Search clinical trials for: Mutation

Total 3274 results

Chinese PLA General Hospital

Unknown

A Chinese Randomized Crossover Study of Erlotinib Versus Docetaxel/Cisplatin in Previously Untreated Stage IIIB/IV Lung Adenocarcinoma With EGFR Mutations

Neoplasms, Lung | Carcinoma, Non-Small Cell Lung | Drug Therapy | Genes, EGFR

China
AstraZeneca

Completed

A Study on the Long Term Survivals in an Expand Access Program (EAP) of Iressa

Non-small Cell Lung Cancer

China
AstraZeneca
Laboratorio Progenetica

Completed

Epidemiologic Study of KRAS Mutation in Brazilian Patients With Advanced or Metastatic Non Small Cell Lung Cancer

Non Small Cell Lung Cancer

Brazil
University of Arizona
National Cancer Institute (NCI)

Completed

Fenretinide in Preventing Ovarian Cancer in Participants Who Are at High Risk for Developing Ovarian Cancer and Planning to Undergo Surgery to Remove the Ovaries

Ovarian Cancer | brca1 Mutation Carrier | brca2 Mutation Carrier

United States
National Taiwan University Hospital

Withdrawn

Efficacy of Type-5 Phosphodiesterase Inhibitors in Primary and Secondary Pulmonary Hypertension

Primary and Secondary Pulmonary Hypertension

Taiwan
Samsung Medical Center

Unknown

Genome Wide SNP Array-based Approach to Detect Micro-cytogenetic Lesions and KIT Mutation to Improve Treatment Outcomes in Patients With Core-binding Factor Positive Acute Myeloid Leukemia

Myeloid Leukemia

Korea, Republic of
University of New Mexico

Completed

Study of Adjuvant Topotecan and Cisplatin With Concurrent Radiation Therapy for Advanced Cervical Cancer

Cervical Cancer

United States
New York Presbyterian Hospital
Women At Risk

Unknown

Women At Risk: The High Risk Breast Cancer Program (WAR)

Breast Cancer

United States
Institut du Cancer de Montpellier - Val d'Aurelle

Unknown

Biological Factors in Predicting Response to Treatment in Patients With Esophageal Cancer or Rectal Cancer

Colorectal Cancer | Esophageal Cancer

France
Women's College Hospital
BioResponse

Unknown

The Potential for Oral Diindolylmethane (DIM) Supplementation to Increase the Production of the BRCA1 Protein in BRCA1 Mutation Carriers

Breast Cancer

Canada
National Taiwan University Hospital

Unknown

Detection of EGFR Mutation in Malignant Pleural Effusion of Lung Cancer Patients and Cancer Cell Lines Establishment (EGFR)

NSCLC

Taiwan
National Taiwan University Hospital

Completed

Correlation of Genetic Polymorphism and Livedo Vasculitis

Livedo Vasculitis | Livedoid Vasculitis | Livedoid Vasculopathy | Genetic Pleomorphism | Leiden Mutation

Taiwan
Yonsei University

Unknown

Sorafenib and Erlotinib in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer That Has Not Responded to Chemotherapy

Lung Cancer

Korea, Republic of
Massachusetts General Hospital

Completed

Study of Sildenafil in Advanced Heart Failure.

Congestive Heart Failure
Memorial Sloan Kettering Cancer Center
American Cancer Society, Inc.

Completed

Adherence to Intensive Surveillance for Hereditary Breast Cancer

Breast Cancer

United States
Oxford University Hospitals NHS Trust

Unknown

Biomarkers in Patients at Risk of Developing Myelodysplastic Syndrome or Other Disorders and in Healthy Participants

Myelodysplastic Syndromes | Leukemia

United Kingdom
National Institute of Arthritis and Musculoskeletal...

Unknown

The Effects of Exercise Versus Inactivity on People With Mitochondrial Muscle Disease

Mitochondrial Myopathy

United States
National Cheng-Kung University Hospital

Unknown

Tailored Second Line Treatment by Epidermal Growth Factor Receptor (EGFR) Mutation in Patients With Advanced Lung Adenocarcinoma

Non-Small Cell Lung Cancer

Taiwan
Erasmus Medical Center
Leiden University Medical Center; ZonMw: The Netherlands Organisation for Health... and other collaborators

Unknown

Cost-Effectiveness in Bladder Cancer

Bladder Cancer
University of Utah
University of Witwatersrand, South Africa

Completed

A Novel Mutation of the Spectrin Gene

Hereditary Elliptocytosis (HE) | Hereditary Pyropoikilocytosis (HPP)

United States
Novartis Pharmaceuticals

Completed

Safety, Efficacy, Pharmacokinetics, Pharmacodynamics of ACZ885 in Patients With NALP3 Mutations and Clinical Symptoms

NALP3 Mutation

United Kingdom, France, Germany, India, Spain
Far Eastern Memorial Hospital
National Taiwan University Hospital; Fu Jen Catholic University

Unknown

Clinical Study and Gene Mutation Analysis of Adrenoleukodystrophy in Taiwanese Children

Adrenoleukodystrophy

Taiwan
Centre Hospitalier Universitaire de Nice

Unknown

Identification of Large-Scale Mutations of POLG Gene by QMPSF in Patients With Mitochondrial DNA Instability.

