Clinical Trials Sponsored by Klinikum Darmstadt

Total 1311 results

Merck KGaA, Darmstadt, Germany

Completed

Clinical Phase I Study Investigating MSC2490484A, an Inhibitor of a DNA-dependent Protein Kinase, in Advanced Solid Tumors or Chronic Lymphocytic Leukemia

Chronic Lymphocytic Leukemia | Advanced Solid Tumors

Belgium, Netherlands, Denmark
Merck KGaA, Darmstadt, Germany

Terminated

A Pilot Study in Participants With Relapsing Remitting Multiple Sclerosis (RR-MS) (INCREASE)

Multiple Sclerosis, Relapsing-Remitting

Italy
Merck KGaA, Darmstadt, Germany

Completed

TiLE (Time Lapse Eeva) Clinical Trial (TiLE)

Fertility

Denmark, Spain, United Kingdom, Italy, Canada, France, Germany, Norway, Sweden
Merck KGaA, Darmstadt, Germany

Completed

Glucophage Extended Release (GXR) China Bioequivalence Study (Nantong - Darmstadt)

Healthy

China
Merck KGaA, Darmstadt, Germany

Completed

An Open Label Dose Finding Safety and Efficacy in Children and Infants Infected With Schistosomiasis (S.Mansoni)

Schistosomiasis

Germany
Merck KGaA, Darmstadt, Germany

Completed

Effect of Renal Impairment on Evobrutinib Pharmacokinetics (PK)

Renal Impairment

Germany
Merck KGaA, Darmstadt, Germany

Completed

Growth Hormone Treatment for the Prevention of Short Stature in Young Girls With Turner Syndrome Before the Age of 4 Years

Turner's Syndrome

France
Merck KGaA, Darmstadt, Germany

Completed

M7583 Relative Bioavailability of Tablet Compared to Powder-in-capsule

Healthy

Germany
Merck KGaA, Darmstadt, Germany

Completed

Bioequivalence Trial of Liquid Versus Freeze-Dried Pergoveris® in Pituitary Suppressed Healthy Premenopausal Female Subjects

Healthy

Germany
Merck KGaA, Darmstadt, Germany

Completed

Prednisone Timed-Release Tablet (TRT) Study: Modified-Release (MR) Formulation of Prednisone Compared to Standard Immediate-Release (IR) Prednisone in Participants With Rheumatoid Arthritis

Rheumatoid Arthritis

Poland, Germany
Merck KGaA, Darmstadt, Germany

Completed

Predictive Markers in Growth Hormone Deficiency (GHD) and Turner Syndrome (TS) Children Treated With SAIZEN®

Growth Hormone Deficiency | Turner Syndrome

Argentina, Australia, Austria, Canada, France, Germany, Italy, Norway, Russian Federation, Singapore, Spain, Sweden, United Kingdom
Merck KGaA, Darmstadt, Germany

Completed

A Randomised, Phase II, Comparative Study With a Parallel Control for Evaluating the Efficacy and Safety of Combined Treatment of Lutropin Alpha and Recombinant Human Luteinizing Hormone in the Middle of the Controlled Ovarian Stimulation Follicular Phase in Women With Reduced Ovarian Reserve

Infertility | Ovulation Induction

Spain
Merck KGaA, Darmstadt, Germany

Completed

An Open-label Phase 4 Study to Explore Immunogenicity of the Liquid Formulation of Saizen® in Subjects With Adult Growth Hormone Deficiency (AGHD)

Adult Growth Hormone Deficiency

United Kingdom, Germany, Australia, Sweden
Merck KGaA, Darmstadt, Germany

Completed

A Phase 4 Study to Assess the Impact of Patient Support Program on Health Related Quality of Life and Adherence in Subjects With Relapsing-Remitting Multiple Sclerosis Administered Rebif® With the RebiSmart™ Device (RebiQoL)

Multiple Sclerosis | Relapsing-Remitting

Sweden, Germany
Merck KGaA, Darmstadt, Germany

Completed

Oral Bioavailability and Mass Balance Trial With Pimasertib

Locally Advanced or Metastatic Solid Tumors

Hungary
Merck KGaA, Darmstadt, Germany

Completed

Relative Bioavailability Trial of Oral Dispersible Praziquantel Tablets in Healthy Volunteers

Healthy

Germany
Merck KGaA, Darmstadt, Germany

Completed

Cetuximab Combined With Irinotecan in First-line Therapy for Metastatic Colorectal Cancer (CRYSTAL) (CRYSTAL)

