Search clinical trials for: CYP3A inhibitors

Total 64766 results

Weill Medical College of Cornell University
Onyx Therapeutics, Inc.

Active, not recruiting

Carfilzomib, Clarithromycin (Biaxin®), Lenalidomide (Revlimid®), and Dexamethasone (Decadron®) [Car-BiRD] Therapy for Subjects With Multiple Myeloma (CarBiRD)

Multiple Myeloma

United States
Merck Sharp & Dohme LLC

Completed

Safety and Efficacy of Doravirine (MK-1439) in Participants With Human Immunodeficiency Virus 1 (HIV-1) (MK-1439-018) (DRIVE-FORWARD)

HIV-1
Vertex Pharmaceuticals Incorporated

Completed

Evaluation of the Effects of Omeprazole and Rifampin on the Pharmacokinetics of VX-548 in Healthy Participants

Pain

Australia
AstraZeneca

Completed

Study to Assess the Effect of Itraconazole (a CYP3A4 Inhibitor) on the Pharmacokinetics of AZD9291, in Patients With EGFR Positive Non-small Cell Lung Cancer. Patients Will be Chosen From Those Who Have Already Been Prescribed an EGFR TKI Medicine (Such as Iressa or Tarceva)

Advanced Non Small Cell Lung Cancer | Advanced (Inoperable) Non Small Cell Lung Cancer

Belgium, United States, Korea, Republic of, Taiwan, United Kingdom, Netherlands
Helwan University

Completed

Safety and Efficacy of Triple and Quadruple Regimens as First Line Therapy for Management of Helicobacter Pylori Infection in Egyptians

H.Pylori Infection

Egypt
University of New Mexico
Patient-Centered Outcomes Research Institute; Montana State University; National... and other collaborators

Terminated

Longitudinal Comparative Effectiveness of Bipolar Disorder Therapies

Bipolar Disorder

United States
Eli Lilly and Company

Terminated

A Study of LY3154885 in Healthy Participants

Healthy

United States
Taro Pharmaceuticals USA

Completed

A Study Comparing Ketoconazole Shampoo, 2% and Ketoconazole 2% Shampoo (RS) in the Treatment of Tinea Versicolor.

Tinea Versicolor

United States
Mario Negri Institute for Pharmacological Research
Ministry of Health, Italy; Azienda Ospedaliera San Gerardo di Monza

Active, not recruiting

Low vs. Standard Daily Doses of Antiepileptic Drugs in Newly Diagnosed, Previously Untreated Epilepsy(STANDLOW) (STANDLOW)

Epilepsies, Partial

Italy
IRCCS Policlinico S. Matteo
Oslo University Hospital; University of the Basque Country (UPV/EHU); The Hospital...

Completed

AMSA and Amiodarone Study in Cardiac Arrest (MOSAIC)

Out-Of-Hospital Cardiac Arrest

Italy, Norway, Spain
Boehringer Ingelheim

Completed

A Study in Healthy Men to Test How Itraconazole Influences the Amount of BI 474121 in the Blood

Healthy

Germany
Global Alliance for TB Drug Development

Completed

Trial to Evaluate the Efficacy, Safety and Tolerability of BPaMZ in Drug-Sensitive (DS-TB) Adult Patients and Drug-Resistant (DR-TB) Adult Patients

Tuberculosis | Tuberculosis, Pulmonary | Tuberculosis, Multidrug-Resistant | Tuberculosis, MDR | Drug-Resistant Tuberculosis

Tanzania, Georgia, Russian Federation, Brazil, Malaysia, Philippines, South Africa, Uganda
Boehringer Ingelheim

Completed

Drug-drug Interaction Trial Between Rifampicin and BI 409306 in Healthy Volunteers

Healthy

Germany
Hutchmed

Completed

HMPL-689 Drug Interaction Study With CYP3A Inhibitor/CYP2C9 Inhibitor/CYP3A Inducer/PPI

Relapsed or Refractory Lymphoma

United States
Harlan M Krumholz
Pfizer

Active, not recruiting

A Decentralized, Randomized Phase 2 Efficacy and Safety Study of Nirmatrelvir/Ritonavir in Adults With Long COVID. (PAXLC)

Long COVID

United States
Scynexis, Inc.

