Search clinical trials for: SPL-01-001

Total 30240 results

Sanofi
Regeneron Pharmaceuticals

Completed

Efficacy and Safety of Alirocumab Versus Placebo on Top of Maximally Tolerated Lipid Lowering Therapy in Patients With Hypercholesterolemia Who Have Type 1 or Type 2 Diabetes and Are Treated With Insulin (ODYSSEY DM - Insulin)

Hypercholesterolaemia

Belgium, Spain, Germany, Austria, Italy, United States, France, Netherlands, Switzerland, United Kingdom
Bristol-Myers Squibb

Completed

Study of Belatacept in Subjects Who Are Undergoing a Renal Transplant (BENEFIT-EXT)

Renal Transplantation

United States, Argentina, Germany, Italy, Chile, Spain, Brazil, Sweden, Belgium, France, Hungary, Australia, South Africa, Austria, Canada, United Kingdom, Poland, Czechia, Norway
Sanofi

Completed

Long Term Safety and Efficacy Study of Teriflunomide 7 mg or 14 mg in Patients With Relapsing-Remitting Multiple Sclerosis

Multiple Sclerosis

United States, Austria, Canada, Chile, Czech Republic, Denmark, Estonia, Finland, France, Germany, Italy, Netherlands, Norway, Poland, Portugal, Russian Federation, Sweden, Switzerland, Turkey, Ukraine, United Kingdom
Children's Cancer and Leukaemia Group

Unknown

Pharmacokinetics of Dactinomycin in Young Patients With Cancer

Unspecified Childhood Solid Tumor, Protocol Specific

Ireland, United Kingdom
University Hospital Birmingham
Wyeth is now a wholly owned subsidiary of Pfizer

Unknown

Remission Induction in Very Early Rheumatoid Arthritis (RIVERA)

Rheumatoid Arthritis

United Kingdom
National Institute of Diabetes and Digestive and...

Completed

Entecavir/Pegylated Interferon in Immune Tolerant Children With Chronic Hepatitis B Virus (HBV) Infection

Hepatitis B

United States, Canada
Cancer Research UK

Terminated

Carboplatin With or Without Decitabine in Treating Patients With Progressive, Advanced Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer

Ovarian Cancer | Fallopian Tube Cancer | Peritoneal Cavity Cancer

United Kingdom
Cancer Research UK

Completed

Capecitabine and Oxaliplatin or Standard Follow-Up Care in Treating Patients Who Have Undergone Surgery for Locally Advanced Rectal Cancer

Colorectal Cancer

United Kingdom
Göteborg University

Completed

Polycystic Ovary Syndrome (PCOS) - Effect Of Physical Exercise And Electroacupuncture (PCOSNTS)

Polycystic Ovary Syndrome

Sweden
Celgene

Completed

A Phase 3, Multicenter, Randomized, Open-Label Study to Compare the Efficacy and Safety of Pomalidomide in Combination With Low-Dose Dexamethasone Versus High-Dose Dexamethasone in Subjects With Refractory Multiple Myeloma or Relapsed and Refractory Multiple Myeloma and Companion Study (NIMBUS)

Multiple Myeloma

United States, Netherlands, Canada, Belgium, United Kingdom, Australia, Denmark, Germany, Spain, Switzerland, France, Italy, Greece, Russian Federation, Sweden, Czechia
National Cancer Institute (NCI)

Active, not recruiting

Testing Atezolizumab Alone or Atezolizumab Plus Bevacizumab in People With Advanced Alveolar Soft Part Sarcoma

Metastatic Alveolar Soft Part Sarcoma | Unresectable Alveolar Soft Part Sarcoma

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Atezolizumab With Chemotherapy in Treating Patients With Anaplastic or Poorly Differentiated Thyroid Cancer

Poorly Differentiated Thyroid Gland Carcinoma | Thyroid Gland Anaplastic Carcinoma | Unresectable Thyroid Gland Carcinoma | Metastatic Thyroid Gland Carcinoma | Stage IVB Thyroid Gland Anaplastic Carcinoma AJCC v8 | Stage IVC Thyroid Gland Anaplastic Carcinoma AJCC v8 | Stage IVA Thyroid Gland...

