Search clinical trials for: drug therapy risk

Total 290928 results

M.D. Anderson Cancer Center

Recruiting

Androgen Ablation Therapy With or Without Niraparib After Radiation Therapy for the Treatment of High-Risk Localized or Locally Advanced Prostate Cancer

Prostate Carcinoma | Stage IIIA Prostate Cancer AJCC v8 | Stage IIIB Prostate Cancer AJCC v8 | Stage IIC Prostate Cancer AJCC v8 | Stage III Prostate Cancer AJCC v8 | Stage IIIC Prostate Cancer AJCC v8 | Stage IVA Prostate Cancer AJCC v8

United States
Cambridge Health Alliance
National Institute of Mental Health (NIMH)

Recruiting

Prevention and Early Identification for High Risk Youth in School-based Clinics

Resilience, Psychological | Screening | Health Equity | Community Mental Health Services | Adolescent Well Being

United States
National Cancer Institute (NCI)

Recruiting

Therapy Adapted for High Risk and Low Risk HIV-Associated Anal Cancer

HIV Infection | Anal Squamous Cell Carcinoma | Anal Canal Cloacogenic Carcinoma | Stage III Anal Cancer AJCC v8 | Stage III Rectal Cancer AJCC v8 | Stage II Rectal Cancer AJCC v8 | Anal Margin Squamous Cell Carcinoma | AIDS-Related Anal Carcinoma | Rectal Squamous Cell Carcinoma | Stage I Anal Cancer AJCC... and other conditions

United States
Jonathan Schoenfeld, MD, MPH
Naveris

Recruiting

Risk-adapted Therapy in HPV+ Oropharyngeal Cancer Using Circulating Tumor (ct)HPV DNA Profile - The ReACT Study

HPV Positive Oropharyngeal Squamous Cell Carcinoma | Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC... and other conditions

United States
National Taiwan University Hospital

Recruiting

Neoadjuvant Hormone and Radiation Therapy Followed by Radical Prostatectomy in Patients With High-Risk Prostate Cancer

Prostate Cancer

Taiwan
Cancer Institute and Hospital, Chinese Academy...

Recruiting

TQB2450 Combined With Anlotinib Hydrochloride in the Perioperative Treatment of Hepatocellular Carcinoma Hydrochloride Neoadjuvant Therapy for Resectable Hepatocellular Carcinoma With a High Risk of Recurrence or Metastasis

Patients With Resectable Hepatocellular Carcinoma Who Are at High Risk of Recurrence or Metastasi

China
Children's Cancer Group, China
Qilu Hospital of Shandong University; Shanghai Children's Medical Center; West... and other collaborators

Recruiting

CCCG-ALCL-2020 for Chinese Children and Adolescents With Newly Diagnosed High-risk ALCL

Pediatric Anaplastic Large Cell Lymphoma

China
Hoffmann-La Roche

Recruiting

A Study Evaluating the Efficacy and Safety of Adjuvant Atezolizumab or Placebo and Trastuzumab Emtansine for Participants With HER2-Positive Breast Cancer at High Risk of Recurrence Following Preoperative Therapy (Astefania)

Breast Cancer

Korea, Republic of, United States, Australia, China, Ukraine, Spain, United Kingdom, Turkey, Mexico, Brazil, Belgium, Denmark, Germany, Greece, Portugal, Russian Federation, Taiwan, France, Kenya, Thailand, Romania, Italy, Czechia, Hu... and more
VA Office of Research and Development

Recruiting

Telehealth Treatment of Veterans With Alcohol Misuse at Risk for Cardiovascular Disease (ACME-TM)

Hypertension | Alcohol Misuse | Elevated Cardiovascular Risk

United States
University of Texas Southwestern Medical Center
Merck Sharp & Dohme LLC

Recruiting

Doravirine Versus Integrase Inhibitors on Backbone of Emtricitabine and Tenofovir Alafenamide in HIV

Lipid Metabolism Disorders | Cardiovascular Risk Factor | HIV I Infection

United States
University of Pittsburgh

Recruiting

Early Intervention for Youth at High Risk for Bipolar Disorder (KEY)

Bipolar Disorder

United States
Fudan University

Recruiting

Adjuvant PD-1 Antibody in Combination With Capecitabine for Patients With ICC at High-Risk of Postoperative Recurrence

Cholangiocarcinoma, Intrahepatic

China
Walter Sisulu University
Medical University of Graz; Nelson Mandela Academic Hospital; Umtata General...

