Search clinical trials for: drug substitution

Total 261002 results

Rophibio, Inc.

Not yet recruiting

A Phase 3 Clinical Trial to Compare RBS-001 to Eylea® in Subjects With Neovascular Age-Related Macular Degeneration

Neovascular Age-related Macular Degeneration (nAMD)

United States
H. Lundbeck A/S

Not yet recruiting

A Trial of Lu AG13909 in Adult Participants With Cushing's Disease (BalanCeD)

Cushing's Disease
Anaveon AG
Merck Sharp & Dohme LLC

Not yet recruiting

A Study Evaluating ANV600 Single Agent or in Combination With Pembrolizumab in Participants With Advanced Solid Tumors (EXPAND-1)

Advanced Solid Tumor
Eske Kvanner Aasvang

Not yet recruiting

CoPainHell: The Analgesic Effect of Alcohol and Music (CPH)

Acute Pain
Xuanwu Hospital, Beijing

Not yet recruiting

A Novel Classification of Sagittal Spinal Alignment to Aid Surgical Planning for Adult Spinal Deformity (CSSAASD)

Adult Spinal Deformity | Sagittal Deformity | Sagittal Imbalance | Sagittal Alignment

China
Tianjin Medical University Cancer Institute and...

Not yet recruiting

The Efficacy of Gemcitabine and Nab-palitaxe Combined With Cadonilimab Sequential Short-course Radiotherapy in the Treatment of Patients With Locally Advanced Pancreatic Ductal Adenocarcinoma

Locally Advanced Pancreatic Ductal Adenocarcinoma

China
Poznan University of Medical Sciences

Not yet recruiting

Dexamethasone vs. Dexmedetomidine for ESPB in Pain Management After Knee Arthroplasty

Knee Osteoarthritis | Knee Arthritis | Knee Pain Chronic | Knee Disease

Poland
Aalborg University

Not yet recruiting

Investigation of Corticospinal Excitability Aspects of Itch and Pain

Pain | Itch
Technical University of Munich

Not yet recruiting

Comparison Between Ureterorenoscopy With Lithotripsy Alone Versus Combination With Hydrogel for Kidney Stone Removal

Nephrolithiasis | Ureteroscopy | Lithotripsy, Laser

Germany
Poznan University of Medical Sciences

Not yet recruiting

Two-level ESPB in Total Knee Arthroplasty

Knee Osteoarthritis | Knee Arthritis | Knee Pain Chronic

Poland
University Hospital, Montpellier

Not yet recruiting

Specific Biomarkers of Immune-mediated Hepatitis Secondary to Immune Checkpoint Inhibitors (Pro-CHILI)

Immune-mediated Hepatitis

France
Yuanquan Yang

Not yet recruiting

Siltuximab for the Prevention of Severe Immune-Related Adverse Events During Immune Checkpoint Inhibitor Rechallenge in Patients With Advanced Cancer, CIRES Trial

Advanced Malignant Solid Neoplasm | Hematopoietic and Lymphatic System Neoplasm

United States
Beijing Chest Hospital, Capital Medical University

Not yet recruiting

Adebrelimab Plus Chemo and Recaticimab Perioperative Treatment for Resectable NSCLC

Non Small Cell Lung Cancer

China
Zhang XIao Mei

Recruiting

To Investigate the Effect of Esketamine Hydrochloride on Pulmonary Complications

Heart Diseases | Heart Valve Diseases

China
Ohio State University
Patient-Centered Outcomes Research Institute; Northwestern University; Preeclampsia...

Not yet recruiting

Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy: ASPIRIN TRIAL (ASPIRIN)

Preeclampsia | Gestational Hypertension | Hypertensive Disorders of Pregnancy

United States
The First Affiliated Hospital with Nanjing Medical...

