Search clinical trials for: loss of therapeutic response

Total 435746 results

Tim Corcoran
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Multilevel Models of Therapeutic Response in the Lungs

Cystic Fibrosis

United States
Cidara Therapeutics Inc.

Completed

Study of Rezafungin Compared to Caspofungin in Subjects With Candidemia and/or Invasive Candidiasis (ReSTORE)

Mycoses | Candidemia | Fungal Infection | Invasive Candidiases

United States, Israel, Spain, Korea, Republic of, Taiwan, Singapore, Thailand, Australia, China, Turkey, Belgium, Germany, France, Argentina, Bulgaria, Colombia, Greece, Italy
ProQR Therapeutics

Terminated

An Open-Label Extension Study to Evaluate Safety & Tolerability of QR-421a in Subjects With Retinitis Pigmentosa (HELIA)

Retinitis Pigmentosa | Usher Syndrome Type 2

United States, Canada, France
Nicholas M Mohr
Washington University School of Medicine; Hennepin County Medical Center, Minneapolis

Withdrawn

Working Toward the Advancement of Recovery Using Modulated Therapeutic Hyperthermia (WARMTH) in Sepsis - Pilot (WARMTH)

Sepsis

United States
Akdeniz University

Completed

The Effects of Qigong Exercise Training After Thoracotomy

Quality of Life | Postoperative Pain | Muscle Weakness | Pain, Shoulder | Respiratory Function Loss | Joint Adhesion

Turkey
Monument Therapeutics Limited
ICON plc

Completed

Safety & PK of Single Doses of MT1980

Neuroinflammatory Response

Netherlands
University of California, Irvine
Beckman Laser Institute University of California Irvine

Completed

The Use of Diffuse Optical Spectroscopy to Characterize in Response to Weight-Loss Intervention

Overweight

United States
AbbVie

Completed

Efficacy, Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy (ADT) in Patients With Major Depressive Disorder (MDD) Who Have Had an Inadequate Response to Antidepressants Alone

Major Depressive Disorder

United States, Bulgaria, Estonia, Germany, Hungary, Ukraine, United Kingdom
Shaare Zedek Medical Center

Completed

Predicting Response to Vedolizumab in Pediatric Inflammatory Bowel Diseases

Crohn's Disease | Ulcerative Colitis | Inflammatory Bowel Disease

United States, Israel, Denmark, Ireland, Slovenia, United Kingdom
Atara Biotherapeutics
Memorial Sloan Kettering Cancer Center

Completed

Therapeutic Effects of Epstein-Barr Virus Immune T-Lymphocytes Derived From a Normal HLA-Compatible Or Partially-Matched Third-Party Donor in the Treatment of EBV Lymphoproliferative Disorders and EBV-Associated Malignancies

EBV-induced Lymphomas | EBV-associated Malignancies | Transplant Patients With EBV Viremia at High Risk for Developing a Recurrent EBV Lymphoma

United States
AbbVie

Completed

The Objective of This Study is to Evaluate the Efficacy, Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy (ADT) in Patients With Major Depressive Disorder (MDD) Who Have Had an Inadequate Response to Antidepressants Alone

Major Depressive Disorder

United States, Canada, Czechia, Finland, Poland, Puerto Rico, Serbia, Slovakia
ProQR Therapeutics

Active, not recruiting

Study to Evaluate the Efficacy Safety and Tolerability of Ultevursen in Subjects With RP Due to Mutations in Exon 13 of the USH2A Gene (Sirius)

Eye Diseases | Retinitis Pigmentosa | Eye Diseases, Hereditary | Vision Disorders | Retinal Disease | Eye Disorders Congenital | Usher Syndrome Type 2 | Deaf Blind

United States, Netherlands, United Kingdom, Germany
University of Pennsylvania
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Completed

Use of Medication to Improve Weight Loss in Suboptimal Early Responders to Behavioral Treatment

Obesity

United States
University of Waterloo

Terminated

Bone Response to Exercise in Women on Antiresorptive Medications (BRRIE)

Osteoporosis | Bone Loss

Canada
Hvidovre University Hospital

Completed

Autonomic Cardiovascular Control in Response to Blood Volume Reduction in Blood Donors

Blood Loss | Autonomic Dysfunction | Autonomic Imbalance

Denmark
Audion Therapeutics BV

Withdrawn

A Trial of LY3056480 in Patients With SNLH (VESTA)

Sensorineural Hearing Loss

United States
Babes-Bolyai University

Completed

Changing Eating Behavior Using Cognitive Training

Obesity | Overweight | Weight Loss

Romania
CymaBay Therapeutics, Inc.

