Search clinical trials for: pharmacodynamics,

Total 2241 results

European Organisation for Research and Treatment...
AstraZeneca

Withdrawn

Chemo-free BRCA-targeted Neoadjuvant Strategy

BRCA1 Mutation | BRCA2 Mutation | TNBC - Triple-Negative Breast Cancer
AstraZeneca

Completed

A Study to Assess the Safety and Pharmacokinetics of an Inhibitor of Poly ADP-Ribose Polymerase-1 (PARP)

Ovarian Neoplasms | BRCA1 Protein | BRCA2 Protein

Netherlands, Belgium, United Kingdom, Poland
Montreal Heart Institute
Institut de Recherches Cliniques de Montreal

Recruiting

Assessing Pharmacokinetics and Pharmacodynamics of Daily Enteric-coated Aspirin in Patients With StablE Diabetes II (APPEASEDII)

Diabetes Mellitus, Type 2 | Type 2 Diabetes | Platelet Aggregation | Aspirin | Platelet Aggregation Inhibitors

Canada
Montreal Heart Institute
Institut de Recherches Cliniques de Montreal

Recruiting

Assessing Pharmacokinetics and Pharmacodynamics of Daily Enteric-coated Aspirin in Patients With StablE Diabetes (APPEASED)

Diabetes Mellitus, Type 2

Canada
Alexion Pharmaceuticals, Inc.

Completed

A Study of Single and Multiple Doses of ALXN1210 in Healthy, Adult Japanese Participants

Healthy

United Kingdom
Alexion

Completed

A Study of a Single Subcutaneous Dose of ALXN1210 in Healthy Adult Participants

Healthy

United Kingdom
Mabwell (Shanghai) Bioscience Co., Ltd.

Completed

Efficacy and Safety of MW032 and Xgeva® in Subjects With Bone Metastases From Solid Tumors

Bone Metastases

China
Seoul National University Hospital
Ministry of Food and Drug Safety, Korea

Completed

Pharmacokinetic-pharmacodynamic Analysis of Sugammadex in Children

Anesthesia, General | Neuromuscular Blockade

Korea, Republic of
GlaxoSmithKline

Completed

A Study to Evaluate the Safety and Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of Melrilimab (GSK3772847) in Healthy Participants

Asthma | Healthy Volunteers

United States
University of Manitoba
Health Sciences Centre, Winnipeg, Manitoba; University at Buffalo; St. Boniface...

Withdrawn

Indomethacin PK-PD in Extremely Preterm Neonates (INDO)

Patent Ductus Arteriosus After Premature Birth

Canada
Children's Hospital Los Angeles
National Institute of General Medical Sciences (NIGMS)

Completed

Prospective Study to Optimize Vancomycin Dosing in Children and Adults Using Computer Software

Bacterial Infections

United States
Golden Jubilee National Hospital

Completed

Validation Study of Covariates Model (VaSCoM) for Propofol (VaSCoM)

Target Controlled Infusion of Propofol

United Kingdom
Collegium Medicum w Bydgoszczy

Completed

Comparison of Ticagrelor Pharmacokinetics and Pharmacodynamics in STEMI and NSTEMI Patients (PINPOINT)

Myocardial Infarction

Poland
Georgetown University
Medstar Health Research Institute

Withdrawn

Pilot Study of Exenatide Pharmacokinetics and Pharmacodynamics in Gestational Diabetes

Gestational Diabetes

United States
Trevena Inc.

Completed

A Safety, Tolerability, PD and PK Study in Healthy Adults

Healthy

United States
Celgene Corporation

Completed

3-part Study to Evaluate Safety, Tolerability, Pharmacokinetics & Pharmacodynamics of Multiple Doses of CC-220 and Relative Bioavailability of a Formulated CC-220 Capsule

Healthy Volunteers

United States
Pfizer

Terminated

A Pharmacokinetic And QT Study Of CP-751,871 In Healthy Subjects

Healthy Volunteers

United States
ViiV Healthcare
Pfizer

Completed

Study To Investigate The Hemodynamic Effects Of Single Dose Vardenafil In Subjects Receiving Maraviroc

AIDS

Belgium
Millennium Pharmaceuticals, Inc.

Completed

A Safety and Pharmacokinetic Study of TAK-285 in Patients With Advanced Cancer

Cancer

United States
Immutep S.A.S.
SGS Aster-Cephac (CRO)

Completed

A Randomized Phase I Study of a Hepatitis B Antigen Combined With IMP321

Healthy

France
Central South University

Completed

Effect of Adiponectin Genetic Polymorphism on Rosiglitazone Response

Diabetes Mellitus

China
Novartis

Completed

Study to Explore the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Oral AHT956 in Healthy Subjects

Healthy

Switzerland
The Second Affiliated Hospital of Chongqing Medical...

