Chemo-free BRCA-targeted Neoadjuvant Strategy

Neoadjuvant Olaparib and Durvalumab for Patients With BRCA-associated Triple Negative Breast Cancer

This is a multicenter randomized phase ll clinical trial to evaluate the pathological complete response (pCR) in the tumour burden (primary and lymph nodes) with olaparib alone or in the olaparib and durvalumab arm in TNBC patients candidate for neoadjuvant strategy showing a t/gBRCAmut or BRCAness/HRD profile.

Study Overview

• Status: Withdrawn
• Conditions: BRCA1 Mutation; BRCA2 Mutation; TNBC - Triple-Negative Breast Cancer
• Intervention / Treatment: Drug: olaparib; Drug: Durvalumab

Detailed Description

Eligible patients will be registered for central testing of BRCA mutatinal status and HRD/BRCAness profile with central review of ER, PgR, TILs and PD-L1.

Eligible patients will be randomly assigned to either olparib or olaparib and durvalumab (=neoadjuvant treatment) in a 1:1 ratio. The treatment duration in both arms will last 16 weeks and both treatments are considered as experimental treatments in this study.

After completion of neoadjuvant systemic treatment, patients will undergo surgery and followed-up for 2 years after investigational drug discontinuation. After surgery, adjuvant treatment will be left at the investigator's decision.

• Study Type: Interventional
• Phase: Phase 2

Contacts and Locations

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 14 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria at registration:

• Histologically confirmed, invasive TNBC, defined as:

  • ER and PR negative (not eligible for endocrine therapy) defined as immunohistochemistry (IHC) nuclear staining ≤ 10% AND
  • HER2 negative (not eligible for anti-HER2 therapy):
• Early-stage disease, defined as cT1c-T2, N0-N1, M0
• Medically fit for a neoadjuvant strategy and for radical surgery as by the investigator's decision
• No prior systemic therapy nor definitive surgery for BC
• Age ≥18 years
• Women and men can be included
• ECOG performance status (PS) 0-1

Exclusion Criteria at registration:

• Previous treatment with a PARPi
• Previous treatment with an anti-PD-1/PD-L1, anti-PD-L2 or anti-CTLA-4 antibody
• Evidence of macroscopic distant metastases, investigated according to local institutional guidelines
• Patients who underwent sentinel node biopsy before neoadjuvant therapy
• History of previous invasive BC
• Bilateral and/or multifocal and/or multicentric BC
• Malabsorption syndrome or other chronic condition that would significantly interfere with enteral absorption
• History of allogenic transplantation of bone marrow or an organ.
• History of another primary malignancy.
• Myelodysplastic syndrome/acute myeloid leukaemia or features suggestive of such.
• Congenital long QT syndrome.
• History of active primary immunodeficiency

Inclusion criteria at randomization:

• Deleterious germline or somatic mutation in BRCA 1 and/or BRCA 2 or homologue repair deficiency (HRD) status as determined by central testing.
• Tumour tissue available from primary tumour (fine needle aspiration cytology or lymph node metastasis tissue are not acceptable).

• Normal organ and bone marrow function measured within 28 days prior to administration of study treatment as defined below:

  • Haemoglobin ≥ 10.0 g/dL with no blood transfusion in the past 28 days
  • Absolute neutrophil count (ANC) ≥ 1.5 x 109/L
  • Platelet count ≥ 100 x 109/L
  • AST (SGOT) and ALT (SGPT) ≤ 2.5 x ULN
  • Total bilirubin ≤ 1.5 x ULN (exception: higher bilirubin in patients with confirmed Gilbert's syndrome are allowed according to the investigator's decision)
  • Creatinine clearance estimated of ≥ 51 mL/min/1.73m2 using the MDRD equation
• Body weight >30 kg
• Participation in translational research is mandatory
• Women of childbearing potential (WOCBP) must have a negative serum pregnancy test in the screening period and confirmed prior to treatment on day 1.

• Female patients of childbearing/reproductive potential must use adequate birth control measures, as defined by the investigator, during the study treatment period and for at least 3 months after the last dose of treatment. A highly effective method of birth control is defined as a method which results in a low failure rate (i.e., less than 1% per year) when used consistently and correctly. Such methods include:

  • Intrauterine device (IUD)
  • Intrauterine hormone-releasing system (IUS)
  • Bilateral tubal occlusion
  • Vasectomized partner
  • Sexual abstinence (the reliability of sexual abstinence needs to be evaluated in relation to the duration of the clinical trial and the preferred and usual lifestyle of the patient)
• Male patients must use a condom during treatment and for 3 months after the last dose of study treatment when having sexual intercourse with a pregnant woman or with a woman of childbearing potential. Female partners of male patients should also use a highly effective form of contraception (see above) if they are of childbearing potential.
• Female subjects who are breast feeding must discontinue nursing prior to the first dose of study treatment and until 3 months after the last study treatment.
• Registration to a National Health Care System

Exclusion criteria at randomization:

• Inability to swallow and/or retain oral tablets
• Blood transfusion within 28 days
• History of human immunodeficiency virus (HIV) (positive HIV 1/2-antibodies)
• Active Hepatitis B or Hepatitis C
• Active bacterial, viral, or fungal infection requiring systemic therapy
• History of active tuberculosis (TB, Bacillus Tuberculosis)
• History of idiopathic pulmonary fibrosis, drug-induced pneumonitis, organizing pneumonia, interstitial lung disease or evidence of active pneumonitis on screening (TAP-CT-scan)
• History of aortic disease (aneurysm or dissection)
• History of myasthenia gravis
• Mean QT interval corrected for heart rate (QTc) ≥ 500ms using Fridericia's Correction
• Uncontrolled intercurrent illness
• Psychiatric illness/social situations or addiction (chronic alcoholism or drug addiction) that would limit compliance with study requirement, substantially increase risk of incurring AEs or compromise the ability of the patient to give written informed consent.
• Any other serious or uncontrolled illness or abnormality that, in the judgment of the investigator, limits compliance with study requirement, substantially increases risk of incurring AEs or compromises the ability to give written informed consent.
• Current or prior use of immunosuppressive medication within 14 days before the first dose of durvalumab.
• Receipt of live attenuated vaccine within 30 days prior to the first dose of study treatment.
• Any concurrent systemic chemotherapy, immunotherapy, biologic or hormonal therapy for cancer treatment.