Epidermal Growth Factor Receptor (EGFR) Expressing Metastatic Colorectal Cancer

Sweden, Australia, Brazil, Bulgaria, France, Italy, Korea, Republic of, Russian Federation, South Africa, Spain, Turkey, United Kingdom, Germany, Hungary, Poland, Romania, Austria, Belgium, Finland, Netherlands, Slovakia, Greece, Ta... and more
Merck KGaA, Darmstadt, Germany

Terminated

Sprifermin (AS902330) in Cartilage Injury Repair (CIR)

Isolated Cartilage Injury of the Knee

Germany
Merck KGaA, Darmstadt, Germany

Completed

Study of Tecemotide (L-BLP25) in Subjects With Slowly Progressive Multiple Myeloma With no Symptoms and Who Have Had no Chemotherapy

Multiple Myeloma

Germany
Merck KGaA, Darmstadt, Germany

Completed

Safety Study of Tecemotide (L-BLP25) in Non-Small Cell Lung Cancer (NSCLC) Subjects With Unresectable Stage III Disease

Carcinoma, Non-Small-Cell Lung | Lung Neoplasms
Merck KGaA, Darmstadt, Germany

Completed

Cetuximab With Radiotherapy for Locally Advanced Squamous Cell Carcinoma of the Head and Neck in Chinese Subjects (CHANCE)

Squamous Cell Carcinoma of the Head and Neck

China
Merck KGaA, Darmstadt, Germany

Completed

Study to Verify Clinical Utility of Point-of-Care (POC) Thyroid Stimulating Hormone (TSH) Test Kits as Compared to Third Generation TSH Test Kit

Hypothyroidism

China
Merck KGaA, Darmstadt, Germany

Completed

An Observational Study on the Progression of Clinically Isolated Syndrome to Multiple Sclerosis Over a 2-year Period (NEO)

Multiple Sclerosis

Taiwan
Merck KGaA, Darmstadt, Germany

Terminated

RESTORE: Raptiva® (Efalizumab) Evaluation of Safety and Treatment Optimization (RESTORE)

Plaque Psoriasis

Canada
Merck KGaA, Darmstadt, Germany

Completed

Prospective, Post Marketing Surveillance Study On Erbitux® (Cetuximab) in Patients With Locally Advanced or Recurrent and/or Metastatic Squamous Cell Cancer of the Head and Neck in Korea

Head and Neck Cancer

Korea, Republic of
Merck KGaA, Darmstadt, Germany

Completed

Comparative Validation of the Growth Hormone Releasing Hormone and Arginine Test for the Diagnosis of Adult Growth Hormone Deficiency

Growth Hormone Deficiency

France
Merck KGaA, Darmstadt, Germany

Completed

An Observational Study to Evaluate the Efficacy of Lodoz in a Population of Hypertensive Patients (Lodoz OS)

Hypertension

Thailand
Merck KGaA, Darmstadt, Germany

Completed

An Observational Study of Gonal-F Filled by Mass Pens in Multifollicular Stimulation Prior to In-vitro Fertilization (IVF) or Intracytoplasmic Sperm Injection (ICSI)

Multifollicular Stimulation

Korea, Republic of
Merck KGaA, Darmstadt, Germany

Completed

A Study Using Micronised Progesterone (Crinone® 8%) in the Luteal Phase Support of Women Undergoing in Vitro Fertilisation (IVF) and Embryo Transfer (ET)

Infertility

China
Merck KGaA, Darmstadt, Germany

Completed

Rebif Compliance Support Program - Assessing Needs in Multiple Sclerosis (AIMS)

Multiple Sclerosis

United Kingdom
Merck KGaA, Darmstadt, Germany

Completed

Cetuximab (Erbitux) in Combination With Cisplatin or Carboplatin and 5-Fluorouracil in the First Line Treatment of Subjects With Recurrent and/or Metastatic Squamous Cell Carcinoma of the Head and Neck (EXTREME)

Head and Neck Cancer

France, Russian Federation, Spain, United Kingdom, Germany, Hungary, Poland, Ukraine, Austria, Netherlands, Slovakia, Sweden, Switzerland, Belgium, Italy, Portugal, Czech Republic
Merck KGaA, Darmstadt, Germany

Completed

A Prospective, Multi-centric Observational Study to Determine the Mono-bifollicular Development in Infertile Women Subjected to Ovulation Induction With Follitropin α (P450)

Ovulation Induction

Spain
Merck KGaA, Darmstadt, Germany

Completed

A Non-interventional Study to Identify the Patients With Severe Luteinizing Hormone Deficiency in the Daily Practice