Completed

ENHANCE: Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) and an Inadequate Response to or an Intolerance to Ursodeoxycholic Acid (UDCA)

Primary Biliary Cholangitis

United States, Spain, United Kingdom, Israel, France, Korea, Republic of, Australia, Italy, Hungary, Germany, Romania, Belgium, Canada, Greece, New Zealand, Austria, Serbia, Russian Federation, Argentina, Mexico, Netherlands, Chile, Polan...
Assistance Publique Hopitaux De Marseille

Completed

Exploratory Study of Predictive Markers of the Therapeutic Response in Patients With Chronic Inflammatory Demyelinating Polyradiculoneuropathy Treated With Intravenous Immunoglobulin (EXPRET)

Chronic Inflammatory Demyelinating Polyradiculoneuropathy

France
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Terminated

An Investigational Scan (18F-Fluciclovine PET-CT) for the Measurement of Therapeutic Response in Patients With Metastatic Prostate Cancer

Metastatic Prostate Carcinoma | Stage IVB Prostate Cancer AJCC v8

United States
VA Office of Research and Development

Completed

Upper Limb Loss Perturbation Response

Amputation

United States
Assistance Publique - Hôpitaux de Paris

Terminated

PET/CT Imaging of Angiogenesis in Lung or Head and Neck Cancers Prior or During Chemotherapy With Antiangiogenic Agents (MLAPOCHI)

Advanced Head and Neck Carcinoma | Advanced Non-small Cell Lung Carcinoma

France
Axsome Therapeutics, Inc.

Completed

Mechanistic Evaluation of Response in TRD (MERIT) (MERIT)

Major Depressive Disorder | Treatment Resistant Depression

United States
University of Campinas, Brazil

Completed

Potential Therapeutic Response In Urogenital Tumors (Avatar)

Urogenital Neoplasms | Drug Therapy

Brazil
Pipeline Therapeutics, Inc.

Completed

Phase I/IIa Study Evaluating Safety and Efficacy of an Intratympanic Dose of PIPE-505 in Subjects With Hearing Loss

Sensorineural Hearing Loss

United States
University Hospital, Clermont-Ferrand

Completed

Role of Mechanical Load on Metabolic Exercise Adaptations in Response to Weight Loss in Obese Adolescents: The POWELL Study (POWELL)

Pediatric Obesity

France
Ogevity Therapeutics, Inc.
National University, Singapore

Completed

Immune Responses With Reduxium

Viral Infection | Immune Tolerance

Singapore
United States Army Research Institute of Environmental...
University of Arkansas; Norwegian Defense Research Establishment

Completed

Physiological Response to Protein and Energy-enhanced Food Products During Winter Military Training

Weight Loss | Military Operational Stress Reaction | Malnutrition (Calorie) | Muscle Wasting

Norway
Frequency Therapeutics

Completed

FX-322 in Adults With Age-Related Sensorineural Hearing Loss

Hearing Loss, Sensorineural | Presbycusis | Noise Induced Hearing Loss | Sudden Hearing Loss

United States
ProQR Therapeutics

Completed

Study to Evaluate Safety and Tolerability of QR-421a in Subjects With RP Due to Mutations in Exon 13 of the USH2A Gene (Stellar)

Eye Diseases | Retinitis Pigmentosa | Eye Diseases, Hereditary | Vision Disorders | Retinal Disease | Eye Disorders Congenital | Usher Syndrome Type 2 | Deaf Blind

United States, Canada, France
University of Pennsylvania

Completed

Towards Predicting the Analgesic Response to Ibuprofen Following Third-molar Extraction

Pain, Acute | Impacted Third Molar Tooth

United States
Alexandria University

Completed

Therapeutic Plasma Exchange in Resistant Cytokine Storm of COVID 19

COVID 19

Egypt
Hospital Sao Domingos

Terminated

Optimized Caloric-proteic Nutrition in Septic and Septic Shock Patients

Sepsis | Septic Shock
Universiti Sultan Zainal Abidin
Universiti Sains Malaysia; National University of Malaysia