• Any unresolved toxicity (Common Terminology Criteria for Adverse Event (CTCAE) grade ≥ 2) caused by previous cancer therapy, excluding alopecia, vitiligo.

  • Patients with Grade ≥ 2 neuropathy will be evaluated on a case-by-case basis after consultation with the study physician.
  • Patients with irreversible toxicity not reasonably expected to be exacerbated by treatment with olaparib and/or durvalumab may be included only after consultation with the study physician.
• Concomitant use of strong CYP3A inhibitors.The required washout period prior to starting study treatment (olaparib) is 2 weeks.
• Concomitant use of strong CYP3A inducers. The required washout period prior to starting study treatment (olaparib) is 5 weeks for phenobarbital and 3 weeks for other agents.
• Major surgery within 4 weeks prior to the first dose of study treatment. Patients must have recovered from the surgical procedure. Implanted port placement is not considered as a major surgery.
• Known allergy or hypersensitivity to olaparib or durvalumab, or to any excipient.
• Contraindication to MRI or to the contrast medium used for MRI (gadolinium).
• Participation in another clinical study, unless it is an observational (non-interventional) clinical study or during the follow-up period of an interventional study
• Female patients who are pregnant or male or female patients of reproductive potential who are not willing to employ effective birth control from screening to 3 months after the last dose of study treatment.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Olaparib; Olaparib treatment for a total of 16 weeks	Drug: olaparib; olaparib 300 mg per os BID
Experimental: Olaparib and durvalumab; Olaparib and durvalumab treatment for a total of 16 weeks	Drug: olaparib; olaparib 300 mg per os BID; Drug: Durvalumab; durvalumab 1500 mg IV Q4 weeks

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
rate of pathological complete response (pCR) at the time of surgery	pCR is defined as the absence of invasive residual disease in the breast and in the axillary lymph nodes (ypT0/is ypN0).	5 years from first patient in

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
2-year overall survival (OS) rate	OS is defined as date of randomization to the date of death, whatever comes first	7.5 years from first patient in
Other pathological response	Residual cancer burden score (RCB), defined on the specimen collected at the time of surgery	7.5 years from first patient in
Probability of being event-free at 2 years	events considered being disease progression on neoadjuvant therapy, any event precluding surgery, locoregional recurrence, distant recurrence, second primary invasive cancer (breast and non-breast origin) and death from any cause	7.5 years from first patient in
Surgery rate		7.5 years from first patient in
Breast conservation rate		7.5 years from first patient in
Treatment response rate according to RECIST v1.1		7.5 years from first patient in
Safety	Rate of Adverse events not related directly with the surgical procedure (NCI-CTCAE Version 5.0) Rate of Post-operative complications (Clavien-Dindo Classification of Surgical Complications)	7.5 years from first patient in
Global health status/QoL score	score according to EORTC QLQ-C30 questionnaire	7.5 years from first patient in
Score on the Systemic side effects scale	according to the modified QLQ-BR45 (IL170) questionnaire	7.5 years from first patient in

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
Exploratory endpoints: the impact of olaparib alone or olaparib in combination with durvalumab on ovarian function (in patients ≤ 50 years)	Change in ovarian reserve over time as measured by AMH; Proportion of premenopausal women at baseline who become postmenopausal after neoadjuvant treatment and during follow-up as measured by FSH and E2	7.5 years from first patient in
Exploratory endpoints: Translational research	Preliminary assessment of biomarkers that might act as pharmacodynamic indicators and predictors of activity of the experimental treatment by IHC, immunomonitoring, genetic and imaging studies.	7.5 years from first patient in
Exploratory endpoints: To assess the evolution of the other scales HRQoL in both arms	according to EORTC QLQ-C30 questionnaire and the modified QLQ-BR45 (IL170) questionnaire	7.5 years from first patient in

Collaborators and Investigators

• Sponsor: European Organisation for Research and Treatment of Cancer - EORTC
• Collaborators: AstraZeneca
• Investigators: Study Chair: Etienne Brain, Institut Curie Paris

Study record dates

Study Major Dates

• Study Start (Estimated): February 1, 2024
• Primary Completion (Estimated): September 6, 2028
• Study Completion (Estimated): July 18, 2030

Study Registration Dates

• First Submitted: January 12, 2022
• First Submitted That Met QC Criteria: January 12, 2022
• First Posted (Actual): January 26, 2022

Study Record Updates

• Last Update Posted (Estimated): February 23, 2024
• Last Update Submitted That Met QC Criteria: February 21, 2024
• Last Verified: February 1, 2024

More Information

Terms related to this study

• Keywords: Olaparib; Durvalumab; PARPi
• Additional Relevant MeSH Terms: Skin Diseases; Neoplasms; Neoplasms by Site; Breast Diseases; Breast Neoplasms; Triple Negative Breast Neoplasms; Molecular Mechanisms of Pharmacological Action; Enzyme Inhibitors; Antineoplastic Agents; Antineoplastic Agents, Immunological; Poly(ADP-ribose) Polymerase Inhibitors; Olaparib; Durvalumab
• Other Study ID Numbers: EORTC-1984-BCG; 2022-003594-33 (EudraCT Number)

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No