Search clinical trials for: safety issues

Total 44679 results

AbbVie

Not yet recruiting

A Study to Assess Disease Activity and Safety of Lutikizumab in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa

Hidradenitis Suppurativa
Chang Gung Memorial Hospital

Not yet recruiting

Efficacy and Safety of Hydroxychloroquine in the Treatment of Sudden Sensorineural Hearing Loss

Sudden Hearing Loss
Loci Orthopaedics

Not yet recruiting

Thumb Hemi-Arthroplasty With Natural Kinematics; a Prospective Multicenter Study to Confirm the Safety and Efficacy of the InDx Implant (THANKS PRO)

CMC Joint Arthritis
Institute of Liver and Biliary Sciences, India

Not yet recruiting

Safety and Adequacy of Trans-jugular Liver Biopsy in Patients With Liver Disease: SAFE-TJLB Study

Liver Cirrhosis

India
Grupo Espanol de Trabajo en Enfermedad de Crohn...
Pfizer

Recruiting

An Active Surveillance, Post-Authorization Study to Characterize the Safety of Tofacitinib in Patients With Moderately to Severely Active Ulcerative Colitis in the Real-World Setting Using Data From the United Registries for Clinical Assessment and Research (UR-CARE) in the European Union (EU) (PASS TOFA)

Ulcerative Colitis

Belgium, Bulgaria, Greece, Lithuania
Kors van der Ent
European Union

Recruiting

Clinical Trial to Evaluate the Efficacy and Safety of Dirocaftor/Posenacaftor/Nesolicaftor in Adults With CF (CHOICES)

Cystic Fibrosis

Netherlands, Spain, France, Germany, Italy, United Kingdom, Portugal, Belgium, Sweden
Septodont

Recruiting

Measurement of the Performance and Safety of RTR+Membrane in Guided Tissue Regeneration (GTR) in Dental Surgical Procedures (ObsR+)

Guided Bone Regeneration

France
BioNTech SE

Not yet recruiting

A First-in-human Safety Trial of BNT331 Administered as Single Ascending Doses in Healthy Women and as Multiple Ascending Doses in Women Diagnosed With Bacterial Vaginosis

Bacterial Vaginosis

United States
Shikai Wu

Recruiting

Development and Application Study of ePRO Software for Managing Cancer Patients Throughout the Treatment Period

Solid Tumor, Adult

China
Luye Pharma Group Ltd.

Recruiting

Phase II Clinical Trial to Evaluate the Efficacy and Safety of LPM3480392 Injection for Moderate to Severe Pain After Orthopedic Surgery

Pain, Postoperative

China
Guangdong Hengrui Pharmaceutical Co., Ltd

Not yet recruiting

Efficacy and Safety Study of SHR-1819 Injection in Adult Patients With Severe Atopic Dermatitis

Moderate to Severe Atopic Dermatitis

China
Duke University

Not yet recruiting

A Phase 1 Open-Label Study to Evaluate the Safety, Tolerability and Efficacy of JCXH-211 (SElf-Replicating RNA IL-12) Intratumoral Injection in Patients With Recurrent or Progressive High-Grade Glioma (SERIL)

Recurrent or Progressive High-grade Glioma
AstraZeneca

Not yet recruiting

A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of AZD5148 in Healthy Adults

Healthy Participants

United States
Shivanka Research, LLC
Eric Solutions LLC; Clinexcel Research, Ahmedabad, India

Not yet recruiting

SAD Study to Evaluate Safety, Tolerability, and Pharmacokinetic Profile of KSHN001126 in Healthy Post-Menopausal Females

Healthy Postmenopausal Women

United States, India
Shanghai Bovax Biotechnology Co., Ltd.

Not yet recruiting

A Phase III Study to Evaluate the Efficacy, Immunogenicity and Safety of the 9-valent HPV Vaccine in Chinese Males

Anal Cancer | HPV-Related Carcinoma | Penile Cancer | Genital Wart | AIN3 | AIN2 | PIN-1 | AIN1 | PIN2 | PIN3

China
Second Affiliated Hospital, School of Medicine,...

Not yet recruiting

Efficacy and Safety of Dupilumab in Combination With Tofacitinib in Moderate to Severe Adult AD Patients

Atopic Dermatitis
The Archer-Daniels-Midland Company
Merieux NutriSciences (China)

Not yet recruiting

Determination of the Safety and Efficacy of Two Probiotic Strains (CODECS)

Gastrointestinal Dysfunction
Longevity Biotech Australia Pty Ltd (subsidiary)

Not yet recruiting

A Two-Part Single and Multiple Ascending Dose Trial of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LBT-3627 in Healthy Participants and in Participants With Parkinson's Disease.

