal Polyposis

China
Peking University Third Hospital

Recruiting

Meniscus Regeneration After Meniscectomy and Its Clinical Significance

Regeneration | Meniscus Rupture

China
University Hospital, Toulouse

Recruiting

Semantic Rehabilitation for Patients With Primary Progressive Semantic Aphasia (SCED-APPvs)

Primary Progressive Aphasia

France
Fudan University

Recruiting

Real World Study of Diagnosis and First-line Treatment Among Patients With Cancer of Unknown Primary in China

Cancer of Unknown Primary Site

China
Murdoch Childrens Research Institute

Recruiting

Early Versus Late Stopping of Antibiotics in Children With Cancer and High-risk Febrile Neutropenia (ELSA-FN)

Febrile Neutropenia

Australia
Nanfang Hospital of Southern Medical University
303rd Hospital of the People's Liberation Army; Liuzhou Municipal Maternity... and other collaborators

Recruiting

Genetic Variants Affecting the Clinical Severity of Beta Thalassemia

Beta Thalassemia

China
Massachusetts General Hospital
Agios Pharmaceuticals, Inc.

Recruiting

Acquired Pyruvate Kinase Deficiency In Clonal Myeloid Neoplasms

Acute Myeloid Leukemia | Myelodysplastic Syndromes | Myeloproliferative Neoplasm | Myelodysplastic/Myeloproliferative Neoplasm | Clonal Cytopenia of Undetermined Significance | Pyruvate Kinase Deficiency | Pyruvate Kinase Deficiency Anemia | Hereditary Hemolytic Anemia | Clonal Myeloid Neoplasm | Other... and other conditions

United States
Yanling Wei

Not yet recruiting

Clinical Study of Selective Fecal Microbiota Transplantation in the Treatment of Irritable Bowel Syndrome.

Irritable Bowel Syndrome Variant of Childhood
Indonesia University

Recruiting

Potential Use of Autologous and Allogeneic Mesenchymal Stem Cells in Patients With Multiple System Atrophy

Parkinsonism | Multiple System Atrophy | Multiple System Atrophy, Parkinson Variant

Indonesia
The University of Hong Kong

Recruiting

Clinical Significance of Subclinical Myocardial Involvement in Recovered COVID-19 Patients Using Cardiovascular Magnetic Resonance (R-COVID-CMR) (R-COVID-CMR)

Covid19 | Viral Respiratory Infection

Hong Kong
Institut National de la Santé Et de la Recherche...

Not yet recruiting

ECOCAPTURE for the Assessment of Apathy Under Real-life Conditions (@HOME)

Alzheimer Disease | Frontotemporal Dementia, Behavioral Variant
Marcelo Bonomi

Recruiting

Cemiplimab, Low-Dose Paclitaxel and Carboplatin for the Treatment of Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck

Recurrent Head and Neck Squamous Cell Carcinoma | Recurrent Hypopharyngeal Squamous Cell Carcinoma | Recurrent Laryngeal Squamous Cell Carcinoma | Recurrent Oral Cavity Squamous Cell Carcinoma | Recurrent Oropharyngeal Squamous Cell Carcinoma | Metastatic Head and Neck Squamous Cell Carcinoma | Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC... and other conditions

United States
ANRS, Emerging Infectious Diseases

Recruiting

Severity of the New UK SARS-Cov2 Variant in COVID-19 Infection (SEVASAR)

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

France, Martinique
Dana-Farber Cancer Institute
National Cancer Institute (NCI)

Recruiting

Investigation of Metformin for the Prevention of Progression of Precursor Multiple Myeloma

Monoclonal Gammopathy of Undetermined Significance | Smoldering Multiple Myeloma

United States
Fudan University

Recruiting

PD-1 Inhibitor and Nab-paclitaxel and Bevacizumab in CUP

Cancer of Unknown Primary

China
Columbia University
National Institute on Aging (NIA)

Recruiting

Discovery and Validation of Genetic Variants Affecting Microglial Activation in Alzheimer's Disease

Alzheimer Disease

United States
Kaohsiung Medical University Chung-Ho Memorial...

Recruiting

Bio-significance of LPC16:0 in Fibromyalgia

Pain | Oxidative Stress | Fibromyalgia, Primary | Metabolomics | Soreness, Muscle | Lipidomics

Taiwan
Hospital San Carlos, Madrid
Fundacion Investigacion Interhospitalaria Cardiovascular

Recruiting

Myocardial Ischemia Without Obstructive Coronary Stenoses

Myocardial Ischemia | Vasospastic Angina | Non-Obstructive Coronary Atherosclerosis | Microvascular Coronary Artery Disease | Myocardial Bridging

Spain
University of Michigan
National Institute on Aging (NIA)

Recruiting

Stimulation of Cingulo-opercular Alertness Network (SCAN)

Lewy Body Dementia With Behavioral Disturbance | Lewy Body Disease | Lewy Body Variant of Alzheimer Disease

United States
National Cancer Institute (NCI)

Recruiting

Phase I Study of Anti-CD22 Chimeric Receptor T Cells in Patients With Relapsed/Refractory Hairy Cell Leukemia and Variant

