Search clinical trials for: variant

Total 704 results

National Human Genome Research Institute (NHGRI)

Completed

The Clinical Study of Sex Chromosome Variants

Male Factor Infertility | Female Factor Infertility

United States
Wuerzburg University Hospital
Takeda

Active, not recruiting

Fabry Disease in High-risk Patients With Left Ventricular Hypertrophy: Prevalence and Implementation of a Clinical Score (FAPREV-HCM)

Lysosomal Storage Diseases | Fabry Disease | Fabry Disease, Cardiac Variant | HCM - Hypertrophic Cardiomyopathy | Anderson Fabry Disease

Germany
Medical College of Wisconsin

Completed

HDtDCS in Logopenic Variant PPA: Effects on Language and Neural Mechanisms

Primary Progressive Aphasia

United States
National Cancer Institute (NCI)

Active, not recruiting

Ibrutinib in Treating Patients With Relapsed Hairy Cell Leukemia

Hairy Cell Leukemia | Recurrent Hairy Cell Leukemia | Hairy Cell Leukemia Variant | Recurrent Hairy Cell Leukemia Variant

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Ibrutinib, Rituximab, and Consolidation Chemotherapy in Treating Young Patients With Newly Diagnosed Mantle Cell Lymphoma

Mantle Cell Lymphoma | Blastoid Variant Mantle Cell Lymphoma | Pleomorphic Variant Mantle Cell Lymphoma

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI); Exelixis

Active, not recruiting

Cabozantinib or Sunitinib Malate in Treating Participants With Metastatic Variant Histology Renal Cell Carcinoma

Renal Cell Carcinoma | Metastatic Renal Cell Carcinoma | Stage IV Renal Cell Cancer AJCC v8 | Sarcomatoid Renal Cell Carcinoma | Chromophobe Renal Cell Carcinoma | Papillary Renal Cell Carcinoma | Malignant Neoplasms of Urinary Tract | Renal Cell Carcinoma Associated With Xp11.2 Translocations/TFE3... and other conditions

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Gemcitabine Hydrochloride, Clofarabine, and Busulfan Before Donor Stem Cell Transplant in Treating Patients With Refractory B-Cell or T-Cell Non-Hodgkin Lymphoma or Hodgkin Lymphoma

Refractory Hodgkin Lymphoma | Refractory B-Cell Non-Hodgkin Lymphoma | Refractory T-Cell Non-Hodgkin Lymphoma | Hematopoietic Cell Transplantation Recipient

United States
Asklepios Biopharmaceutical, Inc.

Active, not recruiting

Pre-Gene Therapy Study in Parkinson's Disease and Multiple System Atrophy

Parkinson's Disease | Multiple System Atrophy | Multiple System Atrophy, Parkinson Variant

United States, Poland
National Institutes of Health Clinical Center (CC)

Completed

Comparing Expectorated and Induced Sputum and Pharyngeal Swabs for Cultures, AFB Smears, and Cytokines in Pulmonary Nontuberculous Mycobacterial Infection

Mycobacterium Infections, Non-tuberculous

United States
National Human Genome Research Institute (NHGRI)

Enrolling by invitation

Reverse Phenotyping Core

Harboring of Unexpected Genetic Variant

United States
Sherifa Ahmed Hamed

Completed

Clinical Characteristics and Treatment of Anosmia and Ageusia Due to SARS-CoV2 Variants

Post-covid-19 Persistent Smell and Taste Disorders

Egypt
University Hospital Muenster

Completed

Establishment of an ELISA for the Recognition of Procalcitonin Variants in Patients With Hyperprocalcitonemia.

Sepsis | Pre-Eclampsia | Adiposity | Microscopic Polyangiitis | Granulomatosis With Polyangiitis | SIRS | Procalcitonin

Germany
M.D. Anderson Cancer Center
Janssen Pharmaceutica

Active, not recruiting

Cabazitaxel, Carboplatin, and Cetrelimab Followed by Niraparib With or Without Cetrelimab for the Treatment of Aggressive Variant Metastatic Prostate Cancer

Castration-Resistant Prostate Carcinoma | Metastatic Prostate Carcinoma | Stage IV Prostate Cancer AJCC v8 | Aggressive Variant Prostate Carcinoma | Metastatic Prostate Neuroendocrine Carcinoma | Metastatic Prostate Small Cell Carcinoma

United States
University of British Columbia

Completed

Evaluation of Low-cost Techniques for Detecting Sickle Cell Disease and β-thalassemia in Nepal and Canada

Sickle Cell Disease | Beta-Thalassemia | Sickle Cell Trait | Sickle Cell-Beta Thalassemia | Sickle Cell-SS Disease

Canada, Nepal
Sinovac Research and Development Co., Ltd.