Parkinson Disease

Australia
KalVista Pharmaceuticals, Ltd.

Not yet recruiting

Open-Label Safety, PK, and Efficacy Trial of Sebetralstat (KVD900) in Pediatric Patients (Ages 2-11) With HAE Type I or II (KONFIDENT-KID)

Hereditary Angioedema
Philips Healthcare (Suzhou) Co., Ltd.

Not yet recruiting

Clinical Study of CT 5400 RT for System Validation

Performance and Safety
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...
EMD Serono Research & Development Institute, Inc.

Not yet recruiting

Efficacy and Safety of a New Formulation of Oral Cladribine Compared With Placebo in Participants With Generalized Myasthenia Gravis (MyClad)

Generalized Myasthenia Gravis

United States, Germany
University of Washington
National Institute of Mental Health (NIMH)

Not yet recruiting

Safety Planning and Cognitive Behavioral Therapy for Adolescent Suicide Prevention in Mozambique

Suicide Prevention
Emory University
The Marcus Foundation

Not yet recruiting

A Phase 1 Open-Label Study of the Safety of Intravenous Allogeneic Neonatal Mesenchymal Cells (nMSCs) in Young Adult (1A) and Pediatric (1B) Patients With Dilated Cardiomyopathy (DCM)

Dilated Cardiomyopathy

United States
IVIEW Therapeutics Inc.

Not yet recruiting

Trial to Evaluate the Efficacy And Safety of IVIEW-1201 In the Treatment of Fungal Keratitis

Fungal Keratitis
Genelux Corporation
Newsoara Biopharma Co., Ltd.

Not yet recruiting

Efficacy & Safety of Olvimulogene Nanivacirepvec & Platinum-doublet + Physician's of Choice Immune Checkpoint Inhibitor Compared to Docetaxel in NSCL Cancer (VIRO-25) ((VIRO-25))

Non-small Cell Lung Cancer Stage III | Non-small Cell Lung Cancer | Advanced Non-squamous Non-small-cell Lung Cancer | Non-small Cell Lung Cancer Stage IV | Metastatic Squamous Non-Small Cell Lung Carcinoma | Non-small Cell Lung Cancer Recurrent | Metastatic Non-squamous Non Small Cell Lung Cancer and other conditions
ResoTher Pharma

Recruiting

A Study of RTP-026 to Assess Safety, Tolerability and Efficacy in Patients With ST-Elevation Myocardial Infarction (STEMI)

ST Elevation Myocardial Infarction

Denmark
Biocodex
Exystat

Not yet recruiting

Evaluation of the Efficacy and Safety of Stiripentol in Patients 6 Years and Older With Primary Hyperoxaluria Type 1, 2 or 3 (CRYSTAL)

Primary Hyperoxaluria Type 3 | Primary Hyperoxaluria Type 2 | Primary Hyperoxaluria Type 1
Wuhan Union Hospital, China
Wuhan Hamilton Biotechnology Co., Ltd; Guangzhou Hamilton Biotechnology Co....

Not yet recruiting

Phase I Clinical Trial of UC-MSCs in the Treatment of Knee Osteoarthritis

Knee Osteoarthritis
MBX Biosciences

Recruiting

Safety, Pharmacokinetics and Efficacy of MBX 2109 in Patients With Hypoparathyroidism

Hypoparathyroidism

United States
InventVacc Biologicals Inc.
Hia Consortium

Recruiting

A Study to Evaluate Safety and Immunogenicity of Haemophilus Influenzae Serotype A Vaccine

Haemophilus Influenzae Meningitis | Invasive Haemophilus Influenzae Disease

Canada
Inozyme Pharma

Not yet recruiting

ADAPT Study: Long-term Safety Study of INZ-701 in Patients With ENPP1 Deficiency and ABCC6 Deficiency

Pseudoxanthoma Elasticum | Arterial Calcification | Gene Mutations | Ectonucleotide Pyrophosphatase/phosphodiesterase1 Deficiency | Autosomal Recessive Hypophosphatemic Rickets Type 2
Beijing 302 Hospital

Not yet recruiting

Safety and Efficacy of Autologous Tumor-infiltrating Lymphocytes Therapy in Patients With Hepatocellular Carcinoma

Hepatocellular Carcinoma

China
Emory University
University of California, San Diego; Ventrix, Inc.