Recruiting

Analysis of Factors Influencing the Efficacy of Levamlodipine Benzoate and Its Population Pharmacodynamic Modeling

Monotherapy | Hypertensive Patients

China
Alexion Pharmaceuticals

Completed

Study of ALXN2050 in Healthy Adult Participants of Japanese Descent

Healthy

United States
Mylan Inc.
Mylan GmbH

Completed

Pharmacokinetic / Pharmacodynamic Study Comparing MYL-1401H, EU-sourced Neulasta and US-licensed Neulasta

Healthy Volunteers

Netherlands
Seoul National University Hospital
Ministry of Food and Drug Safety, Korea

Completed

Pharmacokinetic-pharmacodynamic Analysis of Sugammadex for Conventional Reversal in Children

Anesthesia, General | Neuromuscular Blockade

Korea, Republic of
Boston Pharmaceuticals

Completed

Study to Assess the Safety, Pharmacokinetics and Pharmacodynamics of BOS161721 in Healthy Subjects

Healthy Participants

United States
MedImmune LLC

Completed

A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamic Effects of MEDI5884 in Adults With Stable Coronary Heart Disease

Stable Coronary Heart Disease

United States
Geropharm

Completed

A Study to Compare Pharmacokinetics and Pharmacodynamics of GP-40081 to NovoMix® 30 Penfill® in Healthy Subjects

Clamp Study

Russian Federation
Astellas Pharma Inc

Completed

A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ESN364 in Healthy Japanese Male and Pre- and Post-menopausal Female Subjects

Healthy Subjects

Japan
UCB Pharma SA

Completed

A Study to Investigate the Drug-Drug Interactions of Brivaracetam and Ethanol in Healthy Male Subjects

Healthy Volunteers

Netherlands
Idorsia Pharmaceuticals Ltd.

Completed

A Study to Investigate the Safety, Tolerability, Pharmacokinetics (PK), and Pharmacodynamics (PD) of ACT-541468 in Healthy Young Adults and Elderly Subjects

Healthy Subjects

Netherlands
GlaxoSmithKline

Completed

A Study in Type 2 Diabetics of Single and Multiple Doses of Orally Administered GSK1292263 to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics

Diabetes Mellitus, Type 2

United States
Sutep Jaruratanasirikul
Prince of Songkla University

Completed

Pharmacodynamics Modeling to Optimize Dosage Regimens of Sulbactam in Patients With Acinetobacter Infections

Acinetobacter Infections

Thailand
GlaxoSmithKline

Completed

Injection Site Study In Patients With Type 2 Diabetes Mellitus (T2DM) And Healthy Volunteers

Diabetes Mellitus, Type 2

United States
Mikkel Bring Christensen

Completed

Effects of Lipid Emulsion on the Pharmacokinetic and Pharmacodynamic Properties of Metoprolol.

Blood Pressure | Drug Overdose | Overdose of Beta-adrenergic Blocking Drug

Denmark
Ardelyx

Completed

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RDX5791 in Healthy Volunteers

Healthy
Ajou University School of Medicine

Completed

Sarpogrelate Drug Interaction

Hypertension | Peripheral Artery Disease

Korea, Republic of
Genexine, Inc.

Completed

Phase I Study GX-G3 in Healthy Subjects (GX-G3)

Healthy

Korea, Republic of
LG Life Sciences

Completed

Influence of Hepatic Impairment on Pharmacokinetic (PK) and Pharmacodynamic (PD) of Gemigliptin PK and PD After Multiple Oral Doses in Healthy White Volunteers

Hepatic Impairment

Germany
Yuhan Corporation

Completed

Pharmacokinetic Drug Interaction Between YH4808 and Diclofenac

Healthy

Korea, Republic of
Tasly Pharmaceuticals, Inc.

Completed

A Study to Evaluate the Effect of T89(Dantonic®)on Steady-State Pharmacodynamics of Warfarin

Healthy

United States
Assaf-Harofeh Medical Center

Unknown

Ocsaar and CYP2C9 Ploymorphism, Is There a Connection Between Pharmacokinetics, Pharmacodynamics and Pharmacogenetics?

Hypertension
Centro Hospitalar do Porto

Completed

Propofol Pharmacokinetics and Pharmacodynamics Modelling

Intravenous Anesthetic Agent Overdose

Portugal
University of Saskatchewan
University of Chicago; Emory University; University of Alberta; University of Calgary and other collaborators

Completed

Selenium and Arsenic Pharmacodynamics (SEASP)

Arsenic Poisoning Chronic

Bangladesh
Rutgers, The State University of New Jersey

Completed

Pharmacokinetics and Pharmacodynamics of Anthocyanins

Gout

United States
Ohio State University
National Institute of General Medical Sciences (NIGMS)

Withdrawn

Genetic Influence on Statin Pharmacodynamics

Dyslipidemia | Hypercholesterolemia | Hyperlipidemia

United States
University of Florida

Completed

Pharmacokinetics and Pharmacodynamics of Fructose

Healthy

United States
Spanish Cooperative Group for the Treatment of...
AstraZeneca

Recruiting

Olaparib and Durvalumab (MEDI4736) in Patients With Metastatic Pancreatic Cancer and DNA Damage Repair Genes Alterations

Metastatic Pancreatic Cancer

Spain
University of Maryland, Baltimore
Stanley Medical Research Institute

Completed

Rasagiline in the Treatment of Persistent Negative Symptoms of Schizophrenia

Schizophrenia

United States

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