Recruiting

Predicting Ventilator-associated Lower Respiratory Tract Infection Outcomes Using Sequenced-based Early Microbiological Response: A Multi-center Prospective Study

Respiratory Tract Infections | Pneumonia, Ventilator-Associated | Prognosis

China
Fujian Cancer Hospital

Not yet recruiting

Phase II Study of Different Doses of Radiotherapy Combined With Sintilimab in the Treatment of Locally Advanced Esophageal Squamous Cell Carcinoma

Esophageal Squamous Cell Carcinoma
AstraZeneca
Daiichi Sankyo Company, Limited 3-5-1 Nihonbashihoncho, Chuo-ku, Tokyo

Not yet recruiting

Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary Tract Cancer (DESTINY-BTC01)

Biliary Tract Cancer

Belgium, Canada, Brazil, Japan, Korea, Republic of, Taiwan, Germany, Austria, Netherlands
Ricardo Alberto Moreno, M.D., Ph.D.

Recruiting

Psychoeducational Group for Depression (PEG-D)

Major Depressive Disorder (MDD

Brazil
Chinese University of Hong Kong

Recruiting

Boiled Tree Nut for Oral Immunotherapy in Food-allergic Children

Food Allergy | Food Allergy in Children

Hong Kong
National Taiwan University

Not yet recruiting

The Gather: Town Gaming Intervention for Depression Management

Gamification
Yale University
Food and Drug Administration (FDA)

Not yet recruiting

Electronic Health Record Strategies to Promote Diverse Participation in Research AIM 2

Patient Participation

United States
Ain Shams University

Not yet recruiting

Evaluation of Pulpotomy Using Two Different Agents in Mature Anterior Teeth With Pulpitis

Pulpitis
Fujian Cancer Hospital

Not yet recruiting

Short-course Radiotherapy Combined With Sintilimab for Neoadjuvant Treatment of Esophageal Squamous Cell Carcinoma

Esophageal Squamous Cell Carcinoma
Beijing Tongren Hospital

Recruiting

GDFT on the Postoperative Outcome in Head and Neck Cancer Surgery

Postoperative Complications

China
Chang Gung Memorial Hospital

Not yet recruiting

Efficacy and Safety of Hydroxychloroquine in the Treatment of Sudden Sensorineural Hearing Loss

Sudden Hearing Loss
Central Hospital, Nancy, France

Recruiting

Heart Analysis in GATED-PET in Patients Having a Gallium-68-DOTATOC PET/CT Exam for Oncology Indication (GATEDOTA)

Cardiac Inflammation

France
Institute of Liver and Biliary Sciences, India

Not yet recruiting

Safety and Adequacy of Trans-jugular Liver Biopsy in Patients With Liver Disease: SAFE-TJLB Study

Liver Cirrhosis

India
Assiut University

Recruiting

Efficacy of Hyaluronic Acid in Prevention of Acute Radiation Proctitis

Acute Radiation Enteritis | Acute Radiation Proctitis

Egypt
Tang-Du Hospital

Recruiting

Study on the Therapeutic Effect of Irinotecan Liposomes in Small Cell Lung Cancer

Small Cell Lung Cancer

China
Grupo Espanol de Trabajo en Enfermedad de Crohn...
Pfizer

Recruiting

An Active Surveillance, Post-Authorization Study to Characterize the Safety of Tofacitinib in Patients With Moderately to Severely Active Ulcerative Colitis in the Real-World Setting Using Data From the United Registries for Clinical Assessment and Research (UR-CARE) in the European Union (EU) (PASS TOFA)

Ulcerative Colitis

Belgium, Bulgaria, Greece, Lithuania
IRCCS San Raffaele
GlaxoSmithKline

Not yet recruiting

Antiviral Long Acting Drugs Landing in People Living With HIV (ALADDIN)

HIV | Antiviral Agents

Italy
Innovent Biologics (Suzhou) Co. Ltd.

Recruiting

A Study of IBI363 in Subjects With Advanced Malignancies

Advanced Malignancies

China
University of East Anglia
Clinical Research and Trials Unit (Norfolk & Norwich University Hospital,...

