Search clinical trials for: Primary Immune Deficiency

Total 75817 results

CSL Behring

Completed

A Study to Investigate CSL312 in Subjects With Hereditary Angioedema (HAE)

Hereditary Angioedema

Canada, Australia, Germany, United States, Israel
Baxalta now part of Shire

Completed

Non-Interventional Post-Marketing Safety Study on the Long-Term Safety of HYQVIA (Global)

Primary Immunodeficiency Diseases (PID)

United States
ViiV Healthcare
Pfizer

Completed

Prospective Observational Epidemiologic Study of Maraviroc's Safety (POEM)

Human Immunodeficiency Virus

United States, Canada, Spain, Belgium, France, United Kingdom, Italy, Brazil, Puerto Rico, Germany, Greece
Shire

Completed

Efficacy and Safety of Lanadelumab (SHP643) in Japanese Participants With Hereditary Angioedema (HAE)

Hereditary Angioedema (HAE)

Japan
Albert Einstein College of Medicine
National Institute of Mental Health (NIMH); HIV Center for Clinical & Behavioral...

Completed

PC4PrEP: Integrating PrEP Into Primary Care (PC4PrEP)

Human Immunodeficiency Virus Transmission

United States
National Cancer Institute (NCI)

Withdrawn

Testing the Combination of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) in Children, Adolescent, and Young Adult Patients With Relapsed/Refractory Cancers That Have an Increased Number of Genetic Changes, The 3CI Study

Hematopoietic and Lymphoid Cell Neoplasm | Lynch Syndrome | Refractory Lymphoma | Refractory Malignant Solid Neoplasm | Recurrent Lymphoma | Recurrent Malignant Solid Neoplasm | Recurrent Neuroblastoma | Refractory Neuroblastoma | Recurrent Primary Central Nervous System Neoplasm | Refractory Primary Central... and other conditions

United States, Canada
University Hospital, Akershus
Oslo University Hospital; University Hospital of North Norway; University of... and other collaborators

Active, not recruiting

NAD Supplementation to Prevent Progressive Neurological Disease in Ataxia Telangiectasia

Ataxia Telangiectasia

Norway
Endocrinology Research Centre, Moscow
Russian Science Foundation

Completed

Vitamin D Metabolism in Patients With Endocrine Disorders

Diabetes Mellitus, Type 1 | Primary Hyperparathyroidism | Acromegaly | Pituitary ACTH Hypersecretion

Russian Federation
University of California, Los Angeles
Orchard Therapeutics; California Institute for Regenerative Medicine (CIRM)

Completed

Efficacy and Safety of the Cryopreserved Formulation of OTL-101 in Subjects With ADA-SCID

Severe Combined Immunodeficiency Due to ADA Deficiency

United States
University of California, Los Angeles

Withdrawn

A Clinical Study to Enable Process Validation of Commercial Grade OTL-101

Severe Combined Immunodeficiency Due to ADA Deficiency

United States
Radboud University Medical Center
A-T Children's Project; Twan foundation (https://twanfoundation.nl)

Completed

Effects of Vitamin B3 in Patients With Ataxia Telangiectasia

Ataxia Telangiectasia | ATM Gene Mutation

Netherlands
Federal Research Institute of Pediatric Hematology...

Completed

Videoocular Assessment of Eye Movement Activity in an Ataxia Telangiectasia

Ataxia Telangiectasia | Dysmetria

Russian Federation
Bellicum Pharmaceuticals

Active, not recruiting

Study of Gene Modified Donor T-cells Following TCR Alpha Beta Positive Depleted Stem Cell Transplant

Lymphoma, Non-Hodgkin | Myelodysplastic Syndromes | Acute Lymphoblastic Leukemia | Anemia, Aplastic | Primary Immune Deficiency Disorder | Cytopenia | Osteopetrosis | Leukemia, Acute Myeloid (AML), Child | Hemoglobinopathy in Children

United States
Murdoch Childrens Research Institute
Royal Children's Hospital

Completed

What is the Incidence of an Immune Disorder in Children With Invasive Pneumococcal Disease (IPD)?

