Search clinical trials for: Dose Limited Toxicity

Total 26794 results

Novartis
Novartis Vaccines

Completed

Safety and Immunogenicity of Two Doses, Administered Three Weeks Apart, of Two(Surface Antigen Adjuvanted With MF59C.1) Influenza Vaccines in Non-Elderly Adult and Elderly Subjects

Pandemic Influenza Disease

Italy
Groupe Francophone des Myelodysplasies

Unknown

Bortezomib and Low Dose Cytarabine in the Treatment of High-Risk Myelodysplastic Syndromes

Myelodysplastic Syndromes

France
National Center for Complementary and Integrative...
National Institute of General Medical Sciences (NIGMS); Office of Dietary Supplements...

Completed

Single-Dose Study of Black Cohosh and Red Clover

Menopause
McGill University
McGill University Health Centre/Research Institute of the McGill University...

Unknown

Study Combining Zevalin With High-Dose Chemotherapy Prior to Autologous StemCell Transplant in Patients With Relapsed, Refractory, or Transformed Non-Hodgkin's Lymphoma (Zevalin)

Non-Hodgkin's Lymphoma

Canada
Azienda Ospedaliera San Giovanni Battista
Hoffmann-La Roche; University of Turin, Italy; Gruppo Italiano Trapianto di Midollo... and other collaborators

Unknown

Comparison of High-Dose Chemotherapy + Rituximab and CHOP + Rituximab in High-Risk Follicular Lymphoma

Follicular Lymphoma

Italy
Heidelberg University
Dietmar Hopp Stiftung; Prof. Wolfgang Stremmel

Completed

Dose Finding Study for Retarded Phosphatidylcholine in Pancolitis

Ulcerative Colitis

Germany
Università Politecnica delle Marche

Unknown

High Dose Intravenous N-Acetylcysteine Versus Iloprost for Early, Rapidly Progressive Diffuse Systemic Sclerosis

Scleroderma, Diffuse

Italy
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study Evaluating Sirolimus and Cyclosporine in Kidney Transplant Recipients

Renal Transplantation
Eli Lilly and Company

Completed

Efficacy of High Dose Olanzapine for the Treatment of Schizophrenia and Schizoaffective Disorder

Schizophrenia | Schizoaffective Disorder

United States
Eli Lilly and Company

Completed

Study Comparing Short Infusion Vs. Fixed Dose of Cisplatin + Gemcitabine in Non Small Cell Lung Cancer.

Non-Small-Cell Lung Carcinoma

Argentina, Brazil, Chile, Mexico
Eli Lilly and Company

Completed

A Comparison of Tolerability and Efficacy of Different Doses of Duloxetine for the Treatment of Major Depressive Disorder

Depressive Disorder

United States
Eli Lilly and Company
Aventis Pharmaceuticals

Completed

A Randomized Study Evaluating the Feasibility and Activity of Three Different Combination With Gemcitabine as First Line Therapy for Non Small Cell Lung Cancer

Carcinoma, Non-Small-Cell Lung

Italy
QDose Limited

Unknown

Investigating the Pharmacokinetics and Pharmacodynamics of Recombinant Human Insulin Administered by Dry Powder Inhaler

Diabetes Mellitus

United States
BZL Biologics

Completed

Phase II Trial of Monoclonal Antibody (J591) in Combination With Low-Dose Subcutaneous Interleukin-2

Prostatic Neoplasms

United States
Japan Clinical Oncology Group
Ministry of Health, Labour and Welfare, Japan

Terminated

Study of Standard CHOP Versus Biweekly CHOP in Aggressive Non-Hodgkin's Lymphoma (JCOG9809)

Non-Hodgkin's Lymphoma

Japan
National Cancer Center, Korea

Completed

Early Low Dose Steroid Therapy of Acute Respiratory Distress Syndrome

Postoperative Complications | Acute Respiratory Distress Syndrome | Acute Lung Injury