Recruiting

The Role of SGLT2i in Management of Moderate AS

Moderate Aortic Valve Stenosis

United Kingdom
Kanuni Sultan Suleyman Training and Research Hospital

Not yet recruiting

Evaluation of the Impact of Ejection Fraction on Clinical Outcomes in Patients Undergoing Cardiovascular Surgery

Cardiac Output, Low
Xianmin Song, MD

Recruiting

Reduced Intensity Conditioning With Thiotepa Combined With Bu/Flu/Ara-C in Allo-HSCT for Relapsed or Refractory Peripheral T-cell Lymphoma.

Peripheral T Cell Lymphoma

China
Shanghai Chest Hospital

Not yet recruiting

Neoadjuvant Immunochemotherapy for Adenocarcinoma of the Esophagogastric Junction (TRACE)

Esophageal Cancer

China
Shanghai Zhongshan Hospital

Not yet recruiting

Synergistic Effects of PD-1 Antibody and Chemotherapy Followed by Surgery in Limited-metastatic G/GEJ Adenocarcinoma (ROSETTE)

Gastric Cancer | GastroEsophageal Cancer

China
Chang Gung Memorial Hospital

Not yet recruiting

Novel Augmentation of DAOIB and Antioxidant for Early Dementia

Alzheimer Disease | Mild Cognitive Impairment

Taiwan
L & L biopharma Co., Ltd., Shanghai China
Shanghai East Hospital

Not yet recruiting

A Study to Evaluate LB1410 in Combination With LB4330 in Patients With Advanced or Metastatic Solid Tumors (TRIGGERCD8)

Solid Tumor

China
Central Hospital, Nancy, France

Not yet recruiting

Study of the Indications for Amyloid Positon Emission Tomography (PET) Scans and Their Usefulness for Patients With Suspected Alzheimer's Disease (AD) (TEPAmy)

Alzheimer Disease
Mikko Niemi
University of Helsinki

Recruiting

KF2023#1-Trial: Influence of Statin Intake on Cellular Readouts

Pharmacodynamics

Finland
Centre Hospitalier Universitaire de Saint Etienne
Sanofi Pasteur, a Sanofi Company

Not yet recruiting

Analyzes of Nasal Tissue-resident Memory Immune Cells and Peripheral Memory Cells Able to Migrate to Airway Tissues (MUCOVAC) (MUCOVAC)

Healthy Volunteers

France
Alcon Research

Not yet recruiting

Clinical Performance of Two Frequent Replacement Silicone Hydrogel Multifocal Contact Lenses

Presbyopia

United States
Pamukkale University

Not yet recruiting

Sympatholytic Effects of High Thoracic Erector Spinae Plane Block: Changes in Optic Nerve Sheath Diameter

Complex Regional Pain Syndromes
Taichung Tzu Chi Hospital

Recruiting

The Efficacy of Music on Perioperative Pain Management

Perioperative Pain Management

Taiwan
Xin-Hua Xu

Recruiting

A Prospective, Open-label, Single-center, Single-arm Phase II Clinical Study of Cadonilimab (AK104) Combined With Monotherapy Chemotherapy in Patients With Advanced Non-small Cell Lung Cancer With Negative Driver Genes and Failed Immunotherapy

Non-small Cell Lung Cancer

China
Peking University People's Hospital

Recruiting

Effects of Chinese Medicine and Lactobacillus in Persistent HPV Infection (ELIMVLHPV)

Human Papilloma Virus Infection

China
Peking University First Hospital
Peking University International Hospital; Tianjin Medical University General...

Not yet recruiting

Dexmedetomidine-Esketamine Combination for Sedation and Analgesia in ICU Patients

Delirium | Dexmedetomidine | Aged | Intensive Care Units | Esketamine | Ventilators, Mechanical

China
Hospital de Clinicas de Porto Alegre

Not yet recruiting

The Impact of Geriatric Assessment on the Treatment Plan of Elderly Patients With T2DM

Frail Elderly Syndrome | Frailty | Geriatric Assessment | Type2diabetes

Brazil

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