Search clinical trials for: Locally advanced colorectal cancer

Total 95996 results

Universitätsklinikum Hamburg-Eppendorf
Servier Affaires Médicales; Clinical Trial Center North (CTC North GmbH & Co...

Terminated

Evaluating Trifluridine/Tipiracil Based Chemoradiation in Locally Advanced Rectal Cancer - The Phase I/II TARC Trial

Locally Advanced Rectal Cancer

Germany
Sun Yat-sen University
Guangdong Provincial Hospital of Traditional Chinese Medicine; Guangdong Provincial...

Active, not recruiting

PD-1 Inhibitors Combined With VEGF Inhibitors for Locally Advanced dMMR/MSI-H Colorectal Cancer

Colorectal Cancer | Microsatellite Instability High

China
Sun Yat-sen University
Fudan University; Liaoning Tumor Hospital & Institute

Active, not recruiting

PD-1 Antibody Following Preoperative Chemoradiotherapy for Locally Advanced pMMR/MSS Rectal Cancer

Colorectal Carcinoma

China
Swiss Group for Clinical Cancer Research

Terminated

Neoadjuvant Treatment With Regorafenib and Capecitabine Combined With Radiotherapy in Locally Advanced Rectal Cancer (RECAP)

Rectal Cancer

Switzerland
Genentech, Inc.

Completed

A Study of PRO95780 Administered in Combination With the FOLFOX Regimen and Bevacizumab in Patients With Previously Untreated, Locally Advanced, Recurrent, and Metastatic Colorectal Cancer (APM4566g)

Metastatic Colorectal Cancer
Fundación de investigación HM
Syntax for Science, S.L

Completed

A Study to Evaluate a Chemotherapy Treatment Followed by Chemo and Radiotherapy in Patients With Rectal Cancer

Locally Advanced Rectal Cancer (LARC)

Spain
Centre Francois Baclesse
Accuray Incorporated

Active, not recruiting

Study of SIB-IMRT in Combination With 5-FU and Mitomycin-C Among Patients With Locally Advanced Anal Canal Cancer: Efficacy, Safety and Quality of Life (CANAL-IMRT-01)

Locally Advanced Anal Canal Cancer

France
National Cancer Institute, Egypt

Completed

Prospective Study of Short Course Radiation Therapy Followed by Neoadjuvant Chemotherapy and Surgery in Locally Advanced Rectal Cancer

Locally Advanced Rectal Carcinoma

Egypt
Oslo University Hospital

Active, not recruiting

Computer Navigation-assisted Surgery for Locally Advanced and Recurrent Rectal Cancer (NAVI-LARRC)

Rectal Cancer

Norway
Innovent Biologics (Suzhou) Co. Ltd.

Active, not recruiting

IBI310 in Combination With Sintilimab in Patients With DNA Mismatch Repair Deficient (dMMR)/Microsatellite Instability High (MSI-H) Locally-advanced or Metastatic Colorectal Cancer

Colorectal Cancer

China
Centre Hospitalier Universitaire de Nīmes

Completed

Assessment of Complete Response MRI Criterion After Neoadjuvant Therapy in Locally Advanced Rectal Cancer

Rectal Neoplasms

France
Ipsen

Withdrawn

Study to Assess the Safety and Efficacy of Intravenous Injection of the Imaging Agent 111In-IPN01087 in Patients With Locally Advanced or Metastatic Pancreatic or Colorectal Cancer.

Colorectal Cancer | Pancreatic Ductal Adenocarcinoma

Belgium, France
Hospital San Carlos, Madrid

Completed

"Oncologic Results and Risk Factors for Recurrence in Patients With Locally Advanced Rectal Cancer and Pathologic Complete Response After Neoadjuvant Treatment. Results From an Observational Retrospective Multicenter Long-term Follow-up Study".

Rectal Cancer Stage II | Rectal Cancer Stage III | Rectal Cancer, Adenocarcinoma | Distant Metastasis | Local Recurrence of Malignant Tumor of Rectum

Spain
Medical College of Wisconsin

Withdrawn

Response Assessment by Circulating Tumor DNA in Patients With Locally Advanced Rectal Cancer

Rectal Cancer

United States
Nektar Therapeutics

Terminated

A Study of NKTR-262 in Combination With Bempegaldesleukin (NKTR-214) and With Bempegaldesleukin Plus Nivolumab in Patients With Locally Advanced or Metastatic Solid Tumor Malignancies (REVEAL)

Melanoma | Sarcoma | Renal Cell Carcinoma | Colorectal Cancer | Triple Negative Breast Cancer | Head and Neck Squamous Cell Carcinoma | Merkel Cell Carcinoma

United States
Sun Yat-sen University

Active, not recruiting

FOLFOX or CAPOX Perioperative Chemotherapy Versus Postoperative Chemotherapy for Locally Advanced Colon Cancer (OPTICAL) (OPTICAL)