United States
National Cancer Institute (NCI)

Active, not recruiting

Octreotide Acetate and Recombinant Interferon Alfa-2b or Bevacizumab in Treating Patients With Metastatic or Locally Advanced, High-Risk Neuroendocrine Tumor

Neuroendocrine Tumor | Neuroendocrine Neoplasm | Colorectal Neuroendocrine Tumor G1 | Gastric Neuroendocrine Tumor G1 | Neuroendocrine Tumor G2

United States
Pfizer

Completed

20-valent Pneumococcal Conjugate Vaccine Safety and Immunogenicity Study of a 3-Dose Series in Healthy Infants

Pneumococcal Disease

Denmark, Belgium, Australia, Poland, Norway, Finland, Netherlands, Italy, Czechia, Estonia, Russian Federation, Slovakia
Merck Sharp & Dohme LLC

Completed

A Study to Evaluate the Efficacy and Safety of Gefapixant (MK-7264) in Women With Endometriosis-Related Pain (MK-7264-034)

Endometriosis-related Pain

United States, Australia, Chile, New Zealand, Poland, Puerto Rico, Russian Federation, Spain, Ukraine
University of Wisconsin, Madison
National Institute on Drug Abuse (NIDA)

Not yet recruiting

Testing STAR and TexSTAR: A Video and Text Messaging Intervention

Posttraumatic Stress Disorder | Sexual Violence | Opioid Use | Opioid Misuse

United States
University of Wisconsin, Madison
National Institutes of Health (NIH); National Institute on Aging (NIA)

Recruiting

Rapalog Pharmacology (RAP PAC) Study

Aging

United States
Presage Biosciences
Merck Sharp & Dohme LLC

Recruiting

Phase 0 Master Protocol for CIVO Intratumoral Microdosing of Anti-Cancer Therapies

Solid Tumor

United States
University of Wisconsin, Madison
National Institute on Aging (NIA)

Recruiting

Interventions for Postoperative Delirium: Biomarker-3 (IPOD-B3)

Delirium

United States
University of Wisconsin, Madison
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

ReSET Aim 1a: Restarting Safe Education and Testing for Children With Medical Complexity - Feasibility of In-home Cohort COVID-19 Testing Strategies, and Associations With CMC Parent Perceptions About In-person School Attendance

COVID-19 | Children With Medical Complexity (CMC)

United States
University of Wisconsin, Madison
Johns Hopkins University; University of Colorado, Denver; Northwestern University and other collaborators

Active, not recruiting

A Communication Tool to Assist Older Adults Facing Dialysis Choices

Kidney Diseases | Kidney Failure, Chronic | Communication | End-Stage Renal Disease | Palliative Care | End of Life | Dialysis | Renal Dialysis | Decision Making | Decision Aid | Decision Support Techniques | Nephrologists | Late-Stage Renal Disease | Life-Supporting Treatments

United States
Rutgers, The State University of New Jersey
National Cancer Institute (NCI); Memorial Sloan Kettering Cancer Center; Columbia... and other collaborators

Completed

Facilitating Parent Adaptation to Pediatric Transplant: The P-SCIP Trial (P-SCIP)

Childhood Cancers

United States
University of Wisconsin, Madison
Agency for Healthcare Research and Quality (AHRQ)

Recruiting

Cognitive Behavioral and Faith Fellowship to Improve Thy Health (CB-FAITH)

Depression

United States
Augusta University
University of Wisconsin, Madison; Agency for Healthcare Research and Quality... and other collaborators

Recruiting

Video-based Collaborative Learning to Improve Ventral Hernia Repair

Ventral Hernia

United States
University of Wisconsin, Madison
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

ReSET Aim 1b: Restarting Safe Education and Testing for Children With Medical Complexity - COVID-19 Testing in School With Children and Staff