Not yet recruiting

Cardiometabolic Health of Children Exposed to Anti-retroviral Therapy (ART) in Utero (ARTMOMSBABES)

In Utero Drug Exposure

South Africa
VA Office of Research and Development

Recruiting

Reducing Suicide Risk in Older Veterans Using Problem Solving Therapy

Depressive Disorder | Anxiety Disorders | Suicidal Ideation | Post Traumatic Stress Disorder

United States
Istituto Ortopedico Rizzoli

Recruiting

Metformin as Maintenance Therapy in Patients With Bone Sarcoma and High Risk of Relapse (Metform-Bone)

Osteosarcoma | Ewing Sarcoma

Italy
The First Affiliated Hospital of Soochow University

Recruiting

Individualized Induction Therapy for Non-elderly Acute Myeloid Leukemia Patients With Adverse Risk Features

Acute Myeloid Leukemia, Adult

China
Emory University
National Cancer Institute (NCI)

Recruiting

Proton Radiation Therapy for the Treatment of Patients With High Risk Prostate Cancer

Stage IIIA Prostate Cancer AJCC v8 | Stage IIIB Prostate Cancer AJCC v8 | Stage III Prostate Cancer AJCC v8 | Stage IIIC Prostate Cancer AJCC v8

United States
University Hospital, Ghent
Kom Op Tegen Kanker

Recruiting

Evaluating the Impact of 18F-FDG-PET-CT on Risk Stratification and Treatment Adaptation for Patients With Muscle Invasive Bladder Cancer (EFFORT-MIBC)

Muscle-Invasive Bladder Carcinoma

Belgium
University Hospital, Geneva

Recruiting

Genetic Risks for Childhood Cancer Complications in Switzerland (GECCOS)

Childhood Cancer | Genetic Predisposition | Late Effect

Switzerland
Giselle Sholler

Recruiting

DFMO as Maintenance Therapy for Molecular High/Very High Risk and Relapsed Medulloblastoma

Medulloblastoma

United States
Sun Yat-sen University

Not yet recruiting

Sintilimab Plus Bevacizumab as Adjuvant Therapy in HCC Patients at High Risk of Recurrence After Curative Resection (DaDaLi)

HCC | Immunotherapy | Adjuvant Therapy

China
Hoffmann-La Roche

Recruiting

A Study of Atezolizumab Versus Placebo as Adjuvant Therapy in Patients With High-Risk Muscle-Invasive Bladder Cancer Who Are ctDNA Positive Following Cystectomy (IMvigor011)

Muscle-invasive Bladder Cancer

Belgium, Korea, Republic of, Japan, Brazil, China, United States, Singapore, France, United Kingdom, Canada, Greece, Italy, Spain, Turkey, Russian Federation, Ukraine, Israel, Czechia, Colombia, Hong Kong, Argentina, Germany, Ireland, Polan... and more
Memorial Sloan Kettering Cancer Center

Recruiting

Cord Blood Transplant in Children and Young Adults With Blood Cancers and Non-malignant Disorders

Hemoglobinopathies | AML | MDS | Bone Marrow Failure | ALL | Inherited Metabolic Disorders | HLH | MPD Withou Myelofibrosis | NHL or HL

United States
Centre Hospitalier Universitaire de Nīmes
Saint-Louis Hospital, Paris, France; Institut Paoli-Calmettes; Center Eugene... and other collaborators

Recruiting

Safety & Efficacy of Durvalumab+Neoadjuvant Chemotherapy for High-risk Urothelial Carcinoma of the Upper Urinary Tract (iNDUCT)

Cancer | Urothelial Carcinoma

France
Major Extremity Trauma Research Consortium
United States Department of Defense

Recruiting

Topical Antibiotic Therapy to Reduce Infection After Operative Treatment of Fractures at High Risk of Infection: TOBRA

Post Operative Surgical Site Infection

United States
Fundacio Clinic Barcelona
Roche Pharma AG; SOLTI Breast Cancer Research Group

Recruiting

Omission of Surgery in Clinically Low-risk HER2positive Breast Cancer With High HER2 Addiction and a Complete Response Following Standard Anti-HER2-based Neoadjuvant Therapy (ELPIS)

