Search clinical trials for: mutation

Total 3277 results

Radboud University Medical Center

Unknown

Patient Empowerment by Group Medical Consultations (GMC)

Breast Cancer | BRCA Mutation

Netherlands
University Hospital, Antwerp
AstraZeneca; Universiteit Antwerpen

Completed

Study in NSCLC: is Timely Analysis of EGFR-mutation Status Feasible in Region Antwerp, Belgium. (HERMES)

Non Small Cell Lung Cancer

Belgium
University Hospital, Ghent

Completed

Belgian Screening Project for the Detection of Anderson-Fabry Disease in Hypertrophic Cardiomyopathy

Left Ventricular Hypertrophy

Belgium
Guangxi Medical University

Completed

Study on the Evolution of Genes Mutation Related With Gastrointestinal Stromal Tumors

Full Gene Sequences of c-KIT、PDGFRA and DOG1 Are Analyzed With the Screening-sequencing Approach | Investigate the Characteristics and Variations Associated With the Different Gene Mutations of c-KIT、PDGFRA and DOG1 in GIST Patients
Institut de Recherche pour le Developpement

Completed

One Month Dual Antiretroviral Prophylaxis to Prevent Resistance Mutations in Mothers Exposed to Single Dose Nevirapine

HIV Infections

Thailand
Chinese Lung Cancer Surgical Group
Zhejiang Cancer Hospital; Sun Yat-sen University; Fudan University; Chinese PLA... and other collaborators

Unknown

Erlotinib Versus Vinorelbine/Cisplatin as Adjuvant Treatment in Stage IIIA NSCLC Patients With EGFR Mutations

Non-small Cell Lung Cancer Stage IIIA

China
Gilead Sciences

Completed

CHARM: Chronic Hepatitis B Antihepadnaviral Resistance Mutation Study (CHARM)

Chronic Hepatitis B

Australia
National Cancer Center, Korea
Pfizer; Roche Pharma AG

Unknown

Induction Chemotherapy Followed by CCRT According to EGFR Mutation Status in NSCLC III

NSCLC | Lung Cancer

Korea, Republic of
HaEmek Medical Center, Israel

Completed

Thrombophilic Risk Factors in Pediatric Patients Diagnosed at the Ha'Emek Medical Center

Thrombosis

Israel
Bezmialem Vakif University

Unknown

BRAF V600E Mutations In Papillary Thyroid Carcinoma

Papillary Thyroid Carcinoma

Turkey
Abbott

Completed

Evaluation of Kaletra Therapy Over the Long-term

Human Immunodeficiency Virus

Germany
University of Pennsylvania

Completed

Factor V Leiden Mutation and Implantation Failure

Infertility

United States
University of Utah
National Institutes of Health (NIH)

Completed

The Molecular Biology of Paroxysmal Nocturnal Hemoglobinuria (PNH)

Hemoglobinuria, Paroxysmal

United States
AstraZeneca

Completed

To Study the Changes in Protein in Lung Cells of Asian Patients With Advanced Non-small Cell Lung Cancer (NSCLC) (PIONEER)

Non Small Cell Lung Cancer

Vietnam, Philippines, China, Hong Kong, Taiwan, Thailand, India
University Health Network, Toronto

Terminated

An Evaluation of the Development of Nevirapine Induced Mutations in HIV Patients Initiating or Discontinuing Combination Antiretroviral Therapy

Drug Resistance

Canada
ZhuGuangYing
Zhejiang Cancer Hospital; 307 Hospital of PLA; Fudan University; Cancer Institute... and other collaborators

Unknown

Radiotherapy Combined With Iressa for EGFR Mutation Positive Patients With Locally Advanced Non-small Cell Lung Cancer (NSCLC)

Non-small Cell Lung Cancer

China
IRCCS Policlinico S. Matteo
GlaxoSmithKline; University of Pavia; Azienda Ospedaliera di Padova; Azienda Ospedaliera... and other collaborators

Completed

Efficacy of Eltrombopag to Improve Thrombocytopenia of MYH9-related Disease

Blood Platelet Disorders

Italy
Clinical Research Center for Solid Tumor, Korea
Seoul National University Hospital; Korean Cancer Study Group

Terminated

A Study to Assess the Efficacy of Erlotinib for Leptomeningeal Carcinomatosis in EGFR Mutation Positive Non-small Cell Lung Cancer

Non-small Cell Lung Cancer | Leptomeningeal Carcinomatosis

Korea, Republic of
Peking Union Medical College Hospital
Peking University People's Hospital

Unknown

A Retrospective EGFR Mutation Status Study in Chinese NSCLC Patients Using Paired Plasma and Tissue Samples

Carcinoma, Non-Small-Cell Lung

China
Avexa

Withdrawn

A Long Term Safety Study of Apricitabine in HIV-infected Patients

HIV Infections
Avexa

Completed

AVX754 (a New Nucleoside Reverse Transcriptase Inhibitor [NRTI]) to Treat Drug-resistant HIV

HIV Infections

Australia
Provitro GmbH
Charite University, Berlin, Germany; AstraZeneca

Completed

Pathomolecular Analysis of Rare EGFR Mutations in Advanced NSCLC

Mutations in Exons 18 to 21

Germany
Taipei Medical University WanFang Hospital

Unknown

Mutational Profiling in Colorectal Tumors to Determine Its Role in the Diagnosis, Prognostic Significance and Their Impact in Clinical Management

Colorectal Cancer

Taiwan
Illumina, Inc.

Completed

Detection of Factor V Leiden G1691A and Factor II (Prothrombin) G20210A Point Mutations in DNA

Detection and Genotyping of Factor V and Factor II Point Mutations
Vejle Hospital

Completed

Temsirolimus and Irinotecan for Treatment Resistant Patients With Metastatic Colorectal Cancer and KRAS Mutations (TIRASMUS)

Metastatic Colorectal Cancer

Denmark
SCRI Development Innovations, LLC
GlaxoSmithKline

Completed

Weekly Topotecan in Patients Treated for Metastatic Colorectal Cancer

Colon Cancer

United States
Penwest Pharmaceuticals Co.

Terminated

Safety and Efficacy Study of A0001 in Patients With the A3243G Mitochondrial DNA Point Mutation

Neuromuscular Disease

United Kingdom
Bristol-Myers Squibb

Completed

A Study of Prevalence of the I50L Mutation When ATV Treated Patients Fail the Regimen

HIV Infections

United States
Bristol-Myers Squibb

Completed

Effect of the Atazanavir (ATV) 150L Mutation on Subsequent Treatment Response in HIV Infected Subjects

HIV Infection

United States, Argentina, Brazil, Guatemala, Mexico, Peru, South Africa
Hillel Yaffe Medical Center
Weizmann Institute of Science

Unknown

Functional Role of RUNX1 Mutations in the Etiology of Acute Myeloid Leukemia (AML)

Acute Myeloid Leukemia

Israel
Peking Union Medical College

Suspended

The Chinese Mutation Hotspot of ENaC Causing Liddle's Syndrome and the Association of ENaC Variations and Hypertension

Hypertension

China
Gynecologic Oncology Group
National Cancer Institute (NCI)

Unknown

Studying Breast Cancer Risk in Women Who Are BRCA1/BRCA2 Mutation Carriers

Breast Cancer | brca1 Mutation Carrier | brca2 Mutation Carrier

United States
RostaQuo S.p.A.

Unknown

Antihypertensive Effect of Rostafuroxin Compared With Losartan in Hypertensive Patients Bearing Specified Gene Mutations

Essential Hypertension

Ireland, Italy, Poland
AstraZeneca

Completed

Epidemiological Study to Evaluate the Prevalence of Epidermal Growth Factor Receptor (EGFR) Mutation Status in Patients With Newly Diagnosed Locally Advanced or Metastatic Non Small Cell Lung Cancer (NSCLC) (Spanish REASON)

Non Small Cell Lung Cancer

Spain
Samsung Medical Center

Unknown

Iressa for EGFR Mutation Negative Non-small Cell Lung Cancer (NSCLC)

Nonsmall Cell Lung Cancer

Korea, Republic of
Assistance Publique - Hôpitaux de Paris

Unknown

Efficacy of Nilotinib in First or Second Line Treatment of Primary Melanomas Stage III Unresectable Melanomas. (NILOMEL)

Stage IV Melanoma | Stage III Melanoma | Amplification | Malignant Skin Melanoma T0

France
Peking University
Novartis

Completed

Trial of Imatinib (Gleevec®) in Selected Patients With Metastatic Melanoma

Metastatic Melanoma

China
Medical University of Graz

Completed

Study to Test Genetic Alterations Among Different Dermoscopic Types of Melanocytic Nevi.

Nevi

Austria
Mayo Clinic
GlaxoSmithKline

Completed

Phase I Study of GW572016 With Topotecan to Treat Advanced Solid Malignancies

Advanced Solid Malignancies

United States
Assistance Publique - Hôpitaux de Paris

Completed

Study of Factors of Genetic Susceptibility Associated to Severe Caries Phenotype (Cariogene)

Dental Caries

France
China Medical University Hospital

Unknown

Inherited Myokymia: A Clinical and Genetic Study of a Family

A Study of Clinical and Genetic Mutations in a Family of Neuromyotonia, so Called Isaac's Syndrome

Taiwan
Rambam Health Care Campus

Unknown

Safety and Clinical Effectiveness of 2 Lower Dose Combined PDE5i's vs. Single Maximal Dose PDE5i

Impotence

Israel
Memorial Sloan Kettering Cancer Center
New York University; Hadassah Medical Organization; New York Presbyterian Hospital and other collaborators

Completed

Awareness and Attitudes Regarding Prenatal and Preimplantation Genetic Diagnosis for Inherited Breast/Ovarian Cancer Risk

Breast Cancer | Ovarian Cancer

United States
Gustave Roussy, Cancer Campus, Grand Paris

Unknown

Sorafenib and Temozolomide in Treating Patients With Stage III or Stage IV Melanoma

Melanoma (Skin)

France
Odense University Hospital

Completed

Clinical Assessment of Patients With High Bone Mass Due to Mutation in Lrp5

Osteopetrosis

Denmark
Istituto Clinico Humanitas

Completed

Molecular Features Predicting Response/Resistance to Trastuzumab in Metastatic Breast Cancer Patients

Breast Cancer

Italy
SCRI Development Innovations, LLC
GlaxoSmithKline

Completed

Weekly Topotecan in the Second-Line Treatment of Small Cell Lung Cancer

Lung Cancer
Assistance Publique - Hôpitaux de Paris
Novartis; Association Rhumatisme et Travail

Completed

Genetic Study of Families Affected by Paget's Disease of Bone (PAGET)

Paget's Disease of Bone

France
GlaxoSmithKline

Completed

Meta-analysis of Efficacy of Topotecan

Cervical Intraepithelial Neoplasia
AstraZeneca

Completed

First-line Treatment for Adenocarcinoma Patients With Epidermal Growth Factor Receptor (EGFR) Mutation

Pulmonary Cancer

Korea, Republic of

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