COVID-19 | Children With Medical Complexity (CMC)

United States
Universiti Kebangsaan Malaysia Medical Centre
Institue of Microengineering and Nanoelectronics (IMEN), Universiti Kebangsaan... and other collaborators

Completed

Efficacy of Transdermal Microneedle Patch for Topical Anesthesia Enhancement in Paediatric Thalassemia Patients

Thalassemia in Children

Malaysia
University of Wisconsin, Madison
National Institute on Drug Abuse (NIDA)

Completed

ART-CHESS: A Mobile Health Application to Support People Living With HIV and Addiction

HIV/AIDS | Substance Use Disorders

United States
University of Wisconsin, Madison
National Center for Advancing Translational Sciences (NCATS)

Completed

Improving Right Ventricular Function in Young Adults Born Preterm

Infant,Premature

United States
Sheffield Teaching Hospitals NHS Foundation Trust
King's College Hospital NHS Trust; Cambridge University Hospitals NHS Foundation... and other collaborators

Completed

The REPOSE (Relative Effectiveness of Pumps Over MDI and Structured Education) Trial (REPOSE)

Type 1 Diabetes

United Kingdom
National Cancer Institute (NCI)

Terminated

Erlotinib Hydrochloride in Treating Patients With Bladder Cancer Undergoing Surgery

Bladder Carcinoma | Recurrent Bladder Carcinoma

United States
National Cancer Institute (NCI)

Completed

Combination Chemotherapy in Treating Patients Who Have Advanced Solid Tumors

Unspecified Adult Solid Tumor, Protocol Specific

United States
UNICANCER

Completed

Positron Emission Tomography Using 3'-Deoxy-3'-(18F) Fluorothymidine in Treating Women With Locally Advanced Cancer in One Breast Who Are Receiving Chemotherapy

Breast Cancer

France
National Cancer Institute (NCI)

Completed

Resveratrol in Healthy Adult Participants

Healthy, no Evidence of Disease

United States
Jonsson Comprehensive Cancer Center

Completed

The Biodistribution of 1-[2 Deoxy-2, -18 Fluroarabinfuranosyl]Cytosine [18FAC] in Healthy Subjects and Patients With Cancer, Autoimmune/Inflammatory Diseases

Inflammation | Cancer

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Not yet recruiting

Implantable Microdevice for the Delivery of Drugs and Their Effect on Tumors in Patients With Metastatic or Recurrent Sarcoma

Metastatic Sarcoma | Resectable Sarcoma | Recurrent Sarcoma

United States
National Cancer Institute (NCI)
NRG Oncology

Active, not recruiting

Paclitaxel and Carboplatin With or Without Bevacizumab in Treating Patients With Stage II, Stage III, or Stage IV Ovarian Epithelial Cancer, Primary Peritoneal Cancer, or Fallopian Tube Cancer

Ovarian Endometrioid Adenocarcinoma | Ovarian Seromucinous Carcinoma | Ovarian Undifferentiated Carcinoma | Ovarian Mucinous Adenocarcinoma | Fallopian Tube Transitional Cell Carcinoma | Ovarian Transitional Cell Carcinoma | Fallopian Tube Endometrioid Adenocarcinoma | Fallopian Tube Mucinous Adenocarcinoma and other conditions

United States, Korea, Republic of, Canada
National Cancer Institute (NCI)

Completed

Gemcitabine Hydrochloride and Cisplatin With or Without Bevacizumab in Treating Patients With Advanced Urinary Tract Cancer

Metastatic Prostate Carcinoma | Metastatic Bladder Urothelial Carcinoma | Metastatic Renal Pelvis Urothelial Carcinoma | Metastatic Ureter Urothelial Carcinoma | Metastatic Urethral Urothelial Carcinoma | Metastatic Urothelial Carcinoma | Stage IV Bladder Urothelial Carcinoma AJCC v7 | Stage IV Renal... and other conditions

United States, Puerto Rico
National Cancer Institute (NCI)

