Clinical Trials Sponsored by National Institute for Health and Clinical Excellence

Total 3920 results

National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Williams Syndrome (WS) and Supravalvar Aortic Stenosis (SVAS) DNA and Tissue Bank

Cardiovascular Disease | Williams Syndrome | Supravalvular Aortic Stenosis

United States
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Nebulized or Inhaled Albuterol for Lymphangioleiomyomatosis

Lymphangioleiomyomatosis

United States
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System

Parkinson's Disease | Atherosclerosis | Cardiomyopathy | Li-Fraumeni Syndrome | Cardiovascular Capacity

United States
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Natural History Study of Monoclonal B Cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL), Lymphoplasmacytic Lymphoma (LPL)/Waldenstrom Macroglobulinemia (WM), and Splenic Marginal Zone Lymphoma (SMZL)

Waldenstrom Macroglobulinemia | Lymphoplasmacytic Lymphoma | Small Lymphocytic Lymphoma | CLL (Chronic Lymphocytic Leukemia) | Monoclonal B-Cell Lymphocytosis

United States
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Collection of Lung Fluid and Tissue Samples for Research

Respiratory Tract Diseases | Leukocyte Disorders | Bronchoscopy

United States
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Causes and Natural History of Dyslipidemias

Atherosclerosis | Hypercholesterolemia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Collection of Tissue Specimens From Patients With Solid Tumors or Blood Disorders and Their HLA-Compatible Family Members

Neoplasms | Hematologic Neoplasms | Healthy Volunteers

United States
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Genetic Basis of Immunodeficiency

Severe Combined Immunodeficiency

United States
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Blood Collection for Research Related to Certain Diseases Involving Blood Vessels

Sickle Cell Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Study of the Disease Process of Lymphangioleiomyomatosis

Pneumothorax | Tuberous Sclerosis | Lung Disease | Lymphangioleiomyomatosis

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Intravenous ACP-501 for Familial LCAT Deficiency (rhLCAT)

Familial LCAT Deficiency

United States
National Heart, Lung, and Blood Institute (NHLBI)

Enrolling by invitation

Data Collection of Standard Care and Evaluation of NHLBI Patients and Donors

Hematologic Diseases | Wide Spectrum of Diseases

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Cellular and Molecular Characterization of the Immune Response in Healthy NIH Employees atBaseline, and After Immunization With the H1N1 or Seasonal Influenza Vaccines

Influenza | Healthy Volunteers

United States
National Heart, Lung, and Blood Institute (NHLBI)

Active, not recruiting

Evaluation of Lipoproteins

Evaluation of Plasma Lipoproteins

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Pathophysiology of Acute Pain in Patients With Sickle Cell Disease

Sickle Cell Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

CADASIL Disease Discovery

Cardiovascular Disease | Arterial Stiffness | Germline Mutation in the NOTCH 3 Gene | Pathogenesis of CADASIL | Clinical Phenotype of CADASIL

United States
National Heart, Lung, and Blood Institute (NHLBI)

Enrolling by invitation

Investigating the Mechanistic Effects of Mitapivat in Subjects With Sickle Cell Disease

Sickle Cell Anemia | Sickle Beta Thalassemia | Sickle Cell Thalassemia | Sickle Beta Zero Thalassemia | Sickle Cell Pain | Hbss | Hbsc | Sickle Cell Syndrome Variant

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Lipoprotein Metabolism in Normal Volunteers and Patients With High Levels of Lipoproteins

Dyslipidemia | Hypercholesterolemia | Hyperlipidemia | Hypolipoproteinemia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Active, not recruiting

Venous Thrombosis Biomarkers in Sickle Cell Disease and Sickle Cell Trait

Venous Thrombosis | Sickle Cell Disease | Venous Thromboembolism | Sickle Cell Trait | Hypercoagulable State

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Natural History Study for BEN

Hematologic Diseases | Neutropenia | Agranulocytosis | Leukopenia | Leukocyte Disorders

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Collections of Blood and Stool Samples in Patients With Acute Hepatitis

Hepatitis

United States
National Heart, Lung, and Blood Institute (NHLBI)

Active, not recruiting

Improving the Results of Bone Marrow Transplantation for Patients With Severe Congenital Anemias

Sickle Cell Disease | Congenital Hemolytic Anemia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Terminated

CT COMPARE: CT Coronary Angiography to Measure Plaque Reduction

Cardiovascular Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Characterization of Apolipoprotein A-I Pathways in Idiopathic Pulmonary Fibrosis

Idiopathic Pulmonary Fibrosis

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Extracellular RNAs in Relation to Cardiometabolic Risk

Obesity | Blood Pressure | Subclinical Atherosclerotic Cardiovascular Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)

