- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00002305
A Comparison of Fluconazole and Amphotericin B in the Treatment of Cryptococcal Meningitis
Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal Meningitis
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Phase
- Not Applicable
Contacts and Locations
Study Locations
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Ontario
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Toronto, Ontario, Canada
- Saint Michael's Hosp
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Alabama
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Birmingham, Alabama, United States, 35294
- Univ of Alabama at Birmingham
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Arizona
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Tucson, Arizona, United States, 85724
- Tucson Veterans Administration Med Ctr
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California
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Los Angeles, California, United States, 90095
- UCLA CARE Ctr
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San Francisco, California, United States, 94115
- Dr Shelly Gordon
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San Francisco, California, United States, 94120
- Dr Martin Mass
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Sherman Oaks, California, United States, 91403
- Dr Paul Rothman
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Delaware
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Wilmington, Delaware, United States, 19899
- Christiana Hosp / Med Ctr of Delaware
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District of Columbia
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Washington, District of Columbia, United States, 20037
- George Washington Univ Med Ctr
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Florida
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Miami, Florida, United States, 331361013
- Univ of Miami School of Medicine
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Tampa, Florida, United States, 33612
- Univ of South Florida
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Georgia
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Atlanta, Georgia, United States, 30303
- Emory Univ School of Medicine
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Augusta, Georgia, United States, 30912
- Med College of Georgia
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Decatur, Georgia, United States, 30033
- DeKalb Gen Hosp
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Illinois
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Chicago, Illinois, United States, 60611
- Northwestern Univ Med School
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Louisiana
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New Orleans, Louisiana, United States, 70112
- Tulane Univ School of Medicine
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New Orleans, Louisiana, United States, 70112
- Louisiana State Univ School of Medicine
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Maine
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Portland, Maine, United States, 04102
- Dr Michael Bach
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Maryland
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Baltimore, Maryland, United States, 212011192
- Univ of Maryland / Inst of Human Virology
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Baltimore, Maryland, United States, 21218
- Loch Raven Veterans Hosp
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Massachusetts
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Boston, Massachusetts, United States, 02111
- New England Med Ctr
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Boston, Massachusetts, United States, 02118
- Univ Hosp
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Michigan
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Ann Arbor, Michigan, United States, 48105
- Ann Arbor Veterans Administration Med Ctr
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Detroit, Michigan, United States, 48202
- Henry Ford Hosp
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Detroit, Michigan, United States, 48201
- Harper Hosp
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Missouri
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St. Louis, Missouri, United States, 63108
- Washington Univ School of Medicine
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New York
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Albany, New York, United States, 12203
- Albany Med College / AIDS Treatment Ctr
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Bronx, New York, United States, 10467
- Montefiore Med Ctr / Bronx Municipal Hosp
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Bronx, New York, United States, 10468
- Bronx Veterans Administration / Mount Sinai Hosp
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Jamaica, New York, United States, 11432
- Jewish Hosp Ctr Affiliation
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New York, New York, United States, 10021
- Mem Sloan - Kettering Cancer Ctr
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New York, New York, United States, 10025
- Saint Luke's - Roosevelt Hosp Ctr
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New York, New York, United States, 10037
- Harlem AIDS Treatment Group / Harlem Hosp Ctr
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New York, New York, United States, 10014
- Chelsea Village Med Ctr
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New York, New York, United States, 10032
- Columbia Univ
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North Carolina
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Chapel Hill, North Carolina, United States, 275997215
- Univ of North Carolina School of Medicine
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Ohio
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Cincinnati, Ohio, United States, 452670405
- Cincinnati Veterans Adm Med Ctr / Univ Hosp
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Columbus, Ohio, United States, 43210
- Ohio State Univ Hosp
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Tennessee
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Memphis, Tennessee, United States, 38163
- Univ of Tennessee
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Texas
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Dallas, Texas, United States, 75235
- Dr Daniel Barbaro
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Galveston, Texas, United States, 77550
- Univ TX Galveston Med Branch
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Lackland Air Force Base, Texas, United States, 782365300
- United States Air Force Med Ctr
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San Antonio, Texas, United States, 78284
- Univ TX San Antonio Health Science Ctr
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Virginia
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Richmond, Virginia, United States, 23219
- Richmond AIDS Consortium
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Washington
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Seattle, Washington, United States, 98112
- CHG-118 Group Health / Cooperative of Puget Sound
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria
Concurrent Medication:
Allowed:
- Immunosuppressant therapy.