Colon Cancer

China
Sun Yat-sen University
First Affiliated Hospital, Sun Yat-Sen University; Tongji Hospital; Second Affiliated... and other collaborators

Terminated

Neoadjuvant Chemoradiotherapy Versus Neoadjuvant Chemotherapy For Unresectable Locally Advanced Colon Cancer

Colon Cancer

China
Ege University

Completed

Appropriate Timing of Surgery After Neoadjuvant Chemoradiation for Locally Advanced Rectal Cancer

Neoplasm, Rectum
Alexandria University

Completed

Total Neoadjuvant Therapy Versus Standard Neoadjuvant Chemoradiation for Locally Advanced Rectal Cancer

Rectal Cancer

Egypt
Academic and Community Cancer Research United
National Cancer Institute (NCI)

Completed

Irinotecan and Cetuximab With or Without Bevacizumab in Treating Patients With RAS Wild-Type Locally Advanced or Metastatic Colorectal Cancer That Cannot Be Removed by Surgery

Stage IV Colorectal Cancer AJCC v7 | Stage IVA Colorectal Cancer AJCC v7 | Stage IVB Colorectal Cancer AJCC v7 | Colorectal Adenocarcinoma | RAS Wild Type

United States
Targovax ASA

Terminated

Exploratory Study of TG02-treatment as Monotherapy or in Combination With Pembrolizumab to Assess Safety and Immune Activation in Patients With Locally Advanced Primary and Recurrent Oncogenic RAS Exon 2 Mutant Colorectal Cancer

Rectal Cancer

New Zealand, Australia
EMD Serono Research & Development Institute, Inc.
Merck KGaA, Darmstadt, Germany

Completed

Avelumab in Metastatic or Locally Advanced Solid Tumors (JAVELIN Solid Tumor)

Solid Tumors

United States, Korea, Republic of, Taiwan, France, United Kingdom, Belgium, Czechia, Germany, Poland
University Hospital, Brest

Completed

Prediction of the Response to Neoadjuvant Radiation Chemotherapy Through Texture Analysis Derived From Medical Imaging (RECTOMICS)

Rectal Cancer

France
National Cancer Institute (NCI)

Terminated

A Phase I Study of AZD6244 in Combination With Capecitabine and Radiotherapy in Locally Advanced Adenocarcinoma of the Rectum

Non-Metastatic Adenocarcinoma of the Rectum

United States
Dimitri Christoforidis
Clinical Trial Unit Ente Ospedaliero Cantonale

Terminated

Observational Study on Rectal Cancer to Verify if Response After Chemo-radiotherapy Can be Predicted With a Particular Blood Test. (LiBReCa)

Locally Advanced Rectal Cancer

Switzerland
Shanghai Minimally Invasive Surgery Center

Withdrawn

Anlotinib Hydrochloride Combined With Capeox in the Neoadjuvant Treatment of Locally Advanced Rectal Cancer

Rectal Cancer | Anlotinib | Neoadjuvant Treatment
OHSU Knight Cancer Institute
Oregon Health and Science University; Radiological Society of North America

Terminated

Ferumoxytol-Enhanced MRI in Imaging Lymph Nodes in Patients With Locally Advanced Rectal Cancer

Stage III Rectal Cancer AJCC v7 | Stage IIIA Rectal Cancer AJCC v7 | Stage IIIB Rectal Cancer AJCC v7 | Stage IIIC Rectal Cancer AJCC v7 | Locally Advanced Rectal Carcinoma

United States
Cancer Institute and Hospital, Chinese Academy...

Completed

Preoperative Chemoradiotherapy With Raltitrexed for Intermediate or Locally Advanced Rectal Cancer in the Fit Elderly

Rectal Neoplasms Malignant

China
Centre Hospitalier Universitaire de Besancon

Withdrawn

Immunomonitoring and Biomarker Research in Patients With Squamous Cell Anal Carcinoma (LAND)

Anal Canal Cancer

France
Oslo University Hospital
The Research Council of Norway

Active, not recruiting

Locally Advanced Rectal Cancer - Exfoliated Peritoneal Tumor Cells (LARC-EX)

Rectal Cancer

Norway
Yonsei Hyperthermia Study Group

Active, not recruiting

The Effect of Electro-Hyperthermia in Preoperative Radiotherapy for Locally Advanced Rectal Cancer

Hyperthermia | Rectal Cancer

Korea, Republic of
Nektar Therapeutics

Completed

NKTR-102 in Combination With Cetuximab in Patients With Refractory Solid Tumors (Phase 2a) and Metastatic or Locally Advanced Colorectal Cancer (Phase 2b)

Colorectal Cancer | Tumor

United States
Sixth Affiliated Hospital, Sun Yat-sen University
Sir Run Run Shaw Hospital; The Third Affiliated Hospital of Kunming Medical...