Stage I Breast Cancer | HER2-positive Breast Cancer

Spain
Geron Corporation

Recruiting

A Study Comparing Imetelstat Versus Best Available Therapy for the Treatment of Intermediate-2 or High-risk Myelofibrosis (MF) Who Have Not Responded to Janus Kinase (JAK)-Inhibitor Treatment

Myelofibrosis

United States, Australia, Italy, India, United Kingdom, Israel, Taiwan, Poland, Malaysia, Argentina, Spain, Turkey, Belgium, Germany, Austria, Brazil, Bulgaria, Colombia, Denmark, France, Georgia, Hungary, Korea, Republic of, Portugal, ... and more
University Hospital, Essen
Noscendo GmbH, Germany; Health Economics and Health Care Management, Bielefeld... and other collaborators

Recruiting

Optimization of Sepsis Therapy Based on Patient-specific Digital Precision Diagnostics (DigiSep)

Sepsis | Septic Shock

Germany
Daniel George, MD
Merck Sharp & Dohme LLC

Not yet recruiting

Trimodality Approach of Low Dose iOnizing Radiation With or Without Neoadjuvant Pembrolizumab and Prostatectomy for Men With Intermediate/High Risk Prostate Cancer (TALON) (TALON)

Prostate Cancer

United States
Criterium, Inc.

Recruiting

DNA-Guided Second Line Adjuvant Therapy For High Residual Risk, Stage II-III, Hormone Receptor Positive, HER2 Negative Breast Cancer (DARE)

Breast Cancer

United States
West German Study Group
Eli Lilly and Company; Genomic Health®, Inc.

Recruiting

Adjuvant Therapy With Abemaciclib + SOC ET vs. SOC ET in Clinical or Genomic High Risk, HR+/HER2- EBC (ADAPTlate)

Breast Cancer Female

Germany
M.D. Anderson Cancer Center
National Cancer Institute (NCI); Genentech, Inc.

Recruiting

Venetoclax and Azacitidine for the Treatment of Relapsed or Refractory High-Risk Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia

Recurrent Chronic Myelomonocytic Leukemia | Recurrent Myelodysplastic Syndrome | Refractory Chronic Myelomonocytic Leukemia | Refractory Myelodysplastic Syndrome | Therapy-Related Myelodysplastic Syndrome

United States
The University of Hong Kong

Recruiting

Stress Cardiac Magnetic Resonance of Asymptomatic Type 2 Diabetics With Cardiovascular High Risk to Measure Empagliflozin Impact on Myocardial Blood Flow (CATCH-EM) (CATCH-EM)

Type 2 Diabetes | Microvascular Coronary Artery Disease

Hong Kong
Leipzig Heart Institute GmbH

Not yet recruiting

Personalised Risk scOre For Implantation of Defibrillators in Patients With Reduced LVEF≤35% and a Low Risk for Sudden Cardiac Death (PROFID-Reduced)

Myocardial Infarction | Heart Failure | Sudden Cardiac Death
Leipzig Heart Institute GmbH

Not yet recruiting

Personalised Risk scOre For Implantation of Defibrillators in Patients With Preserved LVEF>35% and a High Risk for Sudden Cardiac Death

Myocardial Infarction | Sudden Cardiac Death
Eastern Hepatobiliary Surgery Hospital

Not yet recruiting

Neoadjuvant Therapy for Resectable Intrahepatic Cholangiocarcinoma With High Predict Risk of Lymph Node Metastasis

Intrahepatic Cholangiocarcinoma Recurrent
Scientific Institute San Raffaele

Recruiting

Role of Endomyocardial Biopsy and Aetiology-based Treatment in Patients With Inflammatory Heart Disease in Arrhythmic and Non-arrhythmic Clinical Presentations: an Integrated Approach for the Optimal Diagnostic and Therapeutic Management (MYOCAR)

Arrhythmia | Myocarditis | Cardiomyopathies | Ventricular Arrythmia | Immunosuppression | Genetic Predisposition | Inflammatory Cardiomyopathy | Catheter Ablation | Autoimmunity

Italy
NRG Oncology
National Cancer Institute (NCI)

Recruiting

Two Studies for Patients With High Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a High Gene Risk Score, The PREDICT-RT Trial

Prostate Adenocarcinoma | Metastatic Malignant Neoplasm in the Bone | Stage IIIA Prostate Cancer AJCC v8 | Stage IIIB Prostate Cancer AJCC v8 | Stage III Prostate Cancer AJCC v8 | Stage IIIC Prostate Cancer AJCC v8 | Stage IVA Prostate Cancer AJCC v8

United States, Canada
University Hospital, Toulouse

Recruiting

Efficacy of Pre-exposure Treatment With Hydroxy-Chloroquine on the Risk and Severity of COVID-19 Infection (PREPCOV)

COVID-19

France
Shengjing Hospital

Recruiting

Sj-subway, a Predictor for the Recurrence of High-risk Hormone Receptor-positive Breast That is Sensitive to Extended Endocrine Therapy

Breast Cancer

China
University of Virginia

Recruiting

EBRT and HDR Brachytherapy for Unfavorable-intermediate, High, and Very High-risk Prostate Cancer (Prostate005)

Prostate Cancer | Prostate Adenocarcinoma

United States
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI); Seagen Inc.

Recruiting

T-DM1 and Tucatinib Compared With T-DM1 Alone in Preventing Relapses in People With High Risk HER2-Positive Breast Cancer, the CompassHER2 RD Trial

Anatomic Stage IA Breast Cancer AJCC v8 | Anatomic Stage II Breast Cancer AJCC v8 | Anatomic Stage IIA Breast Cancer AJCC v8 | Anatomic Stage IIB Breast Cancer AJCC v8 | Anatomic Stage III Breast Cancer AJCC v8 | Anatomic Stage IIIA Breast Cancer AJCC v8 | Anatomic Stage IIIB Breast Cancer AJCC... and other conditions

United States, Canada, Puerto Rico
Sun Yat-sen University
Wuzhou Red Cross Hospital; Fifth Affiliated Hospital, Sun Yat-Sen University; Affiliated Cancer Hospital & Institute of Guangzhou Medical University and other collaborators

Recruiting

Concurrent and Adjuvant PD1 Treatment Combined With Chemo-radiotherapy for High-risk Nasopharyngeal Carcinoma

Nasopharyngeal Cancer | Chemotherapy | Radiotherapy | PD-1 Therapy

China
Emory University
National Cancer Institute (NCI)

Recruiting

Cemiplimab Before and After Surgery for the Treatment of High Risk Cutaneous Squamous Cell Cancer

Metastatic Skin Squamous Cell Carcinoma | Recurrent Skin Squamous Cell Carcinoma

United States
Zhejiang University

Recruiting

Study on the Safety and Efficacy of Donafinib Combined With Anti-PD-1 Antibody as Adjuvant Therapy for HCC Patients (CISLD-8)

Hepatocellular Carcinoma

China
Duk-Woo Park, MD

Recruiting

Potassium-Competitive Acid Blocker Versus pROton-Pump Inhibitor for GastroproTECTion Strategies In Patients at High Gastro-Intestinal Bleeding Risk Receiving Antithrombotic Therapy (PROTECT-HBR)

Myocardial Infarction | Coronary Artery Disease | Acute Coronary Syndrome | Percutaneous Coronary Intervention

Korea, Republic of
Peking University Cancer Hospital & Institute

Recruiting

Total Neoadjuvant Therapy Followed by 'Watch and Wait' Approach or Organ Preservation for Low-risk Rectal Cancer (BJCC-R01)

Rectum Cancer

China
European Organisation for Research and Treatment...

Recruiting

Personalized Risk-Adapted Therapy in Post-Pubertal Patients With Newly-Diagnosed Medulloblastoma (PersoMed-I)

Medulloblastoma

France, Netherlands, Spain, Australia, Germany, Switzerland, Austria, Italy
Weill Medical College of Cornell University
National Cancer Institute (NCI)

Recruiting

Study of PSMA PET/MR Guided Stereotactic Body Radiation Therapy With Simultaneous Integrated Boost (SBRT-SIB) for High-Intermediate and High Risk Prostate Cancer (PSMA SBRT-SIB)

Prostate Cancer

United States
University of California, Los Angeles
National Institute of Mental Health (NIMH)

Recruiting

Family-Focused Therapy for Individuals at High Clinical Risk for Psychosis: A Confirmatory Efficacy Trial

Psychotic Disorders | Psychosis | Prodromal Schizophrenia | Prodromal Symptoms | Family

United States, Canada

Search clinical trials for: drug therapy risk

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