Search clinical trials for: gene transfer

Total 270894 results

Wuerzburg University Hospital
European Union

Active, not recruiting

A Phase I/IIa Clinical Trial to Assess Feasibility, Safety and Antitumor Activity of Autologous SLAMF7 CAR-T Cells in Multiple Myeloma

Multiple Myeloma

France, Germany, Spain
Inception Fertility, LLC
Igenomix

Active, not recruiting

Outcome of Embryos Transferred After Initial Chaotic Results on PGT-A

Infertility

United States
St. Jude Children's Research Hospital
National Heart, Lung, and Blood Institute (NHLBI); Assisi Foundation; California...

Suspended

Gene Transfer for X-Linked Severe Combined Immunodeficiency in Newly Diagnosed Infants (LVXSCID-ND)

Severe Combined Immunodeficiency Disease, X-linked

United States
Instil Bio

Terminated

ITIL-168 in Advanced Melanoma (DELTA-1)

Advanced Cutaneous Melanoma

United States, Canada, United Kingdom
Syntr Health Technologies, Inc.

Active, not recruiting

Open Label, Multi-Center Study, Evaluating the Effect of Adipose Tissue Processed With the SyntrFuge™ System for Facial Fat Grafting

Facial Atrophy and Loss of Contour

United States
Spark Therapeutics, Inc.
Children's Hospital of Philadelphia; University of Iowa

Active, not recruiting

Safety and Efficacy Study in Subjects With Leber Congenital Amaurosis

Leber Congenital Amaurosis | Inherited Retinal Dystrophy Due to RPE65 Mutations

United States
Children's Hospital Medical Center, Cincinnati

Terminated

Gene Transfer for Patients With Sickle Cell Disease

Anemia, Sickle Cell

United States
Institut National de la Santé Et de la Recherche...
Institut Bergonié; Commissariat A L'energie Atomique; Plateforme labellisée Inca... and other collaborators

Active, not recruiting

Molecular Profiling of Advanced Soft-tissue Sarcomas (MULTISARC)

Soft Tissue Sarcoma

France
George Washington University
University of Oklahoma; Addis Ababa University; Pathfinder International; Overseas... and other collaborators

Active, not recruiting

GAGE Act With Her-Ethiopia Evaluation

Adolescent Behavior | Gender

Ethiopia
City of Hope Medical Center
National Cancer Institute (NCI)

Completed

SARS-CoV-2 Donor-Recipient Immunity Transfer

Hematopoietic and Lymphoid Cell Neoplasm | Acute Myeloid Leukemia | Hodgkin Lymphoma | Myelofibrosis | Acute Lymphoblastic Leukemia | Lymphoblastic Lymphoma | Chronic Lymphocytic Leukemia | Non-Hodgkin Lymphoma | Myelodysplastic Syndrome | Myeloproliferative Neoplasm | COVID-19 Infection | Accelerated Phase... and other conditions

United States
University of Cincinnati

Completed

Lingual Endurance Exercise in Treating Post-Stroke Dysphagia

Stroke, Ischemic | Dysphagia, Oral Phase

United States
Prothya Biosolutions

Active, not recruiting

Apotransferrin in Atransferrinemia

Congenital Atransferrinemia

Spain, Germany, Italy
RTI International
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Enrolling by invitation

Early Check: Expanded Screening in Newborns

Primary Hyperoxaluria Type 3 | Diabetes Mellitus | Hemophilia A | Hemophilia B | Hereditary Fructose Intolerance | Cystic Fibrosis | Factor VII Deficiency | Phenylketonurias | Sickle Cell Disease | Dravet Syndrome | Duchenne Muscular Dystrophy | Prader-Willi Syndrome | Fragile X Syndrome | Chronic Granulomatous Disease and other conditions

United States
Washington University School of Medicine
University of Colorado, Denver; University of California, Berkeley; University... and other collaborators

Active, not recruiting

ADAPT for Adolescents Adolescents (A4A)

HIV/AIDS

Kenya
Ultragenyx Pharmaceutical Inc

Active, not recruiting

A Study of Adeno-Associated Virus Serotype 8-Mediated Gene Transfer of Glucose-6-Phosphatase in Patients With Glycogen Storage Disease Type Ia (GSDIa)

Glycogen Storage Disease Type IA

United States, Brazil, Canada, Denmark, Germany, Italy, Netherlands, Spain
Hoffmann-La Roche
PPD; Laboratory Corporation of America; Illingworth Research Group

Active, not recruiting

A Study Evaluating B Cell Levels In Infants Of Lactating Women With CIS Or MS Receiving Ocrelizumab (SOPRANINO)

Multiple Sclerosis | Clinically Isolated Syndrome

United States, Spain, United Kingdom, Germany
Human Development Research Foundation, Pakistan
University of Liverpool; Shifa Tameer-e-Millat University

Active, not recruiting

Thinking Healthy Program-Technology Assisted (THP-TA) (THP-TA)