Not yet recruiting

Study of Intramyocardial Injection of Ventrix Bio Extracellular Matrix (VentriGel) to Assess the Safety and Feasibility in Pediatric Patients With Hypoplastic Left Heart Syndrome (HLHS)

Hypoplastic Left Heart Syndrome

United States
Eisai Inc.

Not yet recruiting

A Study to Evaluate the Efficacy, Safety, and Tolerability of E2086 Compared to Placebo and Active Comparator in Adult Participants With Narcolepsy Type 1

Narcolepsy Type 1 (NT1)
TC Biopharm

Not yet recruiting

ACHIEVE2 - Safety and Preliminary Efficacy of Intravenous TCB008 in Patients With Relapse or Refractory Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)/AML (ACHIEVE2)

Acute Myeloid Leukemia | Myelodysplastic Syndromes
The First Affiliated Hospital with Nanjing Medical...

Not yet recruiting

Efficacy and Safety of Anti-PD-1, Thymosin, and SOX in Neoadjuvant Treatment of cStage III Gastric/GEJ Adenocarcinoma

Gastric Cancer | Esophagogastric Junction Adenocarcinoma
Guangzhou University of Traditional Chinese Medicine
Jiangsu Province Hospital of Traditional Chinese Medicine; The First Affiliated...

Not yet recruiting

Acupuncture for Enhancing Immunotherapy in Advanced NSCLC：a Pilot Study

Non-small Cell Lung Cancer | Non-Small-Cell Lung Carcinoma

China
Rgenta Therapeutics Inc

Not yet recruiting

Study of Safety and Efficacy of RGT-61159 in Adults With Relapsed/Refractory Adenoid Cystic Carcinoma (ACC) or Colorectal Carcinoma (CRC)

Adenoid Cystic Carcinoma | Colorectal Cancer

United States
University of Pittsburgh
University of Oregon; National Institute of Mental Health (NIMH)

Recruiting

Testing an Intergenerational Model of Suicide Risk in Mother-child Dyads

Emotion Regulation

United States
Zheng Liu
National Natural Science Foundation of China

Not yet recruiting

Efficacy and Safety of Arbidol in the Treatment of Allergic Rhinitis

Allergic Rhinitis

China
Samsung Medical Center

Recruiting

Safety of Dose Escalation in Definitive Hypofractionated Radiation Therapy and Hormone Therapy With SpaceOAR TM for Patients With High - Risk Localized Prostate Cancer (DESAR-H) (DESAR-H)

High Risk Prostate Carcinoma

Korea, Republic of
Canadian Blood Services

Not yet recruiting

Surveillance of Emerging Pathogens to Ensure Blood Supply Safety

Babesioses, Human
Novartis Pharmaceuticals

Not yet recruiting

Study of Efficacy and Safety of Ruxolitinib in Patients With Grade II to IV Steroid-refractory Acute Graft vs. Host Disease

Steroid-refractory Acute Graft Versus Host Disease
Samsung Medical Center

Recruiting

Safety of Dose Escalation in Definitive Hypofractionated Radiation Therapy With SPACEOAR TM for Patients With Low-to-intermediate Risk Localized Prostate Cancer (DESAR-L) (DESAR-L)

Low-to-intermediate-risk Prostate Carcinoma

Korea, Republic of
Kaplan Medical Center

Recruiting

Intra-articular Allocetra in Osteoarthritis of the 1st Carpo-metacarpal Joint

Osteoarthritis Thumb

Israel
Ray Therapeutics, Inc.

Not yet recruiting

Study to Evaluate Safety of RTx-015 Injection in Retinitis Pigmentosa Patients

Retinitis Pigmentosa

United States
Vertex Pharmaceuticals Incorporated

Not yet recruiting

Evaluation of Long-term Safety and Efficacy of ELX/TEZ/IVA in Cystic Fibrosis Participants 12 Months of Age and Older

Cystic Fibrosis
Tongji Hospital
The First People's Hospital of Jingzhou; Wuhan Central Hospital; Wuhan No.1 Hospital and other collaborators

Recruiting

Safety, Efficacy, and Compliance of Telitacicept in the Treatment of Systemic Lupus Erythematosus (SLE)

Systemic Lupus Erythematosus

China
Il-Yang Pharm. Co., Ltd.

Not yet recruiting

Clinical Trial to Investigate the Effects of Food on the Pharmacokinetics and Safety of Orally Administered Radotinib

Drug Kinetics

Korea, Republic of
Jennifer Hughes
American Foundation for Suicide Prevention

Recruiting

SAFETY-Parent: Online Learning Module to Support Parents of Suicidal Youth (SAFETY-P)

Suicide, Attempted | Suicide | Suicide Threat | Suicide and Self-harm

United States

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