Infertility

Germany
Merck KGaA, Darmstadt, Germany

Withdrawn

A Multi-centric Study to Assess the Efficacy of Sigmart in Subjects With Recurrent Angina After Coronary Revascularization (SIGMART)

Angina Pectoris
Merck KGaA, Darmstadt, Germany

Completed

A Multicenter Study of rhFGF 18 in Patients With Knee Osteoarthritis Not Requiring Surgery

Knee Osteoarthritis

Germany, Croatia, Bulgaria, Canada, Finland, Poland, Serbia, South Africa, Sweden
Merck KGaA, Darmstadt, Germany

Terminated

EMD 1201081 + 5-FU + Cisplatin + Cetuximab in Subjects With Recurrent / Metastatic Squamous Cell Carcinoma of the Head and Neck

Squamous Cell Carcinoma of the Head and Neck

France
Merck KGaA, Darmstadt, Germany

Completed

A Post-Marketing Surveillance Study On Erbitux® (Cetuximab) In Patients With Metastatic Colorectal Cancer Refractory To Irinotecan Containing Treatment

Metastatic Colorectal Cancer

Taiwan
Merck KGaA, Darmstadt, Germany

Completed

Trial With Cetuximab in Maintenance Therapy After Platinum Based Chemotherapy in First Line Treatment of Non-small Cell Lung Cancer (NSCLC) (NEXT)

Non-Small Cell Lung Cancer (NSCLC)

Germany
Merck KGaA, Darmstadt, Germany

Completed

Tolerability of Rebif® (Interferon-beta 1-A) Therapy in Korean Patients With Multiple Sclerosis

Multiple Sclerosis

Korea, Republic of
Merck KGaA, Darmstadt, Germany

Completed

CONSORT Randomized Controlled Trial in Assisted Reproductive Technology

Infertility

Switzerland
Merck KGaA, Darmstadt, Germany

Terminated

ChangE From Any Systemic psoriasiS therapY to Raptiva (EASY)

Chronic Plaque Psoriasis

Canada
Merck KGaA, Darmstadt, Germany

Completed

A Study to Evaluate Safety and Efficacy of Recombinant Human Luteinizing Hormone (r-hLH) Compared With Urinary Human Chorionic Gonadotrophin (u-hCG) to Trigger Ovulation in Infertile Women

Infertility

Canada
Merck KGaA, Darmstadt, Germany

Completed

An Observational Study to Evaluate Quality of Life (QoL) and Influence of Cognitive Status on QoL in Patients With Relapsing-Remitting Multiple Sclerosis (RRMS) During 2 Years Treatment With Rebif New Formulation (RNF) (MusiClock)

Multiple Sclerosis, Relapsing-Remitting

Poland
Merck KGaA, Darmstadt, Germany

Completed

Cetuximab in Combination With S-1 and Cisplatin in Gastric Cancer

Gastric Cancer

Germany
Merck KGaA, Darmstadt, Germany

Completed

Correlation Between Multiple Sclerosis Functional Composite (MSFC) and Expanded Disability Status Scale (EDSS) in Patients With Multiple Sclerosis (MS) in Argentina

Multiple Sclerosis

Argentina
LMU Klinikum
German Research Foundation

Recruiting

Insight Into Hippocampal Neuroplasticity in Schizophrenia by Investigating Molecular Pathways During Physical Training (BrainTrain)

Schizophrenia | Exercise | Neuronal Plasticity

Germany
Evangelisches Klinikum Köln Weyertal gGmbH

Recruiting

Early Safety of Resection Recopy and Sacrocolpopexy (RRPSCPcomb)

Urinary Incontinence | Pelvic Organ Prolapse | Constipation by Outlet Obstruction

Germany
Wuerzburg University Hospital
Klinikum Stuttgart

Completed

Surveillance Modified by Artificial Intelligence in Endoscopy (SMARTIE) (SMARTIE)

Artificial Intelligence | Polyps of Colon | Surveillance Endoscopy for Colorectal Cancer | CADe

Germany
Michael Lichtenberg, MD

Completed

Prestige Pilot - Phoenix Atherectomy and Stellarex DCB Clinical Investigation in Infrapopliteal Interventions

Peripheral Artery Disease (PAD)

Germany
SRH Wald-Klinikum Gera GmbH

Completed

Neoadjuvant Vismodegib in Patients With Large and/or Recurrent Resectable Basal Cell Carcinoma (NICCI)

Basal Cell Carcinoma

Germany

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