Search clinical trials for: high-grade disease

Total 383643 results

Inozyme Pharma

Not yet recruiting

ADAPT Study: Long-term Safety Study of INZ-701 in Patients With ENPP1 Deficiency and ABCC6 Deficiency

Pseudoxanthoma Elasticum | Arterial Calcification | Gene Mutations | Ectonucleotide Pyrophosphatase/phosphodiesterase1 Deficiency | Autosomal Recessive Hypophosphatemic Rickets Type 2
The First Affiliated Hospital with Nanjing Medical...

Not yet recruiting

The Ameliorative Effects of GLP-1RA on Diabetic Cardiac Autonomatic Neuropathy

Type 2 Diabetes | Diabetes With Diabetic Autonomic Neuropathy (Diagnosis)
Zhou Chengzhi
Guangdong Provincial Hospital of Traditional Chinese Medicine; Sun Yat-sen... and other collaborators

Not yet recruiting

Liposomal Irinotecan Combination Regimen for First-line Treatment of Small Cell Lung Cancer

Small Cell Lung Cancer
AbbVie

Not yet recruiting

A Study to Assess Adverse Events and Change in Disease Activity Comparing Oral Upadacitinib to Subcutaneous Dupilumab in Children From 2 to Less Than 12 Years of Age With Moderate to Severe Atopic Dermatitis (Start Up)

Atopic Dermatitis
Sohag University

Not yet recruiting

Phenotypic and Genotypic Characterization of Escherichia Coli

Antibiotic Sensitivity Testing and Genotypic Caharacterization of Ecoli
Riphah International University

Recruiting

Effects of Sprint Interval Training Versus Arabic Exercises BMI

PCOS

Pakistan
Tr1X, Inc.

Recruiting

Prevention of GvHD in Participants With Hematological Malignancies Undergoing Hematopoietic Stem Cell Transplant (HSCT)

Myelodysplastic Syndromes | Hematologic Malignancy | Hematopoietic Stem Cell Transplant | Acute Myeloid Leukemia in Remission | GVHD, Chronic | GVHD,Acute | GvHD | Acute Lymphoblastic Leukemia, Adult B-Cell | Cancer Remission | Acute Lymphoblastic Leukemia, Adult T-Cell | Chronic Myelomonocytic Leukemia,...

United States
Beijing 302 Hospital

Not yet recruiting

Safety and Efficacy of Autologous Tumor-infiltrating Lymphocytes Therapy in Patients With Hepatocellular Carcinoma

Hepatocellular Carcinoma

China
Shengjing Hospital

Recruiting

Multifrequency MRE for Assessing Chronic Hepatic Disease

Liver Stiffness

China
Zhejiang University
Carbiogene Therapeutics Co. Ltd.

Not yet recruiting

Clinical Trial of Autologous GPC3 CAR-T Cells (CBG166) Therapy for Advanced Hepatocellular Carcinoma

Advanced Hepatocellular Carcinoma

China
NYU Langone Health

Not yet recruiting

Packed Red Blood Cell Transfusion During Cardiac Arrest

Cardiac Arrest

United States
Emory University
University of California, San Diego; Ventrix, Inc.

Not yet recruiting

Study of Intramyocardial Injection of Ventrix Bio Extracellular Matrix (VentriGel) to Assess the Safety and Feasibility in Pediatric Patients With Hypoplastic Left Heart Syndrome (HLHS)

Hypoplastic Left Heart Syndrome

United States
Guangzhou Medical University

Not yet recruiting

Immune Checkpoint Inhibitor Combined With Pemetrexed Intrathecal Injection for Leptomeningeal Metastasis From Solid Tumors

Leptomeningeal Metastasis

China
Toronto Metropolitan University

Not yet recruiting

Cognitive Processing Therapy to Treat PTSD and Sexually Transmitted Infections Among Men Who Have Sex With Men (CPT-T)

Stress Disorders, Post-Traumatic

Canada
American Heart Association

Not yet recruiting

Hypertrophic Cardiomyopathy Federated Learning Implementation Platform (HCM FLIP)

Hypertrophic Cardiomyopathy
Central Hospital, Nancy, France

Not yet recruiting

Comparison of Changes in Tumor Burden in 68Ga-PSMA-11 PET/CT and 177Lu-PSMA SPECT/CT in Metastatic Castration-resistant Prostate Cancer (PROLUT)

Prostate Cancer Metastatic

France
Kaohsiung Veterans General Hospital.

Not yet recruiting

Balance and Executive Function in Middle-age and Older Patients With Heart Failure in Post-Acute Care Program

Heart Failure
Chinese PLA General Hospital

Recruiting

Microwave Ablation Versus Liver Resection for Intrahepatic Cholangiocarcinoma (MALRIC)

Overall Survival | Disease-free Survival

China
National Institute on Deafness and Other Communication...

Recruiting

Study of Dupilumab 300 mg Every Other Week After Endoscopic Sinus Surgery in Patients With Allergic Fungal Rhinosinusitis (AFRS) on a Background Therapy With Intranasal Corticosteroid Spray

Asthma | Nasal Polyps | Allergic Fungal Rhinosinusitis (AFRS) | Chronic Rhinosinusitis (CRS)

United States
Eisai Inc.

Not yet recruiting

A Study to Evaluate the Efficacy, Safety, and Tolerability of E2086 Compared to Placebo and Active Comparator in Adult Participants With Narcolepsy Type 1

Narcolepsy Type 1 (NT1)
University of Melbourne
Monash University; University of Adelaide; University of Sydney; The University... and other collaborators

Not yet recruiting

PLatform for Adaptive Trials In Perinatal UnitS - [Core Protocol] (PLATIPUS)

Preterm Birth
University College Dublin
University of Aarhus; Royal College of Surgeons, Ireland

Not yet recruiting

Exoskeleton Training for Spinal Cord Injury Neuropathic Pain (ExSCIP) (ExSCIP)

Traumatic Spinal Cord Injury
Guy's and St Thomas' NHS Foundation Trust

Not yet recruiting

Left Bundle Branch Area Pacing 3D Guidance System

Heart Failure | Bradycardia | Left Bundle Branch Pacing

United Kingdom
Southwest Hospital, China

Recruiting

Biomarkers and Imaging Markers for ICH

Intracerebral Hemorrhage

China
TC Biopharm

Not yet recruiting

ACHIEVE2 - Safety and Preliminary Efficacy of Intravenous TCB008 in Patients With Relapse or Refractory Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)/AML (ACHIEVE2)

Acute Myeloid Leukemia | Myelodysplastic Syndromes
The First Affiliated Hospital with Nanjing Medical...

Not yet recruiting

Efficacy and Safety of Anti-PD-1, Thymosin, and SOX in Neoadjuvant Treatment of cStage III Gastric/GEJ Adenocarcinoma

Gastric Cancer | Esophagogastric Junction Adenocarcinoma
Riphah International University

Not yet recruiting

Effects of Maze Balance Board Training on Balance in Children With Hearing Impairment.

Hearing Impaired Children

Pakistan
Intra-Cellular Therapies, Inc.

Recruiting

Study of Lumateperone in the Acute Treatment of Patients With Bipolar Mania

Bipolar Disorder, Manic

United States
European Organisation for Research and Treatment...

Not yet recruiting

OligoCare TwiCs (Trials Within Cohorts) Trial Comparing Acute Toxicity in Single-fraction vs Multiple-fraction SBRT for Metastasis-directed Treatment (SPRINT) (SPRINT)

Breast Cancer | Colorectal Cancer | NSCLC | Prostate Cancer | Oligometastatic Disease
Gazi University

Not yet recruiting

The Effect of Online Pilates on Cognitive Function and Dual-Task Performance

Multiple Sclerosis
Pfizer
AbbVie

Not yet recruiting

A Study to Learn About the Study Medicine Aztreonam-Avibactam (ATM-AVI) in Infants and Newborns Admitted in Hospitals With Bacterial Infection (CHERISH) (CHERISH)

Gram-negative Bacterial Infection
Oregon Health and Science University
University of Washington; Bay Area First Step

Recruiting

Rural Community Peer Partnerships for Improving Methamphetamine-Associated Heart Failure Screening and Engagement (PEER-Heart)

Heart Failure | Methamphetamine Use

United States
Unity Health Toronto

Not yet recruiting

Multiplex Near Patient Non-HCP Study

HIV Infections | Syphilis Infection
Guangzhou University of Traditional Chinese Medicine
Jiangsu Province Hospital of Traditional Chinese Medicine; The First Affiliated...