Hairy Cell Leukemia | Hairy Cell Leukemia Variant

United States
Assiut University

Not yet recruiting

The Significance of Release of T-follicular Helper and T-follicular Regulatory Cells in Autoimmune Haemolytic Anemia Before and After Tratment (fhfr)

Autoimmune Hemolytic Anemia
Universitair Ziekenhuis Brussel

Recruiting

Fever of Unknown Origin (FUO) in Elderly Patients (FUO)

Fever of Unknown Origin

Belgium
SOLTI Breast Cancer Research Group
Novartis

Recruiting

Efficacy of Tislelizumab and Spartalizumab Across Multiple Cancer-types in Patients With PD1-high mRNA Expressing Tumors (ACROPOLI)

Melanoma | Sarcoma | Small Cell Lung Cancer | Hepatocellular Carcinoma | Pancreatic Adenocarcinoma | Uterine Carcinosarcoma | Mesothelioma | Cholangiocarcinoma | Lung Adenocarcinoma | Triple Negative Breast Cancer | Epithelial Ovarian Cancer | HER2-positive Breast Cancer | Head and Neck Squamous Cell Carcinoma | Esophageal... and other conditions

Spain
Ohio State University Comprehensive Cancer Center

Recruiting

Combining Immunotherapy Salvage Surgery & IORT Tx Persistent/Recurrent Head & Neck Cancer

Recurrent Laryngeal Squamous Cell Carcinoma | Recurrent Oral Cavity Squamous Cell Carcinoma | Recurrent Pharyngeal Squamous Cell Carcinoma | Locally Recurrent Head and Neck Squamous Cell Carcinoma | Head and Neck Carcinoma of Unknown Primary | Resectable Head and Neck Squamous Cell Carcinoma

United States
M.D. Anderson Cancer Center

Recruiting

Pegloticase for the Reduction of Uric Acid in Patients With Tumor Lysis Syndrome

Hematopoietic and Lymphoid Cell Neoplasm | Malignant Solid Neoplasm | Tumor Lysis Syndrome

United States
Imperial College London
Imperial College Healthcare NHS Trust

Recruiting

Psychological Impact of Pregnancy of Unknown Location (SOUL)

Anxiety | Ectopic Pregnancy | Pregnancy of Unknown Location

United Kingdom
Kirsten Grønbæk
Zealand University Hospital; University of Copenhagen; Herlev Hospital; Steno Diabetes... and other collaborators

Recruiting

Repurposing Metformin as a Leukemia-preventive Drug in CCUS and LR-MDS

Preleukemia | Cytopenia | Myelodysplastic Neoplasm | Preleukemic Anemia

Denmark
Imperial College London
Imperial College Healthcare NHS Trust

Recruiting

Assessment of Biomarkers in Pregnancy on Unknown Location and Ectopic Pregnancy (ABPEP)

Ectopic Pregnancy | Early Pregnancy | Early Pregnancy Loss | Pregnancy of Unknown Location

United Kingdom
University of Rochester

Recruiting

Curcumin and Piperine in Patients on Surveillance for Monoclonal Gammopathy, Smoldering Myeloma or Prostate Cancer

Multiple Myeloma | Prostate Cancer | Monoclonal Gammopathy of Undetermined Significance | Smoldering Multiple Myeloma (SMM)

United States
HealthTree Foundation
GlaxoSmithKline

Recruiting

MGUS, SMM, and MM Patient Experience With Coronavirus 19 (COVID-19) Survey

Multiple Myeloma | Monoclonal Gammopathy of Undetermined Significance | Smoldering Multiple Myeloma | Coronavirus

United States
M.D. Anderson Cancer Center

Recruiting

Baloxavir and Oseltamivir for the Treatment of Severe Influenza Infection in Immunocompromised Patients

Hematopoietic and Lymphoid Cell Neoplasm | Influenza

United States
Andrew J. Armstrong, MD
Bristol-Myers Squibb

Recruiting

A Study of Chemoimmunotherapy for the Treatment of Men With Neuroendocrine or Aggressive Variant Metastatic Prostate Cancer (CHAMP)

Metastatic Prostate Cancer | Metastatic Prostate Neuroendocrine Carcinoma

United States
National Cancer Institute (NCI)

Recruiting

Precision-Based Genomics in Prostate Cancer

Prostate Cancer

United States, Spain
Lund University Hospital

Recruiting

Diffusion-weighted MRI to Predict Treatment Response in Stereotactic Radiotherapy of Central Nervous System (CNS) Metastases

Brain Metastases | Radiotherapy | Sensitivity | Radionecrosis

Sweden
NHS Greater Glasgow and Clyde
Abbott Medical Devices; University of Glasgow

Recruiting

iCorMicA - Stratified Medicine in Angina (iCorMicA)

Coronary Artery Disease | Angina, Stable | Microvascular Angina | Vasospastic Angina | Coronary; Ischemic | Non-Obstructive Coronary Atherosclerosis | Ischemia With No Obstructive Coronary Arteries (INOCA) | Coronary Microvascular Dysfunction (CMD) | Ischaemic Heart Disease | Angina Attacks

United Kingdom

Search clinical trials for: Variant of unknown significance

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