Search clinical trials for: Human Challenge

Total 25057 results

National Institute of Allergy and Infectious Diseases...
Genentech, Inc.

Completed

A Phase I Study of the Safety and Pharmacokinetics of Recombinant Human CD4 Immunoglobulin (rCd4-IgG) Administered by Intravenous Bolus in Patients With AIDS and AIDS Related Complex

HIV Infections

United States
Glaxo Wellcome

Completed

A Phase I Study to Evaluate the Pharmacokinetics, Safety and Antiviral Effects of Concurrent Administration of Zidovudine (AZT) and 2'3'-Dideoxyinosine (ddI) in Patients With Human Immunodeficiency Virus (HIV)

HIV Infections

United States
National Center for Research Resources (NCRR)
University of Vermont

Completed

Phase III Multicenter Double Blind Controlled Trial of Human Immune Globulin Therapy in Previously Untreated Patients With Chronic Inflammatory Demyelinating Neuropathy

Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
Louisiana State University Health Sciences Center...

Completed

Further Evaluation of Thalidomide's Ability to Potentiate the Immune Response to HIV-Infected Patients

HIV Infections

United States
Eunice Kennedy Shriver National Institute of Child...
University of Minnesota

Completed

Phase I/II Study of Retroviral-Mediated Transfer of Iduronate-2-Sulfatase Gene Into Lymphocytes of Patients With Mucopolysaccharidosis II (Mild Hunter Syndrome)

Mucopolysaccharidosis II

United States
National Center for Research Resources (NCRR)
Northwestern University

Completed

Randomized Placebo-Controlled Study of Aerobic Exercise and Resistance Training Plus Megestrol Acetate for HIV-Wasting

HIV Infections | Acquired Immunodeficiency Syndrome | HIV Wasting Syndrome
National Institute of Dental and Craniofacial Research...
Columbia University

Completed

Oral Manifestations of Human Immunodeficiency Virus Infection in High Risk Groups

HIV Infections | Candidiasis, Oral
Sandoz

Completed

A Randomized, Phase I/II Trial to Assess the Safety and Antiviral Effects of Escalating Doses of A Human Anti-Cytomegalovirus Monoclonal Antibody (SDZ MSL-109) in Patients With the Acquired Immunodeficiency Syndrome and CMV Viremia and/or Viruria

HIV Infections | Cytomegalovirus Infections

United States
National Center for Research Resources (NCRR)

Unknown

Identification and Therapy Efficacy of Type 2 Diabetes in Hispanic Patients

Diabetes Mellitus, Non-Insulin-Dependent
Eunice Kennedy Shriver National Institute of Child...

Completed

Evaluating Muscle Function After Ankle Surgery

Muscle Weakness | Muscle Atrophy | Fractures

United States
Triangle Pharmaceuticals

Unknown

A Comparison of Emtricitabine and Stavudine Used With Didanosine Plus Efavirenz in HIV-Infected Patients Who Have Not Taken Anti-HIV Drugs

HIV Infections

United States, Puerto Rico, Canada, Argentina, Chile, Mexico
Sandoz

Completed

An Open Label Phase I Study of Subcutaneously Administered Recombinant Human GM-CSF in Patients With AIDS Virus Infection and Leukopenia

HIV Infections | Cytopenias

United States
Eunice Kennedy Shriver National Institute of Child...

Unknown

Treadmill Training With Body Weight Support in Patients With Spinal Cord Injury

Spinal Cord Injury

United States
Eunice Kennedy Shriver National Institute of Child...

Unknown

Preventing Osteoporosis in Adolescent Girls

Osteoporosis

United States
Eunice Kennedy Shriver National Institute of Child...

Unknown

Preventing Learning Problems in Young Children: A Public Health and Physician-Based Outreach

Developmental Disabilities | Language Development Disorders

United States
Eunice Kennedy Shriver National Institute of Child...
Yale University

Terminated

Longitudinal and Biological Study of Childhood Disintegrative Disorder

Autism | Pervasive Child Development Disorders

United States
Eunice Kennedy Shriver National Institute of Child...

Completed

Preventing Problem Behavior Among Middle School Students

Health Promotion | Substance Use Disorders
National Institute of Allergy and Infectious Diseases...

Completed

A Phase I Safety and Immunogenicity Trial of UBI HIV Lipopeptide Vaccine Component P3C541b in HIV-1 Seronegative Human Subjects

HIV Infections

United States
Eunice Kennedy Shriver National Institute of Child...

Unknown

Delaying Sexual Activity in African American Adolescent Girls

Adolescent Behavior | Sex Behavior

United States
Eunice Kennedy Shriver National Institute of Child...

Unknown

The "Reach For Health" Program: Delaying Sexual Activity in Children

Child Behavior | Sex Behavior

United States
Hoffmann-La Roche

Completed

A Randomized, Double-Blind Study of the Efficacy and Safety of Oral Ganciclovir for the Prevention of CMV Disease in People Infected With the Human Immunodeficiency Virus

HIV Infections | Cytomegalovirus Infections

United States
National Center for Research Resources (NCRR)
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Completed

Establishment of a Database for Long-Term Monitoring of Patients With Nephropathic Cystinosis

Cystinosis

United States
Pfizer

Completed

A Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal Meningitis

HIV Infections | Meningitis, Cryptococcal

United States, Canada
Wageningen Centre for Food Sciences

Completed

Effect of Phosphatidylcholine on Plasma Homocysteine in Healthy Volunteers

Cardiovascular Diseases | Healthy

Netherlands
Biocodex

Completed

Treatment of Patients With Human Immunodeficiency Virus (HIV)-Related Chronic Diarrhea With Saccharomyces Boulardii or Placebo: A Double Blind Trial

HIV Infections | Diarrhea

United States
Eunice Kennedy Shriver National Institute of Child...

