Search clinical trials for: phase 1b

Total 18988 results

Gilead Sciences

Completed

A Phase 1b Study Assessing GS-7340 in Treatment-Naive Adults With Chronic Hepatitis B

Chronic Hepatitis B

Canada, United States, United Kingdom, Australia, New Zealand
MedImmune LLC

Completed

A Phase 1b/2a Randomized, Double-Blind, Placebo-controlled, Dose-escalation Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of MEDI8897, a Monoclonal Antibody With an Extended Half-life Against Respiratory Syncytial Virus, in Healthy Preterm Infants (MEDI8897 1b)

Respiratory Syncytial Virus

United States, South Africa, Chile
OncBioMune Pharmaceuticals
United States Department of Defense

Unknown

Phase 1A/1B Study of PSA/IL-2/GM-CSF Vaccine for Recurrent Prostate Cancer in Hormone Naive and Hormone Independent Patients (PSA)

Prostate Cancer

United States
Novan, Inc.
Novella Clinical

Completed

A Phase 1b Study Assessing the PK, PD, Safety & Tolerability of SB414 in Atopic Dermatitis

Atopic Dermatitis

United States
Amgen

Completed

An Ascending Multiple Dose Study Evaluating AMG 167 in Healthy Men and Postmenopausal Women With Low Bone Mineral Density

Osteopenia
Assembly Biosciences

Completed

Phase 1b/2a Study of ABI-H0731 in Patients With Chronic Hepatitis B

Chronic Hepatitis B

Korea, Republic of, Taiwan, Australia, Hong Kong, United Kingdom
Cascadian Therapeutics Inc.
Celldex Therapeutics

Completed

Study of ONT-10 and Varlilumab to Treat Advanced Ovarian or Breast Cancer

Advanced Breast Carcinoma | Advanced Ovarian Carcinoma

United States
Cascadian Therapeutics Inc.

Completed

Phase 1b Maintenance Therapy Study of ONT-10 in Patients With Solid Tumors

Solid Tumors

United States
University of Texas Southwestern Medical Center

Completed

A Phase 1B Clinical Trial of Trametinib Plus Digoxin in Patients With Unresectable or Metastatic BRAF Wild-type Melanoma

Melanoma

United States
ResMed

Terminated

A Study of Expiratory Pressure Modulation in Moderate to Severe COPD Patients - Phase 1b (ComfortCOPD)

Chronic Obstructive Pulmonary Disease

Germany
National University Hospital, Singapore

Unknown

Phase 1b of ASLAN001 (Varlitinib) in Patients With Advanced/ Metastatic Hepatocellular Carcinoma (HCC)

Advanced/ Metastatic Hepatocellular Carcinoma

Singapore
Horizon Pharma USA, Inc.

Completed

A Phase 1b Study to Evaluate the Safety and PK of MP-376 in Chronic Obstructive Pulmonary Disease (COPD) Patients

Chronic Obstructive Pulmonary Disease

United States
AbbVie (prior sponsor, Abbott)
Bristol-Myers Squibb

Completed

A Phase 1b/2, Dose-Escalation Study of Elotuzumab (Humanized Anti-CS1 Monoclonal IgG1 Antibody) in Relapsed Multiple Myeloma

Hematologic Cancer
DiaMedica Therapeutics Inc
Novotech (Australia) Pty Limited

Completed

An Open Label, Phase 1b, Ascending Dose Study of DM199

Stroke

Australia
AbbVie

Completed

A Phase 1b Study With Volociximab in Combination With Carboplatin and Paclitaxel in First-line, Advanced Non-Small Cell Lung Cancer (NSCLC)

Non-small Cell Lung Cancer
Daiichi Sankyo, Inc.

Terminated

Phase 1b/2 Study of U3-1287 in Combination With Trastuzumab Plus Paclitaxel in Newly Diagnosed Metastatic Breast Cancer (MBC)

Metastatic Breast Cancer

Chile, Argentina
EMD Serono Research & Development Institute, Inc.
Merck KGaA, Darmstadt, Germany

Completed

MSC2364447C Phase 1b in Systemic Lupus Erythematosus

Lupus Erythematosus, Systemic

United States, Bulgaria
Amgen

Completed

Phase 1b/2 Study of Carfilzomib, Carboplatin, and Etoposide in Patients With Previously Untreated Extensive Stage Small-cell Lung Cancer

Extensive-Stage Small-Cell Lung Cancer

Canada, United States, Russian Federation
Amgen

Completed

Phase 1b/2 Study of Carfilzomib in Relapsed Solid Tumors, Multiple Myeloma, or Lymphoma

Lymphoma | Small Cell Lung Cancer | Multiple Myeloma | Ovarian Cancer | Non-small Cell Lung Cancer | Solid Tumors | Renal Cancer

United States
MedImmune LLC

Terminated

A Phase 1b/2 Safety and Tolerability Study of MEDI6469 in Combination With Therapeutic Immune Agents or Monoclonal Antibodies (MEDI6469)

Advanced Solid Tumors | Aggressive B-cell Lymphomas

United States
Aptevo Therapeutics

Completed

Phase 1/1b Study of TRU-016 in Patients With Previously Treated CLL or Select Subtypes of Non-Hodgkin's Lymphoma

Chronic Lymphocytic Leukemia (CLL) | Non-Hodgkin's Lymphoma (NHL)

United States
Sirtris, a GSK Company
GlaxoSmithKline

Completed

A Phase 1b Study to Assess the Safety and Anti-inflammatory Effects of Two Different Doses of SRT2104 in Patients With Ulcerative Colitis

Colitis, Ulcerative

United States
Amgen

Completed

Phase 1b Multicenter Study of Carfilzomib With Lenalidomide and Dexamethasone in Relapsed Multiple Myeloma

Relapsed Multiple Myeloma

United States, Canada
Amgen

Completed

A Multicenter, Open-label, Phase 1b Study of Carfilzomib, Cyclophosphamide and Dexamethasone in Newly Diagnosed Multiple Myeloma Subjects (CHAMPION 2)

Multiple Myeloma

United States
Bristol-Myers Squibb
Nitto Denko Corporation

Completed

Phase 1b/2, Open Label, Repeat Dose, Dose Escalation Study of ND-L02-s0201 Injection in Subjects With Moderate to Extensive Fibrosis (METAVIR F3-4)

Moderate to Extensive Hepatic Fibrosis (METAVIR F3-4)

Bulgaria, United States
Amgen

Withdrawn

Phase 1b/2 Study of Oprozomib in Combination With Sorafenib in Subjects With Advanced Hepatocellular Carcinoma

Advanced Hepatocellular Carcinoma

United States
argenx

Completed

A Phase 1b Study of ARGX-111 in Patients With Advanced Cancer.

Cancer

Belgium
Bristol-Myers Squibb

Completed

A Phase 3 Evaluation of Daclatasvir and Asunaprevir in Treatment-naive Subjects With Chronic Hepatitis C Genotype 1b Infection

Hepatitis C

China, Korea, Republic of, Russian Federation
NantCell, Inc.

Terminated

QUILT-2.017: Phase 1b/2 Study of AMG 479 in Combination With Paclitaxel and Carboplatin for 1st Line Treatment of Advanced Squamous Non-Small Cell Lung Cancer

Advanced Squamous Non-Small Cell Lung Cancer

United States
University Health Network, Toronto
AstraZeneca

Completed

Phase 2 Study Of Neoadjuvant Iressa Treatment In Stage 1 NSCLC

LUNG CANCER

Canada
London School of Hygiene and Tropical Medicine
University of Colorado, Boulder; Ministry of Health, Rwanda; Portland State University and other collaborators

Completed

Evaluation of a Project to Distribute Water Filters and Cook Stoves in Western Rwanda--Phase 1B

Focus of Study is to Assess Filter and Stove Use and Efficacy in Reducing Exposure to Waterborne and Airborne Pathogens

Rwanda
EMD Serono
Sanofi

Completed

Trial of MEK Inhibitor and PI3K/mTOR Inhibitor in Subjects With Locally Advanced or Metastatic Solid Tumors

Melanoma | Breast Cancer | Colorectal Cancer | Non Small Cell Lung Cancer | Metastatic Solid Tumor | Locally Advanced Solid Tumor

United States, Italy, Spain
National Institute on Drug Abuse (NIDA)

Completed

Study to Assess Potential Interactions Between Intravenous Cocaine and Oral Lorcaserin

Cocaine Abuse

United States
University of Texas Southwestern Medical Center

Terminated

A Two-arm, Single Center Phase 1b Trial of Bavituximab Plus Ipilimumab in Advanced Melanoma Patients

Melanoma

United States
AbbVie

Withdrawn

Study of Ombitasvir/Paritaprevir/Ritonavir in Japanese Adults With Genotype 1b Chronic Hepatitis C Virus (HCV) Infection With End Stage Renal Disease (ESRD) on Hemodialysis (HD) (GIFT-R)

Chronic Hepatitis C Virus
Eyegate Pharmaceuticals, Inc.

Completed

OPEN-LABEL, MULTI-CENTER, PHASE 1b/2a CLINICAL TRIAL DESIGNED TO EVALUATE THE SAFETY AND EFFICACY OF IONTOPHORETIC DEXAMETHASONE PHOSPHATE OPHTHALMIC SOLUTION IN PATIENTS HAVING UNDERGONE CATARACT SURGERY WITH IMPLANTATION OF A POSTERIOR CHAMBER INTRAOCULAR LENS (IOL)

Patients Having Undergone Unilateral Cataract Extraction and Implantation of a Monofocal

United States
NantCell, Inc.

Completed

QUILT-2.016: Study of AMG 479 With Biologics or Chemotherapy for Subjects With Advanced Solid Tumors

Cancer | Advanced Solid Tumors | Solid Tumors | Tumors | Advanced Malignancy
Bayer

Withdrawn

Phase 1b/2 Study Testing Radium-223 Dichloride/Bortezomib/Dexamethasone Combination in Relapsed Multiple Myeloma

Multiple Myeloma

Belgium, Spain, Korea, Republic of, Taiwan, United States, Australia, Germany, Israel, Italy, Greece, Canada
Pfizer

Completed

Study Of Two Dosing Regimens Of PF-04937319 Compared To An Approved Agent (Sitagliptin) In Patients With Type 2 Diabetes

Type 2 Diabetes Mellitus

United States
Novartis Pharmaceuticals

Terminated

Phase 1b/2 Study of BKM120 Plus Trastuzumab in Patients With HER2-positive Breast Cancer

Metastatic Breast Cancer | HER2+ Breast Cancer

Belgium, France, Spain, United States, United Kingdom, Italy
Eyegate Pharmaceuticals, Inc.

Terminated

Open-label, Multli-center, Phase 1b/2a Clinical Trial Designed to Evaluate the Safety and Efficacy of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution in Patients With Macular Edema

Macular Edema

United States
Amgen

Completed

Phase 1b/2 Trial of AMG386 With Pemetrexed and Carboplatin in Non-Small Cell Lung Cancer

Non Small Cell Lung Cancer

United States, Canada, Australia, Spain, Belgium, Greece
Gilead Sciences

Completed

A Phase 1b Study Evaluating GS-9820 in Subjects With Lymphoid Malignancies

Lymphoid Malignancies

Netherlands
M.D. Anderson Cancer Center
Novartis

Completed

High-Dose Gleevec Alone or in Combination With Peg-Intron and GM-CSF in Early Phase Chronic Myelogenous Leukemia (CML)

Leukemia, Myeloid, Chronic

United States
Actelion

Terminated

Clinical Study on the Safety and Tolerability of Macitentan in Combination With Dose-dense Temozolomide in Patients With Recurrent Glioblastoma

Glioblastoma

United States
Amgen

Completed

Phase 1/1b Study of Rilotumumab in Japanese Subjects With Advanced Solid Tumors or Advanced or Metastatic Gastric or GEJ

Part 1- Advanced Solid Tumors | Part 2- Advanced or Metastatic Gastric Cancer | Part 2- Advanced or Metastatic GEJ

Japan
Amgen

Completed

A Phase 1b/2 Study of AMG 655 in Combination With Paclitaxel and Carboplatin for the First-Line Treatment of Advanced Non-Small Cell Lung Cancer

Non-Small Cell Lung Cancer
Presidio Pharmaceuticals, Inc.

Completed

A Phase 1a/1b Study of PPI-383 in Healthy Adults and Hepatitis C Patients

Hepatitis C, Chronic

United Kingdom, Mauritius
Bastyr University
University of Washington; Fred Hutchinson Cancer Center

Withdrawn

A Phase 1b Dose Escalation Trial of PSK®/Placebo With Docetaxel to Treat Metastatic Castration-resistant Prostate Cancer

Prostatic Neoplasms

United States
Bristol-Myers Squibb

Completed

Phase II, 2nd Line Melanoma - RAND Monotherapy

Melanoma

France, Italy, United States, Germany, Canada, Denmark

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