Search clinical trials for: ROS1 translocation

Total 388 results

Novartis Pharmaceuticals

Completed

An Extension Study of the Safety and Anti-leukemic Effects of Imatinib Mesylate in Participants With Philadelphia Chromosome-positive Chronic Myeloid Leukemia in Blast Crisis

Philadelphia Chromosome Positive CML

United States, Germany, Italy, France
Novartis Pharmaceuticals

Terminated

Study of Nilotinib in Ph+ CML-CP Patients With Low Imatinib Trough Plasma Concentrations (MACS1148)

CML | Philadelphia Chromosome Positive (Ph+) | Chronic Myelogenous Leukemia Chronic Phase(CML-CP) Patients With Low Imatinib Trough Levels

United States
Pfizer

Completed

A Multicenter Phase 3, Open-Label Study of Bosutinib Versus Imatinib in Adult Patients With Newly Diagnosed Chronic Phase Chronic Myelogenous Leukemia

Leukemia, Myelogenous, Chronic, Breakpoint Cluster Region-Abelson Proto-oncogene (BCR-ABL) Positive

France, United States, Canada, Spain, Czechia, Singapore, Thailand, Denmark, Norway, Korea, Republic of, Finland, Hungary, Sweden, Netherlands, Italy, Germany, Ukraine, South Africa, Taiwan, Australia, Belgium, Israel, Mexico, Poland, S... and more
Hôpital Européen Marseille

Completed

Gut Microbiota Dysbiosis and Translocation During IBD and Parkinson (Medibiote1)

Parkinson Disease | Inflammatory Bowel Diseases

France
M.D. Anderson Cancer Center
Novartis

Terminated

Everolimus Versus Sunitinib in Non-Clear Cell Renal Cell Carcinoma

Kidney Cancer

United States
Hikma Pharmaceuticals LLC

Completed

Effectiveness and Safety Study of Generic Imatinib in Chronic Myeloid Leukemia Patients in Egypt

Philadelphia Chromosome-positive Chronic Myeloid Leukemia in Chronic Phase

Egypt
Aarhus University Hospital
Roche Pharma AG

Enrolling by invitation

Monitoring Alectinib Treatment by Detection of ALK Translocations in Serial Blood Samples From Non-Small Cell Lung Cancer Patients (MonAlec)

Lung Cancer | ALK Gene Mutation | Resistance, Disease | Mutation

Denmark
National Cancer Institute (NCI)

Completed

Sorafenib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Leukemia

Juvenile Myelomonocytic Leukemia | Recurrent Disease | Recurrent Childhood Acute Lymphoblastic Leukemia | Recurrent Childhood Acute Myeloid Leukemia | Childhood Chronic Myelogenous Leukemia, BCR-ABL1 Positive | Childhood Solid Neoplasm | Chronic Myelogenous Leukemia, BCR-ABL1 Positive | Philadelphia... and other conditions

United States, Canada
Tungs' Taichung Metroharbour Hospital

Completed

Association of Constipation Inflammatory and Microbial Translocation Markers

Inflammation | Constipation

Taiwan
Memorial Sloan Kettering Cancer Center

Completed

Molecular Determinants of Acquired Clinical Resistance to Crizotinib in Non-small Cell Lung Cancer Harboring a Translocation or Inversion Event Involving the ALK Gene Locus

Lung Cancer

United States
Centre Hospitalier Universitaire de Nīmes

Terminated

Evaluation of Intestinal Bacterial and Fungal Translocation and Intestinal Microbiota in Febrile Neutropenic Patients in Pediatric Onco-hematology (TRANSNEUTROFEB)

Febrile Neutropenia

France
Centre Hospitalier Universitaire de Nīmes

Completed

Acute Intestinal Failure in Critically Ill Patients and Microbial Translocation (IGA-TM)

Septic Shock

France
Novartis Pharmaceuticals

Completed

Safety and Efficacy of TKI258 in Relapsed or Refractory Multiple Myeloma Patients, Who Are With or Without t(4;14) Chromosomal Translocation

Relapsed or Refractory Multiple Myeloma

United States, Turkey, Canada, Netherlands, Australia, Germany, France
Boston Medical Center
National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Completed

Alcohol's Impact on Inflammatory Markers in HIV Disease - Russia ARCH Cohort

HIV Infection | Alcohol Use

Russian Federation
Novartis Pharmaceuticals

Completed

Study of Safety and Efficacy of LEE011 and Ceritinib in Patients With ALK-positive Non-small Cell Lung Cancer.