Completed

Atypical Neuroleptic Drugs in People With Mental Retardation/Developmental Delay

Mental Retardation | Developmental Delay Disorder

United States
Eunice Kennedy Shriver National Institute of Child...

Unknown

Self-Injury: Diagnosis and Treatment

Self-Injurious Behavior | Mental Retardation

United States
Eunice Kennedy Shriver National Institute of Child...

Completed

Prenatal Testing: Amniocentesis Versus Transabdominal Chorionic Villus Sampling (TA CVS)

Pregnancy
Genentech, Inc.

Completed

A Phase I Study of Recombinant Human CD4 Immunoglobulin G (rCD4-lgG) in Patients With HIV-Associated Immune Thrombocytopenic Purpura

HIV Infections | Immune Thrombocytopenic Purpura ( ITP )

United States
Eunice Kennedy Shriver National Institute of Child...

Completed

How Shoes With Rocker Soles Affect Walking

Diabetic Feet

United States
Eunice Kennedy Shriver National Institute of Child...
National Institute on Deafness and Other Communication Disorders (NIDCD)

Completed

Secretin for the Treatment of Autism

Autism

United States
National Institute of Allergy and Infectious Diseases...
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

Neurodevelopmental and Neurological Study of Infants and Children With HIV-1 Infection and AIDS in Clinical Trials

HIV Infections

United States
National Institute of Allergy and Infectious Diseases...
United Biomedical

Completed

A Phase I Safety and Immunogenicity Trial of UBI Microparticulate Monovalent HIV-1 MN Peptide Immunogen in HIV-1 Seronegative Human Subjects

HIV Infections

United States
Sandoz

Completed

A Pilot Trial Evaluating an Alternating Schedule of Recombinant Human GM-CSF and Azidothymidine in Patients With HIV Infection and Leukopenia

HIV Infections | Cytopenias

United States
Glaxo Wellcome

Completed

A Pilot Study To Evaluate the Effect of Retrovir (Zidovudine: AZT) in the Treatment of Human Immunodeficiency Virus (HIV) Associated Dementia and Neuromuscular Diseases

HIV Infections | Neuromuscular Diseases | AIDS Dementia Complex

United States
Schering-Plough

Completed

Safety and Effectiveness of PEG-Intron in HIV-Infected Patients

HIV Infections

United States, Puerto Rico
National Center for Research Resources (NCRR)
Juvenile Diabetes Research Foundation

Unknown

Modification of the "Edmonton Protocol" to Allow for Successful Islet Transplantation From a Single Pancreas and Extension of the "Edmonton Protocol" to Kidney Transplant Recipients

Diabetes Mellitus

United States
National Center for Research Resources (NCRR)
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Phase I/II Study of Human Anti-Cytomegalovirus (CMV) Monoclonal Antibody MSL-109 in Newborns With Symptomatic Congenital CMV Infection Without Central Nervous System Disease

Cytomegalovirus Infections
ICOS Corporation
Suntory Pharmaceutical

Terminated

Safety and Efficacy of Recombinant Human Platelet-Activating Factor Acetylhydrolase for the Treatment of Severe Sepsis

Sepsis

United States
Eunice Kennedy Shriver National Institute of Child...

Unknown

Education Program to Promote Female Condom Use

HIV Infections

United States
Eunice Kennedy Shriver National Institute of Child...

Completed

Improving Gait in Patients With Spinal Cord Injuries

Spinal Cord Injuries

United States
Lederle Laboratories

Completed

An Open-Label, Crossover Study to Assess the Effect of Food on the Oral Bioavailability and Pharmacokinetic Profile of 3'-Deoxy-3'-Fluorothymidine (FLT) in Asymptomatic Human Immunodeficiency Virus (HIV)-Infected Subjects

HIV Infections

United States
Eunice Kennedy Shriver National Institute of Child...

Unknown

Bone Development in Adolescent Girls: Effects of Calcium and Exercise

Osteoporosis

United States
Sandoz

Completed

A Pilot Study to Evaluate the Effects of Subcutaneously Administered Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor in Pediatric HIV-Infected Patients With Neutropenia Secondary to Azidothymidine

HIV Infections | Cytopenias

United States
Eunice Kennedy Shriver National Institute of Child...

Unknown

Increased Access to Emergency Contraceptive Pills

Sexually Transmitted Diseases | Pregnancy

United States
Glaxo Wellcome

Completed

Treatment and Suppression of Hairy Leukoplakia in ARC Patients With Oral Acyclovir (ACV)

HIV Infections | Leukoplakia, Hairy

United States
Eunice Kennedy Shriver National Institute of Child...

Unknown

Prosthetic Limbs After Leg Amputation: Alternative Method of Socket Design

Amputation

United States
Pfizer

Completed

A Comparison of Fluconazole and Amphotericin B in the Treatment of Cryptococcal Meningitis

HIV Infections | Meningitis, Cryptococcal

United States, Canada
Research Institute for Genetic and Human Therapy

Completed

Safety and Effectiveness of Combining Hydroxyurea (HU) With Didanosine (ddI) and Stavudine (d4T) for Treatment of HIV-Infected Adults

HIV Infections

United States
Hoffmann-La Roche

Completed

An Open-Label, Multicenter Study to Evaluate the Safety and Tolerability of Dideoxycytidine (ddC) in Patients With AIDS or Advanced ARC Who Previously Demonstrated Intolerance to Zidovudine (AZT) in Protocol N3300 or N3492

HIV Infections

United States

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