Completed

Immunogenicity and Safety of Booster Immunization of COVID-19 Vaccine (Vero Cell), Inactivated (Omicron Variant) in Healthy People Aged 18 Years and Above

COVID-19

China
Novavax

Active, not recruiting

Phase 2/3 Heterologous Boosting Study With Different Dose Levels of Monovalent SARS-CoV-2 rS Vaccines (COVID-19)

COVID-19

United States
Novavax

Completed

A Study to Evaluate the Safety and Immunogenicity of an (Omicron Subvariant) COVID-19 Vaccine Booster Dose in Previously Vaccinated Participants and Unvaccinated Participants. (COVID-19)

COVID-19

United States
Grande International Hospital, Nepal

Completed

Prevalence of Variants of Nasal Cavity and Nasal Septum in Nepalese

Nasal Septum; Deviation, Congenital

Nepal
Children's Hospital Medical Center, Cincinnati

Completed

Database Of Clinical Data For Individuals With Variants In The IRF2BPL Gene (IRF2BPL)

Movement Disorders | Seizures | Autism Spectrum Disorder | Dystonia | NEDAMSS

United States
National Heart, Lung, and Blood Institute (NHLBI)

Enrolling by invitation

Investigating the Mechanistic Effects of Mitapivat in Subjects With Sickle Cell Disease

Sickle Cell Anemia | Sickle Beta Thalassemia | Sickle Cell Thalassemia | Sickle Beta Zero Thalassemia | Sickle Cell Pain | Hbss | Hbsc | Sickle Cell Syndrome Variant

United States
M.D. Anderson Cancer Center
Merck Sharp & Dohme LLC; AstraZeneca

Active, not recruiting

Study of Olaparib Maintenance Following Cabazitaxel-Carbo in Men With AVPC

Prostate Carcinoma | Prostate Cancer Aggressiveness

United States
Ospedale San Raffaele

Completed

Natriuretic Effect of Amiloride in Relation to the Alpha Adducin Gene (ADD-AMI) RS4961 Variant (ADD-AMI)

Genetic Hypertension | Hypertension Essential | Salt Excess

Italy
Duke University

Suspended

Identification and Characterization of Novel Non-Coding Variants That Contribute to Genetic Disorders

Lysosomal Storage Diseases | Genetic Disease | Inborn Errors of Metabolism | Glycogen Storage Disease | Storage Disease

United States
COVID-19 Prevention Network
National Institute of Allergy and Infectious Diseases (NIAID); Medical Research...

Completed

Efficacy Study of COVID-19 mRNA Vaccine in Regions With SARS-CoV-2 Variants of Concern (CoVPN3008)

HIV Infections | COVID-19 | SARS-CoV-2 Infection

Uganda, Malawi, South Africa, Botswana, Zambia, Kenya, Swaziland
Novavax

Active, not recruiting

Phase 3 Adolescent Study for SARS-CoV-2 rS Variant Vaccines (COVID-19)

COVID-19

United States
Mayo Clinic

Enrolling by invitation

Clinico-Pathologic-Genetic-Imaging Study of Neurodegenerative and Related Disorders (AND1)

Parkinson Disease | Semantic Dementia | Behavioral Variant of Frontotemporal Dementia | CBD | Apraxia of Speech | MSA - Multiple System Atrophy | FTD | PPA | PSP | PCA | LPA | Semantic Aphasia

United States
RAI Services Company

Completed

CSD200902: Assessment of Indoor Air Quality for a Heated Tobacco Product With Four Non-Combusted Cigarette Variants in an Environmental Testing Chamber

Smoking | Tobacco Use | Tobacco Smoking

United States
Philip Morris Products S.A.

Completed

Nicotine Pharmacokinetics Following Use of the P4M3 Gen 2.0 E-Cigarette Compared to Smoking Cigarettes

Nicotine | Nicotine Vaping | Vaping

United States
Suzhou Abogen Biosciences Co., Ltd.

Active, not recruiting

A Study to Evaluate the Efficacy, Safety, and Immunogenicity of SARS-CoV-2 Variant (BA.4 /5) mRNA Vaccine

COVID-19

Philippines, Pakistan, United Arab Emirates, Indonesia
WestVac Biopharma Co., Ltd.

Active, not recruiting

Phase I Clinical Trial of Recombinant COVID-19 Variant Vaccine (Sf9 Cell) (WSK-V102)

COVID-19

China
WestVac Biopharma Co., Ltd.

Active, not recruiting

Phase II Clinical Trial of Recombinant COVID-19 Variant Vaccine (Sf9 Cell)

COVID-19

China
WestVac Biopharma Co., Ltd.

Active, not recruiting

Safety and Immunogenicity of Recombinant COVID-19 Variant Vaccine (Sf9 Cell) as a Booster

COVID-19 | SARS-CoV-2 Infection

Mexico
Novavax

Completed

Phase 3 Boosting Study for the SARS-CoV-2 rS Variant Vaccines (COVID-19)

COVID-19 | SARS CoV 2 Infection

Australia
National Institute of Allergy and Infectious Diseases...