Depression, Postpartum | Perinatal Depression

Pakistan
Hoffmann-La Roche
PPD; Laboratory Corporation of America; Illingworth Research Group

Active, not recruiting

A Study Evaluating B Cell Levels In Infants Potentially Exposed To Ocrelizumab During Pregnancy (MINORE)

Multiple Sclerosis | Clinically Isolated Syndrome

United States, Spain, Switzerland, France, Germany
MeiraGTx, LLC

Active, not recruiting

A Double-blind Study to Evaluate the Safety of Glutamic Acid Decarboxylase Gene Transfer in Parkinson's Participants

Parkinson Disease

United States
University of New Mexico
Patient-Centered Outcomes Research Institute; Montana State University; National... and other collaborators

Terminated

Longitudinal Comparative Effectiveness of Bipolar Disorder Therapies

Bipolar Disorder

United States
Sarepta Therapeutics, Inc.
Hansa Biopharma AB

Active, not recruiting

A Gene Transfer Therapy Study to Evaluate the Safety and Efficacy of Delandistrogene Moxeparvovec (SRP-9001) Following Imlifidase Infusion in Participants With Duchenne Muscular Dystrophy (DMD) Determined to Have Pre-existing Antibodies to Recombinant Adeno-Associated Virus Serotype (rAAVrh74)

Duchenne Muscular Dystrophy

Spain
ShangHai Ji Ai Genetics & IVF Institute

Completed

Whether Vaginal Microbiota Affects Pregnancy Outcomes After Embryo Transfer

Microbial Colonization | Infertility, Female

China
Fundación Pública Andaluza para la gestión de la...
Hospital Universitario Virgen Macarena; Hospital Universitario La Fe; Complejo... and other collaborators

Active, not recruiting

Potential Use of a POCT for the Direct Transfer of Stroke Patients From the Ambulance to the Thrombectomy Center

Stroke, Acute Ischemic

Spain
Spark Therapeutics

Completed

Dose-finding Study of SPK-8016 Gene Therapy in Patients With Hemophilia A to Support Evaluation in Individuals With FVIII Inhibitors

Hematologic Diseases | Blood Coagulation Disorders, Inherited | Coagulation Protein Disorders | Hemorrhagic Disorders | Genetic Diseases, Inborn | Genetic Diseases, X-Linked | Gene Therapy | Blood Coagulation Disorder | Gene Transfer | Adeno-Associated Virus (AAV) | Factor VIII (FVIII) | Factor VIII (FVIII)... and other conditions

United States
University Hospital, Toulouse
Ministry of Health, France; Agence Régionale de la Santé - Midi Pyrénées

Completed

Factors Predisposing to Inappropriate Transfers of Nursing Home Residents to Emergency Departments (FINE)

Frail Elderly

France
Medical University of Silesia

Completed

Comparison the Effects of TECAR With Dry Needling in the Treatment of Myofascial Trigger Points

Myofascial Trigger Point Pain | Myofascial Pain Syndrome of Neck | Myofascial Trigger Point Syndrome

Poland
Dubai Fertility Center

Withdrawn

Letrozole Versus Hormonal Preparation in Frozen Cycles of PCOS Patients.

Miscarriage | Frozen Embryo Transfer | Hormone Replacement Therapy | Letrozole | Live Birth | Polycystic Ovarian Disease
University of California, Berkeley
National Institute of Mental Health (NIMH); Ministry of Health, Tanzania; Management... and other collaborators

Active, not recruiting

Rudi Kundini, Pamoja Kundini: Phase I (RKPK: Phase I)

HIV (Human Immunodeficiency Virus)

Tanzania
Pharming Technologies B.V.

Completed

Prevention of Severe SARS-CoV-2 Infection in Hospitalized Patients With COVID-19

Confirmed Coronavirus Disease

United States
Vanderbilt-Ingram Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Pevonedistat and Azacitidine in MDS or MDS/MPN Patients Who Fail Primary Therapy With DNA Methyl Transferase Inhibitors

Myelodysplastic Syndromes | Myeloproliferative Neoplasm

United States
Sarepta Therapeutics, Inc.

Active, not recruiting

Gene Delivery Clinical Trial of SRP-9003 (Bidridistrogene Xeboparvovec) for Participants With Limb-Girdle Muscular Dystrophy, Type 2E (LGMD2E) (Beta-Sarcoglycan Deficiency)

Limb-Girdle Muscular Dystrophy, Type 2E

United States
Loma Linda University

Completed

Effect of Integrated Cueing on Functional Transfers in Chronic Stroke Survivors (EOIC)

Hemiplegia and/or Hemiparesis Following Stroke

United States
Biogipuzkoa Health Research Institute

Completed

Cyclo-Ergometry in the Patient With Acute Respiratory Distress Syndrome (NPIDRA2021)

Coronavirus

Spain
Fondazione Telethon

Completed

ADA Gene Transfer Into Hematopoietic Stem/Progenitor Cells for the Treatment of ADA-SCID (Gene-ADA)

