Role of Mechanical Load on Metabolic Exercise Adaptations in Response to Weight Loss in Obese Adolescents: The POWELL Study (POWELL)
July 31, 2026 updated by: University Hospital, Clermont-Ferrand
While interdisciplinary weight loss intervention have been shown successful among adolescents with obesity, a weight regain is most of the time observed within the following weeks or months.
The aim of the present project will be to better identify the independent role played by both the metabolic and mechanical load and their modification during weight loss, on the energy expenditure and energy metabolism of adolescents with obesity.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
A total of 28 adolescents with obesity will be recruited from our local inpatient pediatric obesity centers.
Before their weight loss intervention the adolescents will complete two experimental visits.
During the first visit, anthropometric and body composition measurements will be performed.
Then the participants will be asked to complete a walking exercise on a treadmill during the second visit.
Their energy expenditure and substrate oxidation will be assessed by indirect calorimetry.
They will have to walk at 5 different walking speeds.
Then, they will follow a 12-week weight loss intervention.
By the end of this intervention, their body composition will be assessed and they will be asked to perform the same walking exercise.
On a separate occasion (randomly assigned) they will have to repeat this walking exercise while carrying a load corresponding of their weight loss.
Study Type
Interventional
Enrollment (Actual)
21
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
-
Clermont-Ferrand, France
- CHU clermont-ferrand
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
12 years to 16 years (Child)
Accepts Healthy Volunteers
No
Description
Inclusion Criteria:
- being aged 12-16 years old
- no contraindication to physical exercise
- no cardiovascular disease
- BMI above the 97th percentile
- candidate to a weight loss intervention
Exclusion Criteria:
- surgery and medical conditions preventing them to perform the intervention
- Weight loss during the previous 6 months
- medication that could interfere with energy metabolism.
- pregnancy
- regular tobacco and alcool use
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
|---|---|
|
Experimental: Adolescents with obesity
Adolescents with obesity aged 12-16 years old
|
The adolescents will follow a 12-week intervention combining nutritional education, physical activity 3 times per week and psychological supports.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Change in Energy Expenditure between before and after weight loss
Time Frame: before and after the 12-week weight loss
|
amount of energy expended during the walking tests, measured using indirect calorimetry
|
before and after the 12-week weight loss
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
change in lipid oxidation between before and after weight loss
Time Frame: before and after the 12-week weight loss
|
amount of lipids oxidized during the walking tests, measured using indirect calorimetry
|
before and after the 12-week weight loss
|
|
change in Fat mass between before and after weight loss
Time Frame: before and after the 12-week weight loss
|
The amount of body fat will be assessed by dual energy X-ray absorptiometry
|
before and after the 12-week weight loss
|
|
change physical activity preferences between before and after weight loss
Time Frame: before and after the 12-week weight loss intervention
|
Children will be asked to indicate their prefered physical activties and sedenatry behaviors on a computer task using visual analog scale (from 0 to 150 mm)
|
before and after the 12-week weight loss intervention
|
|
Change in Energy Expenditure between the unloaded and loaded walking test
Time Frame: after the 12_week weight loss
|
amount of energy expended during the walking tests, measured using indirect calorimetry
|
after the 12_week weight loss
|
|
Change in lipid oxidation between the unloaded and loaded walking test
Time Frame: after the 12_week weight loss
|
amount of lipids oxidized during the walking tests, measured using indirect calorimetry
|
after the 12_week weight loss
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: Yves BOIRIE, University Hospital, Clermont-Ferrand
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
August 20, 2021
Primary Completion (Actual)
April 25, 2022
Study Completion (Actual)
April 25, 2022
Study Registration Dates
First Submitted
May 3, 2021
First Submitted That Met QC Criteria
May 25, 2021
First Posted (Actual)
May 26, 2021
Study Record Updates
Last Update Posted (Actual)
August 3, 2026
Last Update Submitted That Met QC Criteria
July 31, 2026
Last Verified
July 1, 2026
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- RBHP 2021 BOIRIE
- 2021-A00756-35 (Other Identifier: 2021-A00756-35)
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
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