Completed

Study to Evaluate the Safety and Efficacy of the Coadministration of Ibrexafungerp (SCY-078) With Voriconazole in Patients With Invasive Pulmonary Aspergillosis (SCYNERGIA)

Invasive Pulmonary Aspergillosis

United States, Belgium, Canada, Germany, South Africa
National Cancer Institute (NCI)

Terminated

Ketoconazole With or Without Alendronate Sodium in Treating Patients With Metastatic Prostate Cancer

Recurrent Prostate Cancer | Bone Metastases | Adenocarcinoma of the Prostate | Stage IV Prostate Cancer

United States
Shionogi

Completed

Effect of Administration of Itraconazole on the Pharmacokinetics of S-309309 in Healthy Participants

Obesity | Healthy Volunteers

United States
Jiangsu HengRui Medicine Co., Ltd.

Completed

Effect of Rifampicin on the Pharmacokinetics of HRS-1167 in Healthy Subjects

Advanced Solid Tumor

China
Vanderbilt University Medical Center
AbbVie

Completed

Trial of Early Therapies During Non-hospitalized Outpatient Window for COVID-19 (TREATNOW)

COVID-19

United States
The HIV Netherlands Australia Thailand Research...
King Chulalongkorn Memorial Hospital; Srinagarind Hospital, Khon Kaen University and other collaborators

Active, not recruiting

Tuberculosis Preventive Therapy Among Latent Tuberculosis Infection in HIV-infected Individuals

HIV-infected Participants With Latent TB Infection in High TB Burden Country

Thailand
The HIV Netherlands Australia Thailand Research...
Khon Kaen University

Active, not recruiting

A Prospective Cohort of Children With HIV Infection

HIV Infections

Thailand
Amgen

Active, not recruiting

AMG 176 First in Human Trial in Participants With Relapsed or Refractory Multiple Myeloma and Participants With Relapsed or Refractory Acute Myeloid Leukemia

Relapsed or Refractory Multiple Myeloma | Relapsed or Refractory Acute Myeloid Leukemia

United States, Australia, Japan, Germany, Canada
KBP Biosciences
Covance

Completed

Drug to Drug Interaction Study of KBP-5074 in Healthy Subjects

Healthy | Drug Drug Interaction

United States
WakeMed Health and Hospitals
Helios Cardio Inc

Completed

Prevention of Post-OP AFib Using Combination of CardiaMend and Amiodarone (CAMP POAF)

Post Operative Atrial Fibrillation

United States
Boehringer Ingelheim

Completed

A Study in Healthy Men to Test How Itraconazole Influences the Amount of BI 1323495 in the Blood

Healthy

Germany
ViiV Healthcare
GlaxoSmithKline

Completed

A Study to Determine Safety and Efficacy of Dolutegravir/Abacavir/Lamivudine (DTG/ABC/3TC) in Human Immunodeficiency Virus (HIV)-1 Infected Antiretroviral Therapy (ART) Naïve Women (ARIA)

HIV Infections | Infection, Human Immunodeficiency Virus

United States, France, Spain, United Kingdom, Canada, Thailand, Italy, Portugal, Russian Federation, Mexico, Argentina, South Africa, Puerto Rico
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Completed

Tepotinib Drug-Drug Interaction Study With Itraconazole in Healthy Participants

Healthy

Germany
Bellus Health Inc. - a GSK company

Completed

Evaluation of the Effect of Rifampin and Rabeprazole on the Pharmacokinetics of Camlipixant

Healthy

Canada
Kilimanjaro Clinical Research Institute
European and Developing Countries Clinical Trials Partnership (EDCTP)

Completed

Evaluation of Pharmacokinetics and Safety Tolerability of Higher Doses of Rifampic (HighRif C)

Clinical Trial

Tanzania
Institute of Tropical Medicine, Belgium
Damien Foundation

Active, not recruiting

Novel Triple-dose Tuberculosis Retreatment Regimen (Tri-Do-Re)

Tuberculosis | Pulmonary Tuberculosis | Multidrug-resistant Tuberculosis | Resistance to Tuberculostatic Drugs

Niger
Castagna Antonella
Bristol-Myers Squibb; ViiV Healthcare

Completed

A Study of a Nucleoside Sparing Regimen in HIV-1 Infected Patients With Detectable Viremia (Dolatav)