Primary Immunodeficiency | Invasive Pneumococcal Disease, Protection Against | Invasive Pneumococcal Disease, Recurrent Isolated, 1 | Invasive Pneumococcal Disease, Recurrent Isolated, 2

Australia, New Zealand
Shire

Completed

A Study of Lanadelumab to Prevent Hereditary Angioedema (HAE) Attacks in Children (SPRING)

Hereditary Angioedema

United States, Canada, Germany, Hungary, Spain
CENTOGENE GmbH Rostock

Completed

Epidemiological Analysis for Hereditary Angioedema Disease (EHA)

Abdominal Pain | Functional Abdominal Pain

United Kingdom, Germany, Turkey, Poland, Italy, Japan
Sanofi Pasteur, a Sanofi Company

Completed

DTaP-IPV-HB-PRP-T Combined Vaccine as a Primary Series and a Second Year of Life Booster in HIV-Exposed Infected and Uninfected Infants

Hepatitis B | Pertussis | Tetanus | Diphtheria | Polio | Human Immunodeficiency Virus Infection

South Africa
Takeda

Completed

A Study of Icatibant (TAK-667) in Japanese Children and Teenagers With Acute Attacks of Hereditary Angioedema

Hereditary Angioedema

Japan
CENTOGENE GmbH Rostock

Completed

Biomarker for Hereditary AngioEdema Disease (BioHAE)

Hereditary Angioedema | Hereditary Angioedema Type I | Hereditary Angioedema Type II | C1 Esterase Inhibitor Deficiency | HAE | Angio Edema | C4 Deficiency | Hereditary Angioedema Type III

Turkey, Armenia, Georgia, India, Peru, Poland, Romania
CENTOGENE GmbH Rostock

Terminated

Hereditary Angioedema Kininogen Assay (HAEKA)

Hereditary Angioedema

Germany
Centre Leon Berard

Withdrawn

A Study to Assess a Physical Activity Program in Children, Adolescents and Young Adults Requiring Hematopoietic Stem Cell Allografts (EVAADE)

Myelodysplastic Syndromes | Severe Combined Immunodeficiency | Acute Leukemia | Haematological Malignancy | Hemoglobinopathy in Children | Bone Marrow Aplasia

France
KalVista Pharmaceuticals, Ltd.

Completed

A Single and Multiple Doses Safety, Tolerability, Pharmacokinetics and Food Effect Study of KVD824 in Healthy Volunteers

Hereditary Angioedema

United Kingdom
AO GENERIUM

Withdrawn

Efficacy and Safety of GNR-038 vs Berinert® in Patients With Hereditary Angioedema

Hereditary Angioedema

Russian Federation
Kedrion S.p.A.

Completed

Clinical Assessment of Pharmacokinetics, Efficacy, and Safety of 10% IVIg in PID Patients (CARES10)

Primary Immunodeficiency Disease

United States
Children's Hospital of Fudan University

Completed

Neonatal Screening of Severe Combined Immunodeficiencies

Severe Combined Immunodeficiency | Neonatal Screening

China
Shire

Completed

Retrospective, Observational Chart Review Study Conducted in Poland to Document the Management and Clinical Outcome of CUVITRU and HYQVIA in Pediatric Participants (< 18 Years) With Primary Immunodeficiency (PID) (IG-TATRY)

Primary Immunodeficiencies (PID)

Poland
University Hospital, Montpellier

Completed

Neurologic and Immunologic Characteristics of CTLA-4 and LRBA Hereditary Deficiency

CTLA4 Haploinsufficiency

France
KalVista Pharmaceuticals, Ltd.

Completed

Phase 1 Crossover Study in Healthy Subjects to Evaluate the PK Profile of KVD824 Following Single and Multiple Doses of Modified Release (MR) Formulations

Hereditary Angioedema

United Kingdom
Prometic Biotherapeutics, Inc.
Atlantic Research Group

Completed

Study of ProMetic BioTherapeutics Immune Globulin Intravenous (Human) 10%

Primary Immunodeficiency

United States
National Institute of Allergy and Infectious Diseases...

Completed

Safety of and Immune Response to a DNA HIV Vaccine (VRC-HIVDNA009-00-VP) in HIV Infected Individuals With Acute HIV Infection

HIV Infections

United States
National Institute of Allergy and Infectious Diseases...
Glaxo Wellcome

Completed

Pilot Study to Evaluate the Efficacy of Zidovudine in Preventing CD4+ Lymphocyte Decline in Patients With Primary HIV Infection. (One Treatment Arm Receives Placebo)

HIV Infections

United States
National Institute of Allergy and Infectious Diseases...