Completed

Delayed Heterologous SARS-CoV-2 Vaccine Dosing (Boost) After Receipt of EUA Vaccines

COVID-19

United States
Mayo Clinic

Completed

Genetic Variants in Nicotinamide Adenine Dinucleotide (NAD) Synthesis Pathway

Congenital Malformation | Vacterl Association

United States
University of Pittsburgh

Completed

Review of Charts From Amish/Mennonite Variant PA Patients

Propionic Acidemia

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Venetoclax and Acalabrutinib in Treating Patients With Relapsed or Refractory Mantle Cell Lymphoma

Recurrent Mantle Cell Lymphoma | CD20 Positive | Refractory Mantle Cell Lymphoma | Blastoid Variant Mantle Cell Lymphoma | CCND1 Protein Overexpression | CD5 Positive | FCER2 Negative | Pleomorphic Variant Mantle Cell Lymphoma | t(11;14)(q13;q32)

United States
Xencor, Inc.
ICON Clinical Research

Active, not recruiting

Study to Evaluate Safety and Tolerability of XmAb13676 (Plamotamab) in Patients With CD20-expressing Hematologic Malignancies

Chronic Lymphocytic Leukemia | B-cell Non-Hodgkins Lymphoma

United States, France, Korea, Republic of, United Kingdom
Sangamo Therapeutics

Enrolling by invitation

Long-Term Follow-up of Subjects Who Were Treated With ST-920

Fabry Disease | Fabry Disease, Cardiac Variant

United States, Australia, United Kingdom
Ankara Etlik City Hospital

Completed

The Impact of Neoadjuvant Chemotherapy on Survival Outcomes in Patients With Variant Histologies Bladder Cancer Who Underwent Radical Cystectomy

Bladder Cancer | Bladder Cancer Stage I | Bladder Cancer Stage II

Turkey
Regeneron Pharmaceuticals

Active, not recruiting

A Trial to Learn if Different Doses of REGN17092 Are Safe in Healthy Adults

Healthy Volunteers

Belgium
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Durvalumab and Tremelimumab in Treating Patients With Muscle-Invasive, High-Risk Urothelial Cancer That Cannot Be Treated With Cisplatin-Based Therapy Before Surgery

Hydronephrosis | Infiltrating Bladder Urothelial Carcinoma, Plasmacytoid Variant | Stage III Bladder Urothelial Carcinoma AJCC v6 and v7 | Stage III Renal Pelvis Cancer AJCC v7 | Stage III Ureter Cancer AJCC v7 | Stage III Urethral Cancer AJCC v7 | Stage IV Renal Pelvis Cancer AJCC v7 | Stage IV... and other conditions

United States
IRCCS Eugenio Medea

Completed

Omic Approaches to Neurodevelopmental Disabilities

Neurodevelopmental Disorders

Italy
University of Pennsylvania

Completed

Improving Self-Care of Behavioral Variant Frontotemporal Dementia Caregivers (ViCCY)

Behavioral Variant of Frontotemporal Dementia | Caregiver Stress Syndrome

United States
Bristol-Myers Squibb

Terminated

Exploratory Study of Danicamtiv in Patients With Primary Dilated Cardiomyopathy (DCM) Due to Genetic Variants or Other Causalities

Primary Familial Dilated Cardiomyopathy

United States, Germany, Spain, United Kingdom
King Hussein Cancer Center

Active, not recruiting

Universal Genetic Testing Versus Guidelines-Directed Testing for Germline Pathogenic Variants Among Non-Western Patients With Breast Cancer

Breast Cancer

Jordan
Meyer Children's Hospital IRCCS

Active, not recruiting

Set-up of a Platform for Personalized Diagnosis of Rare Kidney Diseases (NIKE)

Chronic Kidney Diseases

Italy
King Hussein Cancer Center

Active, not recruiting

Universal- Versus Guidelines-Directed Genetic Testing for Germline Pathogenic Variants Utilizing a Multi-Gene Panel for Inherited Cancers in Non-Western Society.

Genetic Predisposition

Jordan
National Institute of Allergy and Infectious Diseases...
ModernaTX, Inc.

Completed

Safety and Immunogenicity Study of a SARS-CoV-2 (COVID-19) Variant Vaccine (mRNA-1273.351) in Naïve and Previously Vaccinated Adults

COVID-19 | COVID-19 Immunisation

United States
BioNTech SE
Pfizer

Active, not recruiting

A Study to Learn About New COVD-19 RNA Vaccine Candidates for New Variants in Healthy Individuals

COVID-19 | SARS-CoV-2 Infection

United States

Search clinical trials for: variant

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Malawi

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations