Search clinical trials for: NRAS Mutation

Total 3326 results

Children's Oncology Group
National Cancer Institute (NCI)

Completed

Biomarkers in Patients With Acute Myeloid Leukemia

Leukemia
Mansoura University

Unknown

Role of Low-intensity Shock Wave Therapy in Penile Rehabilitation Post Nerve Sparing Radical Cysto-prostatectomy

Bladder Cancer

Egypt
Genzyme, a Sanofi Company

Completed

Screening Protocol to Evaluate Acid Alpha-Glucosidase (GAA) Activity and GAA Gene Mutations in Patients With Late Onset Pompe Disease

Pompe Disease

United States
Northwestern University
ViraCor Laboratories

Completed

Genetic Screening for Filaggrin Mutation in Atopic Dermatitis and Ichthyosis Vulgaris in the African American Population

Atopic Dermatitis | Ichthyosis Vulgaris

United States
National Cancer Institute (NCI)

Completed

Study of a Polymorphism in Patients With Prostate Cancer

Prostate Cancer
National Cancer Institute (NCI)

Completed

Genetic Study of Patients Previously Treated With Flavopiridol on Clinical Trial NCI-97-C-0171C

Unspecified Adult Solid Tumor, Protocol Specific

United States
GlaxoSmithKline

Completed

Regulatory Hycamtin(Oral) PMS (Hycamtin PMS)

Lung Cancer, Small Cell

Korea, Republic of
Hebei Yanda Hospital
Beijing Tiantan Hospital

Unknown

A Study to Evaluate the Safety and Effectiveness of PCV Chemotherapy in Patients With Recurrent High-grade Glioma With IDH1/2 Mutation

Recurrent High-grade Glioma

China
People's Hospital of Guangxi

Unknown

Icotinib With Concurrent Radiotherapy vs. Chemoradiotherapy in Non-small Cell Lung Cancer

Non-small Cell Lung Cancer

China
National Cancer Institute (NCI)

Completed

Pertuzumab and Cetuximab in Treating Patients With Previously Treated Locally Advanced or Metastatic Colorectal Cancer

Stage IV Colon Cancer | Stage IV Rectal Cancer | Recurrent Colon Cancer | Recurrent Rectal Cancer | Adenocarcinoma of the Rectum | Stage III Colon Cancer | Stage III Rectal Cancer | Adenocarcinoma of the Colon

United States
Zhejiang University
Beta Pharma, Inc.; Jiangsu Simcere Pharmaceutical Co., Ltd.

Unknown

Rh-Endostatin in Combination With Icotinib for Advanced NSCLC With EGFR Mutations

Lung Cancer

China
Bai Jun

Unknown

Gefitinib Combined With Thalidomide to Treat NSCLC

NSCLC
Southwest Oncology Group
National Cancer Institute (NCI)

Completed

S9031-9333-0106-0112-A Study of Biomarkers in Samples From Patients With Acute Myeloid Leukemia Treated With Standard Chemotherapy With or Without Gemtuzumab Ozogamicin

Leukemia
Southwest Oncology Group
National Cancer Institute (NCI)

Completed

S9031-S9126-S9333-S9500-B Biomarker Expression in Patients With Acute Myeloid Leukemia

Leukemia
Hoffmann-La Roche

Completed

A Study of Erlotinib (Tarceva) Versus Gemcitabine/Cisplatin as First-line Treatment in Patients With Non-small Cell Lung Cancer With EGFR Mutations

Non-Small Cell Lung Cancer

China, Philippines, Malaysia
Taipei Veterans General Hospital, Taiwan

Unknown

The Role of EGFR Mutations in Pancreatic Cancer Patients Receiving Gemcitabine With or Without Erlotinib

Metastatic Pancreatic Cancer

Taiwan
California Cancer Consortium
National Cancer Institute (NCI)

Terminated

Irinotecan in Treating Patients With Colorectal Cancer

Colorectal Cancer

United States
Vertex Pharmaceuticals Incorporated
Cystic Fibrosis Foundation

Completed

Study of Ivacaftor in Subjects With Cystic Fibrosis (CF) Who Have the R117H-CF Transmembrane Conductance Regulator (CFTR) Mutation (KONDUCT) (KONDUCT)

Cystic Fibrosis

United States, United Kingdom
The First Affiliated Hospital of Guangzhou Medical...

Unknown

Erlotinib 100mg or 150mg in Treating EGFR Mutated NSCLC

NSCLC | EGFR Mutation

China
michal roll

Unknown

Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutation in Familial Adenomatous Polyposis-minors' Adjusted Version

FAP-Familial Adenomatous Polyposis
Shanghai Chest Hospital

Unknown

Comparator-Controlled Study for EGFR(+) Patients With Multiple BMs From NSCLC (BROKE) (EGFR-epidermal Growth Factor Receptor;BM-brain Metastases) (EGFR)

Non-Small Cell Lung Cancer | Brain Metastases | EGFR Gene Mutation

China
Merck Sharp & Dohme LLC
Ariad Pharmaceuticals

Terminated

A Study of Ridaforolimus in Non-Small Cell Lung Cancer (NSCLC) Patients With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Mutations (MK-8669-021 AM1)

Non-Small Cell Lung Cancer
Rabin Medical Center
Charite University, Berlin, Germany; National Institute on Aging (NIA)

Unknown

Finding Genes With NGS Techniques in Whom Mutations Cause Neurological Diseases (NGS)

Neurological Diseases

Israel
Pfizer

Withdrawn

A Study For Patients With EGFRm (Epidermal Growth Factor Receptor Mutant) Lung Cancer

Advanced EGFRm (Del 19 or L858R +/- T790M) NSCLC
Institut Paoli-Calmettes

Unknown

Triple Negative Breast Cancer: Study of Molecular and Genetic Factors

Breast Cancer

France
Children's Healthcare of Atlanta
Emory University; Brigham and Women's Hospital; University of California, San... and other collaborators

Withdrawn

Genes Mutation Pentalogy of Cantrell

Pentalogy of Cantrell | Mutations in Non-muscle Genes

United States
QLT Inc.

Completed

Oral QLT091001 in Retinitis Pigmentosa (RP) Subjects With an Autosomal Dominant Mutation in Retinal Pigment Epithelial 65 Protein (RPE65)

Retinitis Pigmentosa (RP)

Canada, Ireland
OHSU Knight Cancer Institute

Completed

Molecular Markers in Thyroid Cancer

Thyroid Cancer

United States
Hillel Yaffe Medical Center
Technion, Israel Institute of Technology

Unknown

Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases

Retinitis Pigmentosa
Vejle Hospital

Terminated

First-Line Chemotherapy and Panitumumab in Advanced Non-Small Cell Lung Cancer (Lung-TRIO)

Non Small Cell Lung Cancer

Denmark
Andreas Arnold

Completed

EVER/TMC Mutation as Marker of the Risk of Cutaneous Carcinoma in Immunosuppressed Patients (EBVER/TMC)

Immunosuppression | Neoplasm

Switzerland
Ronald Hoffman
National Cancer Institute (NCI); Myeloproliferative Disorders-Research Consortium

Unknown

CEP-701 (Lestaurtinib) in Myelofibrosis

Polycythemia Vera | Essential Thrombocythemia | Myelofibrosis

United States
Nivalis Therapeutics, Inc.