Completed

Acute Effect of MMT Peel Powder on Glycemic Response, Satiety, and Food Intake in Adults at Risk for Type 2 Diabetes

At Risk of Type 2 Diabetes Mellitus

Malaysia
Centre Hospitalier Universitaire de Saint Etienne
Merck Sharp & Dohme LLC

Completed

Golimumab in Ulcerative Colitis (UC) Patients With Loss of Response (LOR) Followed by Dose Optimization (GOLILOR)

Ulcerative Colitis

France
Allarity Therapeutics

Completed

Phase I/II Study to Evaluate the Safety and Tolerability of LiPlaCis in Patients With Advanced or Refractory Tumours (LiPlaCis)

Phase 1: Advanced or Refractory Solid Tumours | Phase 2 Part: Metastatic Breast Cancer, Prostate Cancer and Skin Cancer

Denmark
Immunoflex Therapeutics Inc.
University of British Columbia; Dicentra Inc.

Completed

Immune Diversity Response to Oral Dosing of Nutritional Health Products in Healthy Participants

Immunity Disorders

Canada
T-Balance Therapeutics GmbH

Completed

Effects of Tregalizumab on Allergen-induced Airway Responses and Airway Inflammation in Asthmatic Patients (Tregulaire)

Allergic Asthma | Allergy to House Dust Mite

Germany
Corcept Therapeutics

Completed

A 4-week Study of Mifepristone in the Prevention of Risperidone-induced Weight Gain in Healthy Male Volunteers

Healthy

India
Sage Therapeutics

Completed

A Study to Assess the Electrophysiology, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Response Using Magnetic Resonance Imaging of SAGE-718 Using a Ketamine Challenge in Healthy Subjects

Healthy Volunteer

United States
Elira Therapeutics, Inc.

Completed

ELIRA 2: Safety and Effectiveness of TENS Assisted Weight Loss and Appetite Suppression (ELIRA_2)

Weight Loss

United States
Frequency Therapeutics

Completed

FX-322 in Adults With Severe Sensorineural Hearing Loss

Hearing Loss, Sensorineural | Noise Induced Hearing Loss | Sudden Hearing Loss

United States
Hopital Foch

Terminated

Volatile Organic Compounds in Exhaled Air and Sweat of Patients Treated by Immunotherapy for Lung Cancer: Research on Biomarkers for Early Therapeutic Response (Immuno-VOC)

Lung Cancer, Non-small Cell

France
Canadian Medical and Surgical Knowledge Translation...
HLS Therapeutics, Inc; Amarin Corporation

Completed

An Investigation on the Effects of Icosapent Ethyl (VascepaTM) on Inflammatory Biomarkers in Individuals With COVID-19

COVID-19 | Inflammatory Response

Canada
Ryerson University
Mitacs; Sonova AG

Terminated

Effects of Short-term Choir Participation on Auditory Perception in Hearing-aided Older Adults.

Aging | Hearing Loss | Music Therapy | Auditory Perception

Canada
University of Utah

Completed

Early Prediction of Therapeutic Response to Targeted Therapy in Stage IIIB/IV or Recurrent Lung Cancer Patients

Cancer | Non Small Cell Lung Cancer

United States
Elira Therapeutics, Inc.

Terminated

Safety and Effectiveness of Transcutaneous Electrical Nerve Stimulation (TENS)-Assisted Weight Loss

Obesity | Overweight

United States
National Institute of Allergy and Infectious Diseases...

Completed

Effectiveness of and Immune Response to HIV Vaccination Followed by Treatment Interruption in HIV Infected Patients

HIV Infections

United States, Puerto Rico
National Institute of Allergy and Infectious Diseases...

Completed

Safety and Immune Response of BMS-936559 in HIV-Infected People Taking Combination Antiretroviral Therapy

HIV Infections

United States
National Institute of Allergy and Infectious Diseases...

Completed

Virologic Responses To New Nucleoside Regimens After Prolonged ZDV or ddI Monotherapy

HIV Infections

United States, Puerto Rico, Tanzania

Search clinical trials for: loss of therapeutic response

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