Completed

Temozolomide and Irinotecan Hydrochloride With or Without Bevacizumab in Treating Young Patients With Recurrent or Refractory Medulloblastoma or CNS Primitive Neuroectodermal Tumors

Pineoblastoma | Recurrent Medulloblastoma | Refractory Medulloblastoma | Refractory Peripheral Primitive Neuroectodermal Tumor | Central Nervous System Neoplasm | Recurrent Primitive Neuroectodermal Tumor

United States, Canada, Puerto Rico, Australia, New Zealand
AM-Pharma
FGK Clinical Research GmbH

Recruiting

Ilofotase Alfa for Prevention of Renal Damage After Cardiac Surgery

Open Heart Surgery

Germany
Medisol Development Kft.
University of Debrecen; St. Borbala Hospital; Pest County Pulmonology Hospital; Medical Centre Hungarian Defence Forces and other collaborators

Active, not recruiting

Breathing Parameter Measurements for Lung Deposition Simulation (CHOICE)

Asthma | COPD

Hungary
National Cancer Institute (NCI)
Inovio Pharmaceuticals

Active, not recruiting

DNA Vaccine Therapy in Treating Patients With Chronic Hepatitis C Virus Infection

Hepatitis C Infection | Chronic Hepatitis

United States, Puerto Rico
University of Wisconsin, Madison
National Heart, Lung, and Blood Institute (NHLBI)

Enrolling by invitation

A Study of Communication Between Clinicians, Patients, and Families in the Intensive Care Unit (ICU) (TIME)

Communication | Palliative Care | Critical Care | Acute Respiratory Failure | Mechanical Ventilation | Decision Making | Life-Supporting Treatments

United States
University of Wisconsin, Madison
National Institute on Drug Abuse (NIDA)

Completed

Smartphone Intervention for Overdose and COVID-19

COVID-19 | Substance Use Disorders | Overdose

United States
University of Wisconsin, Madison
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); C...

Active, not recruiting

AlloSure for the Monitoring of Antibody Mediated Processes After Kidney Transplantation (All-MAP)

Kidney Transplant Failure and Rejection

United States
Sanofi
European Organisation for Research and Treatment of Cancer - EORTC; Alliance... and other collaborators

Terminated

Study of Amcenestrant (SAR439859) Versus Tamoxifen for Patients With Hormone Receptor-positive (HR+) Early Breast Cancer, Who Have Discontinued Adjuvant Aromatase Inhibitor Therapy Due to Treatment-related Toxicity (AMEERA-6)

Breast Cancer

Chile, China
Fluisense ApS
Dantrials Aps

Completed

Clinical Validation of the Fluispotter System for Serial Sampling of Venous Dried Blood Spots

Healthy | Blood Sampling Procedure

Denmark
University of California, San Francisco
Roche Pharma AG

Completed

Valganciclovir to Reduce T Cell Activation in HIV Infection

HIV Infections | Cytomegalovirus Infections

United States
National Cancer Institute (NCI)

Completed

Pomegranate-Extract Pill in Preventing Tumor Growth in Patients With Localized Prostate Cancer Undergoing Active Surveillance

Stage IIA Prostate Cancer AJCC v7 | PSA Level Less Than Ten | Stage I Prostate Cancer AJCC v7 | Stage IIB Prostate Cancer AJCC v7 | Stage II Prostate Cancer AJCC v7 | PSA Level Less Than or Equal to Fifteen

United States
Sidney Kimmel Comprehensive Cancer Center at Johns...
National Cancer Institute (NCI)

Completed

Celecoxib Compared With No Treatment Before Surgery in Treating Patients With Localized Prostate Cancer

Prostate Cancer

United States
Tiziana Marangon

Withdrawn

Vorinostat Plus Lenalidomide and Dexamethasone or Lenalidomide Plus Dexamethasone in Multiple Myeloma Patients Who Experience Biochemical Relapse During Lenalidomide Maintenance Therapy (ZLd_Ld)

Multiple Myeloma

Italy

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