- Antiviral therapy such as zidovudine.
- Prophylaxis for Pneumocystis carinii pneumonia.
Concurrent Treatment:
Allowed:
- Radiation therapy for mucocutaneous Kaposi's sarcoma.
Written informed consent must be obtained for each patient, either from the patient himself or from the patient's legal guardian.
- No prior systemic antifungal therapy for cryptococcosis.
- Relapse after prior therapy.
- Success of prior therapy must have been documented by negative cerebrospinal fluid (CSF) culture at the end of therapy. Following prior therapy, such patients may not have received more than 1 mg/kg/wk amphotericin B in the 4 weeks before entry into study.
Prior Medication:
Allowed:
- Immunosuppressant therapy.
- Antiviral therapy (such as zidovudine).
- Prophylaxis for Pneumocystis carinii pneumonia.
Exclusion Criteria
Co-existing Condition:
Patients with the following are excluded:
- Evidence of acute or chronic meningitis based upon any etiology other than cryptococcosis.
- History of allergy to or intolerance of imidazoles, azoles, or amphotericin B.
- Moderate or severe liver disease.
- Comatose.
- Unlikely to survive more than 2 weeks.
- Any exceptions to these prohibitions of concomitant medications must be approved by Pfizer Central Research.
Concurrent Medication:
Excluded:
- Coumadin-type anticoagulants.
- Oral hypoglycemics.
- Barbiturates.
- Phenytoin.
- Immunostimulants.
- Investigational drugs or approved (licensed) drugs for investigational indications.
- Any exceptions to these prohibitions of concomitant medications must be approved by Pfizer Central Research.
- Excluded within 4 weeks of study entry:
- Greater than 1 mg/kg/wk amphotericin B.
Concurrent Treatment:
Excluded:
- Lymphocyte replacement.
Patients with the following are excluded:
- Evidence of acute or chronic meningitis based upon any etiology other than cryptococcosis.
- History of allergy to or intolerance of imidazoles, azoles, or amphotericin B.
- Moderate or severe liver disease.
- Comatose.
- Unlikely to survive more than 2 weeks.
Prior Medication:
Excluded:
- Coumadin-type anticoagulants.
- Oral hypoglycemics.
- Barbiturates.
- Phenytoin.
- Immunostimulants.
- Investigational drugs or approved (licensed) drugs for investigational indications.
- Excluded within 4 weeks of study entry:
- Greater than 1 mg/kg/wk amphotericin B.
Prior Treatment:
Excluded:
- Lymphocyte replacement.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
Collaborators and Investigators
Sponsor
Study record dates
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
- Central Nervous System Diseases
- Nervous System Diseases
- Infections
- Central Nervous System Infections
- Bacterial Infections and Mycoses
- Mycoses
- Meningitis, Fungal
- Central Nervous System Fungal Infections
- Cryptococcosis
- Meningitis
- Meningitis, Cryptococcal
- Physiological Effects of Drugs
- Molecular Mechanisms of Pharmacological Action
- Anti-Infective Agents
- Enzyme Inhibitors
- Antimetabolites
- Hormones, Hormone Substitutes, and Hormone Antagonists
- Anti-Bacterial Agents
- Cytochrome P-450 Enzyme Inhibitors
- Hormone Antagonists
- Antifungal Agents
- Steroid Synthesis Inhibitors
- Antiprotozoal Agents
- Antiparasitic Agents
- Amebicides
- 14-alpha Demethylase Inhibitors
- Cytochrome P-450 CYP2C9 Inhibitors
- Cytochrome P-450 CYP2C19 Inhibitors
- Fluconazole
- Flucytosine
- Amphotericin B
- Liposomal amphotericin B
Other Study ID Numbers
- 012F
- 056-159
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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