Korea, Republic of
Eyetech Pharmaceuticals
Pfizer

Terminated

A Clinical Trial to Explore the Safety and Efficacy of Three Different Doses of Pegaptanib Sodium in Patients With Wet Age-Related Macular Degeneration (AMD)

Macular Degeneration

United States
Istituto Clinico Humanitas
Lega Italiana per la Lotta contro i Tumori

Terminated

The DANTE Trial. A Randomized Study on Lung Cancer Screening With Low-Dose Spiral Computed Tomography

Lung Cancer

Italy
National Institute of Arthritis and Musculoskeletal...

Terminated

Low-Dose Hormone Replacement Therapy and Alendronate for Osteoporosis

Osteoporosis | Osteopenia

United States
Nordic Myeloma Study Group
Nordic Cancer Union

Completed

Pamidronate Prophylaxis in Multiple Myeloma 30 mg/Month Versus 90 mg/Month

Multiple Myeloma

Denmark, Norway, Sweden
Epicentre
University of Oslo; Norwegian Institute of Public Health; Medecins Sans Frontieres...

Completed

Fractional Dose Tetravalent A, C, Y, W135 Meningococcal Polysaccharide Vaccine

Infections, Meningococcal | Meningitis, Meningococcic

Norway, Uganda
Pfizer

Completed

Safety, Toleration and Pharmacokinetics of Single Intravenous Doses of Peptide YY in Overweight Adults

Obesity

United States
Protalix

Completed

Phase I Single Dose-Escalation Safety Study of Human Glucocerebrosidase (prGCD)

Gaucher Disease
University of Turku
Hoffmann-La Roche

Unknown

Safety and Efficacy Study of Intravenous Loading Dose of Ibandronate in Breast Cancer Patients

Breast Cancer

Finland
Seoul National University Hospital

Completed

RECOVER:Comparison of Renal Toxicity Between Visipaque(Iodixanol)and Hexabrix(Ioxaglate)in Renal Insufficiency Undergoing Coronary Angiography

Kidney Failure

Korea, Republic of
Steno Diabetes Center Copenhagen

Completed

Maximal Dose of Angiotensin Converting Enzyme (ACE) Inhibitor for Treatment of Diabetic Kidney Disease

Diabetic Nephropathy | Diabetes Mellitus, Type I

Denmark
National Institute of Cancerología

Unknown

DHPLC Determination of TPMT Polymorphisms.

Acute Lymphoblastic Leukemia

Mexico
Denver Health and Hospital Authority
McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Completed

Effects of Therapeutic Doses of Acetaminophen in Moderate Drinkers

Moderate Alcohol Consumption (1-3 Drinks Per Day)
Novalar Pharmaceuticals, Inc.

Completed

Study of NV-101 for Efficacy, Pharmacodynamics, and Safety in Dental Patients Undergoing Maxillary Procedures

Anesthesia, Dental

United States
Assistance Publique - Hôpitaux de Paris
Danone Institute International

Terminated

Effects of Peptides Derived From Fermented Milk on Blood Pressure Regulation System in Healthy Volunteers.

Healthy

France
AGO Study Group

Completed

Randomized, Multicenter, 2-Dose Level. Open-Label, Phase IIa Study With the Intraperitoneally Infused Trifunctional Bispecific Antibody Removab(TM) (Anti-EpCAM x Anti-CD3) to Select the Better Dose Level in Platinum Refractory Epithelial Ovarian Cancer Patients

Fallopian Tube Neoplasms | Peritoneal Neoplasms | Ovarian Cancer

Germany
Kos Pharmaceuticals

Completed

The Dose Response of Niacin ER/Lovastatin on Peak Walking Time (PWT) in Patients With Intermittent Claudication - TROPIC

Intermittent Claudication | Peripheral Vascular Disease

United States
Novacea

Unknown

Study of High-Dose Pulse Administration DN-101 (Calcitriol) in Patients With Myelodysplastic Syndrome (MDS)