Active, not recruiting

Haploidentical PBMC Transplant for Severe Congenital Anemias

Sickle Cell Anemia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Best Noninvasive Predictor of Renal Function in Assessing Adult Sickle Nephropathy

Sickle Cell Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Stem Cell Transplant Therapy With Campath-1H for Treating Advanced Mycosis Fungoides and Sezary Syndrome

Mycosis Fungoides | Sezary Syndrome

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

A Pilot Study of a Thrombopoietin-Receptor Agonist, Eltrombopag, in Patients With Low to Int-2 Risk Myelodysplastic Syndrome (MDS)

Myelodysplastic Syndromes | Thrombocytopenia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

NHLBI DIR LAMPOON Study: Intentional Laceration of the Anterior Mitral Leaflet to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Implantation

Mitral Valve Failure

United States
National Heart, Lung, and Blood Institute (NHLBI)

Active, not recruiting

PCI-32765 for Special Cases of Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Leukemia | CLL (Chronic Lymphocytic Leukemia) | Leukemia, Lymphocytyc | SLL (Small Lymphocytic Lymphoma)

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

COV2Base-A Rare Disease by COVID Study

Chronic Health Conditions | Older Age is Associated With Increased Pathogenicity

United States
National Heart, Lung, and Blood Institute (NHLBI)

Withdrawn

Structural Heart and Valve Network PROSPECTIVE Registry

Heart Failure | Aortic Valve Stenosis | Mitral Valve Regurgitation | Heart Valve Disease | Tricuspid Valve Regurgitation

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Model System for Transient Forearm Blood Vessel Dysfunction

Ischemic Preconditioning | Limb Ischemia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Fostamatinib for Hospitalized Adults With COVID-19

Coronavirus Disease 2019

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

HEPLISAV-B Hepatitis B Vaccine in Chronic Lymphocytic Leukemia (CLL) and CLL Treated With Bruton's-Tyrosine Kinase Inhibitor (BTK-I)

Hepatitis | Safety and Tolerability

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Effectiveness of the Hepatitis B Vaccine Post-Hematopoietic Stem Cell Transplant

Hepatitis B

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Comparison of Cardiac Computed Tomography and Vasodilator Stress Magnetic Resonance Imaging Perfusion in Patients With Prior Equivocal Stress Test for Detection of Coronary Artery Disease

Coronary Artery Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Role of p53 Gene in Metabolism Regulation in Patients With Li-Fraumeni Syndrome

Mitochondrial Disorders | Li-Fraumeni Syndrome | Carriers of p53 Mutation

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Role of Helicobacter Pylori and Its Toxins in Lung and Digestive System Diseases

Asthma | Pulmonary Fibrosis | Lymphangioleiomyomatosis | Pulmonary Disease | Sarcoidosis | Oropharyngeal Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

G-CSF and AMD3100 to Mobilize Stem Cells in Healthy Volunteers

Healthy

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Phosphodiesterase Type-5 Inhibitor Therapy in Sickle Cell People With Pulmonary Hypertension

Sickle Cell Disease | Pulmonary Hypertension

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Technical Development of Cardiovascular Magnetic Resonance Imaging

Cardiovascular Disease | Congenital Heart Disease | Acute Myocardial Infarction | Cardiomyopathy | Cardiac Magnetic Resonance Imaging

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Horse ATG/CsA in Aplastic Anemia Patients Unresponsive to or With a Suboptimal Response to Rabbit ATG/CsA Treatment

Anemia, Aplastic | Anemia, Hypoplastic

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Evaluation of Patients With Heart Disease Not Eligible for Research Protocols

Cardiovascular Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Genetics and Pain Severity in Sickle Cell Disease

Pain | Genotype | Genetic Variation | Quantitative Sensory Testing (QST) | GCH1

United States
National Heart, Lung, and Blood Institute (NHLBI)

Terminated

The Effect of Nicotinamide Riboside on Skeletal Muscle Function in Heart Failure Subjects

Heart Failure

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Comparing Therapies for the Treatment of Severe Aplastic Anemia

Severe Aplastic Anemia (SAA)

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Extension Study (Extended Access) of Cyclosporine Inhalation Solution (CIS) in Lung Transplant and Hematopoietic Stem Cell Transplant Recipients for the Treatment of Bronchiolitis Obliterans

Bronchiolitis Obliterans | Graft Versus Host Disease | Graft-Versus-Host Disease | Constructive Bronchiolitis | Bronchiolitis, Exudative | Bronchiolitis, Proliferative

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

dbGaP Protocol: The Pediatric Cardiac Genetics Consortium (PCGC)

Congenital Heart Disease

United States

Clinical Trials Sponsored by National Institute for Health and Clinical Excellence

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