Non-small Cell Lung Cancer

Taiwan, Spain, Italy, United States, Korea, Republic of, France
Rothman Institute Orthopaedics

Unknown

S. Aureus Translocation From Skin and Nose to Periprosthetic Tissues

Staphylococcus Aureus

United States
Novartis Pharmaceuticals

Completed

Nilotinib and LDE225 in the Treatment of Chronic or Accelerated Phase Myeloid Leukemia in Patients Who Developed Resistance to Prior Therapy

Philadelphia Chromosome Positive Chronic Myelogenous Leukemia

Germany, Canada, France, Spain, Italy
Novartis Pharmaceuticals

Completed

A Phase l/ll Study of AMN107 in Adult Patients With Glivec-intolerant CML or Relapsed-refractory Ph+ALL

Chronic Myelogenous Leukemia | Acute Lymphoblastic Leukemia (Philadelphia Chromosome Positive)

Japan
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Terminated

Axitinib and Bosutinib in Treating Patients With Chronic, Accelerated, or Blastic Phase Chronic Myeloid Leukemia

Accelerated Phase Chronic Myelogenous Leukemia (CML) | Blast Phase Chronic Myelogenous Leukemia (CML) | Chronic Phase Phase Chronic Myelogenous Leukemia (CML) | Philadelphia Chromosome Positive (Ph+) Phase Chronic Myelogenous Leukemia (CML)

United States
Novartis Pharmaceuticals

Completed

A Study of Imatinib Versus Nilotinib in Adult Patients With Newly Diagnosed Philadelphia Chromosome Positive (Ph+) Chronic Myelogenous Leukemia in Chronic Phase (CML-CP) (ENESTnd)

Myelogenous Leukemia, Chronic

South Africa, Italy, Belgium, Japan, Taiwan, Turkey, Canada, Germany, Spain, Egypt, United States, Singapore, Austria, France, Netherlands, Sweden, United Kingdom, Korea, Republic of, Hong Kong, Thailand, Russian Federation, Brazil, Hungar... and more
Gruppo Italiano Malattie EMatologiche dell'Adulto

Unknown

De Novo Adult Philadelphia Chromosome Positive (Ph+) Acute Lymphoblastic Leukemia (ALL) Patients (LAL1509)

ALL Ph Positive

Italy
Novartis Pharmaceuticals

Completed

Study of Nilotinib as First Line Treatment in Philadelphia Chromosome Positive(Ph+) Chronic Myelogenous Leukemia in Chronic Phase (CML-CP)

Chronic Myelogenous Leukemia

Turkey
Goethe University

Completed

Evaluation of Efficacy and Safety of Nilotinib in Combination With Chemotherapy in Elderly Patients With Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia

Philadelphia Chromsome Positive Acute Lymphoblastic Leukemia

Spain, Germany, France
Centre Hospitalier Universitaire de Nīmes

Completed

Evaluation of the Intestinal Microbiota and Bacterial Translocation in Patients With Rheumatoid Arthritis (MICROPOLY)

Arthritis, Rheumatoid

France
National Cancer Institute (NCI)
Centers for Disease Control and Prevention; National Institute for Occupational...

Completed

Study of Markers of Cosmic Radiation Exposure and Effect Among Flight Crews

Frequency of Chromosome Aberrations

United States
Northwestern University
National Cancer Institute (NCI)

Terminated

Nivolumab and Dasatinib in Treating Patients With Relapsed or Refractory Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia

Recurrent Adult Acute Lymphoblastic Leukemia | Recurrent Childhood Acute Lymphoblastic Leukemia | Refractory Adult Acute Lymphoblastic Leukemia | B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1 | Refractory Childhood Acute Lymphoblastic Leukemia

United States
Massachusetts General Hospital

Completed

Ponatinib in Advanced NSCLC w/ RET Translocations

Non Small Cell Lung Cancer

United States
Gesellschaft fur Medizinische Innovation - Hamatologie...
Crolll Gmbh

Completed

Compliance: Role Emerges for Success in Chronic Myelogenous Leukaemia (CML): Evaluation aND Optimisation (Crescendo)

Chronic Myelogenous Leukemia (CML)

Germany
Nanfang Hospital of Southern Medical University

Unknown

Microbiome Translocation in Different Circulatory Compartments in Decompensated Cirrhosis

Cirrhosis, Liver

China
AB Science

Completed

Masitinib in Relapse or Refractory Multiple Myeloma With t(4/14) Translocation Expressing or Not FGFR3

Multiple Myeloma

France
Istituto Clinico Humanitas

Completed

Risk of Microbial Translocation in Patients Undergoing Per-Oral Endoscopic Myotomy (POEM) for Achalasia: Antibiotic Prophylaxis or Short-therapy (POEM-MT01)

Achalasia

Italy
Hospital Clinic of Barcelona

Unknown

Mediterranean Diet and Bacterial Translocation and Immune-activation in Patients With HIV

Hiv

Spain
Novartis Pharmaceuticals

Completed

A Study of Imatinib and Nilotinib in Patients With Chronic Myelogenous Leukemia in Chronic Phase