HIV-1 Infection

Italy
National Institute of Public Health, Slovenia
Community Healthcare Center dr. Adolf Drolc Maribor (HCM)

Enrolling by invitation

Feasibility Study of the Proposed Test-and-treat Screening Program in Younger Participants With H. Pylori Infection

Helicobacter Pylori Infection

Slovenia
Italfarmaco

Completed

The Potential of Givinostat as DDI Victim in Co-administration P-gp Inhibitor (Part 2)

Drug Drug Interaction

Portugal
IRCCS San Raffaele
Bristol-Myers Squibb

Completed

Efficacy of Atazanavir/Ritonavir Monotherapy as Maintenance in Patients With Viral Suppression

HIV-1 Infection

Italy
Chinese University of Hong Kong

Completed

Safety and Clinical and Virologic Outcomes in CKD Patients Treated With Nirmatrelvir-ritonavir

COVID-19 | Chronic Kidney Disease stage4 | Chronc Kidney Disease Stage 5

Hong Kong
Suzhou Zelgen Biopharmaceuticals Co.,Ltd

Completed

A Study to Evaluate the Effect of Itraconazole and Rifampicin on the Pharmacokinetics of Jaktinib in Healthy Volunteers

Healthy Volunteers

China
Takeda

Completed

A Study of the Interaction of TAK-279 With Substances That Have an Impact on Metabolism in Healthy Adults

Healthy Volunteers

United States
Reata, a wholly owned subsidiary of Biogen
Celerion; Q2 Solutions; Altasciences Company Inc.

Completed

An Open-label DDI Study of Omaveloxolone in Healthy Subjects

Healthy Adult Subjects

United States
Reata, a wholly owned subsidiary of Biogen
Covance

Completed

A Clinical Drug-Drug Interaction (DDI) Study With Omaveloxolone

Healthy Adult Subjects

United States
University of Michigan Rogel Cancer Center

Withdrawn

Phase IV Multi-arm Study of CDK4/6 Pharmacokinetics in Healthy Volunteers With Known CYP3A4*22 Genotype

CYP3A4*22
Reata, a wholly owned subsidiary of Biogen

Completed

Effect of Itraconazole on the Pharmacokinetics of Bardoxolone Methyl in Healthy Adults

Healthy Volunteers

United States
University Hospital, Bordeaux

Completed

Targeting TFPI With Concizumab to Improve Haemostasis in Glanzmann Thrombasthenia Patients: an in Vitro Study (GLAT)

Glanzmann Thrombasthenia

France
Guangdong Raynovent Biotech Co., Ltd

Completed

Drug-durg Interaction of ZSP1273 With Digoxin, Rosuvastatin,Itraconazole and Probenecid

Drug Drug Interaction

China
Alexandria University

Completed

The Antibiogram and Outcomes of Antimicrobial Regimens in Microbial Keratitis: A Prospective Cohort Study

Bacterial Keratitis | Fungal Keratitis | Mixed Bacterial and Fungal Keratitis | Microbial Keratitis

Egypt
Pfizer

Completed

A Study to Learn About the Study Medicines (Nirmatrelvir Plus Ritonavir) in People Aged 12 Years or Older With COVID-19 and a Compromised Immune System

COVID-19

Spain, United States, Australia, Canada, Bulgaria, Slovakia, Mexico, Hungary, Brazil
Dong-A ST Co., Ltd.

Completed

Evaluate the Effect of Clarithromycin/Rifampicin on the Pharmacokinetics of DA-8010 in Healthy Adults

Healthy

Korea, Republic of
Eli Lilly and Company
Loxo Oncology, Inc.

Completed

A Study of the Effects of Itraconazole or Carbamazepine on LY3537982 in Healthy Participants

Healthy

United States
Hill Dermaceuticals, Inc.
Abond CRO Inc.

Completed

Efficacy and Safety Study of Miconazole Oil Versus Vehicle on Fungal Infection of the Ear Canal (Otomycosis)

Otomycosis

United States
Merck Sharp & Dohme LLC

Completed

A Study of the Safety and Efficacy of Posaconazole Versus Voriconazole for the Treatment of Invasive Aspergillosis (MK-5592-069)

Invasive Pulmonary Aspergillosis | Fungal Infections

Search clinical trials for: CYP3A inhibitors

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