Mitochondrial Diseases | Diagnosis | DNA Mutations

France
National Institute of Nursing Research (NINR)

Completed

Family Health After Predictive Huntington Disease (HD) Testing

Huntington Disease

United States
PTC Therapeutics
Muscular Dystrophy Association

Completed

Safety and Efficacy Study of PTC124 in Duchenne Muscular Dystrophy

Duchenne Muscular Dystrophy

United States
PTC Therapeutics
Cystic Fibrosis Foundation; FDA Office of Orphan Products Development

Completed

PTC124 for Cystic Fibrosis

Cystic Fibrosis

United States
Aarhus University Hospital
Hoffmann-La Roche; University of Aarhus; The Ministry of Science, Technology...

Unknown

Mutations in the Epidermal Growth Factor Receptor(EGFR) Gene in Non-Small Cell Lung Carcinoma (NSCLC) and the Relation to Response of Treatment With Erlotinib

Non-Small Cell Lung Cancer

Denmark
Pfizer

Completed

A Randomized, Double-Blinded, Placebo-Controlled, Two-Way Crossover Study to Investigate the Safety and Toleration of Single Dose Sildenafil in Subjects Receiving Chronic UK-369,0031

Urinary Bladder, Overactive | Prostatic Hyperplasia | Erectile Dysfunction

Singapore
Johns Hopkins University

Completed

Effect of Nightly Versus Prn Sildenafil on Early Return of Erectile Function Following Laparoscopic Radical Prostatectomy

Prostate Cancer

United States
National Taiwan University Hospital

Unknown

Applying Proton Pump Inhibitor to Prevent and Treat Acute Fluctuating Hearing Loss in Patients With SLC26A4 Mutation

Hearing Loss

Taiwan
Istituto Clinico Humanitas

Completed

Retrospective Study Assessing Molecular Features Predicting Response to Cetuximab

Colorectal Neoplasms

Italy
HaEmek Medical Center, Israel
National Institutes of Health (NIH)

Completed

TSH Receptor Mutations Among a Consanguineous Community (TSHR)

Hypothyroidism

Israel, United States
Assistance Publique - Hôpitaux de Paris

Terminated

Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Amyotrophic Lateral Sclerosis | Frontotemporal Dementia

France
Orlando Immunology Center
GlaxoSmithKline

Completed

Evolution of L74V or K65R Mutations in VIremic Subjects on Tenofovir Disoproxil Fumarate (TDF) or Abacavir (ABC) (EVITA)

HIV Infections

United States
National Human Genome Research Institute (NHGRI)

Completed

Positional Cloning of the Gene(s) Responsible for Alagille Syndrome

Alagille Syndrome

United States
Eunice Kennedy Shriver National Institute of Child...

Completed

Estimation of the Carrier Frequency and Incidence of Smith-Lemli-Opitz Syndrome in African Americans

Smith-Lemli-Opitz Syndrome

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Factors Contributing to Increased Left Ventricle Size in Patients With Abnormally Enlarged Hearts

Hypertrophic Cardiomyopathy | Left Ventricular Hypertrophy

United States
National Institute of Allergy and Infectious Diseases...

Completed

Blood Factors in Mastocytosis and Unexplained Anaphylaxis and Flushing

Mastocytosis | Anaphylaxis

United States
National Institute of Neurological Disorders and...

Completed

Detecting Malignant Brain Tumor Cells in the Bloodstream During Surgery to Remove the Tumor

Glioma | Glioblastoma | Astrocytoma

United States
National Human Genome Research Institute (NHGRI)

Completed

Study of Skeletal Disorders and Short Stature

Dwarfism | Developmental Bone Disease | Skeletal Dysplasias

United States
National Eye Institute (NEI)

Completed

Cause of Pigment Dispersion Syndrome

Glaucoma | Healthy | Pigment Dispersion Syndrome

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Study of Muscle Abnormalities in Patients With Specific Genetic Mutations

Cardiomyopathy, Hypertrophic | Muscular Dystrophy, Oculopharyngeal

United States
National Cancer Institute (NCI)

Completed

Analysis of NF2 Mutations in Radiation-Related Neural Tumors

Neural Tumors

United States
Pediatrix

Completed

Demographic, Metabolic, and Genomic Description of Neonates With Severe Hyperbilirubinemia

Jaundice | Hyperbilirubinemia

United States
Institut National de la Santé Et de la Recherche...
National Institutes of Health (NIH)

Unknown

Parkin Mutations and Their Functional Consequences

Parkinson's Disease

France
Chungnam National University

Completed

Pyrosequencing of the BRAFV600E Mutation

Thyroid Neoplasms

Korea, Republic of
Eli Lilly and Company
ICOS Corporation

Completed

Study For Which Treatment, Tadalafil or Sildenafil, is Preferred For Problems Getting or Maintaining an Erection

Impotence

United Kingdom
Eli Lilly and Company
ICOS Corporation

Completed

Studying the Preference of Tadalafil to Sildenafil in Men With Problems Getting an Erection Across Nations

Impotence

Brazil
Baystate Medical Center

Completed

Effect of Counseling on Psychological Stress Amongst Women Felt to be at High Risk for Breast Cancer Development

Breast Cancer

United States
Ruhr University of Bochum

Completed

Acute Effects of Sildenafil on Endothelial Function in People With Diabetes

Type 2 Diabetes Mellitus | Endothelial Dysfunction

Germany

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