Completed

Safety and Pharmacokinetic Study of N6022 in Subjects With Cystic Fibrosis Homozygous for the F508del-CFTR Mutation (SNO-1)

Cystic Fibrosis

United States
Groupe Français de Pneumo-Cancérologie

Completed

Retrospective Study in Non Small Cell Lung Cancer (NSCLC) With Epidermal Growth Factor Receptor (EGFR) (EGFR-RETRO)

NSCLC Non Small Cells Lung Cancer

France
Chinese PLA General Hospital

Unknown

Icotinib as the Adjunctive Treatment After Surgery in Stage I-IIIB Lung Adenocarcinoma Patients With EGFR Gene Mutation

Neoplasms, Therapy-Associated

China
Vertex Pharmaceuticals Incorporated
Cystic Fibrosis Foundation

Completed

Study of Ivacaftor in Subjects With Cystic Fibrosis (CF) Who Have a Non-G551D CF Transmembrane Conductance Regulator (CFTR) Gating Mutation (KONNECTION)

Cystic Fibrosis

United States, France, Belgium
National Human Genome Research Institute (NHGRI)
National Cancer Institute (NCI)

Completed

Study of the Results of Education and Counseling for Persons Undergoing Genetic Testing for Hereditary Nonpolyposis Colon Cancer

Colorectal Cancer

United States
Hellenic Oncology Research Group

Completed

Assessment of Clinical Practice Administration of Chemotherapy and Anti-angiogenic Agent (Bevacizumab) in Colorectal Cancer

Metastatic Colorectal Cancer

Greece
Nanfang Hospital of Southern Medical University

Unknown

Study of Chemotherapy Plus Icotinib to Treat EGFR Mutation-positive Non-small-cell Lung Cancer

NSCLC

China
Sidney Kimmel Comprehensive Cancer Center at Johns...
National Cancer Institute (NCI)

Terminated

Everolimus in Treating Patients With Advanced or Metastatic Colorectal Cancer That Did Not Respond to Previous Therapy

Colorectal Cancer

United States
Maggiore Bellaria Hospital, Bologna

Completed

Role of Rapid On-site Evaluation for Mutational Analysis of EBUS-TBNA Specimens

Non-small Cell Lung Cancer

Italy
Wuhan Union Hospital, China

Unknown

Study of EGFR-TKI to Asymptomatic Brain Metastases of NSCLC (EABM)

Asymptomatic Brain Metastases of Non Small Cell Lung Cancer
Tongji University
Sun Yat-sen University; Peking Union Medical College Hospital; RenJi Hospital; Guangdong... and other collaborators

Completed

Erlotinib Versus Gemcitabine/Carboplatin in Chemo-naive Stage IIIB/IV Non-Small Cell Lung Cancer Patients With Epidermal Growth Factor Receptor (EGFR) Exon 19 or 21 Mutation (ML20981)

Non-small Cell Lung Cancer

China
Si-Yu Wang

Completed

Erlotinib Versus Pemetrexed as Second-Line Therapy in Treating Patients With Advanced Lung Adenocarcinoma

Lung Cancer

China
Moshe Flugelman

Terminated

Examining B12 Deficiency Associated With C677T Mutation on MTHFR Gene in Terms of Commonness and Endothelial Function

B12 Deficiency Combined With C677T Mutation on MTHFR Gene

Israel
Shanghai Children's Medical Center

Unknown

Mutation of the BTK Gene and Genotype-phenotype Correlation of Chinese Patients With X-Linked Agammaglobulinemia

Agammaglobulinemia, BTK

China
University Hospital Inselspital, Berne

Terminated

Effects of Mutations of the Glycine Gene Associated With Hyperekplexia on Central Pain Processing

Hyperekplexia

Switzerland
Piramal Enterprises Limited
Melanoma Research Foundation Breakthrough Consortium

Suspended

Study of an Oral Cdk Inhibitor Administered With an Oral BRAF Inhibitor in Patients With Advanced or Inoperable Malignant Melanoma With BRAF Mutation

Advanced or Inoperable Malignant Melanoma With BRAF Mutation

United States
Rhode Island Hospital

Unknown

Molecular Testing of Cancer by Integrated Genomic, Transcriptomic, and Proteomic Analysis

Solid Tumors | Hematological Malignancies

United States
Amsterdam UMC, location VUmc

Unknown

Paclitaxel-trastuzumab in EGFR-mutated NSCLC Patients

NSCLC | EGFR-mutation | HER2-expression

Netherlands

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