Completed

RadioPathomics Artificial Intelligence Model to Predict nCRT Response in Locally Advanced Rectal Cancer (RPAI-pCR)

Rectal Cancer

China
Grupo Espanol Multidisciplinario del Cancer Digestivo
Pivotal S.L.

Completed

Induction FOLFOX With or Without Aflibercept Followed by Chemoradiation in High Risk Locally Advanced Rectal Cancer (RIA)

Rectal Cancer
Yonsei University

Active, not recruiting

Rectal Cancer, Adjuvant Chemotherapy, FOLFOX(5-fluorouracil/Leucovorin/Oxaliplatin), Total Mesorectal Excision

Locally Advanced Rectal Cancer

Korea, Republic of
Sun Yat-sen University

Completed

Neoadjuvant FOLFOXIRI Chemotherapy Alone for Locally Advanced Rectal Cancer (FORTUNE)

Rectal Cancer

China
Amgen

Completed

Open Label Extension Study of Conatumumab and Ganitumab (AMG 479)

Sarcoma | Lymphoma | Colorectal Cancer | Non-Small Cell Lung Cancer | Advanced Solid Tumors | Metastatic Cancer | Solid Tumors | Carcinoid | Locally Advanced

United States, Spain, Poland
Blokhin's Russian Cancer Research Center

Enrolling by invitation

Induction and Consolidation Chemotherapy in Patients With Locally Advanced CRM-positive Rectal Cancer (RuCorT-03)

Rectal Cancer | Rectum Carcinoma | Rectal Neoplasms Malignant

Russian Federation
Hospital Clinic of Barcelona
Hospital Son Espases; Hospital del Mar; Hospital Universitario La Fe; Instituto... and other collaborators

Unknown

Interval Between Neoadjuvant Therapy and Surgery in the Treatment of Locally Advanced Rectal Cancer (CRONOS) (CRONOS)

Rectal Cancer | Neoadjuvant Therapy

Spain
National Cancer Institute, Naples

Completed

Bevacizumab With Pelvic Radiotherapy And Primary Chemotherapy in Patients With Poor-Risk Rectal Cancer (BRANCH)

Rectal Cancer
AIPING ZHOU

Completed

Neoadjuvant Triplet Chemotherapy Regimen in Patients With Locally Advanced Rectal Cancer

Locally Advanced Rectal Cancer

China
Institute of Oncology Ljubljana

Completed

Total Neoadjuvant Therapy Versus Standard Therapy of Locally Advanced Rectal Cancer With High Risk Factors for Failure

Rectal Cancer
Instituto Nacional de Cancer, Brazil

Unknown

Short-course Radiotherapy With Induction and Consolidation Chemotherapy in Patients With Locally Advanced Rectal Cancer (SHORT-ICAR)

Rectal Cancer | Total Neoadjuvant Treatment

Brazil
Instituto Nacional de Cancer, Brazil

Terminated

Induction Chemotherapy Plus Chemoradiotherapy With or Without Aspirin in High Risk Rectal Cancer (ICAR)

Chemoradiation | Rectal Cancer, Adenocarcinoma | Locally Advanced Malignant Neoplasm

Brazil
Santo Spirito Hospital, Italy

Unknown

Surgery for Locally Advanced Colon Cancer: is it Worth it? A Multicenter Retrospective Analysis. (LACC)

Malignant Neoplasm of Large Intestine TNM Staging Primary Tumor (T) T4
Wuhan Union Hospital, China

Active, not recruiting

Preoperative Short Course Radiotherapy With Chemotherapy and Camerelizumab in Locally Advanced Rectal Cancer

Rectal Cancer | Radiotherapy | Immunotherapy

China
UNC Lineberger Comprehensive Cancer Center
Cerulean Pharma Inc.

Terminated

Neoadjuvant Chemoradiotherapy With CRLX-101 and Capecitabine for Rectal Cancer

Rectal Cancer

United States
Radiation Therapy Oncology Group
National Cancer Institute (NCI)

Completed

Radiation Therapy Plus Chemotherapy Followed by Surgery in Treating Patients With Locally Advanced Cancer of the Rectum

Colorectal Cancer

United States, Canada
Yale University

Completed

Pilot Trial of KD018 With Neo-Adjuvant Concurrent Chemo-Radiation Therapy in Patients With Locally Advanced Rectal Cancer

Rectal Cancer

United States
Sidney Kimmel Comprehensive Cancer Center at Johns...

Completed

Study of High-Dose-Rate Endorectal Brachytherapy (HDRBT) in the Treatment of Locally Advanced Low Rectal Cancer (HDRBT)

Rectal Cancer

United States

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