Myelodysplastic Syndrome

United States
Kos Pharmaceuticals

Completed

Safety & Efficacy of a Combination Niacin ER/Simvastatin in Patients With Dyslipidemia: A Dose-Ranging Study - SEACOAST

Hypercholesterolemia
Assistance Publique - Hôpitaux de Paris

Terminated

Analgesic Effect in Children of Low-Dose Ketamine for Mucositis Treated by Patient-Controlled Analgesia With Morphine

Cancer | Mucositis

France
Hospital Clinic of Barcelona

Completed

Study Comparing Reducing the Dose of Stavudine Versus Switching to Tenofovir in HIV-Infected Patients Receiving Antiretroviral Therapy

HIV Infections | Lipoatrophy
University of Padova

Completed

The ERASMUS Study: Limited vs Extended US for DVT Diagnosis

Deep Vein Thrombosis of the Lower Extremities
Chang Gung Memorial Hospital

Completed

Long-Term Lead Chelation Therapy and Progressive Renal Insufficiency

Urologic Disease

China
Angiogenix

Unknown

Efficacy Study of Oral L-Citrulline in Patients Taking Simvastatin With Peripheral Arterial Disease

Peripheral Arterial Disease | Intermittent Claudication

Russian Federation
Washington University School of Medicine

Terminated

Single Dose Thymoglobulin for Induction in Adult Renal Allograft Recipients

Kidney Transplantation

United States
Novartis

Completed

Safety and Efficacy of Lumiracoxib Versus Naproxen in Acute Musculoskeletal Pain

Musculoskeletal Pain

United Kingdom
University Health Network, Toronto

Unknown

Proper Dosage of Ketamine in Intravenous Regional Anesthesia

Pain.

Canada
Odense University Hospital

Unknown

Insulin NovoRapid Versus Actrapid in Treatment of Type 1 Diabetic Patients During Daily Adjustment of Insulin Dose

Type 1 Diabetes Mellitus

Denmark
Eisai Limited

Completed

An Open Label Phase II Study of Indisulam in Combination With Irinotecan in Patients With Metastatic Colorectal Cancer Who Have Been Previously Treated With 5-Fluorouracil/Leucovorin and Oxaliplatin

Colorectal Cancer

United Kingdom, France
GlaxoSmithKline

Completed

Comparison of Adjuvanted Hepatitis B Vaccine to Double Dose of Engerix™-B in Pre- /Haemodialysis Patients Aged ≥15 Years

Hepatitis B

Czech Republic, Malaysia, Spain
MedImmune LLC
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Trial to Compare the Safety, Tolerability, Immunogenicity and Efficacy of Three Dose Levels of a Liquid Formulation of Influenza Virus Vaccine, (CAIV-T) in Healthy Children

Healthy

Philippines, Thailand
Johann Wolfgang Goethe University Hospital

Completed

Fish Oil and Asthma in House Dust Mite Allergy

Allergic Asthma | House Dust Mite Allergy | Bronchial Inflammation
elbion AG

Terminated

ELB139 Given Orally to Patients With Concurrent Panic Disorder, Challenged by CO2 Inhalation After a Single Dose and One Week of Treatment

Panic Disorder

Germany, Netherlands
Mednax Center for Research, Education, Quality...

Completed

Dose Comparison of Amino Acids on Growth in Premature Neonates

Malnutrition

United States
The Alvin and Lois Lapidus Cancer Institute
Ortho Biotech Products, L.P.

Unknown

A Dose Study of Doxil in a Dose Dense, 14 Day CDOP/Rituximab Regimen for Patients With Diffuse Large B-Cell Non-Hodgkin Lymphoma (NHL)> 60 Years or With Compromised Cardiac Status.

Lymphoma, Non-Hodgkin | Diffuse Large B Cell Lymphoma

United States

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