Terminated

Antibody Production in Immune Disorders

Primary Immune Deficiency

United States
University of Nottingham
Nottingham University Hospitals NHS Trust; Royal Papworth Hospital

Active, not recruiting

A National Retrospective Population Based Cohort Study of the Natural History of Ataxia Telangiectasia (N-HAT)

Ataxia Telangiectasia

United Kingdom
Assistance Publique - Hôpitaux de Paris

Completed

Gene Therapy for X-linked Severe Combined Immunodeficiency (SCID2)

X-linked Severe Combined Immunodeficiency

France
Great Ormond Street Hospital for Children NHS Foundation...
Orchard Therapeutics

Completed

Lentiviral (LV) Gene Therapy for Adenosine Deaminase (ADA) Deficiency

Adenosine Deaminase Deficiency | Severe Combined Immunodeficiencies (SCID)

United Kingdom
National Institute of Allergy and Infectious Diseases...
Rare Diseases Clinical Research Network; Primary Immune Deficiency Treatment...

Enrolling by invitation

Patients Treated for Chronic Granulomatous Disease (CGD) Since 1995

Granulomatous Disease, Chronic

United States, Canada
Kirby Institute
Gilead Sciences; Melanoma Institute Australia; St Vincent's Hospital, Sydney; Royal... and other collaborators

Active, not recruiting

Coronavirus (COVID-19) Outcomes Registries in Immunocompromised Individuals Australia (CORIA) (CORIA)

COVID-19 | Cancer | Primary Immune Deficiency Disorder | HIV-1-infection | Immunosuppression Disorders

Australia
Johann Wolfgang Goethe University Hospital

Completed

Oxidative Stress, Low Grade Inflammation, Tissue Breakdown and Biomarkers in Cerebrospinal Fluid of A-T

Ataxia Telangiectasia

Germany
Baxalta now part of Shire

Completed

Safety, Pharmacokinetic and Efficacy Study of a 10% Triple Virally Reduced Intravenous Immune Globulin Solution in Patients With Primary Immunodeficiency (Hypo- or Agammaglobulinemia)

Primary Immunodeficiency Diseases (PID) | Hypogammaglobulinemia | Agammaglobulinemia

Finland, Sweden
Baxalta now part of Shire

Completed

Safety and Efficacy Study of a 10% Intravenous Immune Globulin Solution in Subjects With Primary Immunodeficiency Disorders

Primary Immunodeficiency Diseases (PID) | Immune Thrombocytopenic Purpura (ITP) | Kawasaki Syndrome

United States
Octapharma

Completed

Study of Octanorm Subcutaneous IG in Patients With PID

Primary Immune Deficiency Disorder

United States, Canada, Czechia, Hungary, Poland, Russian Federation, Slovakia
Fred Hutchinson Cancer Center
National Cancer Institute (NCI); National Heart, Lung, and Blood Institute... and other collaborators

Completed

Treosulfan and Fludarabine Phosphate Before Donor Stem Cell Transplant in Treating Patients With Nonmalignant Inherited Disorders

Non-Neoplastic Hematologic and Lymphocytic Disorder

United States
ADMA Biologics, Inc.

Completed

Open Label, Phase III Study of NABI-IGIV 10% [Immune Globulin Intravenous(Human), 10%] In Subjects With Primary Immune Deficiency Disorders (PIDD)

Primary Immune Deficiency Disorders (PIDD)

United States
Association Pour l'Aide a la Recherche en Immunologie...

Completed

Study Through Imaging of Visceral Lymphoid Organs in Patients With SCID Who Have Recieved Bone Marrow Allograft (LymphImaging)

Severe Combined Immunodeficiency

France
Baxalta now part of Shire

Completed

Phase 2/3 Study of IGSC, 20% in PIDD

Primary Immunodeficiency Diseases (PID)

United States, Canada
Shire
Halozyme Therapeutics

Completed

A Study to Evaluate the Safety and Pharmacology of Subcutaneous Administration of CINRYZE With Recombinant Human Hyaluronidase

Hereditary Angioedema

United States
Caja Costarricense de Seguro Social

Completed

Primary Immunodeficiencies in Costa Rican Adults

Primary Immune Deficiency in Adults

Costa Rica
Shire

Completed

A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Subcutaneous CINRYZE Administration

Hereditary Angioedema

United States
Octapharma

Completed

Non-Interventional Study on the Tolerability and Efficacy of IVIG (GAM 10-06)

Primary and Secondary Immunodeficiency and Other Conditions Requiring Regular Administration of Octagam 5% or 10% IVIG

Canada, Austria, France, Spain, United Kingdom
Shire

Completed

A Study to Evaluate the Safety and Effect of Escalating Doses of CINRYZE

Hereditary Angioedema

United States

Search clinical trials for: Primary Immune Deficiency

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