Immunologic Deficiency Syndromes

Italy, Israel
NewAmsterdam Pharma

Active, not recruiting

Evaluate the Effect of Obicetrapib in Patients With HeFH on Top of Maximum Tolerated Lipid-Modifying Therapies. (BROOKLYN)

Dyslipidemias | Hypercholesterolemia | Hyperlipoproteinemias | Lipid Metabolism, Inborn Errors | Familial Hypercholesterolemia | Metabolic Disease | High Cholesterol | Genetic Disease, Inborn | Lipid Metabolism Disorder

United States, Canada, Czechia, Georgia, Netherlands, Norway, Poland, South Africa, Spain, United Kingdom
CytomX Therapeutics

Completed

PROCLAIM-CX-2029: A Trial to Find Safe and Active Doses of an Investigational Drug CX-2029 for Patients With Solid Tumors or DLBCL

Head and Neck Cancer | Esophageal Cancer | Non Small Cell Lung Cancer | Diffuse Large B Cell Lymphoma | Solid Tumor, Adult

United States, Spain, Korea, Republic of, United Kingdom
Dana-Farber Cancer Institute
Massachusetts General Hospital; Brigham and Women's Hospital

Active, not recruiting

Vaccination With Autologous, Lethally Irradiated Melanoma Cells Engineered by Adenoviral Mediated Gene Transfer to Secrete Granulocyte-Macrophage Stimulating Factor (GMSF)

Melanoma

United States
Mikrobiomik Healthcare Company S.L.

Completed

Primary or Recurrent Clostridioides Difficile Infection Treatment With Capsules of Lyophilised Faecal Microbiota vs Fidaxomicin

Recurrent Clostridium Difficile Infection | Primary Clostridium Difficile Infection

Spain
Glostrup University Hospital, Copenhagen
Rigshospitalet, Denmark

Active, not recruiting

Parents in Transition - a Nurse-led Support and Transfer Education Program (ParTNer-STEPs)

Chronic Illness

Denmark
Erasme University Hospital

Completed

Tandem: Skin-to-skin Transfer From the Delivery Room to the Neonatal Unit (Tandem)

Preterm Birth | Neonatal Respiratory Distress | Mother-Infant Interaction

Belgium
Spark Therapeutics

Completed

A Gene Transfer Study for Hemophilia A

Hemophilia A

United States, Australia, Canada, Israel, Thailand
University of Pennsylvania
National Institute on Aging (NIA)

Completed

Pilot Guaranteed Income Study, Philadelphia, April 2023 (PGI)

Cardiovascular Diseases

United States
Bangabandhu Sheikh Mujib Medical University, Dhaka...
Institute of Technology Transfer and Innovation (ITTI)

Completed

Efficacy and Safety of Carica Papaya in Dengue Fever: A Randomised Clinical Trial

Dengue

Bangladesh
Astellas Gene Therapies

Active, not recruiting

Gene Transfer Clinical Study in X-Linked Myotubular Myopathy (ASPIRO)

X-Linked Myotubular Myopathy

United States, Canada, France, Germany
M.D. Anderson Cancer Center
National Cancer Institute (NCI); Alaunos Therapeutics; Intrexon Corporation

Completed

CD19-specific T Cell Infusion in Patients With B-Lineage Lymphoid Malignancies

Lymphoma | B-cell Lymphoma

United States
Nantes University Hospital

Terminated

Elbow Extension Restoration Surgery in People With Tetraplegia: Evolution of the Muscular Co-activations of the Upper Limb During the Post-operative Rehabilitation (MouvSupReaTetr)

Tetraplegia

France
NYU Langone Health
National Heart, Lung, and Blood Institute (NHLBI)

Active, not recruiting

Integration of Hypertension Management Into HIV Care in Nigeria (TASSH NIMR)

Hypertension | Human Immunodeficiency Virus

United States, Nigeria
London School of Economics and Political Science
Bill and Melinda Gates Foundation; Aga Khan University

Completed

Economic Evaluation of the MEWE Intervention (MEWE-EE)

Depression | Domestic Violence | Intimate Partner Violence | Battered Women | Mental Health Issue | Gender-based Violence | Rape Sexual Assault

Pakistan
Takara Bio Inc.

Completed

Study of TBI-1301 (NY-ESO-1 T Cell Receptor Gene Transduced Autologous T Lymphocytes) in Patients With Synovial Sarcoma

Synovial Sarcoma

Japan
Kuopio University Hospital
Medical University of Vienna; Rigshospitalet, Denmark; University College, London and other collaborators

Active, not recruiting

Adenovirus Vascular Endothelial Growth Factor D (AdvVEGF-D) Therapy for Treatment of Refractory Angina Pectoris (ReGenHeart)

Coronary Artery Disease | Refractory Angina Pectoris | Gene Transfer

Denmark, Finland

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