Leukemia

China
University Hospital, Bordeaux

Completed

Study of the Articular Microbiota in Rheumatoid Arthritis. (MICROPORE)

Rheumatoid Arthritis | Arthrosis | Synovial Disorder
Novartis Pharmaceuticals

Terminated

BGJ398 for Patients With Tumors With FGFR Genetic Alterations (CBGJ398XUS04)

Solid Tumor | Hematologic Malignancies

United States
Centre Hospitalier Universitaire de Nīmes

Completed

Study of the Role of Regulator T Cells in the Pathophysiology of Childhood Henoch Schönlein Purpura (FOX-TREG)

Henoch Schönlein Purpura

France
Fundacion para la Investigacion Biomedica del Hospital...

Completed

Randomized Placebo-controlled Pilot Trial of Prebiotics+Glutamine in HIV Infection (MicroVIH)

HIV

Spain
Instituto Nacional de Ciencias Medicas y Nutricion...

Unknown

Evaluation of Intestinal Permeability in Cirrhotic Patients Before and After Treatment With Non-selective Beta Blocker (Propranolol)

Liver Cirrhoses

Mexico
Pfizer
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Compare Bosutinib To Imatinib In Subjects With Newly Diagnosed Chronic Phase Philadelphia Chromosome Positive CML

Chronic Myeloid Leukemia

France, United States, Spain, Belgium, Singapore, Poland, Canada, Japan, United Kingdom, Taiwan, Hungary, Germany, Argentina, Russian Federation, Turkey, Colombia, Italy, South Africa, Brazil, Chile, China, Hong Kong, India, Korea, Republic... and more
Icahn School of Medicine at Mount Sinai
National Cancer Institute (NCI); Myeloproliferative Disorders-Research Consortium

Completed

Correlative Biomarker Study in Patients With Myeloproliferative Disorders

Polycythemia Vera | Essential Thrombocythemia | Myelofibrosis | Idiopathic Myelofibrosis | Myeloproliferative Disease

United States, Canada, Italy, United Kingdom
Boston Medical Center
National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Completed

Zinc for HIV Disease Among Alcohol Users - an RCT in the Russia ARCH Cohort (ZINC)

HIV Infection | Alcohol Use

Russian Federation
University Hospital Inselspital, Berne

Completed

Influence of Polymorphisms in the ATP6V1 Gene of the V-ATPase on the Development of Incomplete Distal Renal Tubular Acidosis

Nephrolithiasis | Acidosis, Renal Tubular | Vacuolar Proton-Translocating ATPases

Switzerland
AIDS Clinical Trials Group
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Rifaximin as a Modulator of Microbial Translocation and Immune Activation

HIV-1 Infection

United States, Puerto Rico
Il-Yang Pharm. Co., Ltd.

Completed

Philadelphia Chromosome Positive CML Patients Without Optimal Response or Tolerance to Bcr-Abl TKI

Hematologic Diseases | Leukemia | Leukemia, Myeloid | Leukemia, Myelogenous, Chronic, BCR-ABL Positive | Philadelphia Chromosome

India, Korea, Republic of, Thailand
Nanfang Hospital of Southern Medical University
Peking University People's Hospital; Guangzhou First People's Hospital; Sun Yat-Sen... and other collaborators

Unknown

Effect of Prophylactic TKI Therapy Post-transplants on Ph+ ALL Undergoing Allo-HSCT With MRD Positive Pre-transplants

Allogeneic Hematopoietic Stem Cell Transplantation | Minimal Residual Disease | Philadelphia Chromosome Positive Acute Lymphocytic Leukemia | Tyrosine Kinase Inhibitor

China
First Affiliated Hospital Xi'an Jiaotong University

Completed

Effectiveness of Probiotics to Treat End Stage Renal Disease

Kidney Failure, Chronic

China
University Health Network, Toronto
CIHR Canadian HIV Trials Network

Unknown

Probiotic Visbiome for Inflammation and Translocation in HIV II (PROOV IT II)

HIV-1 Infection

Canada
Jinling Hospital, China

Terminated

Effect of Soluble Dietary Fiber on Bacterial Translocation in Crohn's Disease

Crohn's Disease

China
Fundació Institut de Recerca de l'Hospital de la...
Spanish Clinical Research Network - SCReN

Withdrawn

Effect of Vivomixx® on Neuroinflammation in Patients Withs Cirrhosis

Cirrhosis, Liver

Spain
University Health Network, Toronto
CIHR Canadian HIV Trials Network

Terminated

Probiotic Visbiome for Inflammation and Translocation in HIV Ι (PROOV IT I)

HIV-1 Infection

Canada

Search clinical trials for: ROS1 translocation

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