Not yet recruiting

Acupuncture for Enhancing Immunotherapy in Advanced NSCLC：a Pilot Study

Non-small Cell Lung Cancer | Non-Small-Cell Lung Carcinoma

China
University of Aarhus
Aarhus University Hospital

Recruiting

Proton Therapy for Locally Advanced Cervical Cancer

Cervical Cancer | Radiotherapy Side Effect | Proton Therapy

Denmark
Hospital Clinic of Barcelona
Spanish Society of Digestive Endoscopy

Recruiting

Multicenter Study Comparing AI-Based Navicam vs. Conventional Pillcam in Small Bowel Pathology (NAVIPILL)

Small Intestine Disease

Spain
Samsun University

Recruiting

The Impact of the Anaesthetic Technique Employed on the Quality of Recovery in Patients Undergoing Hysterectomy Surgery.

Analgesia | Acute Pain | Anesthesia

Turkey
H. Lee Moffitt Cancer Center and Research Institute
EMD Serono Research & Development Institute, Inc.

Not yet recruiting

Study to Assess Xevinapant in Preoperative Subjects With Recurrent High-Grade Glioma (rHGG)

Recurrent High-grade Glioma

United States
Yonsei University
Korea Health Industry Development Institute

Not yet recruiting

Home-based Gait Rehabilitation Service Using the Insole-type Gait Analysis Device for Children With Cerebral Palsy

Cerebral Palsy | Gait Disorders, Neurologic

Korea, Republic of
Sohag University

Recruiting

The Efficacy of Intravenous Pulse in Attaining Remission in Refractory Juvenile Idiopathic Arthritis

Refractory Juvenile Idiopathic Arthritis (Despite 2 DMARDs Still Active)

Egypt
First Affiliated Hospital Bengbu Medical College

Recruiting

Clinical Exploration Trial of YOLT-101 in the Treatment of Familial Hypercholesterolemia (FH)

Familial Hypercholesterolemia

China
Klinikum Floridsdorf

Recruiting

Tablet-based Application for Cognitive Therapy (TACTIC)

Brain Injuries

Austria
University Hospital, Brest

Recruiting

Exploring the Impact of Monocytes in Myeloproliferative Neoplasia (EMYNEM) (EMYNEM)

Myeloproliferative Neoplasm

France
Rgenta Therapeutics Inc

Not yet recruiting

Study of Safety and Efficacy of RGT-61159 in Adults With Relapsed/Refractory Adenoid Cystic Carcinoma (ACC) or Colorectal Carcinoma (CRC)

Adenoid Cystic Carcinoma | Colorectal Cancer

United States
BioGaia AB

Not yet recruiting

Effect of Probiotic Limosilactobacillus Reuteri (L. Reuteri) on Crying and Fussing Time in Infants With Colic

Infantile Colic
Fudan University

Recruiting

Short-course Radiotherapy Combined With CAPOX and PD-1 Antibody Versus Long-course Chemoradiotherapy Combined With CAPOX for Early Low-lying Rectal Cancer (TORCH-E2)

Early Low Rectal Cancer

China
Samsung Medical Center

Recruiting

Safety of Dose Escalation in Definitive Hypofractionated Radiation Therapy and Hormone Therapy With SpaceOAR TM for Patients With High - Risk Localized Prostate Cancer (DESAR-H) (DESAR-H)

High Risk Prostate Carcinoma

Korea, Republic of
Atish Choudhury, MD
Bayer; Pfizer; National Comprehensive Cancer Network; Sumitomo Pharma America,...

Not yet recruiting

Comeback From Long coursE Androgen Deprivation Therapy (ADT) With RElugolix and Darolutamide (CLEARED)

Prostate Cancer | Advanced Prostate Cancer | Hormone Sensitive Prostate Cancer

United States
Sidney Kimmel Comprehensive Cancer Center at Johns...
Canon Medical Systems, USA

Not yet recruiting

Exploration of Personalized Biomarkers During Neoadjuvant Radiation Therapy for Spinal and Sacral Chordoma (Canon)

Chordoma of Sacrum | Chordoma of Spine | Chordoma of Skull Base
Zheng Liu
National Natural Science Foundation of China

Not yet recruiting

Efficacy and Safety of Arbidol in the Treatment of Allergic Rhinitis

Allergic Rhinitis

China

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